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Characterization of human embryonic stem cell lines by the International Stem Cell Initiative

The International Stem Cell Initiative characterized 59 human embryonic stem cell lines from 17 laboratories worldwide. Despite diverse genotypes and different techniques used for derivation and maintenance, all lines exhibited similar expression patterns for several markers of human embryonic stem... Full description

Journal Title: Nature biotechnology 2007-07, Vol.25 (7), p.803-816
Main Author: Adewumi, Oluseun
Other Authors: Aflatoonian, Behrouz , Ahrlund-Richter, Lars , Amit, Michal , Andrews, Peter W , Beighton, Gemma , Bello, Paul A , Benvenisty, Nissim , Berry, Lorraine S , Bevan, Simon , Blum, Barak , Brooking, Justin , Chen, Kevin G , Choo, Andre B H , Churchill, Gary A , Corbel, Marie , Damjanov, Ivan , Draper, Jon S , Dvorak, Petr , Emanuelsson, Katarina , Fleck, Roland A , Ford, Angela , Gertow, Karin , Gertsenstein, Marina , Gokhale, Paul J , Hamilton, Rebecca S , Hampl, Ales , Healy, Lyn E , Hovatta, Outi , Hyllner, Johan , Imreh, Marta P , Itskovitz-Eldor, Joseph , Jackson, Jamie , Johnson, Jacqueline L , Jones, Mark , Kee, Kehkooi , King, Benjamin L , Knowles, Barbara B , Lako, Majlinda , Lebrin, Franck , Mallon, Barbara S , Manning, Daisy , Mayshar, Yoav , McKay, Ronald D G , Michalska, Anna E , Mikkola, Milla , Mileikovsky, Masha , Minger, Stephen L , Moore, Harry D , Mummery, Christine L , Nagy, Andras , Nakatsuji, Norio , O'Brien, Carmel M , Oh, Steve K W , Olsson, Cia , Otonkoski, Timo , Park, Kye-Yoon , Passier, Robert , Patel, Hema , Patel, Minal , Pedersen, Roger , Pera, Martin F , Piekarczyk, Marian S , Pera, Renee A Reijo , Reubinoff, Benjamin E , Robins, Allan J , Rossant, Janet , Rugg-Gunn, Peter , Schulz, Thomas C , Semb, Henrik , Sherrer, Eric S , Siemen, Henrike , Stacey, Glyn N , Stojkovic, Miodrag , Suemori, Hirofumi , Szatkiewicz, Jin , Turetsky, Tikva , Tuuri, Timo , van den Brink, Steineke , Vintersten, Kristina , Vuoristo, Sanna , Ward, Dorien , Weaver, Thomas A , Young, Lesley A , Zhang, Weidong
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: New York, NY: Nature Publishing Group
ID: ISSN: 1087-0156
Zum Text:
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title: Characterization of human embryonic stem cell lines by the International Stem Cell Initiative
format: Article
creator:
  • Adewumi, Oluseun
  • Aflatoonian, Behrouz
  • Ahrlund-Richter, Lars
  • Amit, Michal
  • Andrews, Peter W
  • Beighton, Gemma
  • Bello, Paul A
  • Benvenisty, Nissim
  • Berry, Lorraine S
  • Bevan, Simon
  • Blum, Barak
  • Brooking, Justin
  • Chen, Kevin G
  • Choo, Andre B H
  • Churchill, Gary A
  • Corbel, Marie
  • Damjanov, Ivan
  • Draper, Jon S
  • Dvorak, Petr
  • Emanuelsson, Katarina
  • Fleck, Roland A
  • Ford, Angela
  • Gertow, Karin
  • Gertsenstein, Marina
  • Gokhale, Paul J
  • Hamilton, Rebecca S
  • Hampl, Ales
