schliessen

Filtern

 

Bibliotheken

A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans

Aims/hypothesis It has recently been suggested that the rs738409 G allele in PNPLA3 , which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups. The aims of the present study were as follows: (1) to try to replicate these findings in European... Full description

Journal Title: Diabetologia 2009, Vol.52 (6), p.1056-1060
Main Author: Kotronen, A
Other Authors: Johansson, L. E , Johansson, L. M , Roos, C , Westerbacka, J , Hamsten, A , Bergholm, R , Arkkila, P , Arola, J , Kiviluoto, T , Fisher, R. M , Ehrenborg, E , Orho-Melander, M , Ridderstråle, M , Groop, L , Yki-Järvinen, H
Format: Electronic Article Electronic Article
Language: English
Subjects:
RNA
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0012-186X
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_118678596
title: A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
format: Article
creator:
  • Kotronen, A
  • Johansson, L. E
  • Johansson, L. M
  • Roos, C
  • Westerbacka, J
  • Hamsten, A
  • Bergholm, R
  • Arkkila, P
  • Arola, J
  • Kiviluoto, T
  • Fisher, R. M
  • Ehrenborg, E
  • Orho-Melander, M
  • Ridderstråle, M
  • Groop, L
  • Yki-Järvinen, H
subjects:
  • Adiponutrin
  • Adipose tissue insulin sensitivity
  • Adult
  • Aged
  • Aspartate
  • Atherosclerosis
  • Biological and medical sciences
  • Body Mass Index
  • Clinical Medicine
  • Dextrose
  • Diabetes
  • Diabetes. Impaired glucose tolerance
  • disease
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinology and Diabetes
  • Endocrinopathies
  • Endokrinologi och diabetes
  • Enzymes
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Fatty Liver - blood
  • Fatty Liver - genetics
  • Fatty Liver - metabolism
  • Female
  • Gastroenterology. Liver. Pancreas. Abdomen
  • Gene expression
  • Genes
  • Genetic Predisposition to Disease
  • Genotype
  • Glucose
  • Glucose Clamp Technique
  • Glucose metabolism
  • Hepatic insulin sensitivity
  • Human Physiology
  • Humans
  • Insulin
  • Internal Medicine
  • Klinisk medicin
  • Lipase - genetics
  • Liver
  • Liver diseases
  • Liver enzymes
  • Liver. Biliary tract. Portal circulation. Exocrine pancreas
  • Magnetic Resonance Spectroscopy
  • Male
  • Medical and Health Sciences
  • Medical sciences
  • Medicin och hälsovetenskap
  • Medicine
  • Medicine & Public Health
  • Membrane Proteins - genetics
  • Messenger RNA
  • Metabolic Diseases
  • Middle Aged
  • Non-alcoholic fatty liver
  • Nuclear magnetic resonance spectroscopy
  • Obesity
  • Obesity - genetics
  • Other diseases. Semiology
  • Polymerase Chain Reaction
  • RNA
  • rs738409
  • Short Communication
ispartof: Diabetologia, 2009, Vol.52 (6), p.1056-1060
description: Aims/hypothesis It has recently been suggested that the rs738409 G allele in PNPLA3 , which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups. The aims of the present study were as follows: (1) to try to replicate these findings in European individuals with quantitative measures of hepatic fat content; (2) to study whether the polymorphism influences hepatic and adipose tissue insulin sensitivity; and (3) to investigate whether PNPLA3 expression is altered in the human fatty liver. Methods We genotyped 291 Finnish individuals in whom liver fat had been measured using proton magnetic resonance spectroscopy. Hepatic PNPLA3 expression was measured in 32 participants. Hepatic and adipose tissue insulin sensitivities were measured using a euglycaemic–hyperinsulinaemic (insulin infusion 0.3 mU kg −1 min −1 ) clamp technique combined with infusion of [3- 3 H]glucose in 109 participants. Results The rs738409 G allele in PNPLA3 was associated with increased quantitative measures of liver fat content ( p  = 0.011) and serum aspartate aminotransferase concentrations ( p  = 0.002) independently of age, sex and BMI. Fasting serum insulin and hepatic and adipose tissue insulin sensitivity were related to liver fat content independently of genotype status. PNPLA3 mRNA expression in the liver was positively related to obesity ( r  = 0.62, p  
