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The validity of self-reported antiretroviral use in persons living with HIV: a population-based study

OBJECTIVE:To assess the validity of self-reported antiretroviral therapy use (ART) using population-based cohort data. METHODS:Self-reported ART use and nonuse was compared with a validated laboratory assay in 557 HIV-positive participants in the Rakai Community Cohort Study surveyed between Septemb... Full description

Journal Title: AIDS (London) 2018, Vol.32 (3), p.363-369
Main Author: Grabowski, Mary K
Other Authors: Reynolds, Steven J , Kagaayi, Joseph , Gray, Ronald H , Clarke, William , Chang, Larry W , Nakigozi, Gertrude , Laeyndecker, Oliver , Redd, Andrew D , Billioux, Veena , Ssekubugu, Robert , Nalugoda, Fred , Wawer, Maria J , Serwadda, David , Quinn, Thomas C , Tobian, Aaron A.R
Format: Electronic Article Electronic Article
Language: English
Subjects:
HIV
Publisher: England: Copyright Wolters Kluwer Health, Inc
ID: ISSN: 0269-9370
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title: The validity of self-reported antiretroviral use in persons living with HIV: a population-based study
format: Article
creator:
  • Grabowski, Mary K
  • Reynolds, Steven J
  • Kagaayi, Joseph
  • Gray, Ronald H
  • Clarke, William
  • Chang, Larry W
  • Nakigozi, Gertrude
  • Laeyndecker, Oliver
  • Redd, Andrew D
  • Billioux, Veena
  • Ssekubugu, Robert
  • Nalugoda, Fred
  • Wawer, Maria J
  • Serwadda, David
  • Quinn, Thomas C
  • Tobian, Aaron A.R
subjects:
  • Adolescent
  • Adult
  • AIDS
  • Anti-Retroviral Agents - administration & dosage
  • Anti-Retroviral Agents - blood
  • antiretroviral therapy
  • Care and treatment
  • Chromatography, High Pressure Liquid
  • Cohort Studies
  • combination HIV prevention
  • Drug Monitoring - methods
  • Female
  • Highly active antiretroviral therapy
  • HIV
  • HIV infection
  • HIV Infections - drug therapy
  • Humans
  • Male
  • Medicin och hälsovetenskap
  • Middle Aged
  • Plasma - chemistry
  • Plasma - virology
  • Self Report - standards
  • self-report
  • Sensitivity and Specificity
  • Sub-Saharan Africa
  • Surveys and Questionnaires
  • Tandem Mass Spectrometry
  • Uganda
  • validity
  • Viral Load
  • Young Adult
ispartof: AIDS (London), 2018, Vol.32 (3), p.363-369
description: OBJECTIVE:To assess the validity of self-reported antiretroviral therapy use (ART) using population-based cohort data. METHODS:Self-reported ART use and nonuse was compared with a validated laboratory assay in 557 HIV-positive participants in the Rakai Community Cohort Study surveyed between September and December 2011 in Rakai, Uganda. The study population included participants from seven communities, including one fishing community with high HIV prevalence (∼41%). ART use was assayed using liquid chromatography–tandem mass spectrometry, which detects 20 antiretroviral drugs. HIV viral load measurements were also obtained. Individuals with at least two antiretroviral drugs detected were considered to be using ART. RESULTS:One hundred and fifty-three (27%) participants self-reported ART use of whom 148 (97%) had at least two antiretroviral drugs detected. There were at least two antiretroviral drugs detected in 11% (n = 44/404) of individuals with no self-reported ART use. Overall, the specificity of self-reported ART use was 99% (95% CI 97–100%) and the sensitivity was 77% (70–83%). Positive and negative predictive values were 97% (95% CI 93–99%) and 89% (95% CI 86–92%), respectively. Nondisclosure of ART use was significantly more common in younger persons (
language: eng
source:
identifier: ISSN: 0269-9370
fulltext: no_fulltext
issn:
  • 0269-9370
  • 1473-5571
  • 1473-5571
url: Link


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titleThe validity of self-reported antiretroviral use in persons living with HIV: a population-based study
creatorGrabowski, Mary K ; Reynolds, Steven J ; Kagaayi, Joseph ; Gray, Ronald H ; Clarke, William ; Chang, Larry W ; Nakigozi, Gertrude ; Laeyndecker, Oliver ; Redd, Andrew D ; Billioux, Veena ; Ssekubugu, Robert ; Nalugoda, Fred ; Wawer, Maria J ; Serwadda, David ; Quinn, Thomas C ; Tobian, Aaron A.R
creatorcontribGrabowski, Mary K ; Reynolds, Steven J ; Kagaayi, Joseph ; Gray, Ronald H ; Clarke, William ; Chang, Larry W ; Nakigozi, Gertrude ; Laeyndecker, Oliver ; Redd, Andrew D ; Billioux, Veena ; Ssekubugu, Robert ; Nalugoda, Fred ; Wawer, Maria J ; Serwadda, David ; Quinn, Thomas C ; Tobian, Aaron A.R
