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Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data

Summary Background Published work assessing psychosocial stress (job strain) as a risk factor for coronary heart disease is inconsistent and subject to publication bias and reverse causation bias. We analysed the relation between job strain and coronary heart disease with a meta-analysis of publishe... Full description

Journal Title: Lancet 2012, Vol.380 (9852), p.1491-1497
Main Author: Kivimäki, Mika, Prof
Other Authors: Nyberg, Solja T, MSc , Batty, G David, PhD , Fransson, Eleonor I, PhD , Heikkilä, Katriina, PhD , Alfredsson, Lars, Prof , Bjorner, Jakob B, Prof , Borritz, Marianne, MD , Burr, Hermann, PhD , Casini, Annalisa, PhD , Clays, Els, PhD , De Bacquer, Dirk, Prof , Dragano, Nico, Prof , Ferrie, Jane E, PhD , Geuskens, Goedele A, PhD , Goldberg, Marcel, Prof , Hamer, Mark, PhD , Hooftman, Wendela E, PhD , Houtman, Irene L, PhD , Joensuu, Matti, MSc , Jokela, Markus, PhD , Kittel, France, Prof , Knutsson, Anders, Prof , Koskenvuo, Markku, Prof , Koskinen, Aki, MSc , Kouvonen, Anne, PhD , Kumari, Meena, PhD , Madsen, Ida EH , Marmot, Michael G, Prof , Nielsen, Martin L, MD , Nordin, Maria, PhD , Oksanen, Tuula, MD , Pentti, Jaana, BSc , Rugulies, Reiner, Prof , Salo, Paula, PhD , Siegrist, Johannes, Prof , Singh-Manoux, Archana, PhD , Suominen, Sakari B, MD , Väänänen, Ari, PhD , Vahtera, Jussi, Prof , Virtanen, Marianna, Prof , Westerholm, Peter JM, Prof , Westerlund, Hugo, Prof , Zins, Marie, MD , Steptoe, Andrew, Prof , Theorell, Töres, Prof
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Kidlington: Elsevier Ltd
ID: ISSN: 0140-6736
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title: Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data
format: Article
creator:
  • Kivimäki, Mika, Prof
  • Nyberg, Solja T, MSc
  • Batty, G David, PhD
  • Fransson, Eleonor I, PhD
  • Heikkilä, Katriina, PhD
  • Alfredsson, Lars, Prof
  • Bjorner, Jakob B, Prof
  • Borritz, Marianne, MD
  • Burr, Hermann, PhD
  • Casini, Annalisa, PhD
  • Clays, Els, PhD
  • De Bacquer, Dirk, Prof
  • Dragano, Nico, Prof
  • Ferrie, Jane E, PhD
  • Geuskens, Goedele A, PhD
  • Goldberg, Marcel, Prof
  • Hamer, Mark, PhD
  • Hooftman, Wendela E, PhD
  • Houtman, Irene L, PhD
  • Joensuu, Matti, MSc
  • Jokela, Markus, PhD
  • Kittel, France, Prof
  • Knutsson, Anders, Prof
  • Koskenvuo, Markku, Prof
  • Koskinen, Aki, MSc
  • Kouvonen, Anne, PhD
  • Kumari, Meena, PhD
  • Madsen, Ida EH
  • Marmot, Michael G, Prof
  • Nielsen, Martin L, MD
  • Nordin, Maria, PhD
  • Oksanen, Tuula, MD
  • Pentti, Jaana, BSc
  • Rugulies, Reiner, Prof
  • Salo, Paula, PhD
  • Siegrist, Johannes, Prof
  • Singh-Manoux, Archana, PhD
  • Suominen, Sakari B, MD
  • Väänänen, Ari, PhD
  • Vahtera, Jussi, Prof
  • Virtanen, Marianna, Prof
  • Westerholm, Peter JM, Prof
  • Westerlund, Hugo, Prof
  • Zins, Marie, MD
  • Steptoe, Andrew, Prof
  • Theorell, Töres, Prof
subjects:
  • Abridged Index Medicus
  • Adult
  • Arbetsmedicin och miljömedicin
  • Articles
  • Behavioural
  • Biological and medical sciences
  • Cardiac and Cardiovascular Systems
  • Cardiology. Vascular system
  • Cardiovascular disease
  • Clinical Medicine
  • Coronary Disease
  • Coronary Disease - etiology
