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Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment... Full description

Journal Title: Lancet (London England), 2017-09-16, Vol.390 (10100), p.1211-1259
Main Author: Abd-Allah, Foad
Other Authors: Abdulle, Abdishakur M , Abera, Semaw Ferede , Abu-Raddad, Laith J , Adetokunboh, Olatunji , Afshin, Ashkan , Aggarwal, Rakesh , Agrawal, Anurag , Aichour, Ibtihel , Akseer, Nadia , Alizadeh-Navaei, Reza , Bacha, Umar , Bärnighausen, Till , Beghi, Ettore , Bensenor, Isabela M , Benson, Jennifer , Berhane, Adugnaw , Bhala, Neeraj , Bisanzio, Donal , Bumgarner, Blair R , Carrero, Juan Jesus , Caso, Valeria , Chen, Honglei , Christopher, Devasahayam Jesudas , Ciobanu, Liliana G , Cirillo, Massimo , Crump, John A , das Neves, José , De Leo, Diego De , Des Jarlais, Don C , Dhillon, Preet Kaur , Doyle, Kerrie E , Ermakov, Sergey Petrovich , Fazeli, Mir Sohail , Fischer, Florian , Fitzmaurice, Christina , Flaxman, Abraham D , Foigt, Nataliya , Futran, Neal D , Gebre, Teshome , Gold, Audra L , Goldberg, Ellen M , Gupta, Tanush , Gupta, Vipin , Hafezi-Nejad, Nima , Hao, Yuantao , Harvey, James , Hoffman, Howard J , Hosgood, H Dean , Igumbor, Ehimario Uche , Javanbakht, Mehdi , Kan, Haidong , Kassa, Getachew Mullu , Kravchenko, Michael , Lalloo, Ratilal , Lan, Qing , Lee, Jong-Tae , Li Kappe, Darya , Lorkowski, Stefan , Low, Nicola , Malta, Deborah Carvalho , Mantovani, Lorenzo G , Mapoma, Chabila C , Marczak, Laurie B , März, Winfried , Mazidi, Mohsen , McAlinden, Colm , Mengistie, Mubarek Abera , Monasta, Lorenzo , Morrison, Shane D , Mruts, Kalayu Birhane , Oh, In-Hwan , Olagunju, Andrew Toyin , Oren, Eyal , Ortiz, Alberto , Osgood-Zimmerman, Aaron , Parry, Charles D , Petzold, Max , Rahimi-Movaghar, Afarin , Rao, Paturi Vishnupriya , Rawaf, Salman , Ray, Sarah E , Resnikoff, Serge , Saleem, Huda Omer Ba , Sartorius, Benn , Sawhney, Monika , Shamsipour, Mansour , Smith, David L , Sposato, Luciano A , Stein, Murray B , Stein, Dan J , Stokes, Mark Andrew , Uthman, Olalekan A , Uzochukwu, Benjamin S Chudi , Wadilo, Fiseha , Weintraub, Robert G , Xu, Gelin , Zenebe, Zerihun Menlkalew , Zhou, Maigeng , Murray, Christopher J L
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
Men
VDP
Quelle: Alma/SFX Local Collection
Publisher: England: Elsevier Ltd
ID: ISSN: 0140-6736
Zum Text:
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title: Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
format: Article
creator:
  • Abd-Allah, Foad
  • Abdulle, Abdishakur M
  • Abera, Semaw Ferede
  • Abu-Raddad, Laith J
  • Adetokunboh, Olatunji
  • Afshin, Ashkan
  • Aggarwal, Rakesh
  • Agrawal, Anurag
  • Aichour, Ibtihel
  • Akseer, Nadia
  • Alizadeh-Navaei, Reza
  • Bacha, Umar
  • Bärnighausen, Till
  • Beghi, Ettore
  • Bensenor, Isabela M
  • Benson, Jennifer
  • Berhane, Adugnaw
  • Bhala, Neeraj
  • Bisanzio, Donal
  • Bumgarner, Blair R
  • Carrero, Juan Jesus
  • Caso, Valeria
  • Chen, Honglei
  • Christopher, Devasahayam Jesudas
  • Ciobanu, Liliana G
  • Cirillo, Massimo
  • Crump, John A
  • das Neves, José
  • De Leo, Diego De
  • Des Jarlais, Don C
  • Dhillon, Preet Kaur
  • Doyle, Kerrie E
  • Ermakov, Sergey Petrovich
  • Fazeli, Mir Sohail
  • Fischer, Florian
  • Fitzmaurice, Christina
  • Flaxman, Abraham D
  • Foigt, Nataliya
  • Futran, Neal D
  • Gebre, Teshome
  • Gold, Audra L
  • Goldberg, Ellen M
  • Gupta, Tanush
  • Gupta, Vipin
  • Hafezi-Nejad, Nima
  • Hao, Yuantao
  • Harvey, James
  • Hoffman, Howard J
  • Hosgood, H Dean
  • Igumbor, Ehimario Uche
  • Javanbakht, Mehdi
  • Kan, Haidong
  • Kassa, Getachew Mullu
  • Kravchenko, Michael
  • Lalloo, Ratilal
  • Lan, Qing
  • Lee, Jong-Tae
  • Li Kappe, Darya
  • Lorkowski, Stefan
  • Low, Nicola
  • Malta, Deborah Carvalho
  • Mantovani, Lorenzo G
  • Mapoma, Chabila C
  • Marczak, Laurie B
  • März, Winfried
  • Mazidi, Mohsen
  • McAlinden, Colm
  • Mengistie, Mubarek Abera
  • Monasta, Lorenzo
  • Morrison, Shane D
  • Mruts, Kalayu Birhane
  • Oh, In-Hwan
  • Olagunju, Andrew Toyin
  • Oren, Eyal
  • Ortiz, Alberto
  • Osgood-Zimmerman, Aaron
  • Parry, Charles D
  • Petzold, Max
  • Rahimi-Movaghar, Afarin
  • Rao, Paturi Vishnupriya
  • Rawaf, Salman
  • Ray, Sarah E
  • Resnikoff, Serge
  • Saleem, Huda Omer Ba
  • Sartorius, Benn
  • Sawhney, Monika
  • Shamsipour, Mansour
  • Smith, David L
  • Sposato, Luciano A
  • Stein, Murray B
  • Stein, Dan J
  • Stokes, Mark Andrew
  • Uthman, Olalekan A
  • Uzochukwu, Benjamin S Chudi
  • Wadilo, Fiseha
  • Weintraub, Robert G
  • Xu, Gelin
  • Zenebe, Zerihun Menlkalew
  • Zhou, Maigeng
  • Murray, Christopher J L
subjects:
  • 11 Medical And Health Sciences
  • 3112 Neurosciences
  • 3121 Internal medicine
  • 3142 Public health care science
  • 80 and over
  • Cause of Death
  • Child
  • Child
  • abdominal wall hernia
  • abortion
  • accidental injury
  • accommodation
  • acne vulgaris
  • acute glomerulonephritis
  • acute hepatitis
  • acute hepatitis A
  • acute leukemia
  • acute lymphoblastic leukemia
  • acute myeloid leukemia
  • adult
  • adverse drug reaction
  • African trypanosomiasis
  • aged
  • aging
  • airway
  • alcohol consumption
  • alcoholic cardiomyopathy
  • alcoholism
  • alopecia areata
  • Alzheimer disease
  • amphetamine dependence
  • anemia
  • anorexia nervosa
  • anxiety disorder
  • appendicitis
  • Article
  • asbestosis
  • ascariasis
  • Asperger syndrome
  • assault
  • asthma
  • atrial fibrillation
  • attention deficit disorder
  • autism
  • automutilation
  • biliary tract cancer
  • biliary tract disease
  • bipolar disorder
  • bladder cancer
  • bleeding
  • brain cancer
  • brain disease
  • brain hemorrhage
  • brain ischemia
  • breast cancer
  • bronchus cancer
  • bulimia
  • cannabis addiction
  • cardiomyopathy
  • cardiovascular disease
  • cataract
  • cause of death
  • cellulitis
  • cerebrovascular disease
  • Chagas disease
  • chickenpox
  • chlamydiasis
  • chromosome aberration
  • chronic kidney failure
  • chronic liver disease
  • chronic lymphatic leukemia
  • chronic myeloid leukemia
  • chronic obstructive lung disease
  • chronic respiratory tract disease
  • cocaine dependence
  • cold exposure
  • colon cancer
  • comorbidity
  • conduct disorder
  • conflict
  • congenital heart malformation
  • congenital malformation
  • cutaneous melanoma
  • cyclist
  • cysticercosis
  • deciduous tooth
  • decubitus
  • dementia
  • demography
  • dengue
  • dental caries
  • depression
  • dermatitis
  • dermatomycosis
  • diabetes mellitus
  • diarrhea
  • diphtheria
  • disability
  • disability severity
  • Down syndrome
  • dracunculiasis
  • drowning
  • drug dependence
  • drug resistant tuberculosis
  • duodenitis
  • dysthymia
  • dystocia
  • eating disorder
  • Ebola hemorrhagic fever
  • echinococcosis
  • ectopic pregnancy
  • encephalitis
  • endocarditis
  • endocrine disease
  • endometriosis
  • enteropathy
  • environmental exposure
  • epilepsy
  • esophagus cancer
  • extensively drug resistant tuberculosis
  • falling
  • female
  • female infertility
  • femoral hernia
  • fertility
  • foreign body
  • gallbladder cancer
  • gallbladder disease
  • gastritis
  • gastrointestinal disease
  • gastrointestinal malformation
  • genital herpes
  • geography
  • glaucoma
  • global disease burden
  • glomerulonephritis
  • glucose 6 phosphate dehydrogenase deficiency
  • gonorrhea
  • gout
  • Guillain Barre syndrome
  • gunshot injury
  • gynecologic disease
  • Haemophilus infection
  • hearing impairment
  • heart atrium flutter
  • heart failure
  • hematologic disease
  • hemoglobinopathy
  • hemolytic anemia
  • hepatitis
  • hepatitis B
  • hepatitis C
  • hepatitis E
  • herpes zoster
  • Hodgkin disease
  • hookworm infection
  • human
  • Human immunodeficiency virus infection
  • hypertension
  • idiopathic disease
  • immune deficiency
  • incidence
  • income
  • infertility
  • inflammatory bowel disease
  • inguinal hernia
  • injury
  • intellectual impairment
  • interstitial lung disease
  • interstitial nephritis
  • intestine infection
  • intestine obstruction
  • intoxication
  • iodine deficiency
  • iron deficiency anemia
  • ischemic heart disease
  • kidney cancer
  • Klinefelter syndrome
  • larynx cancer
  • latent tuberculosis
  • leishmaniasis
  • leprosy
  • leukemia
  • limb malformation
  • lip cancer
  • liver cancer
  • liver cirrhosis
  • low back pain
  • lower respiratory tract infection
  • lung cancer
  • lung sarcoidosis
  • lymphatic filariasis
  • macular degeneration
