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Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance

Aims/hypothesis Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 di... Full description

Journal Title: Diabetologia 2012-03-17, Vol.55 (6), p.1668-1678
Main Author: Deleskog, A
Other Authors: Hilding, A , Brismar, K , Hamsten, A , Efendic, S , Östenson, C.-G
Format: Electronic Article Electronic Article
Language: English
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Publisher: Berlin/Heidelberg: Springer-Verlag
ID: ISSN: 0012-186X
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title: Low serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance
format: Article
creator:
  • Deleskog, A
  • Hilding, A
  • Brismar, K
  • Hamsten, A
  • Efendic, S
  • Östenson, C.-G
subjects:
  • Adult
  • Alfacalcidol
  • Article
  • Biological and medical sciences
  • Calcifediol
  • Development and progression
  • Dextrose
  • Diabetes
  • Diabetes Mellitus, Type 2 - blood
  • Diabetes Mellitus, Type 2 - metabolism
  • Diabetes Mellitus, Type 2 - pathology
  • Diabetes. Impaired glucose tolerance
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinopathies
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Female
  • Glucose
  • Glucose Intolerance - blood
  • Glucose Intolerance - metabolism
  • Glucose Intolerance - physiopathology
  • Glucose metabolism
  • Glucose Tolerance Test
  • Human Physiology
  • Humans
  • Internal Medicine
  • Male
  • Medical sciences
  • Medicin och hälsovetenskap
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Middle Aged
  • Peptides
  • Prediabetic state
  • Prediabetic State - blood
  • Prediabetic State - metabolism
  • Prediabetic State - physiopathology
  • Protein binding
  • Somatomedins - metabolism
  • Type 2 diabetes
  • Vitamin D
  • Vitamin D - analogs & derivatives
  • Vitamin D - blood
ispartof: Diabetologia, 2012-03-17, Vol.55 (6), p.1668-1678
description: Aims/hypothesis Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on their own or when combined with serum concentrations of IGF-1 or IGF-binding protein-1 (IGFBP-1), which may interact with 25(OH)D. Methods At baseline, participants aged 35–56 years without known type 2 diabetes were examined using OGTTs, 25(OH)D and IGF peptide measurements, and anthropometric and lifestyle data. Participants who had prediabetes or type 2 diabetes at follow-up 8–10 years later were selected as cases; these were then age- and sex-matched to controls with normal glucose tolerance (NGT) at both baseline and follow-up, giving a total of 980 women and 1,398 men. Results Men but not women in the highest quartile of 25(OH)D level had a decreased OR for developing type 2 diabetes after adjustment for confounders (OR 0.52, 95% CI 0.30, 0.90), an effect accounted for by individuals with prediabetes, but not with NGT, at baseline. In both sexes, progression from prediabetes to type 2 diabetes was reduced by about 25% per 10 nmol/l increase in 25(OH)D. A high IGFBP-1 value was a better predictor of a reduced risk of type 2 diabetes than high 25(OH)D for both sexes, whereas high IGF-1 concentrations predicted a decreased risk only in men. Conclusions/interpretation High serum 25(OH)D concentrations predict a reduced risk of type 2 diabetes in individuals with prediabetes, but not NGT. There were no significant interactions between 25(OH)D and IGFBP-1 or IGF-1 in terms of risk of diabetes. Our data suggest that vitamin D supplementation should be evaluated for the prevention of type 2 diabetes in prediabetic individuals.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
  • 1432-0428
url: Link