  • Healy, Lyn E
  • Hovatta, Outi
  • Hyllner, Johan
  • Imreh, Marta P
  • Itskovitz-Eldor, Joseph
  • Jackson, Jamie
  • Johnson, Jacqueline L
  • Jones, Mark
  • Kee, Kehkooi
  • King, Benjamin L
  • Knowles, Barbara B
  • Lako, Majlinda
  • Lebrin, Franck
  • Mallon, Barbara S
  • Manning, Daisy
  • Mayshar, Yoav
  • McKay, Ronald D G
  • Michalska, Anna E
  • Mikkola, Milla
  • Mileikovsky, Masha
  • Minger, Stephen L
  • Moore, Harry D
  • Mummery, Christine L
  • Nagy, Andras
  • Nakatsuji, Norio
  • O'Brien, Carmel M
  • Oh, Steve K W
  • Olsson, Cia
  • Otonkoski, Timo
  • Park, Kye-Yoon
  • Passier, Robert
  • Patel, Hema
  • Patel, Minal
  • Pedersen, Roger
  • Pera, Martin F
  • Piekarczyk, Marian S
  • Pera, Renee A Reijo
  • Reubinoff, Benjamin E
  • Robins, Allan J
  • Rossant, Janet
  • Rugg-Gunn, Peter
  • Schulz, Thomas C
  • Semb, Henrik
  • Sherrer, Eric S
  • Siemen, Henrike
  • Stacey, Glyn N
  • Stojkovic, Miodrag
  • Suemori, Hirofumi
  • Szatkiewicz, Jin
  • Turetsky, Tikva
  • Tuuri, Timo
  • van den Brink, Steineke
  • Vintersten, Kristina
  • Vuoristo, Sanna
  • Ward, Dorien
  • Weaver, Thomas A
  • Young, Lesley A
  • Zhang, Weidong
subjects:
  • Alkaline Phosphatase - metabolism
  • Antigens, CD - biosynthesis
  • Basic Medicine
  • Biological and medical sciences
  • Biotechnology
  • Biotechnology - methods
  • Cell and Molecular Biology
  • Cell Differentiation
  • Cell Lineage
  • Cell Membrane - metabolism
  • Cell- och molekylärbiologi
  • Cells, Cultured
  • Cluster Analysis
  • Comparative studies
  • Embryonic Stem Cells - cytology
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Gene Expression Profiling
  • Gene Expression Regulation, Developmental
  • Genetic markers
  • Genotype
  • Genotype & phenotype
  • Glycolipids - chemistry
  • Humans
  • Medical and Health Sciences
  • MEDICIN
  • Medicin och hälsovetenskap
  • MEDICINE
  • Medicinska och farmaceutiska grundvetenskaper
  • Membrane Glycoproteins - biosynthesis
  • Mycoplasma
  • Research centers
  • Stem cells
  • Tetraspanin 29
ispartof: Nature biotechnology, 2007-07, Vol.25 (7), p.803-816
description: The International Stem Cell Initiative characterized 59 human embryonic stem cell lines from 17 laboratories worldwide. Despite diverse genotypes and different techniques used for derivation and maintenance, all lines exhibited similar expression patterns for several markers of human embryonic stem cells. They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3. Nevertheless, the lines were not identical: differences in expression of several lineage markers were evident, and several imprinted genes showed generally similar allele-specific expression patterns, but some gene-dependent variation was observed. Also, some female lines expressed readily detectable levels of XIST whereas others did not. No significant contamination of the lines with mycoplasma, bacteria or cytopathic viruses was detected.
