schliessen

Filtern

 

Bibliotheken

Cover Image

Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men

Aims/hypothesis We tested the hypothesis that dietary acid load may increase the risk of type 2 diabetes, and studied the association between acid load and insulin sensitivity as a possible mechanism involved. Methods An observational survey with prospective follow-up including 911 non-diabetic Swed... Full description

Journal Title: Diabetologia 2014-05-31, Vol.57 (8), p.1561-1568
Main Author: Xu, Hong
Other Authors: Jia, Ting , Huang, Xiaoyan , Risérus, Ulf , Cederholm, Tommy , Ärnlöv, Johan , Sjögren, Per , Lindholm, Bengt , Carrero, Juan-Jesús
Format: Electronic Article Electronic Article
Language: English
Subjects:
Acids
Aged
Algorithms
Article
Biological and medical sciences
Clinical Medicine
Diabetes incidence
Diabetes incidence
Dietary acid load
Insulin resistance
Insulin sensitivity
Kidney function
Diabetes Mellitus, Type 2 - epidemiology
Diabetes Mellitus, Type 2 - etiology
Diabetes Mellitus, Type 2 - physiopathology
Diabetes. Impaired glucose tolerance
Diet
Diet therapy
Dietary acid load
Endocrine pancreas. Apud cells (diseases)
Endocrinology and Diabetes
Endocrinopathies
Endokrinologi och diabetes
Etiopathogenesis. Screening. Investigations. Target tissue resistance
Glucose tolerance tests
Health and Welfare
Human Physiology
Humans
Hälsa och välfärd
Incidence
Insulin
Insulin resistance
Insulin Resistance - physiology
Insulin sensitivity
Internal Medicine
Kidney function
Klinisk medicin
Male
Medical and Health Sciences
Medical colleges
Medical sciences
Medicin och hälsovetenskap
Medicine
Medicine & Public Health
Metabolic Diseases
Residence Characteristics
Risk
Risk factors
Type 2 diabetes
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
ID: ISSN: 0012-186X
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_129417473
title: Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men
format: Article
creator:
  • Xu, Hong
  • Jia, Ting
  • Huang, Xiaoyan
  • Risérus, Ulf
  • Cederholm, Tommy
  • Ärnlöv, Johan
  • Sjögren, Per
  • Lindholm, Bengt
  • Carrero, Juan-Jesús
subjects:
  • Acids
  • Aged
  • Algorithms
  • Article
  • Biological and medical sciences
  • Clinical Medicine
  • Diabetes incidence
  • Diabetes incidence
  • Dietary acid load
  • Insulin resistance
  • Insulin sensitivity
  • Kidney function
  • Diabetes Mellitus, Type 2 - epidemiology
  • Diabetes Mellitus, Type 2 - etiology
  • Diabetes Mellitus, Type 2 - physiopathology
  • Diabetes. Impaired glucose tolerance
  • Diet
  • Diet therapy
  • Dietary acid load
  • Endocrine pancreas. Apud cells (diseases)
  • Endocrinology and Diabetes
  • Endocrinopathies
  • Endokrinologi och diabetes
  • Etiopathogenesis. Screening. Investigations. Target tissue resistance
  • Glucose tolerance tests
  • Health and Welfare
  • Human Physiology
  • Humans
  • Hälsa och välfärd
  • Incidence
  • Insulin
  • Insulin resistance
  • Insulin Resistance - physiology
  • Insulin sensitivity
  • Internal Medicine
  • Kidney function
  • Klinisk medicin
  • Male
  • Medical and Health Sciences
  • Medical colleges
  • Medical sciences
  • Medicin och hälsovetenskap
  • Medicine
  • Medicine & Public Health
  • Metabolic Diseases
  • Residence Characteristics
  • Risk
  • Risk factors
  • Type 2 diabetes
ispartof: Diabetologia, 2014-05-31, Vol.57 (8), p.1561-1568
description: Aims/hypothesis We tested the hypothesis that dietary acid load may increase the risk of type 2 diabetes, and studied the association between acid load and insulin sensitivity as a possible mechanism involved. Methods An observational survey with prospective follow-up including 911 non-diabetic Swedish men aged 70–71 years was carried out. The gold standard euglycaemic–hyperinsulinaemic clamp technique and the OGTT were used to determine insulin sensitivity and beta cell function, respectively. Diabetes incidence was assessed during 18 years of follow-up. Renal function was estimated from serum cystatin C concentrations. Dietary acid load was calculated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) algorithms from 7 day food records. Adequate dietary reporters were identified by Goldberg cut-offs. Results PRAL and NEAP were not associated with insulin sensitivity or beta cell function. Underlying kidney function or consideration of dietary adequate reporters did not modify these null findings. During follow-up, 115 new cases of diabetes were validated. Neither PRAL nor NEAP was associated with diabetes incidence. Conclusions/interpretation Our results do not support the hypothesis that dietary acid load influences insulin sensitivity, beta cell function or diabetes risk. Interventional studies modifying acid–base dietary intake are needed to further elucidate a possible role of acid load in the development of type 2 diabetes.
