schliessen

Filtern

 

Bibliotheken

Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis

Summary Background Substantial controversy surrounds the use of estimated glomerular filtration rate (eGFR) and albuminuria to define chronic kidney disease and assign its stages. We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality.... Full description

Journal Title: The Lancet (British edition) 2010, Vol.375 (9731), p.2073-2081
Main Author: Matsushita, Kunihiro
Other Authors: van der Velde, Marije , Astor, Brad C , Woodward, Mark , Levey, Anew S , de Jong, Paul E , Coresh, Josef , Gansevoort, Ron T
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Kidlington: Elsevier Ltd
ID: ISSN: 0140-6736
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_120865197
title: Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
format: Article
creator:
  • Matsushita, Kunihiro
  • van der Velde, Marije
  • Astor, Brad C
  • Woodward, Mark
  • Levey, Anew S
  • de Jong, Paul E
  • Coresh, Josef
  • Gansevoort, Ron T
subjects:
  • Abridged Index Medicus
  • Aged
  • Albuminuria - complications
  • Associated diseases and complications
  • Biological and medical sciences
  • Cardiovascular Diseases - mortality
  • Cardiovascular Diseases - physiopathology
  • Chronic Disease
  • CHRONIC KIDNEY-DISEASE
  • Creatinine - urine
  • CYSTATIN-C
  • Diabetes. Impaired glucose tolerance
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • EQUATION
  • Female
  • General aspects
  • Glomerular Filtration Rate
  • Humans
  • Internal Medicine
  • Kidney Diseases - physiopathology
  • Kidneys
  • Male
  • Medical and Health Sciences
  • Medical sciences
  • Medicin och hälsovetenskap
  • Middle Aged
  • Mortality
  • Nephrology. Urinary tract diseases
  • OLDER-ADULTS
  • OUTCOMES
  • POOLED ANALYSIS
  • PREVALENCE
  • Proportional Hazards Models
  • RENAL-DISEASE
  • RISK-FACTOR
  • SERUM CREATININE
  • Urinary system involvement in other diseases. Miscellaneous
ispartof: The Lancet (British edition), 2010, Vol.375 (9731), p.2073-2081
description: Summary Background Substantial controversy surrounds the use of estimated glomerular filtration rate (eGFR) and albuminuria to define chronic kidney disease and assign its stages. We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality. Methods In this collaborative meta-analysis of general population cohorts, we pooled standardised data for all-cause and cardiovascular mortality from studies containing at least 1000 participants and baseline information about eGFR and urine albumin concentrations. Cox proportional hazards models were used to estimate hazard ratios (HRs) for all-cause and cardiovascular mortality associated with eGFR and albuminuria, adjusted for potential confounders. Findings The analysis included 105 872 participants (730 577 person-years) from 14 studies with urine albumin-to-creatinine ratio (ACR) measurements and 1 128 310 participants (4 732 110 person-years) from seven studies with urine protein dipstick measurements. In studies with ACR measurements, risk of mortality was unrelated to eGFR between 75 mL/min/1·73 m2 and 105 mL/min/1·73 m2 and increased at lower eGFRs. Compared with eGFR 95 mL/min/1·73 m2 , adjusted HRs for all-cause mortality were 1·18 (95% CI 1·05–1·32) for eGFR 60 mL/min/1·73 m2 , 1·57 (1·39–1·78) for 45 mL/min/1·73 m2 , and 3·14 (2·39–4·13) for 15 mL/min/1·73 m2 . ACR was associated with risk of mortality linearly on the log-log scale without threshold effects. Compared with ACR 0·6 mg/mmol, adjusted HRs for all-cause mortality were 1·20 (1·15–1·26) for ACR 1·1 mg/mmol, 1·63 (1·50–1·77) for 3·4 mg/mmol, and 2·22 (1·97–2·51) for 33·9 mg/mmol. eGFR and ACR were multiplicatively associated with risk of mortality without evidence of interaction. Similar findings were recorded for cardiovascular mortality and in studies with dipstick measurements. Interpretation eGFR less than 60 mL/min/1·73 m2 and ACR 1·1 mg/mmol (10 mg/g) or more are independent predictors of mortality risk in the general population. This study provides quantitative data for use of both kidney measures for risk assessment and definition and staging of chronic kidney disease. Funding Kidney Disease: Improving Global Outcomes (KDIGO), US National Kidney Foundation, and Dutch Kidney Foundation.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