descriptionOBJECTIVE:To assess the validity of self-reported antiretroviral therapy use (ART) using population-based cohort data. METHODS:Self-reported ART use and nonuse was compared with a validated laboratory assay in 557 HIV-positive participants in the Rakai Community Cohort Study surveyed between September and December 2011 in Rakai, Uganda. The study population included participants from seven communities, including one fishing community with high HIV prevalence (∼41%). ART use was assayed using liquid chromatography–tandem mass spectrometry, which detects 20 antiretroviral drugs. HIV viral load measurements were also obtained. Individuals with at least two antiretroviral drugs detected were considered to be using ART. RESULTS:One hundred and fifty-three (27%) participants self-reported ART use of whom 148 (97%) had at least two antiretroviral drugs detected. There were at least two antiretroviral drugs detected in 11% (n = 44/404) of individuals with no self-reported ART use. Overall, the specificity of self-reported ART use was 99% (95% CI 97–100%) and the sensitivity was 77% (70–83%). Positive and negative predictive values were 97% (95% CI 93–99%) and 89% (95% CI 86–92%), respectively. Nondisclosure of ART use was significantly more common in younger persons (<30 years) and among those in trading occupations. CONCLUSION:Self-reported ART use has high specificity and moderate sensitivity providing reasonable, but conservative estimates of population-based ART use. There is more under-reporting of ART use among younger persons and traders suggesting a need for more research on barriers to self-reporting of ART use in these sub-groups.
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subjectAdolescent ; Adult ; AIDS ; Anti-Retroviral Agents - administration & dosage ; Anti-Retroviral Agents - blood ; antiretroviral therapy ; Care and treatment ; Chromatography, High Pressure Liquid ; Cohort Studies ; combination HIV prevention ; Drug Monitoring - methods ; Female ; Highly active antiretroviral therapy ; HIV ; HIV infection ; HIV Infections - drug therapy ; Humans ; Male ; Medicin och hälsovetenskap ; Middle Aged ; Plasma - chemistry ; Plasma - virology ; Self Report - standards ; self-report ; Sensitivity and Specificity ; Sub-Saharan Africa ; Surveys and Questionnaires ; Tandem Mass Spectrometry ; Uganda ; validity ; Viral Load ; Young Adult
ispartofAIDS (London), 2018, Vol.32 (3), p.363-369
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1Reynolds, Steven J
2Kagaayi, Joseph
3Gray, Ronald H
4Clarke, William
5Chang, Larry W
6Nakigozi, Gertrude
7Laeyndecker, Oliver
8Redd, Andrew D
9Billioux, Veena
10Ssekubugu, Robert
11Nalugoda, Fred
12Wawer, Maria J
13Serwadda, David
14Quinn, Thomas C
15Tobian, Aaron A.R
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descriptionOBJECTIVE:To assess the validity of self-reported antiretroviral therapy use (ART) using population-based cohort data. METHODS:Self-reported ART use and nonuse was compared with a validated laboratory assay in 557 HIV-positive participants in the Rakai Community Cohort Study surveyed between September and December 2011 in Rakai, Uganda. The study population included participants from seven communities, including one fishing community with high HIV prevalence (∼41%). ART use was assayed using liquid chromatography–tandem mass spectrometry, which detects 20 antiretroviral drugs. HIV viral load measurements were also obtained. Individuals with at least two antiretroviral drugs detected were considered to be using ART. RESULTS:One hundred and fifty-three (27%) participants self-reported ART use of whom 148 (97%) had at least two antiretroviral drugs detected. There were at least two antiretroviral drugs detected in 11% (n = 44/404) of individuals with no self-reported ART use. Overall, the specificity of self-reported ART use was 99% (95% CI 97–100%) and the sensitivity was 77% (70–83%). Positive and negative predictive values were 97% (95% CI 93–99%) and 89% (95% CI 86–92%), respectively. Nondisclosure of ART use was significantly more common in younger persons (<30 years) and among those in trading occupations. CONCLUSION:Self-reported ART use has high specificity and moderate sensitivity providing reasonable, but conservative estimates of population-based ART use. There is more under-reporting of ART use among younger persons and traders suggesting a need for more research on barriers to self-reporting of ART use in these sub-groups.
