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Excessive skeletal muscle recruitment during strenuous exercise in McArdle patients

We compared the cardiorespiratory response and muscle recruitment [as determined by electromyography (EMG)] of 37 McArdle patients [19 males, 37.4 ± 2.8 years, body mass index (BMI): 25.1 ± 4.7 kg m −2 ] and 33 healthy controls (18 males, 36.4 ± 10.0 years, BMI: 25.7 ± 3.8 kg m −2 ) during cycle-erg... Full description

Journal Title: European journal of applied physiology 2010, Vol.110 (5), p.1047-1055
Main Author: Rae, Dale E
Other Authors: Noakes, Timothy D , San Juan, Alejandro F , Pérez, Margarita , Nogales-Gadea, Gisela , Ruiz, Jonatan R , Morán, María , Martín, Miguel A , Andreu, Antoni L , Arenas, Joaquín , Lucia, Alejandro
Format: Electronic Article Electronic Article
Language: English
Subjects:
Adult
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Deporte
Electromyography
Enfermedad nutricional
Exercise
Exercise - physiology
Exercise Test
Female
Fundamental and applied biological sciences. Psychology
Glycogen Storage Disease Type V - physiopathology
Heart beat
Heart Rate - physiology
Human Physiology
Humans
Male
Medicin och hälsovetenskap
Middle Aged
Muscle Contraction - physiology
Muscle Strength - physiology
Muscle, Skeletal - physiology
Muscle, Skeletal - physiopathology
Occupational Medicine/Industrial Medicine
Original Article
Oxygen Consumption - physiology
Sports Medicine
Tratamiento médico
Universities and colleges
Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 1439-6319
Zum Text:
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recordid: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_121641113
title: Excessive skeletal muscle recruitment during strenuous exercise in McArdle patients
format: Article
creator:
  • Rae, Dale E
  • Noakes, Timothy D
  • San Juan, Alejandro F
  • Pérez, Margarita
  • Nogales-Gadea, Gisela
  • Ruiz, Jonatan R
  • Morán, María
  • Martín, Miguel A
  • Andreu, Antoni L
  • Arenas, Joaquín
  • Lucia, Alejandro
subjects:
  • Adult
  • Biological and medical sciences
  • Biomedical and Life Sciences
  • Biomedicine
  • Deporte
  • Electromyography
  • Enfermedad nutricional
  • Exercise
  • Exercise - physiology
  • Exercise Test
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Glycogen Storage Disease Type V - physiopathology
  • Heart beat
  • Heart Rate - physiology
  • Human Physiology
  • Humans
  • Male
  • Medicin och hälsovetenskap
  • Middle Aged
  • Muscle Contraction - physiology
  • Muscle Strength - physiology
  • Muscle, Skeletal - physiology
  • Muscle, Skeletal - physiopathology
  • Occupational Medicine/Industrial Medicine
  • Original Article
  • Oxygen Consumption - physiology
  • Sports Medicine
  • Tratamiento médico
  • Universities and colleges
  • Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
ispartof: European journal of applied physiology, 2010, Vol.110 (5), p.1047-1055
description: We compared the cardiorespiratory response and muscle recruitment [as determined by electromyography (EMG)] of 37 McArdle patients [19 males, 37.4 ± 2.8 years, body mass index (BMI): 25.1 ± 4.7 kg m −2 ] and 33 healthy controls (18 males, 36.4 ± 10.0 years, BMI: 25.7 ± 3.8 kg m −2 ) during cycle-ergometer exercise (an incremental test to exhaustion and a 12-min submaximal constant workload test). We obtained cardiorespiratory [oxygen uptake and heart rate (HR)] and EMG data ( rectus femoris and vastus lateralis muscles). During the incremental test, the patients exhibited the expected hyperkinetic cardiovascular response shown by a marked increase in the slope of the HR:Power relationship ( p  
language: eng
source:
identifier: ISSN: 1439-6319
fulltext: no_fulltext
issn:
  • 1439-6319
  • 1439-6327
  • 1439-6327
url: Link


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titleExcessive skeletal muscle recruitment during strenuous exercise in McArdle patients
creatorRae, Dale E ; Noakes, Timothy D ; San Juan, Alejandro F ; Pérez, Margarita ; Nogales-Gadea, Gisela ; Ruiz, Jonatan R ; Morán, María ; Martín, Miguel A ; Andreu, Antoni L ; Arenas, Joaquín ; Lucia, Alejandro
creatorcontribRae, Dale E ; Noakes, Timothy D ; San Juan, Alejandro F ; Pérez, Margarita ; Nogales-Gadea, Gisela ; Ruiz, Jonatan R ; Morán, María ; Martín, Miguel A ; Andreu, Antoni L ; Arenas, Joaquín ; Lucia, Alejandro
