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Excessive skeletal muscle recruitment during strenuous exercise in McArdle patients

We compared the cardiorespiratory response and muscle recruitment [as determined by electromyography (EMG)] of 37 McArdle patients [19 males, 37.4 ± 2.8 years, body mass index (BMI): 25.1 ± 4.7 kg m −2 ] and 33 healthy controls (18 males, 36.4 ± 10.0 years, BMI: 25.7 ± 3.8 kg m −2 ) during cycle-erg... Full description

Journal Title: European journal of applied physiology 2010, Vol.110 (5), p.1047-1055
Main Author: Rae, Dale E.
Other Authors: Noakes, Timothy D. , San Juan, Alejandro F. , Pérez, Margarita , Nogales-Gadea, Gisela , Ruiz, Jonatan R. , Morán, María , Martín, Miguel A. , Andreu, Antoni L. , Arenas, Joaquín , Lucia, Alejandro
Format: Electronic Article Electronic Article
Language: English
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Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 1439-6319
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title: Excessive skeletal muscle recruitment during strenuous exercise in McArdle patients
format: Article
creator:
  • Rae, Dale E.
  • Noakes, Timothy D.
  • San Juan, Alejandro F.
  • Pérez, Margarita
  • Nogales-Gadea, Gisela
  • Ruiz, Jonatan R.
  • Morán, María
  • Martín, Miguel A.
  • Andreu, Antoni L.
  • Arenas, Joaquín
  • Lucia, Alejandro
subjects:
  • Adult
  • Biological and medical sciences
  • Biomedical and Life Sciences
  • Biomedicine
  • Deporte
  • Electromyography
  • Enfermedad nutricional
  • Exercise
  • Exercise - physiology
  • Exercise Test
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Glycogen Storage Disease Type V - physiopathology
  • Heart beat
  • Heart Rate - physiology
  • Human Physiology
  • Humans
  • Male
  • Medicin och hälsovetenskap
  • Middle Aged
  • Muscle Contraction - physiology
  • Muscle Strength - physiology
  • Muscle, Skeletal - physiology
  • Muscle, Skeletal - physiopathology
  • Occupational Medicine/Industrial Medicine
  • Original Article
  • Oxygen Consumption - physiology
  • Sports Medicine
  • Tratamiento médico
  • Universities and colleges
  • Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
ispartof: European journal of applied physiology, 2010, Vol.110 (5), p.1047-1055
description: We compared the cardiorespiratory response and muscle recruitment [as determined by electromyography (EMG)] of 37 McArdle patients [19 males, 37.4 ± 2.8 years, body mass index (BMI): 25.1 ± 4.7 kg m −2 ] and 33 healthy controls (18 males, 36.4 ± 10.0 years, BMI: 25.7 ± 3.8 kg m −2 ) during cycle-ergometer exercise (an incremental test to exhaustion and a 12-min submaximal constant workload test). We obtained cardiorespiratory [oxygen uptake and heart rate (HR)] and EMG data ( rectus femoris and vastus lateralis muscles). During the incremental test, the patients exhibited the expected hyperkinetic cardiovascular response shown by a marked increase in the slope of the HR:Power relationship ( p  
language: eng
source:
identifier: ISSN: 1439-6319
fulltext: no_fulltext
issn:
  • 1439-6319
  • 1439-6327
  • 1439-6327
url: Link