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
  • 1432-0428
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.6556926
LOCALfalse
PrimoNMBib
record
control
sourceidgale_swepu
recordidTN_cdi_swepub_primary_oai_prod_swepub_kib_ki_se_118678596
sourceformatXML
sourcesystemPC
galeidA229593739
sourcerecordidA229593739
originalsourceidFETCH-LOGICAL-1699t-d01dfa0516ef6d6cf21c52bd8ec6c2ea4225d9e5b7b14b184f265b553e0739720
addsrcrecordideNqNUk1v1DAUjBCILoUfwAVFIDg1xXbir-Oq4ktaQQ8gcbMc-6XrkjhbO-mK_nocErVQ0QpFT7FfZuZF8ybLnmN0jBHibyNCmNACIVlgImhx9SBb4aokBaqIeJitps8FFuz7QfYkxnOEUEkr9jg7wJKQCku-ymCdm77rep9f6uC0H3Ln89PPp5t1eZTvt85sc_CmtxBzbd2u9-MQnD_KXbrH2BunB7D53g3bvHWXEPJGD0nRDzBLbcdO-_g0e9ToNsKz5X2YfXv_7uvJx2Lz5cOnk_WmwEzKobAI20Yjihk0zDLTEGwoqa0AwwwBXRFCrQRa8xpXNRZVQxitKS0B8VJygg4zOevGPezGWu2C63T4qXrt0rm3aun_cFOpCAone7igkiXu5k5uO-5S1akmjpCUc42tSi4yVVFeK20bq6DEGNWWcot0knszy6W5FyPEQXUuGmhb7aEfo2Icy1Kwae7LW8Dzfgw-2aQILkWFhZAJ9GoGnekWlPNNPwRtJkW1LokomUDsfhQhksoy2ZRQx_9ApcdC59LqoHGp_5fsfxH-nIBnggl9jAGaazMxUlNy1ZxclZKrpuSqq8R5sdgw1h3YG8YS1QR4vQB0NLptgvbGxWscmYIvf--R3xpu3KAHlzIZtGvv_QWyJCCJ-jMIN5u4m_QLcdEUrA
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid213841889
display
typearticle
titleA common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
creatorKotronen, A ; Johansson, L. E ; Johansson, L. M ; Roos, C ; Westerbacka, J ; Hamsten, A ; Bergholm, R ; Arkkila, P ; Arola, J ; Kiviluoto, T ; Fisher, R. M ; Ehrenborg, E ; Orho-Melander, M ; Ridderstråle, M ; Groop, L ; Yki-Järvinen, H
creatorcontribKotronen, A ; Johansson, L. E ; Johansson, L. M ; Roos, C ; Westerbacka, J ; Hamsten, A ; Bergholm, R ; Arkkila, P ; Arola, J ; Kiviluoto, T ; Fisher, R. M ; Ehrenborg, E ; Orho-Melander, M ; Ridderstråle, M ; Groop, L ; Yki-Järvinen, H
descriptionAims/hypothesis It has recently been suggested that the rs738409 G allele in PNPLA3 , which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups. The aims of the present study were as follows: (1) to try to replicate these findings in European individuals with quantitative measures of hepatic fat content; (2) to study whether the polymorphism influences hepatic and adipose tissue insulin sensitivity; and (3) to investigate whether PNPLA3 expression is altered in the human fatty liver. Methods We genotyped 291 Finnish individuals in whom liver fat had been measured using proton magnetic resonance spectroscopy. Hepatic PNPLA3 expression was measured in 32 participants. Hepatic and adipose tissue insulin sensitivities were measured using a euglycaemic–hyperinsulinaemic (insulin infusion 0.3 mU kg −1 min −1 ) clamp technique combined with infusion of [3- 3 H]glucose in 109 participants. Results The rs738409 G allele in PNPLA3 was associated with increased quantitative measures of liver fat content ( p  = 0.011) and serum aspartate aminotransferase concentrations ( p  = 0.002) independently of age, sex and BMI. Fasting serum insulin and hepatic and adipose tissue insulin sensitivity were related to liver fat content independently of genotype status. PNPLA3 mRNA expression in the liver was positively related to obesity ( r  = 0.62, p  < 0.0001) and to liver fat content ( r  = 0.58, p  = 0.025) in participants who were not morbidly obese (BMI < 40 kg/m 2 ). Conclusions/interpretation A common variant in PNPLA3 increases the risk of hepatic steatosis in humans.