language: eng
source:
identifier: ISSN: 0012-186X
fulltext: no_fulltext
issn:
  • 0012-186X
  • 1432-0428
  • 1432-0428
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.5671427
LOCALfalse
PrimoNMBib
record
control
sourceidgale_swepu
recordidTN_cdi_swepub_primary_oai_prod_swepub_kib_ki_se_129417473
sourceformatXML
sourcesystemPC
galeidA373552497
sourcerecordidA373552497
originalsourceidFETCH-LOGICAL-1639t-f530219d7983e680d2a88471fb5c87031ffcd453c64d6698ed90ade7f55233330
addsrcrecordideNqFkl9r1TAYxoso7jj9AN5IQAaC68z_tJeHTTdh4I2KdyEnSQ_Z2uSYtI7t0_uWc9x0OG0oDcnvefvmyVNVLwk-IhirdwVjQkWNCa8ZVaK-eVQtCGe0xpw2j6vFvF2TRn7bq56VcoExZoLLp9Ue5Y0SireLanUS_GjyNTI2ONQn4w5RiGXqQ0TFxxLG8COMsB0dyqFcotSh8XrjEUUumJUffQEe2TQMUwSwdle-B_Eapd75jAYfn1dPOtMX_2L33a--fHj_-fisPv90-vF4eV4Tydqx7gTDlLROtQ3zssGOmqbhinQrYRuFGek667hgVnInZdt412LjvOqEoAwevF-127rlym-mld7kMMDJdDIB5snp3fplmF9dvCa05URxNWsPH9SehK9LnfJaT5OmDGMpAX_7f9xNmnBKCNBvtjR08X3yZdRDKBZsMtGnqWgi4M5UK6UA9PU99CJNOYJtM0WBopTeUWvTex1il8Zs7FxUL5liYAhvFVBHf6FgOD8Em6LvAqz_ISBbgc2plOy723MRrOfA6W3gNAROz4HTN6B5tWt4Wg3e3Sp-JQyAgx1gijV9l020odxxjSRc0NlSde_nNoxmDClC16H_Zwt0dxlQNK59_s2zB0U_AbDH_ck
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid1542279222
display
typearticle
titleDietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men
creatorXu, Hong ; Jia, Ting ; Huang, Xiaoyan ; Risérus, Ulf ; Cederholm, Tommy ; Ärnlöv, Johan ; Sjögren, Per ; Lindholm, Bengt ; Carrero, Juan-Jesús
creatorcontribXu, Hong ; Jia, Ting ; Huang, Xiaoyan ; Risérus, Ulf ; Cederholm, Tommy ; Ärnlöv, Johan ; Sjögren, Per ; Lindholm, Bengt ; Carrero, Juan-Jesús
descriptionAims/hypothesis We tested the hypothesis that dietary acid load may increase the risk of type 2 diabetes, and studied the association between acid load and insulin sensitivity as a possible mechanism involved. Methods An observational survey with prospective follow-up including 911 non-diabetic Swedish men aged 70–71 years was carried out. The gold standard euglycaemic–hyperinsulinaemic clamp technique and the OGTT were used to determine insulin sensitivity and beta cell function, respectively. Diabetes incidence was assessed during 18 years of follow-up. Renal function was estimated from serum cystatin C concentrations. Dietary acid load was calculated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) algorithms from 7 day food records. Adequate dietary reporters were identified by Goldberg cut-offs. Results PRAL and NEAP were not associated with insulin sensitivity or beta cell function. Underlying kidney function or consideration of dietary adequate reporters did not modify these null findings. During follow-up, 115 new cases of diabetes were validated. Neither PRAL nor NEAP was associated with diabetes incidence. Conclusions/interpretation Our results do not support the hypothesis that dietary acid load influences insulin sensitivity, beta cell function or diabetes risk. Interventional studies modifying acid–base dietary intake are needed to further elucidate a possible role of acid load in the development of type 2 diabetes.