language: eng
source:
identifier: ISSN: 1087-0156
fulltext: no_fulltext
issn:
  • 1087-0156
  • 1546-1696
  • 1546-1696
url: Link


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titleCharacterization of human embryonic stem cell lines by the International Stem Cell Initiative
creatorAdewumi, Oluseun ; Aflatoonian, Behrouz ; Ahrlund-Richter, Lars ; Amit, Michal ; Andrews, Peter W ; Beighton, Gemma ; Bello, Paul A ; Benvenisty, Nissim ; Berry, Lorraine S ; Bevan, Simon ; Blum, Barak ; Brooking, Justin ; Chen, Kevin G ; Choo, Andre B H ; Churchill, Gary A ; Corbel, Marie ; Damjanov, Ivan ; Draper, Jon S ; Dvorak, Petr ; Emanuelsson, Katarina ; Fleck, Roland A ; Ford, Angela ; Gertow, Karin ; Gertsenstein, Marina ; Gokhale, Paul J ; Hamilton, Rebecca S ; Hampl, Ales ; Healy, Lyn E ; Hovatta, Outi ; Hyllner, Johan ; Imreh, Marta P ; Itskovitz-Eldor, Joseph ; Jackson, Jamie ; Johnson, Jacqueline L ; Jones, Mark ; Kee, Kehkooi ; King, Benjamin L ; Knowles, Barbara B ; Lako, Majlinda ; Lebrin, Franck ; Mallon, Barbara S ; Manning, Daisy ; Mayshar, Yoav ; McKay, Ronald D G ; Michalska, Anna E ; Mikkola, Milla ; Mileikovsky, Masha ; Minger, Stephen L ; Moore, Harry D ; Mummery, Christine L ; Nagy, Andras ; Nakatsuji, Norio ; O'Brien, Carmel M ; Oh, Steve K W ; Olsson, Cia ; Otonkoski, Timo ; Park, Kye-Yoon ; Passier, Robert ; Patel, Hema ; Patel, Minal ; Pedersen, Roger ; Pera, Martin F ; Piekarczyk, Marian S ; Pera, Renee A Reijo ; Reubinoff, Benjamin E ; Robins, Allan J ; Rossant, Janet ; Rugg-Gunn, Peter ; Schulz, Thomas C ; Semb, Henrik ; Sherrer, Eric S ; Siemen, Henrike ; Stacey, Glyn N ; Stojkovic, Miodrag ; Suemori, Hirofumi ; Szatkiewicz, Jin ; Turetsky, Tikva ; Tuuri, Timo ; van den Brink, Steineke ; Vintersten, Kristina ; Vuoristo, Sanna ; Ward, Dorien ; Weaver, Thomas A ; Young, Lesley A ; Zhang, Weidong
creatorcontribAdewumi, Oluseun ; Aflatoonian, Behrouz ; Ahrlund-Richter, Lars ; Amit, Michal ; Andrews, Peter W ; Beighton, Gemma ; Bello, Paul A ; Benvenisty, Nissim ; Berry, Lorraine S ; Bevan, Simon ; Blum, Barak ; Brooking, Justin ; Chen, Kevin G ; Choo, Andre B H ; Churchill, Gary A ; Corbel, Marie ; Damjanov, Ivan ; Draper, Jon S ; Dvorak, Petr ; Emanuelsson, Katarina ; Fleck, Roland A ; Ford, Angela ; Gertow, Karin ; Gertsenstein, Marina ; Gokhale, Paul J ; Hamilton, Rebecca S ; Hampl, Ales ; Healy, Lyn E ; Hovatta, Outi ; Hyllner, Johan ; Imreh, Marta P ; Itskovitz-Eldor, Joseph ; Jackson, Jamie ; Johnson, Jacqueline L ; Jones, Mark ; Kee, Kehkooi ; King, Benjamin L ; Knowles, Barbara B ; Lako, Majlinda ; Lebrin, Franck ; Mallon, Barbara S ; Manning, Daisy ; Mayshar, Yoav ; McKay, Ronald D G ; Michalska, Anna E ; Mikkola, Milla ; Mileikovsky, Masha ; Minger, Stephen L ; Moore, Harry D ; Mummery, Christine L ; Nagy, Andras ; Nakatsuji, Norio ; O'Brien, Carmel M ; Oh, Steve K W ; Olsson, Cia ; Otonkoski, Timo ; Park, Kye-Yoon ; Passier, Robert ; Patel, Hema ; Patel, Minal ; Pedersen, Roger ; Pera, Martin F ; Piekarczyk, Marian S ; Pera, Renee A Reijo ; Reubinoff, Benjamin E ; Robins, Allan J ; Rossant, Janet ; Rugg-Gunn, Peter ; Schulz, Thomas C ; Semb, Henrik ; Sherrer, Eric S ; Siemen, Henrike ; Stacey, Glyn N ; Stojkovic, Miodrag ; Suemori, Hirofumi ; Szatkiewicz, Jin ; Turetsky, Tikva ; Tuuri, Timo ; van den Brink, Steineke ; Vintersten, Kristina ; Vuoristo, Sanna ; Ward, Dorien ; Weaver, Thomas A ; Young, Lesley A ; Zhang, Weidong ; International Stem Cell Initiative ; The International Stem Cell Initiative