  • 1474-547X
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.7937768
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_swepu
recordidTN_cdi_swepub_primary_oai_prod_swepub_kib_ki_se_120865197
sourceformatXML
sourcesystemPC
sourcerecordid733297364
originalsourceidFETCH-LOGICAL-1694t-1f260aaeefc83c28187d9020e98a0bce7eea7920b0d460d028c3ab36cd6079023
addsrcrecordideNqFkl2L1TAQhoso7nH1Jyi9ERWsJm2apgrKsn7Cghd-IHgRknR6Nrtpc0zaXc5_8kc6bY9HWZC9KJlO3nkyzLxJcp-SZ5RQ_vwzoYxkvCr4Y0qecMIrlpU3khVlU8Cq7zeT1V5ykNyJ8YwQwjgpbycHOWGiYCVdJb-OYvTGqsH6PvVtCnGwnRqgSdfOdxBGp0LaWjeERYIHpKpvUuX02Nl-DFall3Y4xYTLjBrjcm1UaKy_UNHMhM6HQTk7bFPbp2voISiXbvwGL2es8aeoiC9ShaFzSvvpvQtIOxhUpnrlttHGu8mtVrkI93bnYfL13dsvxx-yk0_vPx4fnWSU12zIaJtzohRAa0RhckFF1dQkJ1ALRbSBCkBVdU40aXAeDcmFKZQuuGk4qVBYHCb1wo2XsBm13AScSdhKryzGvpG7_LmdPhlB0pwIXtK6wtqn_619Y78dSR_WchwlZUxQjvJHixy5P0ecvuxsNIAj6MGPUVZFkSOVM1SWi9IEH2OAdo-mRE6WkLMl5LTvKTVbQpZY92D3wqg7aPZVfzyAgoc7AW5LuTao3tj4V5cLUQgxTeXllQaMHeb1oTmsu7aNH0t1r8K_-DCul7mOAeaf3mGsnTUzOkrNQRcUSslaCpJpLSRuVEtodF1z1laE10h_vdABbXFhIchoLPQGGhvADLLx9tr-Xl0hGGd77MKdwxbimR8DujBKKmMuyQKZGJTMhLL4DZrjIQI
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid733297364
display
typearticle
titleAssociation of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
sourceAlma/SFX Local Collection
creatorMatsushita, Kunihiro ; van der Velde, Marije ; Astor, Brad C ; Woodward, Mark ; Levey, Anew S ; de Jong, Paul E ; Coresh, Josef ; Gansevoort, Ron T
creatorcontribMatsushita, Kunihiro ; van der Velde, Marije ; Astor, Brad C ; Woodward, Mark ; Levey, Anew S ; de Jong, Paul E ; Coresh, Josef ; Gansevoort, Ron T ; Chronic Kidney Disease Prognosis Consortium
descriptionSummary Background Substantial controversy surrounds the use of estimated glomerular filtration rate (eGFR) and albuminuria to define chronic kidney disease and assign its stages. We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality. Methods In this collaborative meta-analysis of general population cohorts, we pooled standardised data for all-cause and cardiovascular mortality from studies containing at least 1000 participants and baseline information about eGFR and urine albumin concentrations. Cox proportional hazards models were used to estimate hazard ratios (HRs) for all-cause and cardiovascular mortality associated with eGFR and albuminuria, adjusted for potential confounders. Findings The analysis included 105 872 participants (730 577 person-years) from 14 studies with urine albumin-to-creatinine ratio (ACR) measurements and 1 128 310 participants (4 732 110 person-years) from seven studies with urine protein dipstick measurements. In studies with ACR measurements, risk of mortality was unrelated to eGFR between 75 mL/min/1·73 m2 and 105 mL/min/1·73 m2 and increased at lower eGFRs. Compared with eGFR 95 mL/min/1·73 m2 , adjusted HRs for all-cause mortality were 1·18 (95% CI 1·05–1·32) for eGFR 60 mL/min/1·73 m2 , 1·57 (1·39–1·78) for 45 mL/min/1·73 m2 , and 3·14 (2·39–4·13) for 15 mL/min/1·73 m2 . ACR was associated with risk of mortality linearly on the log-log scale without threshold effects. Compared with ACR 0·6 mg/mmol, adjusted HRs for all-cause mortality were 1·20 (1·15–1·26) for ACR 1·1 mg/mmol, 1·63 (1·50–1·77) for 3·4 mg/mmol, and 2·22 (1·97–2·51) for 33·9 mg/mmol. eGFR and ACR were multiplicatively associated with risk of mortality without evidence of interaction. Similar findings were recorded for cardiovascular mortality and in studies with dipstick measurements. Interpretation eGFR less than 60 mL/min/1·73 m2 and ACR 1·1 mg/mmol (10 mg/g) or more are independent predictors of mortality risk in the general population. This study provides quantitative data for use of both kidney measures for risk assessment and definition and staging of chronic kidney disease. Funding Kidney Disease: Improving Global Outcomes (KDIGO), US National Kidney Foundation, and Dutch Kidney Foundation.