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titleLow serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance
creatorDeleskog, A ; Hilding, A ; Brismar, K ; Hamsten, A ; Efendic, S ; Östenson, C.-G
creatorcontribDeleskog, A ; Hilding, A ; Brismar, K ; Hamsten, A ; Efendic, S ; Östenson, C.-G
descriptionAims/hypothesis Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on their own or when combined with serum concentrations of IGF-1 or IGF-binding protein-1 (IGFBP-1), which may interact with 25(OH)D. Methods At baseline, participants aged 35–56 years without known type 2 diabetes were examined using OGTTs, 25(OH)D and IGF peptide measurements, and anthropometric and lifestyle data. Participants who had prediabetes or type 2 diabetes at follow-up 8–10 years later were selected as cases; these were then age- and sex-matched to controls with normal glucose tolerance (NGT) at both baseline and follow-up, giving a total of 980 women and 1,398 men. Results Men but not women in the highest quartile of 25(OH)D level had a decreased OR for developing type 2 diabetes after adjustment for confounders (OR 0.52, 95% CI 0.30, 0.90), an effect accounted for by individuals with prediabetes, but not with NGT, at baseline. In both sexes, progression from prediabetes to type 2 diabetes was reduced by about 25% per 10 nmol/l increase in 25(OH)D. A high IGFBP-1 value was a better predictor of a reduced risk of type 2 diabetes than high 25(OH)D for both sexes, whereas high IGF-1 concentrations predicted a decreased risk only in men. Conclusions/interpretation High serum 25(OH)D concentrations predict a reduced risk of type 2 diabetes in individuals with prediabetes, but not NGT. There were no significant interactions between 25(OH)D and IGFBP-1 or IGF-1 in terms of risk of diabetes. Our data suggest that vitamin D supplementation should be evaluated for the prevention of type 2 diabetes in prediabetic individuals.
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subjectAdult ; Alfacalcidol ; Article ; Biological and medical sciences ; Calcifediol ; Development and progression ; Dextrose ; Diabetes ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - metabolism ; Diabetes Mellitus, Type 2 - pathology ; Diabetes. Impaired glucose tolerance ; Endocrine pancreas. Apud cells (diseases) ; Endocrinopathies ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Female ; Glucose ; Glucose Intolerance - blood ; Glucose Intolerance - metabolism ; Glucose Intolerance - physiopathology ; Glucose metabolism ; Glucose Tolerance Test ; Human Physiology ; Humans ; Internal Medicine ; Male ; Medical sciences ; Medicin och hälsovetenskap ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Middle Aged ; Peptides ; Prediabetic state ; Prediabetic State - blood ; Prediabetic State - metabolism ; Prediabetic State - physiopathology ; Protein binding ; Somatomedins - metabolism ; Type 2 diabetes ; Vitamin D ; Vitamin D - analogs & derivatives ; Vitamin D - blood
ispartofDiabetologia, 2012-03-17, Vol.55 (6), p.1668-1678
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descriptionAims/hypothesis Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on their own or when combined with serum concentrations of IGF-1 or IGF-binding protein-1 (IGFBP-1), which may interact with 25(OH)D. Methods At baseline, participants aged 35–56 years without known type 2 diabetes were examined using OGTTs, 25(OH)D and IGF peptide measurements, and anthropometric and lifestyle data. Participants who had prediabetes or type 2 diabetes at follow-up 8–10 years later were selected as cases; these were then age- and sex-matched to controls with normal glucose tolerance (NGT) at both baseline and follow-up, giving a total of 980 women and 1,398 men. Results Men but not women in the highest quartile of 25(OH)D level had a decreased OR for developing type 2 diabetes after adjustment for confounders (OR 0.52, 95% CI 0.30, 0.90), an effect accounted for by individuals with prediabetes, but not with NGT, at baseline. In both sexes, progression from prediabetes to type 2 diabetes was reduced by about 25% per 10 nmol/l increase in 25(OH)D. A high IGFBP-1 value was a better predictor of a reduced risk of type 2 diabetes than high 25(OH)D for both sexes, whereas high IGF-1 concentrations predicted a decreased risk only in men. Conclusions/interpretation High serum 25(OH)D concentrations predict a reduced risk of type 2 diabetes in individuals with prediabetes, but not NGT. There were no significant interactions between 25(OH)D and IGFBP-1 or IGF-1 in terms of risk of diabetes. Our data suggest that vitamin D supplementation should be evaluated for the prevention of type 2 diabetes in prediabetic individuals.
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13Endocrinopathies
14Etiopathogenesis. Screening. Investigations. Target tissue resistance
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17Glucose Intolerance - blood
18Glucose Intolerance - metabolism
19Glucose Intolerance - physiopathology
20Glucose metabolism
21Glucose Tolerance Test
22Human Physiology
23Humans
24Internal Medicine
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26Medical sciences
27Medicin och hälsovetenskap
28Medicine
29Medicine & Public Health
30Metabolic Diseases
31Middle Aged
32Peptides
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34Prediabetic State - blood
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36Prediabetic State - physiopathology
37Protein binding
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titleLow serum 25-hydroxyvitamin D level predicts progression to type 2 diabetes in individuals with prediabetes but not with normal glucose tolerance
authorDeleskog, A ; Hilding, A ; Brismar, K ; Hamsten, A ; Efendic, S ; Östenson, C.-G
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1Alfacalcidol
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4Calcifediol
5Development and progression
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7Diabetes
8Diabetes Mellitus, Type 2 - blood
9Diabetes Mellitus, Type 2 - metabolism
10Diabetes Mellitus, Type 2 - pathology
11Diabetes. Impaired glucose tolerance
12Endocrine pancreas. Apud cells (diseases)
13Endocrinopathies
14Etiopathogenesis. Screening. Investigations. Target tissue resistance
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abstractAims/hypothesis Vitamin D deficiency may increase the risk of type 2 diabetes. We therefore investigated whether serum concentrations of 25-hydroxyvitamin D [25(OH)D] would predict the development of prediabetes (impaired fasting glucose, impaired glucose tolerance or the two combined) and type 2 diabetes, either on their own or when combined with serum concentrations of IGF-1 or IGF-binding protein-1 (IGFBP-1), which may interact with 25(OH)D. Methods At baseline, participants aged 35–56 years without known type 2 diabetes were examined using OGTTs, 25(OH)D and IGF peptide measurements, and anthropometric and lifestyle data. Participants who had prediabetes or type 2 diabetes at follow-up 8–10 years later were selected as cases; these were then age- and sex-matched to controls with normal glucose tolerance (NGT) at both baseline and follow-up, giving a total of 980 women and 1,398 men. Results Men but not women in the highest quartile of 25(OH)D level had a decreased OR for developing type 2 diabetes after adjustment for confounders (OR 0.52, 95% CI 0.30, 0.90), an effect accounted for by individuals with prediabetes, but not with NGT, at baseline. In both sexes, progression from prediabetes to type 2 diabetes was reduced by about 25% per 10 nmol/l increase in 25(OH)D. A high IGFBP-1 value was a better predictor of a reduced risk of type 2 diabetes than high 25(OH)D for both sexes, whereas high IGF-1 concentrations predicted a decreased risk only in men. Conclusions/interpretation High serum 25(OH)D concentrations predict a reduced risk of type 2 diabetes in individuals with prediabetes, but not NGT. There were no significant interactions between 25(OH)D and IGFBP-1 or IGF-1 in terms of risk of diabetes. Our data suggest that vitamin D supplementation should be evaluated for the prevention of type 2 diabetes in prediabetic individuals.
copBerlin/Heidelberg
pubSpringer-Verlag
pmid22426800
doi10.1007/s00125-012-2529-x
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