identifier
0ISSN: 0012-186X
1ISSN: 1432-0428
2EISSN: 1432-0428
3DOI: 10.1007/s00125-009-1285-z
4PMID: 19224197
languageeng
publisherBerlin/Heidelberg: Springer-Verlag
subjectAdiponutrin ; Adipose tissue insulin sensitivity ; Adult ; Aged ; Aspartate ; Atherosclerosis ; Biological and medical sciences ; Body Mass Index ; Clinical Medicine ; Dextrose ; Diabetes ; Diabetes. Impaired glucose tolerance ; disease ; Endocrine pancreas. Apud cells (diseases) ; Endocrinology and Diabetes ; Endocrinopathies ; Endokrinologi och diabetes ; Enzymes ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Fatty Liver - blood ; Fatty Liver - genetics ; Fatty Liver - metabolism ; Female ; Gastroenterology. Liver. Pancreas. Abdomen ; Gene expression ; Genes ; Genetic Predisposition to Disease ; Genotype ; Glucose ; Glucose Clamp Technique ; Glucose metabolism ; Hepatic insulin sensitivity ; Human Physiology ; Humans ; Insulin ; Internal Medicine ; Klinisk medicin ; Lipase - genetics ; Liver ; Liver diseases ; Liver enzymes ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Magnetic Resonance Spectroscopy ; Male ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; Medicine ; Medicine & Public Health ; Membrane Proteins - genetics ; Messenger RNA ; Metabolic Diseases ; Middle Aged ; Non-alcoholic fatty liver ; Nuclear magnetic resonance spectroscopy ; Obesity ; Obesity - genetics ; Other diseases. Semiology ; Polymerase Chain Reaction ; RNA ; rs738409 ; Short Communication
ispartofDiabetologia, 2009, Vol.52 (6), p.1056-1060
rights
0Springer-Verlag 2009
12009 INIST-CNRS
2COPYRIGHT 2009 Springer
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-1699t-d01dfa0516ef6d6cf21c52bd8ec6c2ea4225d9e5b7b14b184f265b553e0739720
citesFETCH-LOGICAL-1699t-d01dfa0516ef6d6cf21c52bd8ec6c2ea4225d9e5b7b14b184f265b553e0739720
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=21432996$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/19224197$$D View this record in MEDLINE/PubMed
2$$Uhttps://lup.lub.lu.se/record/1428003$$DView record from Swedish Publication Index
3$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:118678596$$DView record from Swedish Publication Index
search
creatorcontrib
0Kotronen, A
1Johansson, L. E
2Johansson, L. M
3Roos, C
4Westerbacka, J
5Hamsten, A
6Bergholm, R
7Arkkila, P
8Arola, J
9Kiviluoto, T
10Fisher, R. M
11Ehrenborg, E
12Orho-Melander, M
13Ridderstråle, M
14Groop, L
15Yki-Järvinen, H
title
0A common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
1Diabetologia
addtitle
0Diabetologia
1Diabetologia
descriptionAims/hypothesis It has recently been suggested that the rs738409 G allele in PNPLA3 , which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups. The aims of the present study were as follows: (1) to try to replicate these findings in European individuals with quantitative measures of hepatic fat content; (2) to study whether the polymorphism influences hepatic and adipose tissue insulin sensitivity; and (3) to investigate whether PNPLA3 expression is altered in the human fatty liver. Methods We genotyped 291 