  • Coronary Disease - psychology
  • Coronary heart disease
  • Employment
  • Epidemiology
  • Female
  • Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
  • General aspects
  • Health aspects
  • Health Sciences
  • Healthy Living
  • Heart
  • Heart attacks
  • Humans
  • Hälsovetenskaper
  • Internal Medicine
  • Job stress
  • Kardiologi
  • Klinisk medicin
  • Life Sciences
  • Male
  • Medical and Health Sciences
  • Medical sciences
  • Medicin och hälsovetenskap
  • Occupational Health and Environmental Health
  • Occupational stress
  • Organisation
  • Psychological
  • Public Health, Global Health, Social Medicine and Epidemiology
  • Public health. Hygiene
  • Public health. Hygiene-occupational medicine
  • Risk factors
  • Santé publique et épidémiologie
  • Societal Sciences
  • Socioeconomic Factors
  • Stress
  • Stress, Psychological
  • Stress, Psychological - complications
  • Studies
  • Systematic review
  • Work
  • Work & Health
  • Workplace
ispartof: Lancet, 2012, Vol.380 (9852), p.1491-1497
description: Summary Background Published work assessing psychosocial stress (job strain) as a risk factor for coronary heart disease is inconsistent and subject to publication bias and reverse causation bias. We analysed the relation between job strain and coronary heart disease with a meta-analysis of published and unpublished studies. Methods We used individual records from 13 European cohort studies (1985–2006) of men and women without coronary heart disease who were employed at time of baseline assessment. We measured job strain with questions from validated job-content and demand-control questionnaires. We extracted data in two stages such that acquisition and harmonisation of job strain measure and covariables occurred before linkage to records for coronary heart disease. We defined incident coronary heart disease as the first non-fatal myocardial infarction or coronary death. Findings 30 214 (15%) of 197 473 participants reported job strain. In 1·49 million person-years at risk (mean follow-up 7·5 years [SD 1·7]), we recorded 2358 events of incident coronary heart disease. After adjustment for sex and age, the hazard ratio for job strain versus no job strain was 1·23 (95% CI 1·10–1·37). This effect estimate was higher in published (1·43, 1·15–1·77) than unpublished (1·16, 1·02–1·32) studies. Hazard ratios were likewise raised in analyses addressing reverse causality by exclusion of events of coronary heart disease that occurred in the first 3 years (1·31, 1·15–1·48) and 5 years (1·30, 1·13–1·50) of follow-up. We noted an association between job strain and coronary heart disease for sex, age groups, socioeconomic strata, and region, and after adjustments for socioeconomic status, and lifestyle and conventional risk factors. The population attributable risk for job strain was 3·4%. Interpretation Our findings suggest that prevention of workplace stress might decrease disease incidence; however, this strategy would have a much smaller effect than would tackling of standard risk factors, such as smoking. Funding Finnish Work Environment Fund, the Academy of Finland, the Swedish Research Council for Working Life and Social Research, the German Social Accident Insurance, the Danish National Research Centre for the Working Environment, the BUPA Foundation, the Ministry of Social Affairs and Employment, the Medical Research Council, the Wellcome Trust, and the US National Institutes of Health.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
