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Enhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara

The immunogenicity of two vector-based vaccines, either given alone or in a prime-boost regimen, was investigated. Cynomolgus macaques were immunised with modified vaccinia virus Ankara (MVA) expressing simian immunodeficiency virus (SIV)macJ5 env, gag–pol, nef, rev, and tat genes (MVA–SIVmac) or pr... Full description

Journal Title: Vaccine 2001, Vol.19 (25), p.3526-3536
Main Author: Nilsson, Charlotta
Other Authors: Mäkitalo, Barbro , Berglund, Peter , Bex, Francoise , Liljeström, Peter , Sutter, Gerd , Erfle, Volker , ten Haaft, Peter , Heeney, Jonathan , Biberfeld, Gunnel , Thorstensson, Rigmor
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Alma/SFX Local Collection
Publisher: Oxford: Elsevier Ltd
ID: ISSN: 0264-410X
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title: Enhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara
format: Article
creator:
  • Nilsson, Charlotta
  • Mäkitalo, Barbro
  • Berglund, Peter
  • Bex, Francoise
  • Liljeström, Peter
  • Sutter, Gerd
  • Erfle, Volker
  • ten Haaft, Peter
  • Heeney, Jonathan
  • Biberfeld, Gunnel
  • Thorstensson, Rigmor
subjects:
  • AIDS Vaccines - administration & dosage
  • AIDS Vaccines - isolation & purification
  • Animals
  • Antibodies, Viral - biosynthesis
  • Antibody Specificity
  • Bacteriology
  • Biological and medical sciences
  • Fundamental and applied biological sciences. Psychology
  • Genetic Vectors
  • Immunity, Cellular
  • Immunization, Secondary
  • Immunogenicity
  • Lymphocyte Activation
  • Lymphocyte Count
  • Macaca fascicularis
  • Macaca mulatta
  • Medicin och hälsovetenskap
  • Microbiology
  • Modified vaccinia virus Ankara
  • Prime-boost
  • RNA, Viral - blood
  • SAIDS Vaccines - administration & dosage
  • SAIDS Vaccines - genetics
  • Semliki Forest virus
  • Semliki forest virus - genetics
  • Semliki forest virus - immunology
  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus - immunology
  • T-Lymphocytes - immunology
  • Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
  • Vaccines, Synthetic - administration & dosage
  • Vaccines, Synthetic - genetics
  • vaccinia virus
  • Vaccinia virus - genetics
  • Vaccinia virus - immunology
  • Virology
ispartof: Vaccine, 2001, Vol.19 (25), p.3526-3536
description: The immunogenicity of two vector-based vaccines, either given alone or in a prime-boost regimen, was investigated. Cynomolgus macaques were immunised with modified vaccinia virus Ankara (MVA) expressing simian immunodeficiency virus (SIV)macJ5 env, gag–pol, nef, rev, and tat genes (MVA–SIVmac) or primed with a Semliki forest virus (SFV) vaccine expressing the same genes (SFV–SIVmac) and boosted with MVA–SIVmac. Generally, antibody responses, T-cell proliferative responses and cytotoxic T-cell responses remained low or undetectable in vaccinees receiving MVA–SIVmac or SFV–SIVmac alone. In contrast, monkeys who first received SFV–SIVmac twice and then were boosted with MVA–SIVmac showed increased antibody responses as well as high T-cell proliferative responses. Three of these vaccinees had cytotoxic T-lymphocytes directed against three or four of the gene products. No evidence of protection was seen against an intrarectal heterologous SIVsm challenge given 3 months after the last immunisation. The study demonstrates a prime-boost strategy that efficiently induces both humoral and cellular immune responses.
language: eng
source: Alma/SFX Local Collection
identifier: ISSN: 0264-410X
fulltext: fulltext
issn:
  • 0264-410X
  • 1873-2518
url: Link