identifier
0ISSN: 0140-6736
1ISSN: 1474-547X
2EISSN: 1474-547X
3DOI: 10.1016/S0140-6736(10)60674-5
4PMID: 20483451
5CODEN: LANCAO
languageeng
publisherKidlington: Elsevier Ltd
subjectAbridged Index Medicus ; Aged ; Albuminuria - complications ; Associated diseases and complications ; Biological and medical sciences ; Cardiovascular Diseases - mortality ; Cardiovascular Diseases - physiopathology ; Chronic Disease ; CHRONIC KIDNEY-DISEASE ; Creatinine - urine ; CYSTATIN-C ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; EQUATION ; Female ; General aspects ; Glomerular Filtration Rate ; Humans ; Internal Medicine ; Kidney Diseases - physiopathology ; Kidneys ; Male ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; Middle Aged ; Mortality ; Nephrology. Urinary tract diseases ; OLDER-ADULTS ; OUTCOMES ; POOLED ANALYSIS ; PREVALENCE ; Proportional Hazards Models ; RENAL-DISEASE ; RISK-FACTOR ; SERUM CREATININE ; Urinary system involvement in other diseases. Miscellaneous
ispartofThe Lancet (British edition), 2010, Vol.375 (9731), p.2073-2081
rights
0Elsevier Ltd
12010 Elsevier Ltd
2info:eu-repo/semantics/restrictedAccess
32015 INIST-CNRS
4Copyright 2010 Elsevier Ltd. All rights reserved.
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-1694t-1f260aaeefc83c28187d9020e98a0bce7eea7920b0d460d028c3ab36cd6079023
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22883882$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/20483451$$D View this record in MEDLINE/PubMed
2$$Uhttp://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-144816$$DView record from Swedish Publication Index
3$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:120865197$$DView record from Swedish Publication Index
search
creatorcontrib
0Matsushita, Kunihiro
1van der Velde, Marije
2Astor, Brad C
3Woodward, Mark
4Levey, Anew S
5de Jong, Paul E
6Coresh, Josef
7Gansevoort, Ron T
8Chronic Kidney Disease Prognosis Consortium
title
0Association of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
1The Lancet (British edition)
addtitleLancet
descriptionSummary Background Substantial controversy surrounds the use of estimated glomerular filtration rate (eGFR) and albuminuria to define chronic kidney disease and assign its stages. We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality. Methods In this collaborative meta-analysis of general population cohorts, we pooled standardised data for all-cause and cardiovascular mortality from studies containing at least 1000 participants and baseline information about eGFR and urine albumin concentrations. Cox proportional hazards models were used to estimate hazard ratios (HRs) for all-cause and cardiovascular mortality associated with eGFR and albuminuria, adjusted for potential confounders. Findings The analysis included 105 872 participants (730 577 person-years) from 14 studies with urine albumin-to-creatinine ratio (ACR) measurements and 1 128 310 participants (4 732 110 person-years) from seven studies with urine protein dipstick measurements. In studies with ACR measurements, risk of mortality was unrelated to eGFR between 75 mL/min/1·73 m2 and 105 mL/min/1·73 m2 and increased at lower eGFRs. Compared with eGFR 95 mL/min/1·73 m2 , adjusted HRs for all-cause mortality were 1·18 (95% CI 1·05–1·32) for eGFR 60 mL/min/1·73 m2 , 1·57 (1·39–1·78) for 45 mL/min/1·73 m2 , and 3·14 (2·39–4·13) for 15 mL/min/1·73 m2 . ACR was associated with risk of mortality linearly on the log-log scale without threshold effects. Compared with ACR 0·6 mg/mmol, adjusted HRs for all-cause mortality were 1·20 (1·15–1·26) for ACR 1·1 mg/mmol, 1·63 (1·50–1·77) for 3·4 mg/mmol, and 2·22 (1·97–2·51) for 33·9 mg/mmol. eGFR and ACR were multiplicatively associated with risk of mortality without evidence of interaction. Similar findings were recorded for cardiovascular mortality and in studies with dipstick measurements. Interpretation eGFR less than 60 mL/min/1·73 m2 and ACR 1·1 mg/mmol (10 mg/g) or more are independent predictors of mortality risk in the general population. This study provides quantitative data for use of both kidney measures for risk assessment and definition and staging of chronic kidney disease. Funding Kidney Disease: Improving Global Outcomes (KDIGO), US National Kidney Foundation, and Dutch Kidney Foundation.