descriptionWe compared the cardiorespiratory response and muscle recruitment [as determined by electromyography (EMG)] of 37 McArdle patients [19 males, 37.4 ± 2.8 years, body mass index (BMI): 25.1 ± 4.7 kg m −2 ] and 33 healthy controls (18 males, 36.4 ± 10.0 years, BMI: 25.7 ± 3.8 kg m −2 ) during cycle-ergometer exercise (an incremental test to exhaustion and a 12-min submaximal constant workload test). We obtained cardiorespiratory [oxygen uptake and heart rate (HR)] and EMG data ( rectus femoris and vastus lateralis muscles). During the incremental test, the patients exhibited the expected hyperkinetic cardiovascular response shown by a marked increase in the slope of the HR:Power relationship ( p  < 0.001). Throughout the incremental test and at the point of fatigue, the patients produced significantly less power than the controls (peak power output: 67 ± 21 vs. 214 ± 56 watts respectively, p  < 0.001), yet they demonstrated significantly higher levels of muscle activity for a given absolute power. During the constant workload test, patients displayed higher levels of EMG activity than the controls during the second half of the test, despite a lower power production (34 ± 13 vs. 94 ± 29 watts respectively, p  < 0.001). In conclusion, since the McArdle patients required more motor unit recruitment for a given power output, our data suggest that the state of contractility of their muscles is reduced compared with healthy people. Excessive muscle recruitment for a given load could be one of the mechanisms explaining the exercise intolerance of these patients.
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languageeng
publisherBerlin/Heidelberg: Springer-Verlag
subjectAdult ; Biological and medical sciences ; Biomedical and Life Sciences ; Biomedicine ; Deporte ; Electromyography ; Enfermedad nutricional ; Exercise ; Exercise - physiology ; Exercise Test ; Female ; Fundamental and applied biological sciences. Psychology ; Glycogen Storage Disease Type V - physiopathology ; Heart beat ; Heart Rate - physiology ; Human Physiology ; Humans ; Male ; Medicin och hälsovetenskap ; Middle Aged ; Muscle Contraction - physiology ; Muscle Strength - physiology ; Muscle, Skeletal - physiology ; Muscle, Skeletal - physiopathology ; Occupational Medicine/Industrial Medicine ; Original Article ; Oxygen Consumption - physiology ; Sports Medicine ; Tratamiento médico ; Universities and colleges ; Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
ispartofEuropean journal of applied physiology, 2010, Vol.110 (5), p.1047-1055
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0Rae, Dale E
1Noakes, Timothy D
2San Juan, Alejandro F
3Pérez, Margarita
4Nogales-Gadea, Gisela
5Ruiz, Jonatan R
6Morán, María
7Martín, Miguel A
8Andreu, Antoni L
9Arenas, Joaquín
10Lucia, Alejandro
title
0Excessive skeletal muscle recruitment during strenuous exercise in McArdle patients
1European journal of applied physiology
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0Eur J Appl Physiol
1Eur J Appl Physiol
descriptionWe compared the cardiorespiratory response and muscle recruitment [as determined by electromyography (EMG)] of 37 McArdle patients [19 males, 37.4 ± 2.8 years, body mass index (BMI): 25.1 ± 4.7 kg m −2 ] and 33 healthy controls (18 males, 36.4 ± 10.0 years, BMI: 25.7 ± 3.8 kg m −2 ) during cycle-ergometer exercise (an incremental test to exhaustion and a 12-min submaximal constant workload test). We obtained cardiorespiratory [oxygen uptake and heart rate (HR)] and EMG data ( rectus femoris and vastus lateralis muscles). During the incremental test, the patients exhibited the expected hyperkinetic cardiovascular response shown by a marked increase in the slope of the HR:Power relationship ( p  < 0.001). Throughout the incremental test and at the point of fatigue, the patients produced significantly less power than the controls (peak power output: 67 ± 21 vs. 214 ± 56 watts respectively, p  < 0.001), yet they demonstrated significantly higher levels of muscle activity for a given absolute power. During the constant workload test, patients displayed higher levels of EMG activity than the controls during the second half of the test, despite a lower power production (34 ± 13 vs. 94 ± 29 watts respectively, p  < 0.001). In conclusion, since the McArdle patients required more motor unit recruitment for a given power output, our data suggest that the state of contractility of their muscles is reduced compared with healthy people. Excessive muscle recruitment for a given load could be one of the mechanisms explaining the exercise intolerance of these patients.