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1Adult
2AIDS
3Anti-Retroviral Agents - administration & dosage
4Anti-Retroviral Agents - blood
5antiretroviral therapy
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7Chromatography, High Pressure Liquid
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26Surveys and Questionnaires
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titleThe validity of self-reported antiretroviral use in persons living with HIV: a population-based study
authorGrabowski, Mary K ; Reynolds, Steven J ; Kagaayi, Joseph ; Gray, Ronald H ; Clarke, William ; Chang, Larry W ; Nakigozi, Gertrude ; Laeyndecker, Oliver ; Redd, Andrew D ; Billioux, Veena ; Ssekubugu, Robert ; Nalugoda, Fred ; Wawer, Maria J ; Serwadda, David ; Quinn, Thomas C ; Tobian, Aaron A.R
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8Redd, Andrew D
9Billioux, Veena
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11Nalugoda, Fred
12Wawer, Maria J
13Serwadda, David
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7Laeyndecker, Oliver
8Redd, Andrew D
9Billioux, Veena
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11Nalugoda, Fred
12Wawer, Maria J
13Serwadda, David
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atitleThe validity of self-reported antiretroviral use in persons living with HIV: a population-based study
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date2018-01-28
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volume32
issue3
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pages363-369
issn
00269-9370
11473-5571
eissn1473-5571
abstractOBJECTIVE:To assess the validity of self-reported antiretroviral therapy use (ART) using population-based cohort data. METHODS:Self-reported ART use and nonuse was compared with a validated laboratory assay in 557 HIV-positive participants in the Rakai Community Cohort Study surveyed between September and December 2011 in Rakai, Uganda. The study population included participants from seven communities, including one fishing community with high HIV prevalence (∼41%). ART use was assayed using liquid chromatography–tandem mass spectrometry, which detects 20 antiretroviral drugs. HIV viral load measurements were also obtained. Individuals with at least two antiretroviral drugs detected were considered to be using ART. RESULTS:One hundred and fifty-three (27%) participants self-reported ART use of whom 148 (97%) had at least two antiretroviral drugs detected. There were at least two antiretroviral drugs detected in 11% (n = 44/404) of individuals with no self-reported ART use. Overall, the specificity of self-reported ART use was 99% (95% CI 97–100%) and the sensitivity was 77% (70–83%). Positive and negative predictive values were 97% (95% CI 93–99%) and 89% (95% CI 86–92%), respectively. Nondisclosure of ART use was significantly more common in younger persons (<30 years) and among those in trading occupations. CONCLUSION:Self-reported ART use has high specificity and moderate sensitivity providing reasonable, but conservative estimates of population-based ART use. There is more under-reporting of ART use among younger persons and traders suggesting a need for more research on barriers to self-reporting of ART use in these sub-groups.
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pubCopyright Wolters Kluwer Health, Inc
pmid29194115
doi10.1097/QAD.0000000000001706
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