subject
0Abridged Index Medicus
1Aged
2Albuminuria - complications
3Associated diseases and complications
4Biological and medical sciences
5Cardiovascular Diseases - mortality
6Cardiovascular Diseases - physiopathology
7Chronic Disease
8CHRONIC KIDNEY-DISEASE
9Creatinine - urine
10CYSTATIN-C
11Diabetes. Impaired glucose tolerance
12Endocrine pancreas. Apud cells (diseases)
13Endocrinopathies
14EQUATION
15Female
16General aspects
17Glomerular Filtration Rate
18Humans
19Internal Medicine
20Kidney Diseases - physiopathology
21Kidneys
22Male
23Medical and Health Sciences
24Medical sciences
25Medicin och hälsovetenskap
26Middle Aged
27Mortality
28Nephrology. Urinary tract diseases
29OLDER-ADULTS
30OUTCOMES
31POOLED ANALYSIS
32PREVALENCE
33Proportional Hazards Models
34RENAL-DISEASE
35RISK-FACTOR
36SERUM CREATININE
37Urinary system involvement in other diseases. Miscellaneous
issn
00140-6736
11474-547X
21474-547X
fulltexttrue
rsrctypearticle
creationdate2010
recordtypearticle
recordideNqFkl2L1TAQhoso7nH1Jyi9ERWsJm2apgrKsn7Cghd-IHgRknR6Nrtpc0zaXc5_8kc6bY9HWZC9KJlO3nkyzLxJcp-SZ5RQ_vwzoYxkvCr4Y0qecMIrlpU3khVlU8Cq7zeT1V5ykNyJ8YwQwjgpbycHOWGiYCVdJb-OYvTGqsH6PvVtCnGwnRqgSdfOdxBGp0LaWjeERYIHpKpvUuX02Nl-DFall3Y4xYTLjBrjcm1UaKy_UNHMhM6HQTk7bFPbp2voISiXbvwGL2es8aeoiC9ShaFzSvvpvQtIOxhUpnrlttHGu8mtVrkI93bnYfL13dsvxx-yk0_vPx4fnWSU12zIaJtzohRAa0RhckFF1dQkJ1ALRbSBCkBVdU40aXAeDcmFKZQuuGk4qVBYHCb1wo2XsBm13AScSdhKryzGvpG7_LmdPhlB0pwIXtK6wtqn_619Y78dSR_WchwlZUxQjvJHixy5P0ecvuxsNIAj6MGPUVZFkSOVM1SWi9IEH2OAdo-mRE6WkLMl5LTvKTVbQpZY92D3wqg7aPZVfzyAgoc7AW5LuTao3tj4V5cLUQgxTeXllQaMHeb1oTmsu7aNH0t1r8K_-DCul7mOAeaf3mGsnTUzOkrNQRcUSslaCpJpLSRuVEtodF1z1laE10h_vdABbXFhIchoLPQGGhvADLLx9tr-Xl0hGGd77MKdwxbimR8DujBKKmMuyQKZGJTMhLL4DZrjIQI
startdate2010
enddate2010
creator
0Matsushita, Kunihiro
1van der Velde, Marije
2Astor, Brad C
3Woodward, Mark
4Levey, Anew S
5de Jong, Paul E
6Coresh, Josef
7Gansevoort, Ron T
general
0Elsevier Ltd
1Elsevier
scope
05DI
15DJ
2QVL
3IQODW
4CGR
5CUY
6CVF
7ECM
8EIF
9NPM
10AAYXX
11CITATION
127X8
13ADTPV
14AOWAS
15D8T
sort
creationdate2010
titleAssociation of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
authorMatsushita, Kunihiro ; van der Velde, Marije ; Astor, Brad C ; Woodward, Mark ; Levey, Anew S ; de Jong, Paul E ; Coresh, Josef ; Gansevoort, Ron T
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1694t-1f260aaeefc83c28187d9020e98a0bce7eea7920b0d460d028c3ab36cd6079023
rsrctypearticles
prefilterarticles
languageeng
creationdate2010
topic
0Abridged Index Medicus
1Aged
2Albuminuria - complications
3Associated diseases and complications
4Biological and medical sciences
5Cardiovascular Diseases - mortality
6Cardiovascular Diseases - physiopathology
7Chronic Disease
8CHRONIC KIDNEY-DISEASE
9Creatinine - urine
10CYSTATIN-C
11Diabetes. Impaired glucose tolerance
12Endocrine pancreas. Apud cells (diseases)
13Endocrinopathies
14EQUATION
15Female
16General aspects
17Glomerular Filtration Rate
18Humans
19Internal Medicine
20Kidney Diseases - physiopathology
21Kidneys
22Male
23Medical and Health Sciences
24Medical sciences
25Medicin och hälsovetenskap
26Middle Aged
27Mortality
28Nephrology. Urinary tract diseases
29OLDER-ADULTS
30OUTCOMES
31POOLED ANALYSIS
32PREVALENCE
33Proportional Hazards Models
34RENAL-DISEASE
35RISK-FACTOR
36SERUM CREATININE
37Urinary system involvement in other diseases. Miscellaneous
toplevel
0peer_reviewed
1online_resources
creatorcontrib
0Matsushita, Kunihiro
1van der Velde, Marije