Finnish individuals in whom liver fat had been measured using proton magnetic resonance spectroscopy. Hepatic PNPLA3 expression was measured in 32 participants. Hepatic and adipose tissue insulin sensitivities were measured using a euglycaemic–hyperinsulinaemic (insulin infusion 0.3 mU kg −1 min −1 ) clamp technique combined with infusion of [3- 3 H]glucose in 109 participants. Results The rs738409 G allele in PNPLA3 was associated with increased quantitative measures of liver fat content ( p  = 0.011) and serum aspartate aminotransferase concentrations ( p  = 0.002) independently of age, sex and BMI. Fasting serum insulin and hepatic and adipose tissue insulin sensitivity were related to liver fat content independently of genotype status. PNPLA3 mRNA expression in the liver was positively related to obesity ( r  = 0.62, p  < 0.0001) and to liver fat content ( r  = 0.58, p  = 0.025) in participants who were not morbidly obese (BMI < 40 kg/m 2 ). Conclusions/interpretation A common variant in PNPLA3 increases the risk of hepatic steatosis in humans.
subject
0Adiponutrin
1Adipose tissue insulin sensitivity
2Adult
3Aged
4Aspartate
5Atherosclerosis
6Biological and medical sciences
7Body Mass Index
8Clinical Medicine
9Dextrose
10Diabetes
11Diabetes. Impaired glucose tolerance
12disease
13Endocrine pancreas. Apud cells (diseases)
14Endocrinology and Diabetes
15Endocrinopathies
16Endokrinologi och diabetes
17Enzymes
18Etiopathogenesis. Screening. Investigations. Target tissue resistance
19Fatty Liver - blood
20Fatty Liver - genetics
21Fatty Liver - metabolism
22Female
23Gastroenterology. Liver. Pancreas. Abdomen
24Gene expression
25Genes
26Genetic Predisposition to Disease
27Genotype
28Glucose
29Glucose Clamp Technique
30Glucose metabolism
31Hepatic insulin sensitivity
32Human Physiology
33Humans
34Insulin
35Internal Medicine
36Klinisk medicin
37Lipase - genetics
38Liver
39Liver diseases
40Liver enzymes
41Liver. Biliary tract. Portal circulation. Exocrine pancreas
42Magnetic Resonance Spectroscopy
43Male
44Medical and Health Sciences
45Medical sciences
46Medicin och hälsovetenskap
47Medicine
48Medicine & Public Health
49Membrane Proteins - genetics
50Messenger RNA
51Metabolic Diseases
52Middle Aged
53Non-alcoholic fatty liver
54Nuclear magnetic resonance spectroscopy
55Obesity
56Obesity - genetics
57Other diseases. Semiology
58Polymerase Chain Reaction
59RNA
60rs738409
61Short Communication
issn
00012-186X
11432-0428
21432-0428
fulltextfalse
rsrctypearticle
creationdate2009
recordtypearticle
recordideNqNUk1v1DAUjBCILoUfwAVFIDg1xXbir-Oq4ktaQQ8gcbMc-6XrkjhbO-mK_nocErVQ0QpFT7FfZuZF8ybLnmN0jBHibyNCmNACIVlgImhx9SBb4aokBaqIeJitps8FFuz7QfYkxnOEUEkr9jg7wJKQCku-ymCdm77rep9f6uC0H3Ln89PPp5t1eZTvt85sc_CmtxBzbd2u9-MQnD_KXbrH2BunB7D53g3bvHWXEPJGD0nRDzBLbcdO-_g0e9ToNsKz5X2YfXv_7uvJx2Lz5cOnk_WmwEzKobAI20Yjihk0zDLTEGwoqa0AwwwBXRFCrQRa8xpXNRZVQxitKS0B8VJygg4zOevGPezGWu2C63T4qXrt0rm3aun_cFOpCAone7igkiXu5k5uO-5S1akmjpCUc42tSi4yVVFeK20bq6DEGNWWcot0knszy6W5FyPEQXUuGmhb7aEfo2Icy1Kwae7LW8Dzfgw-2aQILkWFhZAJ9GoGnekWlPNNPwRtJkW1LokomUDsfhQhksoy2ZRQx_9ApcdC59LqoHGp_5fsfxH-nIBnggl9jAGaazMxUlNy1ZxclZKrpuSqq8R5sdgw1h3YG8YS1QR4vQB0NLptgvbGxWscmYIvf--R3xpu3KAHlzIZtGvv_QWyJCCJ-jMIN5u4m_QLcdEUrA