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9Exercise Test
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11Fundamental and applied biological sciences. Psychology
12Glycogen Storage Disease Type V - physiopathology
13Heart beat
14Heart Rate - physiology
15Human Physiology
16Humans
17Male
18Medicin och hälsovetenskap
19Middle Aged
20Muscle Contraction - physiology
21Muscle Strength - physiology
22Muscle, Skeletal - physiology
23Muscle, Skeletal - physiopathology
24Occupational Medicine/Industrial Medicine
25Original Article
26Oxygen Consumption - physiology
27Sports Medicine
28Tratamiento médico
29Universities and colleges
30Vertebrates: body movement. Posture. Locomotion. Flight. Swimming. Physical exercise. Rest. Sports
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titleExcessive skeletal muscle recruitment during strenuous exercise in McArdle patients
authorRae, Dale E ; Noakes, Timothy D ; San Juan, Alejandro F ; Pérez, Margarita ; Nogales-Gadea, Gisela ; Ruiz, Jonatan R ; Morán, María ; Martín, Miguel A ; Andreu, Antoni L ; Arenas, Joaquín ; Lucia, Alejandro
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1Biological and medical sciences
2Biomedical and Life Sciences
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7Exercise
8Exercise - physiology
9Exercise Test
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11Fundamental and applied biological sciences. Psychology
12Glycogen Storage Disease Type V - physiopathology
13Heart beat
14Heart Rate - physiology
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21Muscle Strength - physiology
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29Universities and colleges
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0Rae, Dale E
1Noakes, Timothy D
2San Juan, Alejandro F
3Pérez, Margarita
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7Martín, Miguel A
8Andreu, Antoni L
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atitleExcessive skeletal muscle recruitment during strenuous exercise in McArdle patients
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abstractWe compared the cardiorespiratory response and muscle recruitment [as determined by electromyography (EMG)] of 37 McArdle patients [19 males, 37.4 ± 2.8 years, body mass index (BMI): 25.1 ± 4.7 kg m −2 ] and 33 healthy controls (18 males, 36.4 ± 10.0 years, BMI: 25.7 ± 3.8 kg m −2 ) during cycle-ergometer exercise (an incremental test to exhaustion and a 12-min submaximal constant workload test). We obtained cardiorespiratory [oxygen uptake and heart rate (HR)] and EMG data ( rectus femoris and vastus lateralis muscles). During the incremental test, the patients exhibited the expected hyperkinetic cardiovascular response shown by a marked increase in the slope of the HR:Power relationship ( p  < 0.001). Throughout the incremental test and at the point of fatigue, the patients produced significantly less power than the controls (peak power output: 67 ± 21 vs. 214 ± 56 watts respectively, p  < 0.001), yet they demonstrated significantly higher levels of muscle activity for a given absolute power. During the constant workload test, patients displayed higher levels of EMG activity than the controls during the second half of the test, despite a lower power production (34 ± 13 vs. 94 ± 29 watts respectively, p  < 0.001). In conclusion, since the McArdle patients required more motor unit recruitment for a given power output, our data suggest that the state of contractility of their muscles is reduced compared with healthy people. Excessive muscle recruitment for a given load could be one of the mechanisms explaining the exercise intolerance of these patients.
copBerlin/Heidelberg
pubSpringer-Verlag
pmid20683610
doi10.1007/s00421-010-1585-5
oafree_for_read