  • major clinical study
  • major depression
  • malaria
  • male
  • male infertility
  • malignant neoplasm
  • maternal disease
  • maternal hypertension
  • measles
  • meningococcosis
  • mental disease
  • mesothelioma
  • metabolic disorder
  • migraine
  • mortality rate
  • motor neuron disease
  • motor vehicle
  • motorcyclist
  • mouth cancer
  • mouth disease
  • multidrug resistant tuberculosis
  • multiple myeloma
  • multiple sclerosis
  • musculoskeletal disease
  • myocarditis
  • nasopharynx cancer
  • neck pain
  • nematodiasis
  • nervous system cancer
  • neural tube defect
  • neurologic disease
  • newborn
  • newborn disease
  • newborn infection
  • newborn jaundice
  • newborn sepsis
  • non communicable disease
  • non melanoma skin cancer
  • nonhodgkin lymphoma
  • nutritional deficiency
  • nutritional disorder
  • onchocerciasis
  • opiate addiction
  • osteoarthritis
  • otitis media
  • ovary cancer
  • ovary polycystic disease
  • pancreas cancer
  • pancreatitis
  • paralytic ileus
  • paratyphoid fever
  • Parkinson disease
  • pedestrian
  • pelvic inflammatory disease
  • pelvic organ prolapse
  • peptic ulcer
  • perinatal asphyxia
  • periodontal disease
  • peripheral vascular disease
  • permanent tooth
  • pertussis
  • pharynx cancer
  • physical disease
  • pneumococcal meningitis
  • pneumoconiosis
  • poisonous animal
  • population growth
  • practice guideline
  • premature labor
  • premature mortality
  • premenstrual syndrome
  • prevalence
  • priority journal
  • prostate cancer
  • prostate hypertrophy
  • protein calorie malnutrition
  • pruritus
  • psoriasis
  • pulmonary aspiration
  • pyoderma
  • rabies
  • rectum cancer
  • refraction error
  • remission
  • retinol deficiency
  • rheumatic heart disease
  • rheumatoid arthritis
  • scabies
  • schistosomiasis
  • schizophrenia
  • school
  • sensory dysfunction
  • sepsis
  • sex difference
  • sexual violence
  • sexually transmitted disease
  • sickle cell anemia
  • sickle cell trait
  • silicosis
  • skin leishmaniasis
  • social status
  • spontaneous abortion
  • squamous cell skin carcinoma
  • stomach cancer
  • suffocation
  • syphilis
  • tension headache
  • terrorism
  • testis cancer
  • tetanus
  • thalassemia
  • thermal exposure
  • thyroid cancer
  • trachea cancer
  • trachoma
  • traffic accident
  • trichomoniasis
  • trichuriasis
  • tropical disease
  • tuberculosis
  • Turner syndrome
  • typhoid fever
  • upper respiratory tract infection
  • urinary tract disease
  • urinary tract infection
  • urogenital tract malformation
  • urolithiasis
  • urticaria
  • uterine cervix cancer
  • uterus cancer
  • uterus myoma
  • uterus rupture
  • viral skin disease
  • visceral leishmaniasis
  • visual impairment
  • yellow fever
  • Zika fever
  • adolescent
  • age distribution
  • child
  • communicable disease
  • disabled person
  • global disease burden
  • global health
  • infant
  • injury
  • middle aged
  • mortality
  • non communicable disease
  • preschool child
  • sex ratio
  • statistics and numerical data
  • trends
  • very elderly
  • young adult
  • Adolescent
  • Adolescent
  • Adult
  • Age Distribution
  • Aged
  • Aged
  • Adult
  • Adults
  • Age
  • Age disdtribution
  • Age Distribution
  • Aged
  • Aged, 80 and over
  • Aggression
  • Aging
  • Aldraðir
  • Allmänmedicin
  • Alzheimer's disease
  • Anemia
  • Anxiety
  • atira
  • Bakverkir
  • Bayesian analysis
  • Cardiovascular diseases
  • Cause of Death
  • Cause of Death - trends
  • Charities
  • Child
  • Child, Preschool
  • Children
  • Chronic illnesses
  • CHRONIC PAIN
  • CLIMATE-CHANGE
  • Clinical Medicine
  • Communicable Diseases
  • Communicable Diseases - mortality
  • Community medicine
  • Community medicine, Social medicine: 801
  • Complications
  • Demographics
  • Dental caries
  • dental statistics
  • DEPRESSION
  • Diabetes mellitus
  • Disability
  • Disabled Persons
  • Disabled Persons - statistics & numerical data
  • Disease
  • Disease control
  • Diseases
  • DISORDERS
  • Dánarmein
  • Dánartíðni
  • environmental
  • Epidemiologi medisinsk og odontologisk statistikk
  • Epidemiologi medisinsk og odontologisk statistikk: 803
  • Epidemiology medical
  • Epidemiology medical and dental statistics: 803
  • Estimates
  • Fatlaðir
  • Female
  • Fertility
  • Firearms
  • Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
  • FUTURE
  • Félagshagfræði
  • Fólksfjölgun
  • GBD 2016 Disease
  • General & Internal Medicine
  • General Practice
  • Global Burden of Disease
  • Global Burden of Disease - statistics & numerical data
  • Global Health
  • Global Health - statistics & numerical data
  • Global Health Metrics
  • Gout
  • Guillain-Barre syndrome
  • Halk sağlığı
  • Headache
  • Health and Welfare
  • Health care
  • Health policy
  • Health risks
  • Health Sciences
  • Health sciences: 800
  • Health service
  • Hearing loss
  • Heart diseases
  • Heilbrigðiskerfi
  • Heilbrigðisstefna
  • Heilbrigðisþjónusta
  • Heilsufar
  • Heilsugæsla
  • Helsefag
  • Helsefag: 800
  • Hospitals
  • Humans
  • Hälsa och välfärd
  • Hälsovetenskap
  • Hälsovetenskaper
  • Incidence
  • Infant
  • Infant, Newborn
  • Injuries
  • injury
  • Injury analysis
  • Injury Incidence
  • Iron
  • Journal Article
  • Karlar
  • Klinisk medicin
  • Konur
  • Langlífi
  • Life expectancy
  • Life span
  • living with disability
  • Low back pain
  • Lýðfræði
  • Male
  • Mannfjöldi
  • Medical and Health Sciences
  • Medical disciplines
  • Medical disciplines: 700
  • Medical research
  • Medicin och hälsovetenskap
  • Medicine (all)
  • Medicine, Experimental
  • Medisinske Fag
  • Medisinske Fag: 700
  • Men
  • Mental depression
  • Mental disorders
  • Mental health
  • Middle Aged
  • Migraine
  • MORTALITY
  • Musculoskeletal diseases
  • Neurodegenerative diseases
  • Newborn
  • Newborn
  • Male
  • Middle Aged
  • Noncommunicable Diseases
  • Prevalence
  • Sex Distribution
  • Wounds and Injuries
  • Young Adult
  • Noncommunicable Diseases
  • Noncommunicable Diseases - mortality
  • numerical data
  • Nutrient deficiency
  • occupational health
  • Older people
  • over
  • Pain
  • People with disabilities
  • Personal health
  • PERSONAL HEALTH-CARE
  • Population aging
  • Population growth
  • Preschool
  • Preschool
  • Communicable Diseases
  • Disabled Persons
  • Female
  • Global Burden of Disease
  • Global Health
  • Humans
  • Incidence
  • Infant
  • Infant
  • Prevalence
  • Prevalence Collaborators
  • Public health
  • Public health systems
  • Public Health, Global Health, Social Medicine and Epidemiology
  • pubmedpublicationtype
  • pure
  • Ratios
  • Regression analysis
  • Remission
  • researchoutput
  • Respiratory infections
  • Risk factors
  • Samfunnsmedisin
  • Samfunnsmedisin, sosialmedisin: 801
  • Self destructive behavior
  • Sex Distribution
  • Sexual assault
  • Sjúkdómar
  • Social medicine
  • Socioeconomic factors
  • sosialmedisin
  • statistics
  • statistics & numerical data
  • Staðtölur
  • Substance use
  • Tannskemmdir
  • TRENDS
  • Tropical diseases
  • Tuberculosis
  • Tölfræði
  • VDP
  • Violence
  • Women
  • World health
  • Wounds
  • Wounds and Injuries - mortality
  • Young Adult
  • Áverkar
  • Öndunarfærasjúkdómar
  • Þjóðir
ispartof: Lancet (London, England), 2017-09-16, Vol.390 (10100), p.1211-1259
description: As mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between incidence, prevalence, remission, and cause of death rates for each condition. For some causes, we used alternative modelling strategies if incidence or prevalence needed to be derived from other data. YLDs were estimated as the product of prevalence and a disability weight for all mutually exclusive sequelae, corrected for comorbidity and aggregated to cause level. We updated the Socio-demographic Index (SDI), a summary indicator of income per capita, years of schooling, and total fertility rate. GBD 2016 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Globally, low back pain, migraine, age-related and other hearing loss, iron-deficiency anaemia, and major depressive disorder were the five leading causes of YLDs in 2016, contributing 57·6 million (95% uncertainty interval [UI] 40·8–75·9 million [7·2%, 6·0–8·3]), 45·1 million (29·0–62·8 million [5·6%, 4·0–7·2]), 36·3 million (25·3–50·9 million [4·5%, 3·8–5·3]), 34·7 million (23·0–49·6 million [4·3%, 3·5–5·2]), and 34·1 million (23·5–46·0 million [4·2%, 3·2–5·3]) of total YLDs, respectively. Age-standardised rates of YLDs for all causes combined decreased between 1990 and 2016 by 2·7% (95% UI 2·3–3·1). Despite mostly stagnant age-standardised rates, the absolute number of YLDs from non-communicable diseases has been growing rapidly across all SDI quintiles, partly because of population growth, but also the ageing of populations. The largest absolute increases in total numbers of YLDs globally were between the ages of 40 and 69 years. Age-standardised YLD rates for all conditions combined were 10·4% (95% UI 9·0–11·8) higher in women than in men. Iron-deficiency anaemia, migraine, Alzheimer's disease and other dementias, major depressive disorder, anxiety, and all musculoskeletal disorders apart from gout w