  • 1474-547X
url: Link


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titleJob strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data
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creatorKivimäki, Mika, Prof ; Nyberg, Solja T, MSc ; Batty, G David, PhD ; Fransson, Eleonor I, PhD ; Heikkilä, Katriina, PhD ; Alfredsson, Lars, Prof ; Bjorner, Jakob B, Prof ; Borritz, Marianne, MD ; Burr, Hermann, PhD ; Casini, Annalisa, PhD ; Clays, Els, PhD ; De Bacquer, Dirk, Prof ; Dragano, Nico, Prof ; Ferrie, Jane E, PhD ; Geuskens, Goedele A, PhD ; Goldberg, Marcel, Prof ; Hamer, Mark, PhD ; Hooftman, Wendela E, PhD ; Houtman, Irene L, PhD ; Joensuu, Matti, MSc ; Jokela, Markus, PhD ; Kittel, France, Prof ; Knutsson, Anders, Prof ; Koskenvuo, Markku, Prof ; Koskinen, Aki, MSc ; Kouvonen, Anne, PhD ; Kumari, Meena, PhD ; Madsen, Ida EH ; Marmot, Michael G, Prof ; Nielsen, Martin L, MD ; Nordin, Maria, PhD ; Oksanen, Tuula, MD ; Pentti, Jaana, BSc ; Rugulies, Reiner, Prof ; Salo, Paula, PhD ; Siegrist, Johannes, Prof ; Singh-Manoux, Archana, PhD ; Suominen, Sakari B, MD ; Väänänen, Ari, PhD ; Vahtera, Jussi, Prof ; Virtanen, Marianna, Prof ; Westerholm, Peter JM, Prof ; Westerlund, Hugo, Prof ; Zins, Marie, MD ; Steptoe, Andrew, Prof ; Theorell, Töres, Prof
creatorcontribKivimäki, Mika, Prof ; Nyberg, Solja T, MSc ; Batty, G David, PhD ; Fransson, Eleonor I, PhD ; Heikkilä, Katriina, PhD ; Alfredsson, Lars, Prof ; Bjorner, Jakob B, Prof ; Borritz, Marianne, MD ; Burr, Hermann, PhD ; Casini, Annalisa, PhD ; Clays, Els, PhD ; De Bacquer, Dirk, Prof ; Dragano, Nico, Prof ; Ferrie, Jane E, PhD ; Geuskens, Goedele A, PhD ; Goldberg, Marcel, Prof ; Hamer, Mark, PhD ; Hooftman, Wendela E, PhD ; Houtman, Irene L, PhD ; Joensuu, Matti, MSc ; Jokela, Markus, PhD ; Kittel, France, Prof ; Knutsson, Anders, Prof ; Koskenvuo, Markku, Prof ; Koskinen, Aki, MSc ; Kouvonen, Anne, PhD ; Kumari, Meena, PhD ; Madsen, Ida EH ; Marmot, Michael G, Prof ; Nielsen, Martin L, MD ; Nordin, Maria, PhD ; Oksanen, Tuula, MD ; Pentti, Jaana, BSc ; Rugulies, Reiner, Prof ; Salo, Paula, PhD ; Siegrist, Johannes, Prof ; Singh-Manoux, Archana, PhD ; Suominen, Sakari B, MD ; Väänänen, Ari, PhD ; Vahtera, Jussi, Prof ; Virtanen, Marianna, Prof ; Westerholm, Peter JM, Prof ; Westerlund, Hugo, Prof ; Zins, Marie, MD ; Steptoe, Andrew, Prof ; Theorell, Töres, Prof ; for the IPD-Work Consortium ; IPD-Work Consortium
descriptionSummary Background Published work assessing psychosocial stress (job strain) as a risk factor for coronary heart disease is inconsistent and subject to publication bias and reverse causation bias. We analysed the relation between job strain and coronary heart disease with a meta-analysis of published and unpublished studies. Methods We used individual records from 13 European cohort studies (1985–2006) of men and women without coronary heart disease who were employed at time of baseline assessment. We measured job strain with questions from validated job-content and demand-control questionnaires. We extracted data in two stages such that acquisition and harmonisation of job