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Are iron oxide nanoparticles safe? Current knowledge and future perspectives

Due to their unique physicochemical properties, including superparamagnetism, iron oxide nanoparticles (ION) have a number of interesting applications, especially in the biomedical field, that make them one of the most fascinating nanomaterials. They are used as contrast agents for magnetic resonanc... Full description

Journal Title: Journal of trace elements in medicine and biology 2016-12, Vol.38, p.53-63
Main Author: Valdiglesias, Vanessa
Other Authors: Fernández-Bertólez, Natalia , Kiliç, Gözde , Costa, Carla , Costa, Solange , Fraga, Sonia , Bessa, Maria Joao , Pásaro, Eduardo , Teixeira, João Paulo , Laffon, Blanca
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Germany: Elsevier GmbH
ID: ISSN: 0946-672X
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title: Are iron oxide nanoparticles safe? Current knowledge and future perspectives
format: Article
creator:
  • Valdiglesias, Vanessa
  • Fernández-Bertólez, Natalia
  • Kiliç, Gözde
  • Costa, Carla
  • Costa, Solange
  • Fraga, Sonia
  • Bessa, Maria Joao
  • Pásaro, Eduardo
  • Teixeira, João Paulo
  • Laffon, Blanca
subjects:
  • Animals
  • Drug delivery systems
  • Drugs
  • Epidemiological Studies
  • Epidemiology
  • Ferric Compounds - analysis
  • Ferric Compounds - metabolism
  • Ferric Compounds - toxicity
  • Ferric oxide
  • Fever
  • Humans
  • Hyperthermia
  • In vitro studies
  • In vivo studies
  • Iron compounds
  • Iron oxide nanoparticles
  • Medicin och hälsovetenskap
  • Molecular biology
  • Nanoparticles
  • Nanoparticles - analysis
  • Nanoparticles - metabolism
  • Nanoparticles - toxicity
  • Reactive Oxygen Species - metabolism
  • Toxicity
  • Toxicologia
  • Usage
  • Vehicles
ispartof: Journal of trace elements in medicine and biology, 2016-12, Vol.38, p.53-63
description: Due to their unique physicochemical properties, including superparamagnetism, iron oxide nanoparticles (ION) have a number of interesting applications, especially in the biomedical field, that make them one of the most fascinating nanomaterials. They are used as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Together with these valuable uses, concerns regarding the onset of unexpected adverse health effects following exposure have been also raised. Nevertheless, despite the numerous ION purposes being explored, currently available information on their potential toxicity is still scarce and controversial data have been reported. Although ION have traditionally been considered as biocompatible – mainly on the basis of viability tests results – influence of nanoparticle surface coating, size, or dose, and of other experimental factors such as treatment time or cell type, has been demonstrated to be important for ION in vitro toxicity manifestation. In vivo studies have shown distribution of ION to different tissues and organs, including brain after passing the blood-brain barrier; nevertheless results from acute toxicity, genotoxicity, immunotoxicity, neurotoxicity and reproductive toxicity investigations in different animal models do not provide a clear overview on ION safety yet, and epidemiological studies are almost inexistent. Much work has still to be done to fully understand how these nanomaterials interact with cellular systems and what, if any, potential adverse health consequences can derive from ION exposure.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0946-672X
fulltext: fulltext
issn:
  • 0946-672X
  • 1878-3252
  • 1878-3252
url: Link


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descriptionDue to their unique physicochemical properties, including superparamagnetism, iron oxide nanoparticles (ION) have a number of interesting applications, especially in the biomedical field, that make them one of the most fascinating nanomaterials. They are used as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Together with these valuable uses, concerns regarding the onset of unexpected adverse health effects following exposure have been also raised. Nevertheless, despite the numerous ION purposes being explored, currently available information on their potential toxicity is still scarce and controversial data have been reported. Although ION have traditionally been considered as biocompatible – mainly on the basis of viability tests results – influence of nanoparticle surface coating, size, or dose, and of other experimental factors such as treatment time or cell type, has been demonstrated to be important for ION in vitro toxicity manifestation. In vivo studies have shown distribution of ION to different tissues and organs, including brain after passing the blood-brain barrier; nevertheless results from acute toxicity, genotoxicity, immunotoxicity, neurotoxicity and reproductive toxicity investigations in different animal models do not provide a clear overview on ION safety yet, and epidemiological studies are almost inexistent. Much work has still to be done to fully understand how these nanomaterials interact with cellular systems and what, if any, potential adverse health consequences can derive from ION exposure.
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descriptionDue to their unique physicochemical properties, including superparamagnetism, iron oxide nanoparticles (ION) have a number of interesting applications, especially in the biomedical field, that make them one of the most fascinating nanomaterials. They are used as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Together with these valuable uses, concerns regarding the onset of unexpected adverse health effects following exposure have been also raised. Nevertheless, despite the numerous ION purposes being explored, currently available information on their potential toxicity is still scarce and controversial data have been reported. Although ION have traditionally been considered as biocompatible – mainly on the basis of viability tests results – influence of nanoparticle surface coating, size, or dose, and of other experimental factors such as treatment time or cell type, has been demonstrated to be important for ION in vitro toxicity manifestation. In vivo studies have shown distribution of ION to different tissues and organs, including brain after passing the blood-brain barrier; nevertheless results from acute toxicity, genotoxicity, immunotoxicity, neurotoxicity and reproductive toxicity investigations in different animal models do not provide a clear overview on ION safety yet, and epidemiological studies are almost inexistent. Much work has still to be done to fully understand how these nanomaterials interact with cellular systems and what, if any, potential adverse health consequences can derive from ION exposure.
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authorValdiglesias, Vanessa ; Fernández-Bertólez, Natalia ; Kiliç, Gözde ; Costa, Carla ; Costa, Solange ; Fraga, Sonia ; Bessa, Maria Joao ; Pásaro, Eduardo ; Teixeira, João Paulo ; Laffon, Blanca
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abstractDue to their unique physicochemical properties, including superparamagnetism, iron oxide nanoparticles (ION) have a number of interesting applications, especially in the biomedical field, that make them one of the most fascinating nanomaterials. They are used as contrast agents for magnetic resonance imaging, in targeted drug delivery, and for induced hyperthermia cancer treatments. Together with these valuable uses, concerns regarding the onset of unexpected adverse health effects following exposure have been also raised. Nevertheless, despite the numerous ION purposes being explored, currently available information on their potential toxicity is still scarce and controversial data have been reported. Although ION have traditionally been considered as biocompatible – mainly on the basis of viability tests results – influence of nanoparticle surface coating, size, or dose, and of other experimental factors such as treatment time or cell type, has been demonstrated to be important for ION in vitro toxicity manifestation. In vivo studies have shown distribution of ION to different tissues and organs, including brain after passing the blood-brain barrier; nevertheless results from acute toxicity, genotoxicity, immunotoxicity, neurotoxicity and reproductive toxicity investigations in different animal models do not provide a clear overview on ION safety yet, and epidemiological studies are almost inexistent. Much work has still to be done to fully understand how these nanomaterials interact with cellular systems and what, if any, potential adverse health consequences can derive from ION exposure.
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