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0140-6736
fulltext: fulltext
issn:
  • 0140-6736
  • 1474-547X
  • 1474-547X
url: Link


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titleGlobal, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
sourceAlma/SFX Local Collection
creatorAbd-Allah, Foad ; Abdulle, Abdishakur M ; Abera, Semaw Ferede ; Abu-Raddad, Laith J ; Adetokunboh, Olatunji ; Afshin, Ashkan ; Aggarwal, Rakesh ; Agrawal, Anurag ; Aichour, Ibtihel ; Akseer, Nadia ; Alizadeh-Navaei, Reza ; Bacha, Umar ; Bärnighausen, Till ; Beghi, Ettore ; Bensenor, Isabela M ; Benson, Jennifer ; Berhane, Adugnaw ; Bhala, Neeraj ; Bisanzio, Donal ; Bumgarner, Blair R ; Carrero, Juan Jesus ; Caso, Valeria ; Chen, Honglei ; Christopher, Devasahayam Jesudas ; Ciobanu, Liliana G ; Cirillo, Massimo ; Crump, John A ; das Neves, José ; De Leo, Diego De ; Des Jarlais, Don C ; Dhillon, Preet Kaur ; Doyle, Kerrie E ; Ermakov, Sergey Petrovich ; Fazeli, Mir Sohail ; Fischer, Florian ; Fitzmaurice, Christina ; Flaxman, Abraham D ; Foigt, Nataliya ; Futran, Neal D ; Gebre, Teshome ; Gold, Audra L ; Goldberg, Ellen M ; Gupta, Tanush ; Gupta, Vipin ; Hafezi-Nejad, Nima ; Hao, Yuantao ; Harvey, James ; Hoffman, Howard J ; Hosgood, H Dean ; Igumbor, Ehimario Uche ; Javanbakht, Mehdi ; Kan, Haidong ; Kassa, Getachew Mullu ; Kravchenko, Michael ; Lalloo, Ratilal ; Lan, Qing ; Lee, Jong-Tae ; Li Kappe, Darya ; Lorkowski, Stefan ; Low, Nicola ; Malta, Deborah Carvalho ; Mantovani, Lorenzo G ; Mapoma, Chabila C ; Marczak, Laurie B ; März, Winfried ; Mazidi, Mohsen ; McAlinden, Colm ; Mengistie, Mubarek Abera ; Monasta, Lorenzo ; Morrison, Shane D ; Mruts, Kalayu Birhane ; Oh, In-Hwan ; Olagunju, Andrew Toyin ; Oren, Eyal ; Ortiz, Alberto ; Osgood-Zimmerman, Aaron ; Parry, Charles D ; Petzold, Max ; Rahimi-Movaghar, Afarin ; Rao, Paturi Vishnupriya ; Rawaf, Salman ; Ray, Sarah E ; Resnikoff, Serge ; Saleem, Huda Omer Ba ; Sartorius, Benn ; Sawhney, Monika ; Shamsipour, Mansour ; Smith, David L ; Sposato, Luciano A ; Stein, Murray B ; Stein, Dan J ; Stokes, Mark Andrew ; Uthman, Olalekan A ; Uzochukwu, Benjamin S Chudi ; Wadilo, Fiseha ; Weintraub, Robert G ; Xu, Gelin ; Zenebe, Zerihun Menlkalew ; Zhou, Maigeng ; Murray, Christopher J L
creatorcontribAbd-Allah, Foad ; Abdulle, Abdishakur M ; Abera, Semaw Ferede ; Abu-Raddad, Laith J ; Adetokunboh, Olatunji ; Afshin, Ashkan ; Aggarwal, Rakesh ; Agrawal, Anurag ; Aichour, Ibtihel ; Akseer, Nadia ; Alizadeh-Navaei, Reza ; Bacha, Umar ; Bärnighausen, Till ; Beghi, Ettore ; Bensenor, Isabela M ; Benson, Jennifer ; Berhane, Adugnaw ; Bhala, Neeraj ; Bisanzio, Donal ; Bumgarner, Blair R ; Carrero, Juan Jesus ; Caso, Valeria ; Chen, Honglei ; Christopher, Devasahayam Jesudas ; Ciobanu, Liliana G ; Cirillo, Massimo ; Crump, John A ; das Neves, José ; De Leo, Diego De ; Des Jarlais, Don C ; Dhillon, Preet Kaur ; Doyle, Kerrie E ; Ermakov, Sergey Petrovich ; Fazeli, Mir Sohail ; Fischer, Florian ; Fitzmaurice, Christina ; Flaxman, Abraham D ; Foigt, Nataliya ; Futran, Neal D ; Gebre, Teshome ; Gold, Audra L ; Goldberg, Ellen M ; Gupta, Tanush ; Gupta, Vipin ; Hafezi-Nejad, Nima ; Hao, Yuantao ; Harvey, James ; Hoffman, Howard J ; Hosgood, H Dean ; Igumbor, Ehimario Uche ; Javanbakht, Mehdi ; Kan, Haidong ; Kassa, Getachew Mullu ; Kravchenko, Michael ; Lalloo, Ratilal ; Lan, Qing ; Lee, Jong-Tae ; Li Kappe, Darya ; Lorkowski, Stefan ; Low, Nicola ; Malta, Deborah Carvalho ; Mantovani, Lorenzo G ; Mapoma, Chabila C ; Marczak, Laurie B ; März, Winfried ; Mazidi, Mohsen ; McAlinden, Colm ; Mengistie, Mubarek Abera ; Monasta, Lorenzo ; Morrison, Shane D ; Mruts, Kalayu Birhane ; Oh, In-Hwan ; Olagunju, Andrew Toyin ; Oren, Eyal ; Ortiz, Alberto ; Osgood-Zimmerman, Aaron ; Parry, Charles D ; Petzold, Max ; Rahimi-Movaghar, Afarin ; Rao, Paturi Vishnupriya ; Rawaf, Salman ; Ray, Sarah E ; Resnikoff, Serge ; Saleem, Huda Omer Ba ; Sartorius, Benn ; Sawhney, Monika ; Shamsipour, Mansour ; Smith, David L ; Sposato, Luciano A ; Stein, Murray B ; Stein, Dan J ; Stokes, Mark Andrew ; Uthman, Olalekan A ; Uzochukwu, Benjamin S Chudi ; Wadilo, Fiseha ; Weintraub, Robert G ; Xu, Gelin ; Zenebe, Zerihun Menlkalew ; Zhou, Maigeng ; Murray, Christopher J L ; GBD 2016 Disease and Injury Incidence and Prevalence Collaborators ; Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa ; Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för hälsometri ; Göteborgs universitet ; Gothenburg University ; Institute of Medicine, School of Public Health and Community Medicine ; Sahlgrenska Academy ; Sahlgrenska akademin ; Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics
descriptionAs mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between incidence, prevalence, remission, and cause of death rates for each condition. For some causes, we used alternative modelling strategies if incidence or prevalence needed to be derived from other data. YLDs were estimated as the product of prevalence and a disability weight for all mutually exclusive sequelae, corrected for comorbidity and aggregated to cause level. We updated the Socio-demographic Index (SDI), a summary indicator of income per capita, years of schooling, and total fertility rate. GBD 2016 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Globally, low back pain, migraine, age-related and other hearing loss, iron-deficiency anaemia, and major depressive disorder were the five leading causes of YLDs in 2016, contributing 57·6 million (95% uncertainty interval [UI] 40·8–75·9 million [7·2%, 6·0–8·3]), 45·1 million (29·0–62·8 million [5·6%, 4·0–7·2]), 36·3 million (25·3–50·9 million [4·5%, 3·8–5·3]), 34·7 million (23·0–49·6 million [4·3%, 3·5–5·2]), and 34·1 million (23·5–46·0 million [4·2%, 3·2–5·3]) of total YLDs, respectively. Age-standardised rates of YLDs for all causes combined decreased between 1990 and 2016 by 2·7% (95% UI 2·3–3·1). Despite mostly stagnant age-standardised rates, the absolute number of YLDs from non-communicable diseases has been growing rapidly across all SDI quintiles, partly because of population growth, but also the ageing of populations. The largest absolute increases in total numbers of YLDs globally were between the ages of 40 and 69 years. Age-standardised YLD rates for all conditions combined were 10·4% (95% UI 9·0–11·8) higher in women than in men. Iron-deficiency anaemia, migraine, Alzheimer's disease and other dementias, major depressive disorder, anxiety, and all musculoskeletal disorders apart from gout were the main conditions contributing to higher YLD rates in women. Men had higher age-standardised rates of substance use disorders, diabetes, cardiovascular diseases, cancers, and all injuries apart from sexual violence. Globally, we noted much less geographical variation in disability than has been documented for premature mortality. In 2016, there was a less than two times difference in age-standardised YLD rates for all causes between the location with the lowest rate (China, 9201 YLDs per 100 000, 95% UI 6862–11943) and highest rate (Yemen, 14 774 YLDs per 100 000, 11 018–19 228). The decrease in death rates since 1990 for most causes has not been matched by a similar decline in age-standardised YLD rates. For many large causes, YLD rates have either been stagnant or have increased for some causes, such as diabetes. As populations are ageing, and the prevalence of disabling disease generally increases steeply with age, health systems will face increasing demand for services that are generally costlier than the interventions that have led to declines in mortality in childhood or for the major causes of mortality in adults. Up-to-date information about the trends of disease and how this varies between countries is essential to plan for an adequate health-system response. Bill & Melinda Gates Foundation, and the National Institute on Aging and the National Institute of Mental Health of the National Institutes of Health.