strain measure and covariables occurred before linkage to records for coronary heart disease. We defined incident coronary heart disease as the first non-fatal myocardial infarction or coronary death. Findings 30 214 (15%) of 197 473 participants reported job strain. In 1·49 million person-years at risk (mean follow-up 7·5 years [SD 1·7]), we recorded 2358 events of incident coronary heart disease. After adjustment for sex and age, the hazard ratio for job strain versus no job strain was 1·23 (95% CI 1·10–1·37). This effect estimate was higher in published (1·43, 1·15–1·77) than unpublished (1·16, 1·02–1·32) studies. Hazard ratios were likewise raised in analyses addressing reverse causality by exclusion of events of coronary heart disease that occurred in the first 3 years (1·31, 1·15–1·48) and 5 years (1·30, 1·13–1·50) of follow-up. We noted an association between job strain and coronary heart disease for sex, age groups, socioeconomic strata, and region, and after adjustments for socioeconomic status, and lifestyle and conventional risk factors. The population attributable risk for job strain was 3·4%. Interpretation Our findings suggest that prevention of workplace stress might decrease disease incidence; however, this strategy would have a much smaller effect than would tackling of standard risk factors, such as smoking. Funding Finnish Work Environment Fund, the Academy of Finland, the Swedish Research Council for Working Life and Social Research, the German Social Accident Insurance, the Danish National Research Centre for the Working Environment, the BUPA Foundation, the Ministry of Social Affairs and Employment, the Medical Research Council, the Wellcome Trust, and the US National Institutes of Health.
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0ISSN: 0140-6736
1ISSN: 1474-547X
2EISSN: 1474-547X
3DOI: 10.1016/S0140-6736(12)60994-5
4PMID: 22981903
5CODEN: LANCAO
languageeng
publisherKidlington: Elsevier Ltd
subjectAbridged Index Medicus ; Adult ; Arbetsmedicin och miljömedicin ; Articles ; Behavioural ; Biological and medical sciences ; Cardiac and Cardiovascular Systems ; Cardiology. Vascular system ; Cardiovascular disease ; Clinical Medicine ; Coronary Disease ; Coronary Disease - etiology ; Coronary Disease - psychology ; Coronary heart disease ; Employment ; Epidemiology ; Female ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; General aspects ; Health aspects ; Health Sciences ; Healthy Living ; Heart ; Heart attacks ; Humans ; Hälsovetenskaper ; Internal Medicine ; Job stress ; Kardiologi ; Klinisk medicin ; Life Sciences ; Male ; Medical and Health Sciences ; Medical sciences ; Medicin och hälsovetenskap ; Occupational Health and Environmental Health ; Occupational stress ; Organisation ; Psychological ; Public Health, Global Health, Social Medicine and Epidemiology ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Risk factors ; Santé publique et épidémiologie ; Societal Sciences ; Socioeconomic Factors ; Stress ; Stress, Psychological ; Stress, Psychological - complications ; Studies ; Systematic review ; Work ; Work & Health ; Workplace
ispartofLancet, 2012, Vol.380 (9852), p.1491-1497
rights
0Elsevier Ltd
12012 Elsevier Ltd
22015 INIST-CNRS
3Copyright © 2012 Elsevier Ltd. All rights reserved.
4COPYRIGHT 2012 Elsevier B.V.