descriptionThe International Stem Cell Initiative characterized 59 human embryonic stem cell lines from 17 laboratories worldwide. Despite diverse genotypes and different techniques used for derivation and maintenance, all lines exhibited similar expression patterns for several markers of human embryonic stem cells. They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3. Nevertheless, the lines were not identical: differences in expression of several lineage markers were evident, and several imprinted genes showed generally similar allele-specific expression patterns, but some gene-dependent variation was observed. Also, some female lines expressed readily detectable levels of XIST whereas others did not. No significant contamination of the lines with mycoplasma, bacteria or cytopathic viruses was detected.
identifier
0ISSN: 1087-0156
1ISSN: 1546-1696
2EISSN: 1546-1696
3DOI: 10.1038/nbt1318
4PMID: 17572666
5CODEN: NABIF9
languageeng
publisherNew York, NY: Nature Publishing Group
subjectAlkaline Phosphatase - metabolism ; Antigens, CD - biosynthesis ; Basic Medicine ; Biological and medical sciences ; Biotechnology ; Biotechnology - methods ; Cell and Molecular Biology ; Cell Differentiation ; Cell Lineage ; Cell Membrane - metabolism ; Cell- och molekylärbiologi ; Cells, Cultured ; Cluster Analysis ; Comparative studies ; Embryonic Stem Cells - cytology ; Female ; Fundamental and applied biological sciences. Psychology ; Gene Expression Profiling ; Gene Expression Regulation, Developmental ; Genetic markers ; Genotype ; Genotype & phenotype ; Glycolipids - chemistry ; Humans ; Medical and Health Sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Medicinska och farmaceutiska grundvetenskaper ; Membrane Glycoproteins - biosynthesis ; Mycoplasma ; Research centers ; Stem cells ; Tetraspanin 29
ispartofNature biotechnology, 2007-07, Vol.25 (7), p.803-816
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0Adewumi, Oluseun
1Aflatoonian, Behrouz
2Ahrlund-Richter, Lars
3Amit, Michal
4Andrews, Peter W
5Beighton, Gemma
6Bello, Paul A
7Benvenisty, Nissim
8Berry, Lorraine S
9Bevan, Simon
10Blum, Barak
11Brooking, Justin
12Chen, Kevin G
13Choo, Andre B H
14Churchill, Gary A
15Corbel, Marie
16Damjanov, Ivan
17Draper, Jon S
18Dvorak, Petr
19Emanuelsson, Katarina
20Fleck, Roland A
21Ford, Angela
22Gertow, Karin
23Gertsenstein, Marina
24Gokhale, Paul J
25Hamilton, Rebecca S
26Hampl, Ales
27Healy, Lyn E
28Hovatta, Outi
29Hyllner, Johan
30Imreh, Marta P
31Itskovitz-Eldor, Joseph
32Jackson, Jamie
33Johnson, Jacqueline L
34Jones, Mark
35Kee, Kehkooi
36King, Benjamin L
37Knowles, Barbara B
38Lako, Majlinda
39Lebrin, Franck
40Mallon, Barbara S
41Manning, Daisy
42Mayshar, Yoav
43McKay, Ronald D G
44Michalska, Anna E
45Mikkola, Milla
46Mileikovsky, Masha
47Minger, Stephen L
48Moore, Harry D
49Mummery, Christine L
50Nagy, Andras