identifier
0ISSN: 0140-6736
1ISSN: 1474-547X
2EISSN: 1474-547X
3DOI: 10.1016/S0140-6736(17)32154-2
4PMID: 28919117
languageeng
publisherEngland: Elsevier Ltd
subject11 Medical And Health Sciences ; 3112 Neurosciences ; 3121 Internal medicine ; 3142 Public health care science ; 80 and over; Cause of Death; Child; Child ; abdominal wall hernia; abortion; accidental injury; accommodation; acne vulgaris; acute glomerulonephritis; acute hepatitis; acute hepatitis A; acute leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; adult; adverse drug reaction; African trypanosomiasis; aged; aging; airway; alcohol consumption; alcoholic cardiomyopathy; alcoholism; alopecia areata; Alzheimer disease; amphetamine dependence; anemia; anorexia nervosa; anxiety disorder; appendicitis; Article; asbestosis; ascariasis; Asperger syndrome; assault; asthma; atrial fibrillation; attention deficit disorder; autism; automutilation; biliary tract cancer; biliary tract disease; bipolar disorder; bladder cancer; bleeding; brain cancer; brain disease; brain hemorrhage; brain ischemia; breast cancer; bronchus cancer; bulimia; cannabis addiction; cardiomyopathy; cardiovascular disease; cataract; cause of death; cellulitis; cerebrovascular disease; Chagas disease; chickenpox; chlamydiasis; chromosome aberration; chronic kidney failure; chronic liver disease; chronic lymphatic leukemia; chronic myeloid leukemia; chronic obstructive lung disease; chronic respiratory tract disease; cocaine dependence; cold exposure; colon cancer; comorbidity; conduct disorder; conflict; congenital heart malformation; congenital malformation; cutaneous melanoma; cyclist; cysticercosis; deciduous tooth; decubitus; dementia; demography; dengue; dental caries; depression; dermatitis; dermatomycosis; diabetes mellitus; diarrhea; diphtheria; disability; disability severity; Down syndrome; dracunculiasis; drowning; drug dependence; drug resistant tuberculosis; duodenitis; dysthymia; dystocia; eating disorder; Ebola hemorrhagic fever; echinococcosis; ectopic pregnancy; encephalitis; endocarditis; endocrine disease; endometriosis; enteropathy; environmental exposure; epilepsy; esophagus cancer; extensively drug resistant tuberculosis; falling; female; female infertility; femoral hernia; fertility; foreign body; gallbladder cancer; gallbladder disease; gastritis; gastrointestinal disease; gastrointestinal malformation; genital herpes; geography; glaucoma; global disease burden; glomerulonephritis; glucose 6 phosphate dehydrogenase deficiency; gonorrhea; gout; Guillain Barre syndrome; gunshot injury; gynecologic disease; Haemophilus infection; hearing impairment; heart atrium flutter; heart failure; hematologic disease; hemoglobinopathy; hemolytic anemia; hepatitis; hepatitis B; hepatitis C; hepatitis E; herpes zoster; Hodgkin disease; hookworm infection; human; Human immunodeficiency virus infection; hypertension; idiopathic disease; immune deficiency; incidence; income; infertility; inflammatory bowel disease; inguinal hernia; injury; intellectual impairment; interstitial lung disease; interstitial nephritis; intestine infection; intestine obstruction; intoxication; iodine deficiency; iron deficiency anemia; ischemic heart disease; kidney cancer; Klinefelter syndrome; larynx cancer; latent tuberculosis; leishmaniasis; leprosy; leukemia; limb malformation; lip cancer; liver cancer; liver cirrhosis; low back pain; lower respiratory tract infection; lung cancer; lung sarcoidosis; lymphatic filariasis; macular degeneration; major clinical study; major depression; malaria; male; male infertility; malignant neoplasm; maternal disease; maternal hypertension; measles; meningococcosis; mental disease; mesothelioma; metabolic disorder; migraine; mortality rate; motor neuron disease; motor vehicle; motorcyclist; mouth cancer; mouth disease; multidrug resistant tuberculosis; multiple myeloma; multiple sclerosis; musculoskeletal disease; myocarditis; nasopharynx cancer; neck pain; nematodiasis; nervous system cancer; neural tube defect; neurologic disease; newborn; newborn disease; newborn infection; newborn jaundice; newborn sepsis; non communicable disease; non melanoma skin cancer; nonhodgkin lymphoma; nutritional deficiency; nutritional disorder; onchocerciasis; opiate addiction; osteoarthritis; otitis media; ovary cancer; ovary polycystic disease; pancreas cancer; pancreatitis; paralytic ileus; paratyphoid fever; Parkinson disease; pedestrian; pelvic inflammatory disease; pelvic organ prolapse; peptic ulcer; perinatal asphyxia; periodontal disease; peripheral vascular disease; permanent tooth; pertussis; pharynx cancer; physical disease; pneumococcal meningitis; pneumoconiosis; poisonous animal; population growth; practice guideline; premature labor; premature mortality; premenstrual syndrome; prevalence; priority journal; prostate cancer; prostate hypertrophy; protein calorie malnutrition; pruritus; psoriasis; pulmonary aspiration; pyoderma; rabies; rectum cancer; refraction error; remission; retinol deficiency; rheumatic heart disease; rheumatoid arthritis; scabies; schistosomiasis; schizophrenia; school; sensory dysfunction; sepsis; sex difference; sexual violence; sexually transmitted disease; sickle cell anemia; sickle cell trait; silicosis; skin leishmaniasis; social status; spontaneous abortion; squamous cell skin carcinoma; stomach cancer; suffocation; syphilis; tension headache; terrorism; testis cancer; tetanus; thalassemia; thermal exposure; thyroid cancer; trachea cancer; trachoma; traffic accident; trichomoniasis; trichuriasis; tropical disease; tuberculosis; Turner syndrome; typhoid fever; upper respiratory tract infection; urinary tract disease; urinary tract infection; urogenital tract malformation; urolithiasis; urticaria; uterine cervix cancer; uterus cancer; uterus myoma; uterus rupture; viral skin disease; visceral leishmaniasis; visual impairment; yellow fever; Zika fever; adolescent; age distribution; child; communicable disease; disabled person; global disease burden; global health; infant; injury; middle aged; mortality; non communicable disease; preschool child; sex ratio; statistics and numerical data; trends; very elderly; young adult ; Adolescent ; Adolescent; Adult; Age Distribution; Aged; Aged ; Adult ; Adults ; Age ; Age disdtribution ; Age Distribution ; Aged ; Aged, 80 and over ; Aggression ; Aging ; Aldraðir ; Allmänmedicin ; Alzheimer's disease ; Anemia ; Anxiety ; atira ; Bakverkir ; Bayesian analysis ; Cardiovascular diseases ; Cause of Death ; Cause of Death - trends ; Charities ; Child ; Child, Preschool ; Children ; Chronic illnesses ; CHRONIC PAIN ; CLIMATE-CHANGE ; Clinical Medicine ; Communicable Diseases ; Communicable Diseases - mortality ; Community medicine ; Community medicine, Social medicine: 801 ; Complications ; Demographics ; Dental caries ; dental statistics ; DEPRESSION ; Diabetes mellitus ; Disability ; Disabled Persons ; Disabled Persons - statistics & numerical data ; Disease ; Disease control ; Diseases ; DISORDERS ; Dánarmein ; Dánartíðni ; environmental ; Epidemiologi medisinsk og odontologisk statistikk ; Epidemiologi medisinsk og odontologisk statistikk: 803 ; Epidemiology medical ; Epidemiology medical and dental statistics: 803 ; Estimates ; Fatlaðir ; Female ; Fertility ; Firearms ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; FUTURE ; Félagshagfræði ; Fólksfjölgun ; GBD 2016 Disease ; General & Internal Medicine ; General Practice ; Global Burden of Disease ; Global Burden of Disease - statistics & numerical data ; Global Health ; Global Health - statistics & numerical data ; Global Health Metrics ; Gout ; Guillain-Barre syndrome ; Halk sağlığı ; Headache ; Health and Welfare ; Health care ; Health policy ; Health risks ; Health Sciences ; Health sciences: 800 ; Health service ; Hearing loss ; Heart diseases ; Heilbrigðiskerfi ; Heilbrigðisstefna ; Heilbrigðisþjónusta ; Heilsufar ; Heilsugæsla ; Helsefag ; Helsefag: 800 ; Hospitals ; Humans ; Hälsa och välfärd ; Hälsovetenskap ; Hälsovetenskaper ; Incidence ; Infant ; Infant, Newborn ; Injuries ; injury ; Injury analysis ; Injury Incidence ; Iron ; Journal Article ; Karlar ; Klinisk medicin ; Konur ; Langlífi ; Life expectancy ; Life span ; living with disability ; Low back pain ; Lýðfræði ; Male ; Mannfjöldi ; Medical and Health Sciences ; Medical disciplines ; Medical disciplines: 700 ; Medical research ; Medicin och hälsovetenskap ; Medicine (all) ; Medicine, Experimental ; Medisinske Fag ; Medisinske Fag: 700 ; Men ; Mental depression ; Mental disorders ; Mental health ; Middle Aged ; Migraine ; MORTALITY ; Musculoskeletal diseases ; Neurodegenerative diseases ; Newborn ; Newborn; Male; Middle Aged; Noncommunicable Diseases; Prevalence; Sex Distribution; Wounds and Injuries; Young Adult ; Noncommunicable Diseases ; Noncommunicable Diseases - mortality ; numerical data ; Nutrient deficiency ; occupational health ; Older people ; over ; Pain ; People with disabilities ; Personal health ; PERSONAL HEALTH-CARE ; Population aging ; Population growth ; Preschool ; Preschool; Communicable Diseases; Disabled Persons; Female; Global Burden of Disease; Global Health; Humans; Incidence; Infant; Infant ; Prevalence ; Prevalence Collaborators ; Public health ; Public health systems ; Public Health, Global Health, Social Medicine and Epidemiology ; pubmedpublicationtype ; pure ; Ratios ; Regression analysis ; Remission ; researchoutput ; Respiratory infections ; Risk factors ; Samfunnsmedisin ; Samfunnsmedisin, sosialmedisin: 801 ; Self destructive behavior ; Sex Distribution ; Sexual assault ; Sjúkdómar ; Social medicine ; Socioeconomic factors ; sosialmedisin ; statistics ; statistics & numerical data ; Staðtölur ; Substance use ; Tannskemmdir ; TRENDS ; Tropical diseases ; Tuberculosis ; Tölfræði ; VDP ; Violence ; Women ; World health ; Wounds ; Wounds and Injuries - mortality ; Young Adult ; Áverkar ; Öndunarfærasjúkdómar ; Þjóðir
ispartofLancet (London, England), 2017-09-16, Vol.390 (10100), p.1211-1259
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02017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
1info:eu-repo/semantics/openAccess
2Copyright © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license. Published by Elsevier Ltd.. All rights reserved.
3COPYRIGHT 2017 Elsevier B.V.