5Distributed under a Creative Commons Attribution 4.0 International License
62012 Elsevier Ltd. All rights reserved. 2012 Elsevier Ltd
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creatorcontrib
0Kivimäki, Mika, Prof
1Nyberg, Solja T, MSc
2Batty, G David, PhD
3Fransson, Eleonor I, PhD
4Heikkilä, Katriina, PhD
5Alfredsson, Lars, Prof
6Bjorner, Jakob B, Prof
7Borritz, Marianne, MD
8Burr, Hermann, PhD
9Casini, Annalisa, PhD
10Clays, Els, PhD
11De Bacquer, Dirk, Prof
12Dragano, Nico, Prof
13Ferrie, Jane E, PhD
14Geuskens, Goedele A, PhD
15Goldberg, Marcel, Prof
16Hamer, Mark, PhD
17Hooftman, Wendela E, PhD
18Houtman, Irene L, PhD
19Joensuu, Matti, MSc
20Jokela, Markus, PhD
21Kittel, France, Prof
22Knutsson, Anders, Prof
23Koskenvuo, Markku, Prof
24Koskinen, Aki, MSc
25Kouvonen, Anne, PhD
26Kumari, Meena, PhD
27Madsen, Ida EH
28Marmot, Michael G, Prof
29Nielsen, Martin L, MD
30Nordin, Maria, PhD
31Oksanen, Tuula, MD
32Pentti, Jaana, BSc
33Rugulies, Reiner, Prof
34Salo, Paula, PhD
35Siegrist, Johannes, Prof
36Singh-Manoux, Archana, PhD
37Suominen, Sakari B, MD
38Väänänen, Ari, PhD
39Vahtera, Jussi, Prof
40Virtanen, Marianna, Prof
41Westerholm, Peter JM, Prof
42Westerlund, Hugo, Prof
43Zins, Marie, MD
44Steptoe, Andrew, Prof
45Theorell, Töres, Prof
46for the IPD-Work Consortium
47IPD-Work Consortium
title
0Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data
1Lancet
addtitleLancet
descriptionSummary Background Published work assessing psychosocial stress (job strain) as a risk factor for coronary heart disease is inconsistent and subject to publication bias and reverse causation bias. We analysed the relation between job strain and coronary heart disease with a meta-analysis of published and unpublished studies. Methods We used individual records from 13 European cohort studies (1985–2006) of men and women without coronary heart disease who were employed at time of baseline assessment. We measured job strain with questions from validated job-content and demand-control questionnaires. We extracted data in two stages such that acquisition and harmonisation of job strain measure and covariables occurred before linkage to records for coronary heart disease. We defined incident coronary heart disease as the first non-fatal myocardial infarction or coronary death. Findings 30 214 (15%) of 197 473 participants reported job strain. In 1·49 million person-years at risk (mean follow-up 7·5 years [SD 1·7]), we recorded 2358 events of incident coronary heart disease. After adjustment for sex and age, the hazard ratio for job strain versus no job strain was 1·23 (95% CI 1·10–1·37). This effect estimate was higher in published (1·43, 1·15–1·77) than unpublished (1·16, 1·02–1·32) studies. Hazard ratios were likewise raised in analyses addressing reverse causality by exclusion of events of coronary heart disease that occurred in the first 3 years (1·31, 1·15–1·48) and 5 years (1·30, 1·13–1·50) of follow-up. We noted an association between job strain and coronary heart disease for sex, age groups, socioeconomic strata, and region, and after adjustments for socioeconomic status, and lifestyle and conventional risk factors. The population attributable risk for job strain was 3·4%. Interpretation Our findings suggest that prevention of workplace stress might decrease disease incidence; however, this strategy would have a much smaller effect than would tackling of standard risk factors, such as smoking. Funding Finnish Work Environment Fund, the Academy of Finland, the Swedish Research Council for Working Life and Social Research, the German Social Accident Insurance, the Danish National Research Centre for the Working Environment, the BUPA Foundation, the Ministry of Social Affairs and Employment, the Medical Research Council, the Wellcome Trust, and the US National Institutes of Health.