51Nakatsuji, Norio
52O'Brien, Carmel M
53Oh, Steve K W
54Olsson, Cia
55Otonkoski, Timo
56Park, Kye-Yoon
57Passier, Robert
58Patel, Hema
59Patel, Minal
60Pedersen, Roger
61Pera, Martin F
62Piekarczyk, Marian S
63Pera, Renee A Reijo
64Reubinoff, Benjamin E
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66Rossant, Janet
67Rugg-Gunn, Peter
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75Szatkiewicz, Jin
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77Tuuri, Timo
78van den Brink, Steineke
79Vintersten, Kristina
80Vuoristo, Sanna
81Ward, Dorien
82Weaver, Thomas A
83Young, Lesley A
84Zhang, Weidong
85International Stem Cell Initiative
86The International Stem Cell Initiative
title
0Characterization of human embryonic stem cell lines by the International Stem Cell Initiative
1Nature biotechnology
addtitleNat Biotechnol
descriptionThe International Stem Cell Initiative characterized 59 human embryonic stem cell lines from 17 laboratories worldwide. Despite diverse genotypes and different techniques used for derivation and maintenance, all lines exhibited similar expression patterns for several markers of human embryonic stem cells. They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3. Nevertheless, the lines were not identical: differences in expression of several lineage markers were evident, and several imprinted genes showed generally similar allele-specific expression patterns, but some gene-dependent variation was observed. Also, some female lines expressed readily detectable levels of XIST whereas others did not. No significant contamination of the lines with mycoplasma, bacteria or cytopathic viruses was detected.
subject
0Alkaline Phosphatase - metabolism
1Antigens, CD - biosynthesis
2Basic Medicine
3Biological and medical sciences
4Biotechnology
5Biotechnology - methods
6Cell and Molecular Biology
7Cell Differentiation
8Cell Lineage
9Cell Membrane - metabolism
10Cell- och molekylärbiologi
11Cells, Cultured
12Cluster Analysis
13Comparative studies
14Embryonic Stem Cells - cytology
15Female
16Fundamental and applied biological sciences. Psychology
17Gene Expression Profiling
18Gene Expression Regulation, Developmental
19Genetic markers
20Genotype
21Genotype & phenotype
22Glycolipids - chemistry
23Humans
24Medical and Health Sciences
25MEDICIN
26Medicin och hälsovetenskap
27MEDICINE
28Medicinska och farmaceutiska grundvetenskaper
29Membrane Glycoproteins - biosynthesis
30Mycoplasma
31Research centers
32Stem cells
33Tetraspanin 29
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7Benvenisty, Nissim
8Berry, Lorraine S
9Bevan, Simon
10Blum, Barak
11Brooking, Justin
12Chen, Kevin G
13Choo, Andre B H
14Churchill, Gary A
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18Dvorak, Petr
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75Szatkiewicz, Jin
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77Tuuri, Timo
78van den Brink, Steineke
79Vintersten, Kristina
80Vuoristo, Sanna
81Ward, Dorien
82Weaver, Thomas A
83Young, Lesley A
84Zhang, Weidong
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creationdate200707
titleCharacterization of human embryonic stem cell lines by the International Stem Cell Initiative