4Copyright Elsevier Limited Sep 16, 2017
52017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license 2017
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-12924t-7da29fb3360911f492fffcc397b91d43198492702db1f3648fb8b4fe52a4ec883
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creatorcontrib
0Abd-Allah, Foad
1Abdulle, Abdishakur M
2Abera, Semaw Ferede
3Abu-Raddad, Laith J
4Adetokunboh, Olatunji
5Afshin, Ashkan
6Aggarwal, Rakesh
7Agrawal, Anurag
8Aichour, Ibtihel
9Akseer, Nadia
10Alizadeh-Navaei, Reza
11Bacha, Umar
12Bärnighausen, Till
13Beghi, Ettore
14Bensenor, Isabela M
15Benson, Jennifer
16Berhane, Adugnaw
17Bhala, Neeraj
18Bisanzio, Donal
19Bumgarner, Blair R
20Carrero, Juan Jesus
21Caso, Valeria
22Chen, Honglei
23Christopher, Devasahayam Jesudas
24Ciobanu, Liliana G
25Cirillo, Massimo
26Crump, John A
27das Neves, José
28De Leo, Diego De
29Des Jarlais, Don C
30Dhillon, Preet Kaur
31Doyle, Kerrie E
32Ermakov, Sergey Petrovich
33Fazeli, Mir Sohail
34Fischer, Florian
35Fitzmaurice, Christina
36Flaxman, Abraham D
37Foigt, Nataliya
38Futran, Neal D
39Gebre, Teshome
40Gold, Audra L
41Goldberg, Ellen M
42Gupta, Tanush
43Gupta, Vipin
44Hafezi-Nejad, Nima
45Hao, Yuantao
46Harvey, James
47Hoffman, Howard J
48Hosgood, H Dean
49Igumbor, Ehimario Uche
50Javanbakht, Mehdi
51Kan, Haidong
52Kassa, Getachew Mullu
53Kravchenko, Michael
54Lalloo, Ratilal
55Lan, Qing
56Lee, Jong-Tae
57Li Kappe, Darya
58Lorkowski, Stefan
59Low, Nicola
60Malta, Deborah Carvalho
61Mantovani, Lorenzo G
62Mapoma, Chabila C
63Marczak, Laurie B
64März, Winfried
65Mazidi, Mohsen
66McAlinden, Colm
67Mengistie, Mubarek Abera
68Monasta, Lorenzo
69Morrison, Shane D
70Mruts, Kalayu Birhane
71Oh, In-Hwan
72Olagunju, Andrew Toyin
73Oren, Eyal
74Ortiz, Alberto
75Osgood-Zimmerman, Aaron
76Parry, Charles D
77Petzold, Max
78Rahimi-Movaghar, Afarin
79Rao, Paturi Vishnupriya
80Rawaf, Salman
81Ray, Sarah E
82Resnikoff, Serge
83Saleem, Huda Omer Ba
84Sartorius, Benn
85Sawhney, Monika
86Shamsipour, Mansour
87Smith, David L
88Sposato, Luciano A
89Stein, Murray B
90Stein, Dan J
91Stokes, Mark Andrew
92Uthman, Olalekan A
93Uzochukwu, Benjamin S Chudi
94Wadilo, Fiseha
95Weintraub, Robert G
96Xu, Gelin
97Zenebe, Zerihun Menlkalew
98Zhou, Maigeng
99Murray, Christopher J L
100GBD 2016 Disease and Injury Incidence and Prevalence Collaborators
101Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
102Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för hälsometri
103Göteborgs universitet
104Gothenburg University
105Institute of Medicine, School of Public Health and Community Medicine
106Sahlgrenska Academy
107Sahlgrenska akademin
108Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics
title
0Global, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
1Lancet (London, England)
addtitleLancet
descriptionAs mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between incidence, prevalence, remission, and cause of death rates for each condition. For some causes, we used alternative modelling strategies if incidence or prevalence needed to be derived from other data. YLDs were estimated as the product of prevalence and a disability weight for all mutually exclusive sequelae, corrected for comorbidity and aggregated to cause level. We updated the Socio-demographic Index (SDI), a summary indicator of income per capita, years of schooling, and total fertility rate. GBD 2016 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Globally, low back pain, migraine, age-related and other hearing loss, iron-deficiency anaemia, and major depressive disorder were the five leading causes of YLDs in 2016, contributing 57·6 million (95% uncertainty interval [UI] 40·8–75·9 million [7·2%, 6·0–8·3]), 45·1 million (29·0–62·8 million [5·6%, 4·0–7·2]), 36·3 million (25·3–50·9 million [4·5%, 3·8–5·3]), 34·7 million (23·0–49·6 million [4·3%, 3·5–5·2]), and 34·1 million (23·5–46·0 million [4·2%, 3·2–5·3]) of total YLDs, respectively. Age-standardised rates of YLDs for all causes combined decreased between 1990 and 2016 by 2·7% (95% UI 2·3–3·1). Despite mostly stagnant age-standardised rates, the absolute number of YLDs from non-communicable diseases has been growing rapidly across all SDI quintiles, partly because of population growth, but also the ageing of populations. The largest absolute increases in total numbers of YLDs globally were between the ages of 40 and 69 years. Age-standardised YLD rates for all conditions combined were 10·4% (95% UI 9·0–11·8) higher in women than in men. Iron-deficiency anaemia, migraine, Alzheimer's disease and other dementias, major depressive disorder, anxiety, and all musculoskeletal disorders apart from gout were the main conditions contributing to higher YLD rates in women. Men had higher age-standardised rates of substance use disorders, diabetes, cardiovascular diseases, cancers, and all injuries apart from sexual violence. Globally, we noted much less geographical variation in disability than has been documented for premature mortality. In 2016, there was a less than two times difference in age-standardised YLD rates for all causes between the location with the lowest rate (China, 9201 YLDs per 100 000, 95% UI 6862–11943) and highest rate (Yemen, 14 774 YLDs per 100 000, 11 018–19 228). The decrease in death rates since 1990 for most causes has not been matched by a similar decline in age-standardised YLD rates. For many large causes, YLD rates have either been stagnant or have increased for some causes, such as diabetes. As populations are ageing, and the prevalence of disabling disease generally increases steeply with age, health systems will face increasing demand for services that are generally costlier than the interventions that have led to declines in mortality in childhood or for the major causes of mortality in adults. Up-to-date information about the trends of disease and how this varies between countries is essential to plan for an adequate health-system response. Bill & Melinda Gates Foundation, and the National Institute on Aging and the National Institute of Mental Health of the National Institutes of Health.
subject
011 Medical And Health Sciences
13112 Neurosciences
23121 Internal medicine
33142 Public health care science
480 and over; Cause of Death; Child; Child
5abdominal wall hernia; abortion; accidental injury; accommodation; acne vulgaris; acute glomerulonephritis; acute hepatitis; acute hepatitis A; acute leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; adult; adverse drug reaction; African trypanosomiasis; aged; aging; airway; alcohol consumption; alcoholic cardiomyopathy; alcoholism; alopecia areata; Alzheimer disease; amphetamine dependence; anemia; anorexia nervosa; anxiety disorder; appendicitis; Article; asbestosis; ascariasis; Asperger syndrome; assault; asthma; atrial fibrillation; attention deficit disorder; autism; automutilation; biliary tract cancer; biliary tract disease; bipolar disorder; bladder cancer; bleeding; brain cancer; brain disease; brain hemorrhage; brain ischemia; breast cancer; bronchus cancer; bulimia; cannabis addiction; cardiomyopathy; cardiovascular disease; cataract; cause of death; cellulitis; cerebrovascular disease; Chagas disease; chickenpox; chlamydiasis; chromosome aberration; chronic kidney failure; chronic liver disease; chronic lymphatic leukemia; chronic myeloid leukemia; chronic obstructive lung disease; chronic respiratory tract disease; cocaine dependence; cold exposure; colon cancer; comorbidity; conduct disorder; conflict; congenital heart malformation; congenital malformation; cutaneous melanoma; cyclist; cysticercosis; deciduous tooth; decubitus; dementia; demography; dengue; dental caries; depression; dermatitis; dermatomycosis; diabetes mellitus; diarrhea; diphtheria; disability; disability severity; Down syndrome; dracunculiasis; drowning; drug dependence; drug resistant tuberculosis; duodenitis; dysthymia; dystocia; eating disorder; Ebola hemorrhagic fever; echinococcosis; ectopic pregnancy; encephalitis; endocarditis; endocrine disease; endometriosis; enteropathy; environmental exposure; epilepsy; esophagus cancer; extensively drug resistant tuberculosis; falling; female; female infertility; femoral hernia; fertility; foreign body; gallbladder cancer; gallbladder disease; gastritis; gastrointestinal disease; gastrointestinal malformation; genital herpes; geography; glaucoma; global disease burden; glomerulonephritis; glucose 6 phosphate dehydrogenase deficiency; gonorrhea; gout; Guillain Barre syndrome; gunshot injury; gynecologic disease; Haemophilus infection; hearing impairment; heart atrium flutter; heart failure; hematologic disease; hemoglobinopathy; hemolytic anemia; hepatitis; hepatitis B; hepatitis C; hepatitis E; herpes zoster; Hodgkin disease; hookworm infection; human; Human immunodeficiency virus infection; hypertension; idiopathic disease; immune deficiency; incidence; income; infertility; inflammatory bowel disease; inguinal hernia; injury; intellectual impairment; interstitial lung disease; interstitial nephritis; intestine infection; intestine obstruction; intoxication; iodine deficiency; iron deficiency anemia; ischemic heart disease; kidney cancer; Klinefelter syndrome; larynx cancer; latent tuberculosis; leishmaniasis; leprosy; leukemia; limb malformation; lip cancer; liver cancer; liver cirrhosis; low back pain; lower respiratory tract infection; lung cancer; lung sarcoidosis; lymphatic filariasis; macular degeneration; major clinical study; major depression; malaria; male; male infertility; malignant neoplasm; maternal disease; maternal hypertension; measles; meningococcosis; mental disease; mesothelioma; metabolic disorder; migraine; mortality rate; motor neuron disease; motor vehicle; motorcyclist; mouth cancer; mouth disease; multidrug resistant tuberculosis; multiple myeloma; multiple sclerosis; musculoskeletal disease; myocarditis; nasopharynx cancer; neck pain; nematodiasis; nervous system cancer; neural