identifier
0ISSN: 0012-186X
1ISSN: 1432-0428
2EISSN: 1432-0428
3DOI: 10.1007/s00125-014-3275-z
4PMID: 24875749
languageeng
publisherBerlin/Heidelberg: Springer Berlin Heidelberg
subjectAcids ; Aged ; Algorithms ; Article ; Biological and medical sciences ; Clinical Medicine ; Diabetes incidence ; Diabetes incidence; Dietary acid load; Insulin resistance; Insulin sensitivity; Kidney function ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetes Mellitus, Type 2 - etiology ; Diabetes Mellitus, Type 2 - physiopathology ; Diabetes. Impaired glucose tolerance ; Diet ; Diet therapy ; Dietary acid load ; Endocrine pancreas. Apud cells (diseases) ; Endocrinology and Diabetes ; Endocrinopathies ; Endokrinologi och diabetes ; Etiopathogenesis. Screening. Investigations. Target tissue resistance ; Glucose tolerance tests ; Health and Welfare ; Human Physiology ; Humans ; Hälsa och välfärd ; Incidence ; Insulin ; Insulin resistance ; Insulin Resistance - physiology ; Insulin sensitivity ; Internal Medicine ; Kidney function ; Klinisk medicin ; Male ; Medical and Health Sciences ; Medical colleges ; Medical sciences ; Medicin och hälsovetenskap ; Medicine ; Medicine & Public Health ; Metabolic Diseases ; Residence Characteristics ; Risk ; Risk factors ; Type 2 diabetes
ispartofDiabetologia, 2014-05-31, Vol.57 (8), p.1561-1568
rights
0Springer-Verlag Berlin Heidelberg 2014
12015 INIST-CNRS
2COPYRIGHT 2014 Springer
lds50peer_reviewed
citedbyFETCH-LOGICAL-1639t-f530219d7983e680d2a88471fb5c87031ffcd453c64d6698ed90ade7f55233330
citesFETCH-LOGICAL-1639t-f530219d7983e680d2a88471fb5c87031ffcd453c64d6698ed90ade7f55233330
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=28614526$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24875749$$D View this record in MEDLINE/PubMed
2$$Uhttp://urn.kb.se/resolve?urn=urn:nbn:se:du-14211$$DView record from Swedish Publication Index
3$$Uhttp://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-230066$$DView record from Swedish Publication Index
4$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:129417473$$DView record from Swedish Publication Index
search
creatorcontrib
0Xu, Hong
1Jia, Ting
2Huang, Xiaoyan
3Risérus, Ulf
4Cederholm, Tommy
5Ärnlöv, Johan
6Sjögren, Per
7Lindholm, Bengt
8Carrero, Juan-Jesús
title
0Dietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men
1Diabetologia
addtitle
0Diabetologia
1Diabetologia
descriptionAims/hypothesis We tested the hypothesis that dietary acid load may increase the risk of type 2 diabetes, and studied the association between acid load and insulin sensitivity as a possible mechanism involved. Methods An observational survey with prospective follow-up including 911 non-diabetic Swedish men aged 70–71 years was carried out. The gold standard euglycaemic–hyperinsulinaemic clamp technique and the OGTT were used to determine insulin sensitivity and beta cell function, respectively. Diabetes incidence was assessed during 18 years of follow-up. Renal function was estimated from serum cystatin C concentrations. Dietary acid load was calculated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) algorithms from 7 day food records. Adequate dietary reporters were identified by Goldberg cut-offs. Results PRAL and NEAP were not associated with insulin sensitivity or beta cell function. Underlying kidney function or consideration of dietary adequate reporters did not modify these null findings. During follow-up, 115 new cases of diabetes were validated. Neither PRAL nor NEAP was associated with diabetes incidence. Conclusions/interpretation Our results do not support the hypothesis that dietary acid load influences insulin sensitivity, beta cell function or diabetes risk. Interventional studies modifying acid–base dietary intake are needed to further elucidate a possible role of acid load in the development of type 2 diabetes.