subject
0Abridged Index Medicus
1Adult
2Arbetsmedicin och miljömedicin
3Articles
4Behavioural
5Biological and medical sciences
6Cardiac and Cardiovascular Systems
7Cardiology. Vascular system
8Cardiovascular disease
9Clinical Medicine
10Coronary Disease
11Coronary Disease - etiology
12Coronary Disease - psychology
13Coronary heart disease
14Employment
15Epidemiology
16Female
17Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
18General aspects
19Health aspects
20Health Sciences
21Healthy Living
22Heart
23Heart attacks
24Humans
25Hälsovetenskaper
26Internal Medicine
27Job stress
28Kardiologi
29Klinisk medicin
30Life Sciences
31Male
32Medical and Health Sciences
33Medical sciences
34Medicin och hälsovetenskap
35Occupational Health and Environmental Health
36Occupational stress
37Organisation
38Psychological
39Public Health, Global Health, Social Medicine and Epidemiology
40Public health. Hygiene
41Public health. Hygiene-occupational medicine
42Risk factors
43Santé publique et épidémiologie
44Societal Sciences
45Socioeconomic Factors
46Stress
47Stress, Psychological
48Stress, Psychological - complications
49Studies
50Systematic review
51Work
52Work & Health
53Workplace
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0Kivimäki, Mika, Prof
1Nyberg, Solja T, MSc
2Batty, G David, PhD
3Fransson, Eleonor I, PhD
4Heikkilä, Katriina, PhD
5Alfredsson, Lars, Prof
6Bjorner, Jakob B, Prof
7Borritz, Marianne, MD
8Burr, Hermann, PhD
9Casini, Annalisa, PhD
10Clays, Els, PhD
11De Bacquer, Dirk, Prof
12Dragano, Nico, Prof
13Ferrie, Jane E, PhD
14Geuskens, Goedele A, PhD
15Goldberg, Marcel, Prof
16Hamer, Mark, PhD
17Hooftman, Wendela E, PhD
18Houtman, Irene L, PhD
19Joensuu, Matti, MSc
20Jokela, Markus, PhD
21Kittel, France, Prof
22Knutsson, Anders, Prof
23Koskenvuo, Markku, Prof
24Koskinen, Aki, MSc
25Kouvonen, Anne, PhD
26Kumari, Meena, PhD
27Madsen, Ida EH
28Marmot, Michael G, Prof
29Nielsen, Martin L, MD
30Nordin, Maria, PhD
31Oksanen, Tuula, MD
32Pentti, Jaana, BSc
33Rugulies, Reiner, Prof
34Salo, Paula, PhD
35Siegrist, Johannes, Prof
36Singh-Manoux, Archana, PhD
37Suominen, Sakari B, MD
38Väänänen, Ari, PhD
39Vahtera, Jussi, Prof
40Virtanen, Marianna, Prof
41Westerholm, Peter JM, Prof
42Westerlund, Hugo, Prof
43Zins, Marie, MD
44Steptoe, Andrew, Prof
45Theorell, Töres, Prof
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creationdate2012
titleJob strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data
authorKivimäki, Mika, Prof ; Nyberg, Solja T, MSc ; Batty, G David, PhD ; Fransson, Eleonor I, PhD ; Heikkilä, Katriina, PhD ; Alfredsson, Lars, Prof ; Bjorner, Jakob B, Prof ; Borritz, Marianne, MD ; Burr, Hermann, PhD ; Casini, Annalisa, PhD ; Clays, Els, PhD ; De Bacquer, Dirk, Prof ; Dragano, Nico, Prof ; Ferrie, Jane E, PhD ; Geuskens, Goedele A, PhD ; Goldberg, Marcel, Prof ; Hamer, Mark, PhD ; Hooftman, Wendela E, PhD ; Houtman, Irene L, PhD ; Joensuu, Matti, MSc ; Jokela, Markus, PhD ; Kittel, France, Prof ; Knutsson, Anders, Prof ; Koskenvuo, Markku, Prof ; Koskinen, Aki, MSc ; Kouvonen, Anne, PhD ; Kumari, Meena, PhD ; Madsen, Ida EH ; Marmot, Michael G, Prof ; Nielsen, Martin L, MD ; Nordin, Maria, PhD ; Oksanen, Tuula, MD ; Pentti, Jaana, BSc ; Rugulies, Reiner, Prof ; Salo, Paula, PhD ; Siegrist, Johannes, Prof ; Singh-Manoux, Archana, PhD ; Suominen, Sakari B, MD ; Väänänen, Ari, PhD ; Vahtera, Jussi, Prof ; Virtanen, Marianna, Prof ; Westerholm, Peter JM, Prof ; Westerlund, Hugo, Prof ; Zins, Marie, MD ; Steptoe, Andrew, Prof ; Theorell, Töres, Prof