tube defect; neurologic disease; newborn; newborn disease; newborn infection; newborn jaundice; newborn sepsis; non communicable disease; non melanoma skin cancer; nonhodgkin lymphoma; nutritional deficiency; nutritional disorder; onchocerciasis; opiate addiction; osteoarthritis; otitis media; ovary cancer; ovary polycystic disease; pancreas cancer; pancreatitis; paralytic ileus; paratyphoid fever; Parkinson disease; pedestrian; pelvic inflammatory disease; pelvic organ prolapse; peptic ulcer; perinatal asphyxia; periodontal disease; peripheral vascular disease; permanent tooth; pertussis; pharynx cancer; physical disease; pneumococcal meningitis; pneumoconiosis; poisonous animal; population growth; practice guideline; premature labor; premature mortality; premenstrual syndrome; prevalence; priority journal; prostate cancer; prostate hypertrophy; protein calorie malnutrition; pruritus; psoriasis; pulmonary aspiration; pyoderma; rabies; rectum cancer; refraction error; remission; retinol deficiency; rheumatic heart disease; rheumatoid arthritis; scabies; schistosomiasis; schizophrenia; school; sensory dysfunction; sepsis; sex difference; sexual violence; sexually transmitted disease; sickle cell anemia; sickle cell trait; silicosis; skin leishmaniasis; social status; spontaneous abortion; squamous cell skin carcinoma; stomach cancer; suffocation; syphilis; tension headache; terrorism; testis cancer; tetanus; thalassemia; thermal exposure; thyroid cancer; trachea cancer; trachoma; traffic accident; trichomoniasis; trichuriasis; tropical disease; tuberculosis; Turner syndrome; typhoid fever; upper respiratory tract infection; urinary tract disease; urinary tract infection; urogenital tract malformation; urolithiasis; urticaria; uterine cervix cancer; uterus cancer; uterus myoma; uterus rupture; viral skin disease; visceral leishmaniasis; visual impairment; yellow fever; Zika fever; adolescent; age distribution; child; communicable disease; disabled person; global disease burden; global health; infant; injury; middle aged; mortality; non communicable disease; preschool child; sex ratio; statistics and numerical data; trends; very elderly; young adult
6Adolescent
7Adolescent; Adult; Age Distribution; Aged; Aged
8Adult
9Adults
10Age
11Age disdtribution
12Age Distribution
13Aged
14Aged, 80 and over
15Aggression
16Aging
17Aldraðir
18Allmänmedicin
19Alzheimer's disease
20Anemia
21Anxiety
22atira
23Bakverkir
24Bayesian analysis
25Cardiovascular diseases
26Cause of Death
27Cause of Death - trends
28Charities
29Child
30Child, Preschool
31Children
32Chronic illnesses
33CHRONIC PAIN
34CLIMATE-CHANGE
35Clinical Medicine
36Communicable Diseases
37Communicable Diseases - mortality
38Community medicine
39Community medicine, Social medicine: 801
40Complications
41Demographics
42Dental caries
43dental statistics
44DEPRESSION
45Diabetes mellitus
46Disability
47Disabled Persons
48Disabled Persons - statistics & numerical data
49Disease
50Disease control
51Diseases
52DISORDERS
53Dánarmein
54Dánartíðni
55environmental
56Epidemiologi medisinsk og odontologisk statistikk
57Epidemiologi medisinsk og odontologisk statistikk: 803
58Epidemiology medical
59Epidemiology medical and dental statistics: 803
60Estimates
61Fatlaðir
62Female
63Fertility
64Firearms
65Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
66FUTURE
67Félagshagfræði
68Fólksfjölgun
69GBD 2016 Disease
70General & Internal Medicine
71General Practice
72Global Burden of Disease
73Global Burden of Disease - statistics & numerical data
74Global Health
75Global Health - statistics & numerical data
76Global Health Metrics
77Gout
78Guillain-Barre syndrome
79Halk sağlığı
80Headache
81Health and Welfare
82Health care
83Health policy
84Health risks
85Health Sciences
86Health sciences: 800
87Health service
88Hearing loss
89Heart diseases
90Heilbrigðiskerfi
91Heilbrigðisstefna
92Heilbrigðisþjónusta
93Heilsufar
94Heilsugæsla
95Helsefag
96Helsefag: 800
97Hospitals
98Humans
99Hälsa och välfärd
100Hälsovetenskap
101Hälsovetenskaper
102Incidence
103Infant
104Infant, Newborn
105Injuries
106injury
107Injury analysis
108Injury Incidence
109Iron
110Journal Article
111Karlar
112Klinisk medicin
113Konur
114Langlífi
115Life expectancy
116Life span
117living with disability
118Low back pain
119Lýðfræði
120Male
121Mannfjöldi
122Medical and Health Sciences
123Medical disciplines
124Medical disciplines: 700
125Medical research
126Medicin och hälsovetenskap
127Medicine (all)
128Medicine, Experimental
129Medisinske Fag
130Medisinske Fag: 700
131Men
132Mental depression
133Mental disorders
134Mental health
135Middle Aged
136Migraine
137MORTALITY
138Musculoskeletal diseases
139Neurodegenerative diseases
140Newborn
141Newborn; Male; Middle Aged; Noncommunicable Diseases; Prevalence; Sex Distribution; Wounds and Injuries; Young Adult
142Noncommunicable Diseases
143Noncommunicable Diseases - mortality
144numerical data
145Nutrient deficiency
146occupational health
147Older people
148over
149Pain
150People with disabilities
151Personal health
152PERSONAL HEALTH-CARE
153Population aging
154Population growth
155Preschool
156Preschool; Communicable Diseases; Disabled Persons; Female; Global Burden of Disease; Global Health; Humans; Incidence; Infant; Infant
157Prevalence
158Prevalence Collaborators
159Public health
160Public health systems
161Public Health, Global Health, Social Medicine and Epidemiology
162pubmedpublicationtype
163pure
164Ratios
165Regression analysis
166Remission
167researchoutput
168Respiratory infections
169Risk factors
170Samfunnsmedisin
171Samfunnsmedisin, sosialmedisin: 801
172Self destructive behavior
173Sex Distribution
174Sexual assault
175Sjúkdómar
176Social medicine
177Socioeconomic factors
178sosialmedisin
179statistics
180statistics & numerical data
181Staðtölur
182Substance use
183Tannskemmdir
184TRENDS
185Tropical diseases
186Tuberculosis
187Tölfræði
188VDP
189Violence
190Women
191World health
192Wounds
193Wounds and Injuries - mortality
194Young Adult
195Áverkar
196Öndunarfærasjúkdómar
197Þjóðir
issn
00140-6736
11474-547X
21474-547X
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startdate20170916
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0Abd-Allah, Foad
1Abdulle, Abdishakur M
2Abera, Semaw Ferede
3Abu-Raddad, Laith J
4Adetokunboh, Olatunji
5Afshin, Ashkan
6Aggarwal, Rakesh
7Agrawal, Anurag
8Aichour, Ibtihel
9Akseer, Nadia
10Alizadeh-Navaei, Reza
11Bacha, Umar
12Bärnighausen, Till
13Beghi, Ettore
14Bensenor, Isabela M
15Benson, Jennifer
16Berhane, Adugnaw
17Bhala, Neeraj
18Bisanzio, Donal
19Bumgarner, Blair R
20Carrero, Juan Jesus
21Caso, Valeria
22Chen, Honglei
23Christopher, Devasahayam Jesudas
24Ciobanu, Liliana G
25Cirillo, Massimo
26Crump, John A
27das Neves, José
28De Leo, Diego De
29Des Jarlais, Don C
30Dhillon, Preet Kaur
31Doyle, Kerrie E
32Ermakov, Sergey Petrovich
33Fazeli, Mir Sohail
34Fischer, Florian
35Fitzmaurice, Christina
36Flaxman, Abraham D
37Foigt, Nataliya
38Futran, Neal D
39Gebre, Teshome
40Gold, Audra L
41Goldberg, Ellen M
42Gupta, Tanush
43Gupta, Vipin
44Hafezi-Nejad, Nima
45Hao, Yuantao
46Harvey, James
47Hoffman, Howard J
48Hosgood, H Dean
49Igumbor, Ehimario Uche
50Javanbakht, Mehdi
51Kan, Haidong
52Kassa, Getachew Mullu
53Kravchenko, Michael
54Lalloo, Ratilal
55Lan, Qing
56Lee, Jong-Tae
57Li Kappe, Darya
58Lorkowski, Stefan
59Low, Nicola
60Malta, Deborah Carvalho
61Mantovani, Lorenzo G
62Mapoma, Chabila C
63Marczak, Laurie B
64März, Winfried
65Mazidi, Mohsen
66McAlinden, Colm
67Mengistie, Mubarek Abera
68Monasta, Lorenzo
69Morrison, Shane D
70Mruts, Kalayu Birhane
71Oh, In-Hwan
72Olagunju, Andrew Toyin
73Oren, Eyal
74Ortiz, Alberto
75Osgood-Zimmerman, Aaron
76Parry, Charles D
77Petzold, Max
78Rahimi-Movaghar, Afarin
79Rao, Paturi Vishnupriya
80Rawaf, Salman
81Ray, Sarah E
82Resnikoff, Serge
83Saleem, Huda Omer Ba
84Sartorius, Benn
85Sawhney, Monika
86Shamsipour, Mansour
87Smith, David L
88Sposato, Luciano A
89Stein, Murray B
90Stein, Dan J
91Stokes, Mark Andrew
92Uthman, Olalekan A
93Uzochukwu, Benjamin S Chudi
94Wadilo, Fiseha
95Weintraub, Robert G
96Xu, Gelin
97Zenebe, Zerihun Menlkalew
98Zhou, Maigeng
99Murray, Christopher J L
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2Elsevier Limited
3Elsevier
4Lancet Publishing Group
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6Netherlands : Elsevier BV
7Elsevier BV
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creationdate20170916
titleGlobal, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
authorAbd-Allah, Foad ; Abdulle, Abdishakur M ; Abera, Semaw Ferede ; Abu-Raddad, Laith J ; Adetokunboh, Olatunji ; Afshin, Ashkan ; Aggarwal, Rakesh ; Agrawal, Anurag ; Aichour, Ibtihel ; Akseer, Nadia ; Alizadeh-Navaei, Reza ; Bacha, Umar ; Bärnighausen, Till ; Beghi, Ettore ; Bensenor, Isabela M ; Benson, Jennifer ; Berhane, Adugnaw ; Bhala, Neeraj ; Bisanzio, Donal ; Bumgarner, Blair R ; Carrero, Juan Jesus ; Caso, Valeria ; Chen, Honglei ; Christopher, Devasahayam Jesudas ; Ciobanu, Liliana G ; Cirillo, Massimo ; Crump, John A ; das Neves, José ; De Leo, Diego De ; Des Jarlais, Don C ; Dhillon, Preet Kaur ; Doyle, Kerrie E ; Ermakov, Sergey Petrovich ; Fazeli, Mir Sohail ; Fischer, Florian ; Fitzmaurice, Christina ; Flaxman, Abraham D ; Foigt, Nataliya ; Futran, Neal D ; Gebre, Teshome ; Gold, Audra L ; Goldberg, Ellen M ; Gupta, Tanush ; Gupta, Vipin ; Hafezi-Nejad, Nima ; Hao, Yuantao ; Harvey, James ; Hoffman, Howard J ; Hosgood, H Dean ; Igumbor, Ehimario Uche ; Javanbakht, Mehdi ; Kan, Haidong ; Kassa, Getachew Mullu ; Kravchenko, Michael ; Lalloo, Ratilal ; Lan, Qing ; Lee, Jong-Tae ; Li Kappe, Darya ; Lorkowski, Stefan ; Low, Nicola ; Malta, Deborah Carvalho ; Mantovani, Lorenzo G ; Mapoma, Chabila C ; Marczak, Laurie B ; März, Winfried ; Mazidi, Mohsen ; McAlinden, Colm ; Mengistie, Mubarek Abera ; Monasta, Lorenzo ; Morrison, Shane D ; Mruts, Kalayu Birhane ; Oh, In-Hwan ; Olagunju, Andrew Toyin ; Oren, Eyal ; Ortiz, Alberto ; Osgood-Zimmerman, Aaron ; Parry, Charles D ; Petzold, Max ; Rahimi-Movaghar, Afarin ; Rao, Paturi Vishnupriya ; Rawaf, Salman ; Ray, Sarah E ; Resnikoff, Serge ; Saleem, Huda Omer Ba ; Sartorius, Benn ; Sawhney, Monika ; Shamsipour, Mansour ; Smith, David L ; Sposato, Luciano A ; Stein, Murray B ; Stein, Dan J ; Stokes, Mark Andrew ; Uthman, Olalekan A ; Uzochukwu, Benjamin S Chudi ; Wadilo, Fiseha ; Weintraub, Robert G ; Xu, Gelin ; Zenebe, Zerihun Menlkalew ; Zhou, Maigeng ; Murray, Christopher J L