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titleExcessive skeletal muscle recruitment during strenuous exercise in McArdle patients
creatorRae, Dale E. ; Noakes, Timothy D. ; San Juan, Alejandro F. ; Pérez, Margarita ; Nogales-Gadea, Gisela ; Ruiz, Jonatan R. ; Morán, María ; Martín, Miguel A. ; Andreu, Antoni L. ; Arenas, Joaquín ; Lucia, Alejandro
creatorcontribRae, Dale E. ; Noakes, Timothy D. ; San Juan, Alejandro F. ; Pérez, Margarita ; Nogales-Gadea, Gisela ; Ruiz, Jonatan R. ; Morán, María ; Martín, Miguel A. ; Andreu, Antoni L. ; Arenas, Joaquín ; Lucia, Alejandro
descriptionWe compared the cardiorespiratory response and muscle recruitment [as determined by electromyography (EMG)] of 37 McArdle patients [19 males, 37.4 ± 2.8 years, body mass index (BMI): 25.1 ± 4.7 kg m −2 ] and 33 healthy controls (18 males, 36.4 ± 10.0 years, BMI: 25.7 ± 3.8 kg m −2 ) during cycle-ergometer exercise (an incremental test to exhaustion and a 12-min submaximal constant workload test). We obtained cardiorespiratory [oxygen uptake and heart rate (HR)] and EMG data ( rectus femoris and vastus lateralis muscles). During the incremental test, the patients exhibited the expected hyperkinetic cardiovascular response shown by a marked increase in the slope of the HR:Power relationship ( p  < 0.001). Throughout the incremental test and at the point of fatigue, the patients produced significantly less power than the controls (peak power output: 67 ± 21 vs. 214 ± 56 watts respectively, p  < 0.001), yet they demonstrated significantly higher levels of muscle activity for a given absolute power. During the constant workload test, patients displayed higher levels of EMG activity than the controls during the second half of the test, despite a lower power production (34 ± 13 vs. 94 ± 29 watts respectively, p  < 0.001). In conclusion, since the McArdle patients required more motor unit recruitment for a given power output, our data suggest that the state of contractility of their muscles is reduced compared with healthy people. Excessive muscle recruitment for a given load could be one of the mechanisms explaining the exercise intolerance of these patients.
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subjectAdult ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Deporte ; Electromyography ; Enfermedad nutricional ; Exercise ; Exercise - physiology ; Exercise Test ; Female ; Fundamental and applied biological sciences. Psychology ; Glycogen Storage Disease Type V - physiopathology ; Heart beat ; Heart Rate - physiology ; Human Physiology ; Humans ; Male ; Medicin och hälsovetenskap ; Middle Aged ; Muscle Contraction - physiology ; Muscle Strength - physiology ; Muscle, Skeletal - physiology ; Muscle, Skeletal - physiopathology ; Occupational Medicine/Industrial Medicine ; Original Article ; Oxygen Consumption - physiology ; Sports Medicine ; Tratamiento médico ; Universities and colleges ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
ispartofEuropean journal of applied physiology, 2010, Vol.110 (5), p.1047-1055
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0Rae, Dale E.
1Noakes, Timothy D.
2San Juan, Alejandro F.
3Pérez, Margarita
4Nogales-Gadea, Gisela
5Ruiz, Jonatan R.
6Morán, María
7Martín, Miguel A.
8Andreu, Antoni L.
9Arenas, Joaquín
10Lucia, Alejandro
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0Excessive skeletal muscle recruitment during strenuous exercise in McArdle patients
1European journal of applied physiology
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descriptionWe compared the cardiorespiratory response and muscle recruitment [as determined by electromyography (EMG)] of 37 McArdle patients [19 males, 37.4 ± 2.8 years, body mass index (BMI): 25.1 ± 4.7 kg m −2 ] and 33 healthy controls (18 males, 36.4 ± 10.0 years, BMI: 25.7 ± 3.8 kg m −2 ) during cycle-ergometer exercise (an incremental test to exhaustion and a 12-min submaximal constant workload test). We obtained cardiorespiratory [oxygen uptake and heart rate (HR)] and EMG data ( rectus femoris and vastus lateralis muscles). During the incremental test, the patients exhibited the expected hyperkinetic cardiovascular response shown by a marked increase in the slope of the HR:Power relationship ( p  < 0.001). Throughout the incremental test and at the point of fatigue, the patients produced significantly less power than the controls (peak power output: 67 ± 21 vs. 214 ± 56 watts respectively, p  < 0.001), yet they demonstrated significantly higher levels of muscle activity for a given absolute power. During the constant workload test, patients displayed higher levels of EMG activity than the controls during the second half of the test, despite a lower power production (34 ± 13 vs. 94 ± 29 watts respectively, p  < 0.001). In conclusion, since the McArdle patients required more motor unit recruitment for a given power output, our data suggest that the state of contractility of their muscles is reduced compared with healthy people. Excessive muscle recruitment for a given load could be one of the mechanisms explaining the exercise intolerance of these patients.
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9Exercise Test
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11Fundamental and applied biological sciences. Psychology
12Glycogen Storage Disease Type V - physiopathology
13Heart beat
14Heart Rate - physiology
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18Medicin och hälsovetenskap
19Middle Aged
20Muscle Contraction - physiology
21Muscle Strength - physiology
22Muscle, Skeletal - physiology
23Muscle, Skeletal - physiopathology
24Occupational Medicine/Industrial Medicine
25Original Article
26Oxygen Consumption - physiology
27Sports Medicine
28Tratamiento médico
29Universities and colleges
30Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
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9Exercise Test
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7Martín, Miguel A.
8Andreu, Antoni L.
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abstractWe compared the cardiorespiratory response and muscle recruitment [as determined by electromyography (EMG)] of 37 McArdle patients [19 males, 37.4 ± 2.8 years, body mass index (BMI): 25.1 ± 4.7 kg m −2 ] and 33 healthy controls (18 males, 36.4 ± 10.0 years, BMI: 25.7 ± 3.8 kg m −2 ) during cycle-ergometer exercise (an incremental test to exhaustion and a 12-min submaximal constant workload test). We obtained cardiorespiratory [oxygen uptake and heart rate (HR)] and EMG data ( rectus femoris and vastus lateralis muscles). During the incremental test, the patients exhibited the expected hyperkinetic cardiovascular response shown by a marked increase in the slope of the HR:Power relationship ( p  < 0.001). Throughout the incremental test and at the point of fatigue, the patients produced significantly less power than the controls (peak power output: 67 ± 21 vs. 214 ± 56 watts respectively, p  < 0.001), yet they demonstrated significantly higher levels of muscle activity for a given absolute power. During the constant workload test, patients displayed higher levels of EMG activity than the controls during the second half of the test, despite a lower power production (34 ± 13 vs. 94 ± 29 watts respectively, p  < 0.001). In conclusion, since the McArdle patients required more motor unit recruitment for a given power output, our data suggest that the state of contractility of their muscles is reduced compared with healthy people. Excessive muscle recruitment for a given load could be one of the mechanisms explaining the exercise intolerance of these patients.
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