startdate20090218
enddate20090218
creator
0Kotronen, A
1Johansson, L. E
2Johansson, L. M
3Roos, C
4Westerbacka, J
5Hamsten, A
6Bergholm, R
7Arkkila, P
8Arola, J
9Kiviluoto, T
10Fisher, R. M
11Ehrenborg, E
12Orho-Melander, M
13Ridderstråle, M
14Groop, L
15Yki-Järvinen, H
general
0Springer-Verlag
1Springer
2Springer Nature B.V
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
9BSHEE
103V.
117T5
127X7
137XB
1488E
158AO
168C1
178FI
188FJ
198FK
20ABUWG
21BENPR
22FYUFA
23GHDGH
24H94
25K9.
26M0S
27M1P
28PQEST
29PQQKQ
30PQUKI
31PRINS
327X8
33ADTPV
34AOWAS
35D95
36D8T
sort
creationdate20090218
titleA common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
authorKotronen, A ; Johansson, L. E ; Johansson, L. M ; Roos, C ; Westerbacka, J ; Hamsten, A ; Bergholm, R ; Arkkila, P ; Arola, J ; Kiviluoto, T ; Fisher, R. M ; Ehrenborg, E ; Orho-Melander, M ; Ridderstråle, M ; Groop, L ; Yki-Järvinen, H
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1699t-d01dfa0516ef6d6cf21c52bd8ec6c2ea4225d9e5b7b14b184f265b553e0739720
rsrctypearticles
prefilterarticles
languageeng
creationdate2009
topic
0Adiponutrin
1Adipose tissue insulin sensitivity
2Adult
3Aged
4Aspartate
5Atherosclerosis
6Biological and medical sciences
7Body Mass Index
8Clinical Medicine
9Dextrose
10Diabetes
11Diabetes. Impaired glucose tolerance
12disease
13Endocrine pancreas. Apud cells (diseases)
14Endocrinology and Diabetes
15Endocrinopathies
16Endokrinologi och diabetes
17Enzymes
18Etiopathogenesis. Screening. Investigations. Target tissue resistance
19Fatty Liver - blood
20Fatty Liver - genetics
21Fatty Liver - metabolism
22Female
23Gastroenterology. Liver. Pancreas. Abdomen
24Gene expression
25Genes
26Genetic Predisposition to Disease
27Genotype
28Glucose
29Glucose Clamp Technique
30Glucose metabolism
31Hepatic insulin sensitivity
32Human Physiology
33Humans
34Insulin
35Internal Medicine
36Klinisk medicin
37Lipase - genetics
38Liver
39Liver diseases
40Liver enzymes
41Liver. Biliary tract. Portal circulation. Exocrine pancreas
42Magnetic Resonance Spectroscopy
43Male
44Medical and Health Sciences
45Medical sciences
46Medicin och hälsovetenskap
47Medicine
48Medicine & Public Health
49Membrane Proteins - genetics
50Messenger RNA
51Metabolic Diseases
52Middle Aged
53Non-alcoholic fatty liver
54Nuclear magnetic resonance spectroscopy
55Obesity
56Obesity - genetics
57Other diseases. Semiology
58Polymerase Chain Reaction
59RNA
60rs738409
61Short Communication
toplevelpeer_reviewed
creatorcontrib
0Kotronen, A
1Johansson, L. E
2Johansson, L. M
3Roos, C
4Westerbacka, J
5Hamsten, A
6Bergholm, R
7Arkkila, P
8Arola, J
9Kiviluoto, T
10Fisher, R. M
11Ehrenborg, E
12Orho-Melander, M
13Ridderstråle, M
14Groop, L
15Yki-Järvinen, H
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8Academic OneFile (A&I only)
9ProQuest Central (Corporate)
10Immunology Abstracts
11Health & Medical Collection
12ProQuest Central (purchase pre-March 2016)
13Medical Database (Alumni Edition)
