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Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies

Summary Background Half the epidemiological studies with information about menopausal hormone therapy and ovarian cancer risk remain unpublished, and some retrospective studies could have been biased by selective participation or recall. We aimed to assess with minimal bias the effects of hormone th... Full description

Journal Title: Lancet 2015, Vol.385 (9980), p.1835-1842
Main Author: Schouten, L.J
Other Authors: van den Brandt, P.A , Collaborative Group on Epidemiological Studies of Ovarian Cancer, the , Gapstur, S. M
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Ltd
ID: ISSN: 0140-6736
Zum Text:
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title: Menopausal hormone use and ovarian cancer risk: individual participant meta-analysis of 52 epidemiological studies
format: Article
creator:
  • Schouten, L.J
  • van den Brandt, P.A
  • Collaborative Group on Epidemiological Studies of Ovarian Cancer, the
  • Gapstur, S. M
subjects:
  • 11 Medical And Health Sciences
  • Articles
  • Cancer
  • Cancer and Oncology
  • Cancer och onkologi
  • Clinical Medicine
  • Drug Administration Schedule
  • Epidemiology
  • estrogen replacement therapy
  • Estrogen Replacement Therapy - adverse effects
  • Estrogen Replacement Therapy - statistics & numerical data
  • Estrogen Replacement Therapy - trends
  • Female
  • General & Internal
  • General & Internal Medicine
  • Health aspects
  • Health risk assessment
  • Hormone replacement therapy
  • Humans
  • Incidence
  • Internal Medicine
  • Klinisk medicin
  • Life Sciences & Biomedicine
  • Medical and Health Sciences
  • Medical research
  • Medicin och hälsovetenskap
  • Medicine
  • medicine (all)
  • Menopause
  • Middle Aged
  • Oncology
  • Oncology, Experimental
  • Ovarian cancer
  • ovarian neoplasms
  • Ovarian Neoplasms - chemically induced
  • Ovarian Neoplasms - epidemiology
  • Postmenopause
  • Research
  • risk assessment
  • Risk Assessment - methods
  • Risk factors
  • Science & Technology
  • Settore MED
  • Statistica Medica
  • Systematic review
  • Womens health
ispartof: Lancet, 2015, Vol.385 (9980), p.1835-1842
description: Summary Background Half the epidemiological studies with information about menopausal hormone therapy and ovarian cancer risk remain unpublished, and some retrospective studies could have been biased by selective participation or recall. We aimed to assess with minimal bias the effects of hormone therapy on ovarian cancer risk. Methods Individual participant datasets from 52 epidemiological studies were analysed centrally. The principal analyses involved the prospective studies (with last hormone therapy use extrapolated forwards for up to 4 years). Sensitivity analyses included the retrospective studies. Adjusted Poisson regressions yielded relative risks (RRs) versus never-use. Findings During prospective follow-up, 12 110 postmenopausal women, 55% (6601) of whom had used hormone therapy, developed ovarian cancer. Among women last recorded as current users, risk was increased even with
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
  • 1474-547X
url: Link


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creatorcontribSchouten, L.J ; van den Brandt, P.A ; Collaborative Group on Epidemiological Studies of Ovarian Cancer, the ; Gapstur, S. M ; Collaborative Group On Epidemiological Studies Of Ovarian Cancer ; Collaborative Group on Epidemiological Studies of Ovarian Cancer
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publisherEngland: Elsevier Ltd
subject11 Medical And Health Sciences ; Articles ; Cancer ; Cancer and Oncology ; Cancer och onkologi ; Clinical Medicine ; Drug Administration Schedule ; Epidemiology ; estrogen replacement therapy ; Estrogen Replacement Therapy - adverse effects ; Estrogen Replacement Therapy - statistics & numerical data ; Estrogen Replacement Therapy - trends ; Female ; General & Internal ; General & Internal Medicine ; Health aspects ; Health risk assessment ; Hormone replacement therapy ; Humans ; Incidence ; Internal Medicine ; Klinisk medicin ; Life Sciences & Biomedicine ; Medical and Health Sciences ; Medical research ; Medicin och hälsovetenskap ; Medicine ; medicine (all) ; Menopause ; Middle Aged ; Oncology ; Oncology, Experimental ; Ovarian cancer ; ovarian neoplasms ; Ovarian Neoplasms - chemically induced ; Ovarian Neoplasms - epidemiology ; Postmenopause ; Research ; risk assessment ; Risk Assessment - methods ; Risk factors ; Science & Technology ; Settore MED ; Statistica Medica ; Systematic review ; Womens health
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0Collaborative Group on Epidemiological Studies of Ovarian Cancer. Open Access article distributed under the terms of CC BY
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5Copyright Elsevier Limited May 9, 2015
62015 Collaborative Group on Epidemiological Studies of Ovarian Cancer. Open Access article distributed under the terms of CC BY 2015
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