subject
0Acids
1Aged
2Algorithms
3Article
4Biological and medical sciences
5Clinical Medicine
6Diabetes incidence
7Diabetes incidence; Dietary acid load; Insulin resistance; Insulin sensitivity; Kidney function
8Diabetes Mellitus, Type 2 - epidemiology
9Diabetes Mellitus, Type 2 - etiology
10Diabetes Mellitus, Type 2 - physiopathology
11Diabetes. Impaired glucose tolerance
12Diet
13Diet therapy
14Dietary acid load
15Endocrine pancreas. Apud cells (diseases)
16Endocrinology and Diabetes
17Endocrinopathies
18Endokrinologi och diabetes
19Etiopathogenesis. Screening. Investigations. Target tissue resistance
20Glucose tolerance tests
21Health and Welfare
22Human Physiology
23Humans
24Hälsa och välfärd
25Incidence
26Insulin
27Insulin resistance
28Insulin Resistance - physiology
29Insulin sensitivity
30Internal Medicine
31Kidney function
32Klinisk medicin
33Male
34Medical and Health Sciences
35Medical colleges
36Medical sciences
37Medicin och hälsovetenskap
38Medicine
39Medicine & Public Health
40Metabolic Diseases
41Residence Characteristics
42Risk
43Risk factors
44Type 2 diabetes
issn
00012-186X
11432-0428
21432-0428
fulltextfalse
rsrctypearticle
creationdate2014
recordtypearticle
recordideNqFkl9r1TAYxoso7jj9AN5IQAaC68z_tJeHTTdh4I2KdyEnSQ_Z2uSYtI7t0_uWc9x0OG0oDcnvefvmyVNVLwk-IhirdwVjQkWNCa8ZVaK-eVQtCGe0xpw2j6vFvF2TRn7bq56VcoExZoLLp9Ue5Y0SireLanUS_GjyNTI2ONQn4w5RiGXqQ0TFxxLG8COMsB0dyqFcotSh8XrjEUUumJUffQEe2TQMUwSwdle-B_Eapd75jAYfn1dPOtMX_2L33a--fHj_-fisPv90-vF4eV4Tydqx7gTDlLROtQ3zssGOmqbhinQrYRuFGek667hgVnInZdt412LjvOqEoAwevF-127rlym-mld7kMMDJdDIB5snp3fplmF9dvCa05URxNWsPH9SehK9LnfJaT5OmDGMpAX_7f9xNmnBKCNBvtjR08X3yZdRDKBZsMtGnqWgi4M5UK6UA9PU99CJNOYJtM0WBopTeUWvTex1il8Zs7FxUL5liYAhvFVBHf6FgOD8Em6LvAqz_ISBbgc2plOy723MRrOfA6W3gNAROz4HTN6B5tWt4Wg3e3Sp-JQyAgx1gijV9l020odxxjSRc0NlSde_nNoxmDClC16H_Zwt0dxlQNK59_s2zB0U_AbDH_ck
startdate20140531
enddate20140531
creator
0Xu, Hong
1Jia, Ting
2Huang, Xiaoyan
3Risérus, Ulf
4Cederholm, Tommy
5Ärnlöv, Johan
6Sjögren, Per
7Lindholm, Bengt
8Carrero, Juan-Jesús
general
0Springer Berlin Heidelberg
1Springer
2Springer Nature B.V
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
9BSHEE
103V.
117T5
127X7
137XB
1488E
158AO
168C1
178FI
188FJ
198FK
20ABUWG
21BENPR
22FYUFA
23GHDGH
24H94
25K9.