2Astor, Brad C
3Woodward, Mark
4Levey, Anew S
5de Jong, Paul E
6Coresh, Josef
7Gansevoort, Ron T
8Chronic Kidney Disease Prognosis Consortium
collection
0NARCIS
1NARCIS: Datasets
2NARCIS:Publications
3Pascal-Francis
4Medline
5MEDLINE
6MEDLINE (Ovid)
7MEDLINE
8MEDLINE
9PubMed
10CrossRef
11MEDLINE - Academic
12SwePub
13SwePub Articles
14SWEPUB Freely available online
jtitleThe Lancet (British edition)
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Matsushita, Kunihiro
1van der Velde, Marije
2Astor, Brad C
3Woodward, Mark
4Levey, Anew S
5de Jong, Paul E
6Coresh, Josef
7Gansevoort, Ron T
aucorpChronic Kidney Disease Prognosis Consortium
formatjournal
genrearticle
ristypeJOUR
atitleAssociation of estimated glomerular filtration rate and albuminuria with all-cause and cardiovascular mortality in general population cohorts: a collaborative meta-analysis
jtitleThe Lancet (British edition)
addtitleLancet
date2010
risdate2010
volume375
issue9731
spage2073
epage2081
pages2073-2081
issn
00140-6736
11474-547X
eissn1474-547X
codenLANCAO
abstractSummary Background Substantial controversy surrounds the use of estimated glomerular filtration rate (eGFR) and albuminuria to define chronic kidney disease and assign its stages. We undertook a meta-analysis to assess the independent and combined associations of eGFR and albuminuria with mortality. Methods In this collaborative meta-analysis of general population cohorts, we pooled standardised data for all-cause and cardiovascular mortality from studies containing at least 1000 participants and baseline information about eGFR and urine albumin concentrations. Cox proportional hazards models were used to estimate hazard ratios (HRs) for all-cause and cardiovascular mortality associated with eGFR and albuminuria, adjusted for potential confounders. Findings The analysis included 105 872 participants (730 577 person-years) from 14 studies with urine albumin-to-creatinine ratio (ACR) measurements and 1 128 310 participants (4 732 110 person-years) from seven studies with urine protein dipstick measurements. In studies with ACR measurements, risk of mortality was unrelated to eGFR between 75 mL/min/1·73 m2 and 105 mL/min/1·73 m2 and increased at lower eGFRs. Compared with eGFR 95 mL/min/1·73 m2 , adjusted HRs for all-cause mortality were 1·18 (95% CI 1·05–1·32) for eGFR 60 mL/min/1·73 m2 , 1·57 (1·39–1·78) for 45 mL/min/1·73 m2 , and 3·14 (2·39–4·13) for 15 mL/min/1·73 m2 . ACR was associated with risk of mortality linearly on the log-log scale without threshold effects. Compared with ACR 0·6 mg/mmol, adjusted HRs for all-cause mortality were 1·20 (1·15–1·26) for ACR 1·1 mg/mmol, 1·63 (1·50–1·77) for 3·4 mg/mmol, and 2·22 (1·97–2·51) for 33·9 mg/mmol. eGFR and ACR were multiplicatively associated with risk of mortality without evidence of interaction. Similar findings were recorded for cardiovascular mortality and in studies with dipstick measurements. Interpretation eGFR less than 60 mL/min/1·73 m2 and ACR 1·1 mg/mmol (10 mg/g) or more are independent predictors of mortality risk in the general population. This study provides quantitative data for use of both kidney measures for risk assessment and definition and staging of chronic kidney disease. Funding Kidney Disease: Improving Global Outcomes (KDIGO), US National Kidney Foundation, and Dutch Kidney Foundation.
copKidlington
pubElsevier Ltd
pmid20483451
doi10.1016/S0140-6736(10)60674-5
oafree_for_read