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languageeng
creationdate2017
topic
011 Medical And Health Sciences
13112 Neurosciences
23121 Internal medicine
33142 Public health care science
480 and over; Cause of Death; Child; Child
5abdominal wall hernia; abortion; accidental injury; accommodation; acne vulgaris; acute glomerulonephritis; acute hepatitis; acute hepatitis A; acute leukemia; acute lymphoblastic leukemia; acute myeloid leukemia; adult; adverse drug reaction; African trypanosomiasis; aged; aging; airway; alcohol consumption; alcoholic cardiomyopathy; alcoholism; alopecia areata; Alzheimer disease; amphetamine dependence; anemia; anorexia nervosa; anxiety disorder; appendicitis; Article; asbestosis; ascariasis; Asperger syndrome; assault; asthma; atrial fibrillation; attention deficit disorder; autism; automutilation; biliary tract cancer; biliary tract disease; bipolar disorder; bladder cancer; bleeding; brain cancer; brain disease; brain hemorrhage; brain ischemia; breast cancer; bronchus cancer; bulimia; cannabis addiction; cardiomyopathy; cardiovascular disease; cataract; cause of death; cellulitis; cerebrovascular disease; Chagas disease; chickenpox; chlamydiasis; chromosome aberration; chronic kidney failure; chronic liver disease; chronic lymphatic leukemia; chronic myeloid leukemia; chronic obstructive lung disease; chronic respiratory tract disease; cocaine dependence; cold exposure; colon cancer; comorbidity; conduct disorder; conflict; congenital heart malformation; congenital malformation; cutaneous melanoma; cyclist; cysticercosis; deciduous tooth; decubitus; dementia; demography; dengue; dental caries; depression; dermatitis; dermatomycosis; diabetes mellitus; diarrhea; diphtheria; disability; disability severity; Down syndrome; dracunculiasis; drowning; drug dependence; drug resistant tuberculosis; duodenitis; dysthymia; dystocia; eating disorder; Ebola hemorrhagic fever; echinococcosis; ectopic pregnancy; encephalitis; endocarditis; endocrine disease; endometriosis; enteropathy; environmental exposure; epilepsy; esophagus cancer; extensively drug resistant tuberculosis; falling; female; female infertility; femoral hernia; fertility; foreign body; gallbladder cancer; gallbladder disease; gastritis; gastrointestinal disease; gastrointestinal malformation; genital herpes; geography; glaucoma; global disease burden; glomerulonephritis; glucose 6 phosphate dehydrogenase deficiency; gonorrhea; gout; Guillain Barre syndrome; gunshot injury; gynecologic disease; Haemophilus infection; hearing impairment; heart atrium flutter; heart failure; hematologic disease; hemoglobinopathy; hemolytic anemia; hepatitis; hepatitis B; hepatitis C; hepatitis E; herpes zoster; Hodgkin disease; hookworm infection; human; Human immunodeficiency virus infection; hypertension; idiopathic disease; immune deficiency; incidence; income; infertility; inflammatory bowel disease; inguinal hernia; injury; intellectual impairment; interstitial lung disease; interstitial nephritis; intestine infection; intestine obstruction; intoxication; iodine deficiency; iron deficiency anemia; ischemic heart disease; kidney cancer; Klinefelter syndrome; larynx cancer; latent tuberculosis; leishmaniasis; leprosy; leukemia; limb malformation; lip cancer; liver cancer; liver cirrhosis; low back pain; lower respiratory tract infection; lung cancer; lung sarcoidosis; lymphatic filariasis; macular degeneration; major clinical study; major depression; malaria; male; male infertility; malignant neoplasm; maternal disease; maternal hypertension; measles; meningococcosis; mental disease; mesothelioma; metabolic disorder; migraine; mortality rate; motor neuron disease; motor vehicle; motorcyclist; mouth cancer; mouth disease; multidrug resistant tuberculosis; multiple myeloma; multiple sclerosis; musculoskeletal disease; myocarditis; nasopharynx cancer; neck pain; nematodiasis; nervous system cancer; neural tube defect; neurologic disease; newborn; newborn disease; newborn infection; newborn jaundice; newborn sepsis; non communicable disease; non melanoma skin cancer; nonhodgkin lymphoma; nutritional deficiency; nutritional disorder; onchocerciasis; opiate addiction; osteoarthritis; otitis media; ovary cancer; ovary polycystic disease; pancreas cancer; pancreatitis; paralytic ileus; paratyphoid fever; Parkinson disease; pedestrian; pelvic inflammatory disease; pelvic organ prolapse; peptic ulcer; perinatal asphyxia; periodontal disease; peripheral vascular disease; permanent tooth; pertussis; pharynx cancer; physical disease; pneumococcal meningitis; pneumoconiosis; poisonous animal; population growth; practice guideline; premature labor; premature mortality; premenstrual syndrome; prevalence; priority journal; prostate cancer; prostate hypertrophy; protein calorie malnutrition; pruritus; psoriasis; pulmonary aspiration; pyoderma; rabies; rectum cancer; refraction error; remission; retinol deficiency; rheumatic heart disease; rheumatoid arthritis; scabies; schistosomiasis; schizophrenia; school; sensory dysfunction; sepsis; sex difference; sexual violence; sexually transmitted disease; sickle cell anemia; sickle cell trait; silicosis; skin leishmaniasis; social status; spontaneous abortion; squamous cell skin carcinoma; stomach cancer; suffocation; syphilis; tension headache; terrorism; testis cancer; tetanus; thalassemia; thermal exposure; thyroid cancer; trachea cancer; trachoma; traffic accident; trichomoniasis; trichuriasis; tropical disease; tuberculosis; Turner syndrome; typhoid fever; upper respiratory tract infection; urinary tract disease; urinary tract infection; urogenital tract malformation; urolithiasis; urticaria; uterine cervix cancer; uterus cancer; uterus myoma; uterus rupture; viral skin disease; visceral leishmaniasis; visual impairment; yellow fever; Zika fever; adolescent; age distribution; child; communicable disease; disabled person; global disease burden; global health; infant; injury; middle aged; mortality; non communicable disease; preschool child; sex ratio; statistics and numerical data; trends; very elderly; young adult
6Adolescent
7Adolescent; Adult; Age Distribution; Aged; Aged
8Adult
9Adults
10Age
11Age disdtribution
12Age Distribution
13Aged
14Aged, 80 and over
15Aggression
16Aging
17Aldraðir
18Allmänmedicin
19Alzheimer's disease
20Anemia
21Anxiety
22atira
23Bakverkir
24Bayesian analysis
25Cardiovascular diseases
26Cause of Death
27Cause of Death - trends
28Charities
29Child
30Child, Preschool
31Children
32Chronic illnesses
33CHRONIC PAIN
34CLIMATE-CHANGE
35Clinical Medicine
36Communicable Diseases
37Communicable Diseases - mortality
38Community medicine
39Community medicine, Social medicine: 801
40Complications
41Demographics
42Dental caries
43dental statistics
44DEPRESSION
45Diabetes mellitus
46Disability
47Disabled Persons
48Disabled Persons - statistics & numerical data
49Disease
50Disease control
51Diseases
52DISORDERS
53Dánarmein
54Dánartíðni
55environmental
56Epidemiologi medisinsk og odontologisk statistikk
57Epidemiologi medisinsk og odontologisk statistikk: 803
58Epidemiology medical
59Epidemiology medical and dental statistics: 803
60Estimates
61Fatlaðir
62Female
63Fertility
64Firearms
65Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
66FUTURE
67Félagshagfræði
68Fólksfjölgun
69GBD 2016 Disease
70General & Internal Medicine
71General Practice
72Global Burden of Disease
73Global Burden of Disease - statistics & numerical data
74Global Health
75Global Health - statistics & numerical data
76Global Health Metrics
77Gout
78Guillain-Barre syndrome
79Halk sağlığı
80Headache
81Health and Welfare
82Health care
83Health policy
84Health risks
85Health Sciences
86Health sciences: 800
87Health service
88Hearing loss
89Heart diseases
90Heilbrigðiskerfi
91Heilbrigðisstefna
92Heilbrigðisþjónusta
93Heilsufar
94Heilsugæsla
95Helsefag
96Helsefag: 800
97Hospitals
98Humans
99Hälsa och välfärd
100Hälsovetenskap
101Hälsovetenskaper
102Incidence
103Infant
104Infant, Newborn
105Injuries
106injury
107Injury analysis
108Injury Incidence
109Iron
110Journal Article
111Karlar
112Klinisk medicin
113Konur
114Langlífi
115Life expectancy
116Life span
117living with disability
118Low back pain
119Lýðfræði
120Male
121Mannfjöldi
122Medical and Health Sciences
123Medical disciplines
124Medical disciplines: 700
125Medical research
126Medicin och hälsovetenskap
127Medicine (all)
128Medicine, Experimental
129Medisinske Fag
130Medisinske Fag: 700
131Men
132Mental depression
133Mental disorders
134Mental health
135Middle Aged
136Migraine
137MORTALITY
138Musculoskeletal diseases
139Neurodegenerative diseases
140Newborn
141Newborn; Male; Middle Aged; Noncommunicable Diseases; Prevalence; Sex Distribution; Wounds and Injuries; Young Adult
142Noncommunicable Diseases
143Noncommunicable Diseases - mortality
144numerical data
145Nutrient deficiency
146occupational health
147Older people
148over
149Pain
150People with disabilities
151Personal health
152PERSONAL HEALTH-CARE
153Population aging
154Population growth
155Preschool
156Preschool; Communicable Diseases; Disabled Persons; Female; Global Burden of Disease; Global Health; Humans; Incidence; Infant; Infant
157Prevalence
158Prevalence Collaborators
159Public health
160Public health systems
161Public Health, Global Health, Social Medicine and Epidemiology
162pubmedpublicationtype
163pure
164Ratios
165Regression analysis
166Remission
167researchoutput
168Respiratory infections