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frbrtype5
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creationdate2012
topic
0Abridged Index Medicus
1Adult
2Arbetsmedicin och miljömedicin
3Articles
4Behavioural
5Biological and medical sciences
6Cardiac and Cardiovascular Systems
7Cardiology. Vascular system
8Cardiovascular disease
9Clinical Medicine
10Coronary Disease
11Coronary Disease - etiology
12Coronary Disease - psychology
13Coronary heart disease
14Employment
15Epidemiology
16Female
17Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
18General aspects
19Health aspects
20Health Sciences
21Healthy Living
22Heart
23Heart attacks
24Humans
25Hälsovetenskaper
26Internal Medicine
27Job stress
28Kardiologi
29Klinisk medicin
30Life Sciences
31Male
32Medical and Health Sciences
33Medical sciences
34Medicin och hälsovetenskap
35Occupational Health and Environmental Health
36Occupational stress
37Organisation
38Psychological
39Public Health, Global Health, Social Medicine and Epidemiology
40Public health. Hygiene
41Public health. Hygiene-occupational medicine
42Risk factors
43Santé publique et épidémiologie
44Societal Sciences
45Socioeconomic Factors
46Stress
47Stress, Psychological
48Stress, Psychological - complications
49Studies
50Systematic review
51Work
52Work & Health
53Workplace
toplevel
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1online_resources
creatorcontrib
0Kivimäki, Mika, Prof
1Nyberg, Solja T, MSc
2Batty, G David, PhD
3Fransson, Eleonor I, PhD
4Heikkilä, Katriina, PhD
5Alfredsson, Lars, Prof
6Bjorner, Jakob B, Prof
7Borritz, Marianne, MD
8Burr, Hermann, PhD
9Casini, Annalisa, PhD
10Clays, Els, PhD
11De Bacquer, Dirk, Prof
12Dragano, Nico, Prof
13Ferrie, Jane E, PhD
14Geuskens, Goedele A, PhD
15Goldberg, Marcel, Prof
16Hamer, Mark, PhD
17Hooftman, Wendela E, PhD
18Houtman, Irene L, PhD
19Joensuu, Matti, MSc
20Jokela, Markus, PhD
21Kittel, France, Prof
22Knutsson, Anders, Prof
23Koskenvuo, Markku, Prof
24Koskinen, Aki, MSc
25Kouvonen, Anne, PhD
26Kumari, Meena, PhD
27Madsen, Ida EH
28Marmot, Michael G, Prof
29Nielsen, Martin L, MD
30Nordin, Maria, PhD
31Oksanen, Tuula, MD
32Pentti, Jaana, BSc
33Rugulies, Reiner, Prof
34Salo, Paula, PhD
35Siegrist, Johannes, Prof
36Singh-Manoux, Archana, PhD
37Suominen, Sakari B, MD
38Väänänen, Ari, PhD
39Vahtera, Jussi, Prof
40Virtanen, Marianna, Prof
41Westerholm, Peter JM, Prof
42Westerlund, Hugo, Prof
43Zins, Marie, MD
44Steptoe, Andrew, Prof
45Theorell, Töres, Prof
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47IPD-Work Consortium
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jtitleLancet
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Kivimäki, Mika, Prof
1Nyberg, Solja T, MSc
2Batty, G David, PhD
3Fransson, Eleonor I, PhD
4Heikkilä, Katriina, PhD
5Alfredsson, Lars, Prof
6Bjorner, Jakob B, Prof
7Borritz, Marianne, MD
8Burr, Hermann, PhD
9Casini, Annalisa, PhD
10Clays, Els, PhD
11De Bacquer, Dirk, Prof
12Dragano, Nico, Prof
13Ferrie, Jane E, PhD
14Geuskens, Goedele A, PhD
15Goldberg, Marcel, Prof
16Hamer, Mark, PhD
17Hooftman, Wendela E, PhD
18Houtman, Irene L, PhD
19Joensuu, Matti, MSc
20Jokela, Markus, PhD
21Kittel, France, Prof
22Knutsson, Anders, Prof
23Koskenvuo, Markku, Prof