authorAdewumi, Oluseun ; Aflatoonian, Behrouz ; Ahrlund-Richter, Lars ; Amit, Michal ; Andrews, Peter W ; Beighton, Gemma ; Bello, Paul A ; Benvenisty, Nissim ; Berry, Lorraine S ; Bevan, Simon ; Blum, Barak ; Brooking, Justin ; Chen, Kevin G ; Choo, Andre B H ; Churchill, Gary A ; Corbel, Marie ; Damjanov, Ivan ; Draper, Jon S ; Dvorak, Petr ; Emanuelsson, Katarina ; Fleck, Roland A ; Ford, Angela ; Gertow, Karin ; Gertsenstein, Marina ; Gokhale, Paul J ; Hamilton, Rebecca S ; Hampl, Ales ; Healy, Lyn E ; Hovatta, Outi ; Hyllner, Johan ; Imreh, Marta P ; Itskovitz-Eldor, Joseph ; Jackson, Jamie ; Johnson, Jacqueline L ; Jones, Mark ; Kee, Kehkooi ; King, Benjamin L ; Knowles, Barbara B ; Lako, Majlinda ; Lebrin, Franck ; Mallon, Barbara S ; Manning, Daisy ; Mayshar, Yoav ; McKay, Ronald D G ; Michalska, Anna E ; Mikkola, Milla ; Mileikovsky, Masha ; Minger, Stephen L ; Moore, Harry D ; Mummery, Christine L ; Nagy, Andras ; Nakatsuji, Norio ; O'Brien, Carmel M ; Oh, Steve K W ; Olsson, Cia ; Otonkoski, Timo ; Park, Kye-Yoon ; Passier, Robert ; Patel, Hema ; Patel, Minal ; Pedersen, Roger ; Pera, Martin F ; Piekarczyk, Marian S ; Pera, Renee A Reijo ; Reubinoff, Benjamin E ; Robins, Allan J ; Rossant, Janet ; Rugg-Gunn, Peter ; Schulz, Thomas C ; Semb, Henrik ; Sherrer, Eric S ; Siemen, Henrike ; Stacey, Glyn N ; Stojkovic, Miodrag ; Suemori, Hirofumi ; Szatkiewicz, Jin ; Turetsky, Tikva ; Tuuri, Timo ; van den Brink, Steineke ; Vintersten, Kristina ; Vuoristo, Sanna ; Ward, Dorien ; Weaver, Thomas A ; Young, Lesley A ; Zhang, Weidong
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-c707t-86ef472496b9c5a21340b1d44176074835df28d2347388b8304fafa5da3686190
rsrctypearticles
prefilterarticles
languageeng
creationdate2007
topic
0Alkaline Phosphatase - metabolism
1Antigens, CD - biosynthesis
2Basic Medicine
3Biological and medical sciences
4Biotechnology
5Biotechnology - methods
6Cell and Molecular Biology
7Cell Differentiation
8Cell Lineage
9Cell Membrane - metabolism
10Cell- och molekylärbiologi
11Cells, Cultured
12Cluster Analysis
13Comparative studies
14Embryonic Stem Cells - cytology
15Female
16Fundamental and applied biological sciences. Psychology
17Gene Expression Profiling
18Gene Expression Regulation, Developmental
19Genetic markers
20Genotype
21Genotype & phenotype
22Glycolipids - chemistry
23Humans
24Medical and Health Sciences
25MEDICIN
26Medicin och hälsovetenskap
27MEDICINE
28Medicinska och farmaceutiska grundvetenskaper
29Membrane Glycoproteins - biosynthesis
30Mycoplasma
31Research centers
32Stem cells
33Tetraspanin 29
toplevelpeer_reviewed
creatorcontrib
0Adewumi, Oluseun
1Aflatoonian, Behrouz
2Ahrlund-Richter, Lars
3Amit, Michal
4Andrews, Peter W
5Beighton, Gemma
6Bello, Paul A
7Benvenisty, Nissim
8Berry, Lorraine S
9Bevan, Simon
10Blum, Barak
11Brooking, Justin
12Chen, Kevin G
13Choo, Andre B H
14Churchill, Gary A
15Corbel, Marie
16Damjanov, Ivan
17Draper, Jon S
18Dvorak, Petr
19Emanuelsson, Katarina
20Fleck, Roland A
21Ford, Angela
22Gertow, Karin
23Gertsenstein, Marina
24Gokhale, Paul J
25Hamilton, Rebecca S
26Hampl, Ales
27Healy, Lyn E
28Hovatta, Outi
29Hyllner, Johan
30Imreh, Marta P