14ProQuest Pharma Collection
15Public Health Database
16Hospital Premium Collection
17Hospital Premium Collection (Alumni Edition)
18ProQuest Central (Alumni) (purchase pre-March 2016)
19ProQuest Central (Alumni Edition)
20ProQuest Central
21Health Research Premium Collection
22Health Research Premium Collection (Alumni)
23AIDS and Cancer Research Abstracts
24ProQuest Health & Medical Complete (Alumni)
25Health & Medical Collection (Alumni Edition)
26Medical Database
27ProQuest One Academic Eastern Edition
28ProQuest One Academic
29ProQuest One Academic UKI Edition
30ProQuest Central China
31MEDLINE - Academic
32SwePub
33SwePub Articles
34SWEPUB Lunds universitet
35SWEPUB Freely available online
jtitleDiabetologia
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Kotronen, A
1Johansson, L. E
2Johansson, L. M
3Roos, C
4Westerbacka, J
5Hamsten, A
6Bergholm, R
7Arkkila, P
8Arola, J
9Kiviluoto, T
10Fisher, R. M
11Ehrenborg, E
12Orho-Melander, M
13Ridderstråle, M
14Groop, L
15Yki-Järvinen, H
formatjournal
genrearticle
ristypeJOUR
atitleA common variant in PNPLA3, which encodes adiponutrin, is associated with liver fat content in humans
jtitleDiabetologia
stitleDiabetologia
addtitleDiabetologia
date2009-02-18
risdate2009
volume52
issue6
spage1056
epage1060
pages1056-1060
issn
00012-186X
11432-0428
eissn1432-0428
abstractAims/hypothesis It has recently been suggested that the rs738409 G allele in PNPLA3 , which encodes adiponutrin, is strongly associated with increased liver fat content in three different ethnic groups. The aims of the present study were as follows: (1) to try to replicate these findings in European individuals with quantitative measures of hepatic fat content; (2) to study whether the polymorphism influences hepatic and adipose tissue insulin sensitivity; and (3) to investigate whether PNPLA3 expression is altered in the human fatty liver. Methods We genotyped 291 Finnish individuals in whom liver fat had been measured using proton magnetic resonance spectroscopy. Hepatic PNPLA3 expression was measured in 32 participants. Hepatic and adipose tissue insulin sensitivities were measured using a euglycaemic–hyperinsulinaemic (insulin infusion 0.3 mU kg −1 min −1 ) clamp technique combined with infusion of [3- 3 H]glucose in 109 participants. Results The rs738409 G allele in PNPLA3 was associated with increased quantitative measures of liver fat content ( p  = 0.011) and serum aspartate aminotransferase concentrations ( p  = 0.002) independently of age, sex and BMI. Fasting serum insulin and hepatic and adipose tissue insulin sensitivity were related to liver fat content independently of genotype status. PNPLA3 mRNA expression in the liver was positively related to obesity ( r  = 0.62, p  < 0.0001) and to liver fat content ( r  = 0.58, p  = 0.025) in participants who were not morbidly obese (BMI < 40 kg/m 2 ). Conclusions/interpretation A common variant in PNPLA3 increases the risk of hepatic steatosis in humans.
copBerlin/Heidelberg
pubSpringer-Verlag
pmid19224197
doi10.1007/s00125-009-1285-z
oafree_for_read