24Koskinen, Aki, MSc
25Kouvonen, Anne, PhD
26Kumari, Meena, PhD
27Madsen, Ida EH
28Marmot, Michael G, Prof
29Nielsen, Martin L, MD
30Nordin, Maria, PhD
31Oksanen, Tuula, MD
32Pentti, Jaana, BSc
33Rugulies, Reiner, Prof
34Salo, Paula, PhD
35Siegrist, Johannes, Prof
36Singh-Manoux, Archana, PhD
37Suominen, Sakari B, MD
38Väänänen, Ari, PhD
39Vahtera, Jussi, Prof
40Virtanen, Marianna, Prof
41Westerholm, Peter JM, Prof
42Westerlund, Hugo, Prof
43Zins, Marie, MD
44Steptoe, Andrew, Prof
45Theorell, Töres, Prof
aucorp
0for the IPD-Work Consortium
1IPD-Work Consortium
formatjournal
genrearticle
ristypeJOUR
atitleJob strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data
jtitleLancet
addtitleLancet
date2012
risdate2012
volume380
issue9852
spage1491
epage1497
pages1491-1497
issn
00140-6736
11474-547X
eissn1474-547X
codenLANCAO
notesPMCID: PMC3486012
abstractSummary Background Published work assessing psychosocial stress (job strain) as a risk factor for coronary heart disease is inconsistent and subject to publication bias and reverse causation bias. We analysed the relation between job strain and coronary heart disease with a meta-analysis of published and unpublished studies. Methods We used individual records from 13 European cohort studies (1985–2006) of men and women without coronary heart disease who were employed at time of baseline assessment. We measured job strain with questions from validated job-content and demand-control questionnaires. We extracted data in two stages such that acquisition and harmonisation of job strain measure and covariables occurred before linkage to records for coronary heart disease. We defined incident coronary heart disease as the first non-fatal myocardial infarction or coronary death. Findings 30 214 (15%) of 197 473 participants reported job strain. In 1·49 million person-years at risk (mean follow-up 7·5 years [SD 1·7]), we recorded 2358 events of incident coronary heart disease. After adjustment for sex and age, the hazard ratio for job strain versus no job strain was 1·23 (95% CI 1·10–1·37). This effect estimate was higher in published (1·43, 1·15–1·77) than unpublished (1·16, 1·02–1·32) studies. Hazard ratios were likewise raised in analyses addressing reverse causality by exclusion of events of coronary heart disease that occurred in the first 3 years (1·31, 1·15–1·48) and 5 years (1·30, 1·13–1·50) of follow-up. We noted an association between job strain and coronary heart disease for sex, age groups, socioeconomic strata, and region, and after adjustments for socioeconomic status, and lifestyle and conventional risk factors. The population attributable risk for job strain was 3·4%. Interpretation Our findings suggest that prevention of workplace stress might decrease disease incidence; however, this strategy would have a much smaller effect than would tackling of standard risk factors, such as smoking. Funding Finnish Work Environment Fund, the Academy of Finland, the Swedish Research Council for Working Life and Social Research, the German Social Accident Insurance, the Danish National Research Centre for the Working Environment, the BUPA Foundation, the Ministry of Social Affairs and Employment, the Medical Research Council, the Wellcome Trust, and the US National Institutes of Health.
copKidlington
pubElsevier Ltd
pmid22981903
doi10.1016/S0140-6736(12)60994-5
oafree_for_read