169Risk factors
170Samfunnsmedisin
171Samfunnsmedisin, sosialmedisin: 801
172Self destructive behavior
173Sex Distribution
174Sexual assault
175Sjúkdómar
176Social medicine
177Socioeconomic factors
178sosialmedisin
179statistics
180statistics & numerical data
181Staðtölur
182Substance use
183Tannskemmdir
184TRENDS
185Tropical diseases
186Tuberculosis
187Tölfræði
188VDP
189Violence
190Women
191World health
192Wounds
193Wounds and Injuries - mortality
194Young Adult
195Áverkar
196Öndunarfærasjúkdómar
197Þjóðir
toplevel
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creatorcontrib
0Abd-Allah, Foad
1Abdulle, Abdishakur M
2Abera, Semaw Ferede
3Abu-Raddad, Laith J
4Adetokunboh, Olatunji
5Afshin, Ashkan
6Aggarwal, Rakesh
7Agrawal, Anurag
8Aichour, Ibtihel
9Akseer, Nadia
10Alizadeh-Navaei, Reza
11Bacha, Umar
12Bärnighausen, Till
13Beghi, Ettore
14Bensenor, Isabela M
15Benson, Jennifer
16Berhane, Adugnaw
17Bhala, Neeraj
18Bisanzio, Donal
19Bumgarner, Blair R
20Carrero, Juan Jesus
21Caso, Valeria
22Chen, Honglei
23Christopher, Devasahayam Jesudas
24Ciobanu, Liliana G
25Cirillo, Massimo
26Crump, John A
27das Neves, José
28De Leo, Diego De
29Des Jarlais, Don C
30Dhillon, Preet Kaur
31Doyle, Kerrie E
32Ermakov, Sergey Petrovich
33Fazeli, Mir Sohail
34Fischer, Florian
35Fitzmaurice, Christina
36Flaxman, Abraham D
37Foigt, Nataliya
38Futran, Neal D
39Gebre, Teshome
40Gold, Audra L
41Goldberg, Ellen M
42Gupta, Tanush
43Gupta, Vipin
44Hafezi-Nejad, Nima
45Hao, Yuantao
46Harvey, James
47Hoffman, Howard J
48Hosgood, H Dean
49Igumbor, Ehimario Uche
50Javanbakht, Mehdi
51Kan, Haidong
52Kassa, Getachew Mullu
53Kravchenko, Michael
54Lalloo, Ratilal
55Lan, Qing
56Lee, Jong-Tae
57Li Kappe, Darya
58Lorkowski, Stefan
59Low, Nicola
60Malta, Deborah Carvalho
61Mantovani, Lorenzo G
62Mapoma, Chabila C
63Marczak, Laurie B
64März, Winfried
65Mazidi, Mohsen
66McAlinden, Colm
67Mengistie, Mubarek Abera
68Monasta, Lorenzo
69Morrison, Shane D
70Mruts, Kalayu Birhane
71Oh, In-Hwan
72Olagunju, Andrew Toyin
73Oren, Eyal
74Ortiz, Alberto
75Osgood-Zimmerman, Aaron
76Parry, Charles D
77Petzold, Max
78Rahimi-Movaghar, Afarin
79Rao, Paturi Vishnupriya
80Rawaf, Salman
81Ray, Sarah E
82Resnikoff, Serge
83Saleem, Huda Omer Ba
84Sartorius, Benn
85Sawhney, Monika
86Shamsipour, Mansour
87Smith, David L
88Sposato, Luciano A
89Stein, Murray B
90Stein, Dan J
91Stokes, Mark Andrew
92Uthman, Olalekan A
93Uzochukwu, Benjamin S Chudi
94Wadilo, Fiseha
95Weintraub, Robert G
96Xu, Gelin
97Zenebe, Zerihun Menlkalew
98Zhou, Maigeng
99Murray, Christopher J L
100GBD 2016 Disease and Injury Incidence and Prevalence Collaborators
101Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
102Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för hälsometri
103Göteborgs universitet
104Gothenburg University
105Institute of Medicine, School of Public Health and Community Medicine
106Sahlgrenska Academy
107Sahlgrenska akademin
108Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics
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jtitleLancet (London, England)
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
au
0Abd-Allah, Foad
1Abdulle, Abdishakur M
2Abera, Semaw Ferede
3Abu-Raddad, Laith J
4Adetokunboh, Olatunji
5Afshin, Ashkan
6Aggarwal, Rakesh
7Agrawal, Anurag
8Aichour, Ibtihel
9Akseer, Nadia
10Alizadeh-Navaei, Reza
11Bacha, Umar
12Bärnighausen, Till
13Beghi, Ettore
14Bensenor, Isabela M
15Benson, Jennifer
16Berhane, Adugnaw
17Bhala, Neeraj
18Bisanzio, Donal
19Bumgarner, Blair R
20Carrero, Juan Jesus
21Caso, Valeria
22Chen, Honglei
23Christopher, Devasahayam Jesudas
24Ciobanu, Liliana G
25Cirillo, Massimo
26Crump, John A
27das Neves, José
28De Leo, Diego De
29Des Jarlais, Don C
30Dhillon, Preet Kaur
31Doyle, Kerrie E
32Ermakov, Sergey Petrovich
33Fazeli, Mir Sohail
34Fischer, Florian
35Fitzmaurice, Christina
36Flaxman, Abraham D
37Foigt, Nataliya
38Futran, Neal D
39Gebre, Teshome
40Gold, Audra L
41Goldberg, Ellen M
42Gupta, Tanush
43Gupta, Vipin
44Hafezi-Nejad, Nima
45Hao, Yuantao
46Harvey, James
47Hoffman, Howard J
48Hosgood, H Dean
49Igumbor, Ehimario Uche
50Javanbakht, Mehdi
51Kan, Haidong
52Kassa, Getachew Mullu
53Kravchenko, Michael
54Lalloo, Ratilal
55Lan, Qing
56Lee, Jong-Tae
57Li Kappe, Darya
58Lorkowski, Stefan
59Low, Nicola
60Malta, Deborah Carvalho
61Mantovani, Lorenzo G
62Mapoma, Chabila C
63Marczak, Laurie B
64März, Winfried
65Mazidi, Mohsen
66McAlinden, Colm
67Mengistie, Mubarek Abera
68Monasta, Lorenzo
69Morrison, Shane D
70Mruts, Kalayu Birhane
71Oh, In-Hwan
72Olagunju, Andrew Toyin
73Oren, Eyal
74Ortiz, Alberto
75Osgood-Zimmerman, Aaron
76Parry, Charles D
77Petzold, Max
78Rahimi-Movaghar, Afarin
79Rao, Paturi Vishnupriya
80Rawaf, Salman
81Ray, Sarah E
82Resnikoff, Serge
83Saleem, Huda Omer Ba
84Sartorius, Benn
85Sawhney, Monika
86Shamsipour, Mansour
87Smith, David L
88Sposato, Luciano A
89Stein, Murray B
90Stein, Dan J
91Stokes, Mark Andrew
92Uthman, Olalekan A
93Uzochukwu, Benjamin S Chudi
94Wadilo, Fiseha
95Weintraub, Robert G
96Xu, Gelin
97Zenebe, Zerihun Menlkalew
98Zhou, Maigeng
99Murray, Christopher J L
aucorp
0GBD 2016 Disease and Injury Incidence and Prevalence Collaborators
1Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa
2Institutionen för medicin, avdelningen för samhällsmedicin och folkhälsa, enheten för hälsometri
3Göteborgs universitet
4Gothenburg University
5Institute of Medicine, School of Public Health and Community Medicine
6Sahlgrenska Academy
7Sahlgrenska akademin
8Institute of Medicine, Department of Public Health and Community Medicine, Health Metrics
formatjournal
genrearticle
ristypeJOUR
atitleGlobal, regional, and national incidence, prevalence, and years lived with disability for 328 diseases and injuries for 195 countries, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
jtitleLancet (London, England)
addtitleLancet
date2017-09-16
risdate2017
volume390
issue10100
spage1211
epage1259
pages1211-1259
issn
00140-6736
11474-547X
eissn1474-547X
notes
0The Lancet
1Collaborators listed at the end of the Article
abstractAs mortality rates decline, life expectancy increases, and populations age, non-fatal outcomes of diseases and injuries are becoming a larger component of the global burden of disease. The Global Burden of Diseases, Injuries, and Risk Factors Study 2016 (GBD 2016) provides a comprehensive assessment of prevalence, incidence, and years lived with disability (YLDs) for 328 causes in 195 countries and territories from 1990 to 2016. We estimated prevalence and incidence for 328 diseases and injuries and 2982 sequelae, their non-fatal consequences. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between incidence, prevalence, remission, and cause of death rates for each condition. For some causes, we used alternative modelling strategies if incidence or prevalence needed to be derived from other data. YLDs were estimated as the product of prevalence and a disability weight for all mutually exclusive sequelae, corrected for comorbidity and aggregated to cause level. We updated the Socio-demographic Index (SDI), a summary indicator of income per capita, years of schooling, and total fertility rate. GBD 2016 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting (GATHER). Globally, low back pain, migraine, age-related and other hearing loss, iron-deficiency anaemia, and major depressive disorder were the five leading causes of YLDs in 2016, contributing 57·6 million (95% uncertainty interval [UI] 40·8–75·9 million [7·2%, 6·0–8·3]), 45·1 million (29·0–62·8 million [5·6%, 4·0–7·2]), 36·3 million (25·3–50·9 million [4·5%, 3·8–5·3]), 34·7 million (23·0–49·6 million [4·3%, 3·5–5·2]), and 34·1 million (23·5–46·0 million [4·2%, 3·2–5·3]) of total YLDs, respectively. Age-standardised rates of YLDs for all causes combined decreased between 1990 and 2016 by 2·7% (95% UI 2·3–3·1). Despite mostly stagnant age-standardised rates, the absolute number of YLDs from non-communicable diseases has been growing rapidly across all SDI quintiles, partly because of population growth, but also the ageing of populations. The largest absolute increases in total numbers of YLDs globally were between the ages of 40 and 69 years. Age-standardised YLD rates for all conditions combined were 10·4% (95% UI 9·0–11·8) higher in women than in men. Iron-deficiency anaemia, migraine, Alzheimer's disease and other dementias, major depressive disorder, anxiety, and all musculoskeletal disorders apart from gout were the main conditions contributing to higher YLD rates in women. Men had higher age-standardised rates of substance use disorders, diabetes, cardiovascular diseases, cancers, and all injuries apart from sexual violence. Globally, we noted much less geographical variation in disability than has been documented for premature mortality. In 2016, there was a less than two times difference in age-standardised YLD rates for all causes between the location with the lowest rate (China, 9201 YLDs per 100 000, 95% UI 6862–11943) and highest rate (Yemen, 14 774 YLDs per 100 000, 11 018–19 228). The decrease in death rates since 1990 for most causes has not been matched by a similar decline in age-standardised YLD rates. For many large causes, YLD rates have either been stagnant or have increased for some causes, such as diabetes. As populations are ageing, and the prevalence of disabling disease generally increases steeply with age, health systems will face increasing demand for services that are generally costlier than the interventions that have led to declines in mortality in childhood or for the major causes of mortality in adults. Up-to-date information about the trends of disease and how this varies between countries is essential to plan for an adequate health-system response. Bill & Melinda Gates Foundation, and the National Institute on Aging and the National Institute of Mental Health of the National Institutes of Health.
copEngland
pubElsevier Ltd
pmid28919117
doi10.1016/S0140-6736(17)32154-2
oafree_for_read