31Itskovitz-Eldor, Joseph
32Jackson, Jamie
33Johnson, Jacqueline L
34Jones, Mark
35Kee, Kehkooi
36King, Benjamin L
37Knowles, Barbara B
38Lako, Majlinda
39Lebrin, Franck
40Mallon, Barbara S
41Manning, Daisy
42Mayshar, Yoav
43McKay, Ronald D G
44Michalska, Anna E
45Mikkola, Milla
46Mileikovsky, Masha
47Minger, Stephen L
48Moore, Harry D
49Mummery, Christine L
50Nagy, Andras
51Nakatsuji, Norio
52O'Brien, Carmel M
53Oh, Steve K W
54Olsson, Cia
55Otonkoski, Timo
56Park, Kye-Yoon
57Passier, Robert
58Patel, Hema
59Patel, Minal
60Pedersen, Roger
61Pera, Martin F
62Piekarczyk, Marian S
63Pera, Renee A Reijo
64Reubinoff, Benjamin E
65Robins, Allan J
66Rossant, Janet
67Rugg-Gunn, Peter
68Schulz, Thomas C
69Semb, Henrik
70Sherrer, Eric S
71Siemen, Henrike
72Stacey, Glyn N
73Stojkovic, Miodrag
74Suemori, Hirofumi
75Szatkiewicz, Jin
76Turetsky, Tikva
77Tuuri, Timo
78van den Brink, Steineke
79Vintersten, Kristina
80Vuoristo, Sanna
81Ward, Dorien
82Weaver, Thomas A
83Young, Lesley A
84Zhang, Weidong
85International Stem Cell Initiative
86The International Stem Cell Initiative
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8ProQuest Central (Corporate)
9Biotechnology Research Abstracts
10Calcium & Calcified Tissue Abstracts
11Chemoreception Abstracts
12Industrial and Applied Microbiology Abstracts (Microbiology A)
13Neurosciences Abstracts
14Nucleic Acids Abstracts
15Health & Medical Collection
16ProQuest Central (purchase pre-March 2016)
17Biology Database (Alumni Edition)
18Medical Database (Alumni Edition)
19Science Database (Alumni Edition)
20ProQuest Pharma Collection
21Technology Research Database
22ProQuest SciTech Collection
23ProQuest Technology Collection
24ProQuest Natural Science Collection
25Hospital Premium Collection
26Hospital Premium Collection (Alumni Edition)
27ProQuest Central (Alumni) (purchase pre-March 2016)
28Research Library (Alumni Edition)
29Materials Science & Engineering Collection
30ProQuest Central (Alumni Edition)
31ProQuest Central Essentials
32Biological Science Collection
33ProQuest Central
34Technology Collection
35Natural Science Collection
36Environmental Sciences and Pollution Management
37ProQuest Central Korea
38Engineering Research Database
39Health Research Premium Collection
40Health Research Premium Collection (Alumni)
41ProQuest Central Student
42Research Library Prep
43SciTech Premium Collection
44ProQuest Health & Medical Complete (Alumni)
45ProQuest Engineering Collection
46ProQuest Biological Science Collection
47Health & Medical Collection (Alumni Edition)
48Medical Database
49Research Library
50Science Database
51Biological Science Database
52Engineering Database
53Research Library (Corporate)
54Biotechnology and BioEngineering Abstracts
55Research Library China
56ProQuest One Academic Eastern Edition
57ProQuest One Academic
58ProQuest One Academic UKI Edition
59ProQuest Central China
60Engineering Collection
61ProQuest Central Basic
62Genetics Abstracts
63Bacteriology Abstracts (Microbiology B)
64Virology and AIDS Abstracts
65AIDS and Cancer Research Abstracts
66MEDLINE - Academic
67SwePub
68SwePub Articles
69SWEPUB Lunds universitet
jtitleNature biotechnology