26M0S
27M1P
28PQEST
29PQQKQ
30PQUKI
31PRINS
327X8
33ADTPV
34AOWAS
sort
creationdate20140531
titleDietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men
authorXu, Hong ; Jia, Ting ; Huang, Xiaoyan ; Risérus, Ulf ; Cederholm, Tommy ; Ärnlöv, Johan ; Sjögren, Per ; Lindholm, Bengt ; Carrero, Juan-Jesús
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-1639t-f530219d7983e680d2a88471fb5c87031ffcd453c64d6698ed90ade7f55233330
rsrctypearticles
prefilterarticles
languageeng
creationdate2014
topic
0Acids
1Aged
2Algorithms
3Article
4Biological and medical sciences
5Clinical Medicine
6Diabetes incidence
7Diabetes incidence; Dietary acid load; Insulin resistance; Insulin sensitivity; Kidney function
8Diabetes Mellitus, Type 2 - epidemiology
9Diabetes Mellitus, Type 2 - etiology
10Diabetes Mellitus, Type 2 - physiopathology
11Diabetes. Impaired glucose tolerance
12Diet
13Diet therapy
14Dietary acid load
15Endocrine pancreas. Apud cells (diseases)
16Endocrinology and Diabetes
17Endocrinopathies
18Endokrinologi och diabetes
19Etiopathogenesis. Screening. Investigations. Target tissue resistance
20Glucose tolerance tests
21Health and Welfare
22Human Physiology
23Humans
24Hälsa och välfärd
25Incidence
26Insulin
27Insulin resistance
28Insulin Resistance - physiology
29Insulin sensitivity
30Internal Medicine
31Kidney function
32Klinisk medicin
33Male
34Medical and Health Sciences
35Medical colleges
36Medical sciences
37Medicin och hälsovetenskap
38Medicine
39Medicine & Public Health
40Metabolic Diseases
41Residence Characteristics
42Risk
43Risk factors
44Type 2 diabetes
toplevelpeer_reviewed
creatorcontrib
0Xu, Hong
1Jia, Ting
2Huang, Xiaoyan
3Risérus, Ulf
4Cederholm, Tommy
5Ärnlöv, Johan
6Sjögren, Per
7Lindholm, Bengt
8Carrero, Juan-Jesús
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8Academic OneFile (A&I only)
9ProQuest Central (Corporate)
10Immunology Abstracts
11Health & Medical Collection
12ProQuest Central (purchase pre-March 2016)
13Medical Database (Alumni Edition)
14ProQuest Pharma Collection
15Public Health Database
16Hospital Premium Collection
17Hospital Premium Collection (Alumni Edition)
18ProQuest Central (Alumni) (purchase pre-March 2016)
19ProQuest Central (Alumni Edition)
20ProQuest Central
21Health Research Premium Collection
22Health Research Premium Collection (Alumni)
23AIDS and Cancer Research Abstracts
24ProQuest Health & Medical Complete (Alumni)
25Health & Medical Collection (Alumni Edition)
26Medical Database
27ProQuest One Academic Eastern Edition
28ProQuest One Academic
29ProQuest One Academic UKI Edition
30ProQuest Central China
31MEDLINE - Academic
32SwePub
33SwePub Articles
jtitleDiabetologia
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Xu, Hong
1Jia, Ting
2Huang, Xiaoyan
3Risérus, Ulf
4Cederholm, Tommy
5Ärnlöv, Johan
6Sjögren, Per
7Lindholm, Bengt
8Carrero, Juan-Jesús
formatjournal
genrearticle
ristypeJOUR
atitleDietary acid load, insulin sensitivity and risk of type 2 diabetes in community-dwelling older men
jtitleDiabetologia
stitleDiabetologia
addtitleDiabetologia
date2014-05-31
risdate2014
volume57
issue8
spage1561
epage1568
pages1561-1568
issn
00012-186X
11432-0428
eissn1432-0428
abstractAims/hypothesis We tested the hypothesis that dietary acid load may increase the risk of type 2 diabetes, and studied the association between acid load and insulin sensitivity as a possible mechanism involved. Methods An observational survey with prospective follow-up including 911 non-diabetic Swedish men aged 70–71 years was carried out. The gold standard euglycaemic–hyperinsulinaemic clamp technique and the OGTT were used to determine insulin sensitivity and beta cell function, respectively. Diabetes incidence was assessed during 18 years of follow-up. Renal function was estimated from serum cystatin C concentrations. Dietary acid load was calculated as potential renal acid load (PRAL) and net endogenous acid production (NEAP) algorithms from 7 day food records. Adequate dietary reporters were identified by Goldberg cut-offs. Results PRAL and NEAP were not associated with insulin sensitivity or beta cell function. Underlying kidney function or consideration of dietary adequate reporters did not modify these null findings. During follow-up, 115 new cases of diabetes were validated. Neither PRAL nor NEAP was associated with diabetes incidence. Conclusions/interpretation Our results do not support the hypothesis that dietary acid load influences insulin sensitivity, beta cell function or diabetes risk. Interventional studies modifying acid–base dietary intake are needed to further elucidate a possible role of acid load in the development of type 2 diabetes.
copBerlin/Heidelberg
pubSpringer Berlin Heidelberg
pmid24875749
doi10.1007/s00125-014-3275-z