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Adewumi, Oluseun
1Aflatoonian, Behrouz
2Ahrlund-Richter, Lars
3Amit, Michal
4Andrews, Peter W
5Beighton, Gemma
6Bello, Paul A
7Benvenisty, Nissim
8Berry, Lorraine S
9Bevan, Simon
10Blum, Barak
11Brooking, Justin
12Chen, Kevin G
13Choo, Andre B H
14Churchill, Gary A
15Corbel, Marie
16Damjanov, Ivan
17Draper, Jon S
18Dvorak, Petr
19Emanuelsson, Katarina
20Fleck, Roland A
21Ford, Angela
22Gertow, Karin
23Gertsenstein, Marina
24Gokhale, Paul J
25Hamilton, Rebecca S
26Hampl, Ales
27Healy, Lyn E
28Hovatta, Outi
29Hyllner, Johan
30Imreh, Marta P
31Itskovitz-Eldor, Joseph
32Jackson, Jamie
33Johnson, Jacqueline L
34Jones, Mark
35Kee, Kehkooi
36King, Benjamin L
37Knowles, Barbara B
38Lako, Majlinda
39Lebrin, Franck
40Mallon, Barbara S
41Manning, Daisy
42Mayshar, Yoav
43McKay, Ronald D G
44Michalska, Anna E
45Mikkola, Milla
46Mileikovsky, Masha
47Minger, Stephen L
48Moore, Harry D
49Mummery, Christine L
50Nagy, Andras
51Nakatsuji, Norio
52O'Brien, Carmel M
53Oh, Steve K W
54Olsson, Cia
55Otonkoski, Timo
56Park, Kye-Yoon
57Passier, Robert
58Patel, Hema
59Patel, Minal
60Pedersen, Roger
61Pera, Martin F
62Piekarczyk, Marian S
63Pera, Renee A Reijo
64Reubinoff, Benjamin E
65Robins, Allan J
66Rossant, Janet
67Rugg-Gunn, Peter
68Schulz, Thomas C
69Semb, Henrik
70Sherrer, Eric S
71Siemen, Henrike
72Stacey, Glyn N
73Stojkovic, Miodrag
74Suemori, Hirofumi
75Szatkiewicz, Jin
76Turetsky, Tikva
77Tuuri, Timo
78van den Brink, Steineke
79Vintersten, Kristina
80Vuoristo, Sanna
81Ward, Dorien
82Weaver, Thomas A
83Young, Lesley A
84Zhang, Weidong
aucorp
0International Stem Cell Initiative
1The International Stem Cell Initiative
formatjournal
genrearticle
ristypeJOUR
atitleCharacterization of human embryonic stem cell lines by the International Stem Cell Initiative
jtitleNature biotechnology
addtitleNat Biotechnol
date2007-07
risdate2007
volume25
issue7
spage803
epage816
pages803-816
issn
01087-0156
11546-1696
eissn1546-1696
codenNABIF9
abstractThe International Stem Cell Initiative characterized 59 human embryonic stem cell lines from 17 laboratories worldwide. Despite diverse genotypes and different techniques used for derivation and maintenance, all lines exhibited similar expression patterns for several markers of human embryonic stem cells. They expressed the glycolipid antigens SSEA3 and SSEA4, the keratan sulfate antigens TRA-1-60, TRA-1-81, GCTM2 and GCT343, and the protein antigens CD9, Thy1 (also known as CD90), tissue-nonspecific alkaline phosphatase and class 1 HLA, as well as the strongly developmentally regulated genes NANOG, POU5F1 (formerly known as OCT4), TDGF1, DNMT3B, GABRB3 and GDF3. Nevertheless, the lines were not identical: differences in expression of several lineage markers were evident, and several imprinted genes showed generally similar allele-specific expression patterns, but some gene-dependent variation was observed. Also, some female lines expressed readily detectable levels of XIST whereas others did not. No significant contamination of the lines with mycoplasma, bacteria or cytopathic viruses was detected.
copNew York, NY
pubNature Publishing Group
pmid17572666
doi10.1038/nbt1318
tpages14