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titleEnhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara
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creatorNilsson, Charlotta ; Mäkitalo, Barbro ; Berglund, Peter ; Bex, Francoise ; Liljeström, Peter ; Sutter, Gerd ; Erfle, Volker ; ten Haaft, Peter ; Heeney, Jonathan ; Biberfeld, Gunnel ; Thorstensson, Rigmor
creatorcontribNilsson, Charlotta ; Mäkitalo, Barbro ; Berglund, Peter ; Bex, Francoise ; Liljeström, Peter ; Sutter, Gerd ; Erfle, Volker ; ten Haaft, Peter ; Heeney, Jonathan ; Biberfeld, Gunnel ; Thorstensson, Rigmor
descriptionThe immunogenicity of two vector-based vaccines, either given alone or in a prime-boost regimen, was investigated. Cynomolgus macaques were immunised with modified vaccinia virus Ankara (MVA) expressing simian immunodeficiency virus (SIV)macJ5 env, gag–pol, nef, rev, and tat genes (MVA–SIVmac) or primed with a Semliki forest virus (SFV) vaccine expressing the same genes (SFV–SIVmac) and boosted with MVA–SIVmac. Generally, antibody responses, T-cell proliferative responses and cytotoxic T-cell responses remained low or undetectable in vaccinees receiving MVA–SIVmac or SFV–SIVmac alone. In contrast, monkeys who first received SFV–SIVmac twice and then were boosted with MVA–SIVmac showed increased antibody responses as well as high T-cell proliferative responses. Three of these vaccinees had cytotoxic T-lymphocytes directed against three or four of the gene products. No evidence of protection was seen against an intrarectal heterologous SIVsm challenge given 3 months after the last immunisation. The study demonstrates a prime-boost strategy that efficiently induces both humoral and cellular immune responses.
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languageeng
publisherOxford: Elsevier Ltd
subjectAIDS Vaccines - administration & dosage ; AIDS Vaccines - isolation & purification ; Animals ; Antibodies, Viral - biosynthesis ; Antibody Specificity ; Bacteriology ; Biological and medical sciences ; Fundamental and applied biological sciences. Psychology ; Genetic Vectors ; Immunity, Cellular ; Immunization, Secondary ; Immunogenicity ; Lymphocyte Activation ; Lymphocyte Count ; Macaca fascicularis ; Macaca mulatta ; Medicin och hälsovetenskap ; Microbiology ; Modified vaccinia virus Ankara ; Prime-boost ; RNA, Viral - blood ; SAIDS Vaccines - administration & dosage ; SAIDS Vaccines - genetics ; Semliki Forest virus ; Semliki forest virus - genetics ; Semliki forest virus - immunology ; Simian immunodeficiency virus ; Simian Immunodeficiency Virus - immunology ; T-Lymphocytes - immunology ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, Synthetic - administration & dosage ; Vaccines, Synthetic - genetics ; vaccinia virus ; Vaccinia virus - genetics ; Vaccinia virus - immunology ; Virology
ispartofVaccine, 2001, Vol.19 (25), p.3526-3536
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0Nilsson, Charlotta
1Mäkitalo, Barbro
2Berglund, Peter
3Bex, Francoise
4Liljeström, Peter
5Sutter, Gerd
6Erfle, Volker
7ten Haaft, Peter
8Heeney, Jonathan
9Biberfeld, Gunnel
10Thorstensson, Rigmor
title
0Enhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara
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descriptionThe immunogenicity of two vector-based vaccines, either given alone or in a prime-boost regimen, was investigated. Cynomolgus macaques were immunised with modified vaccinia virus Ankara (MVA) expressing simian immunodeficiency virus (SIV)macJ5 env, gag–pol, nef, rev, and tat genes (MVA–SIVmac) or primed with a Semliki forest virus (SFV) vaccine expressing the same genes (SFV–SIVmac) and boosted with MVA–SIVmac. Generally, antibody responses, T-cell proliferative responses and cytotoxic T-cell responses remained low or undetectable in vaccinees receiving MVA–SIVmac or SFV–SIVmac alone. In contrast, monkeys who first received SFV–SIVmac twice and then were boosted with MVA–SIVmac showed increased antibody responses as well as high T-cell proliferative responses. Three of these vaccinees had cytotoxic T-lymphocytes directed against three or four of the gene products. No evidence of protection was seen against an intrarectal heterologous SIVsm challenge given 3 months after the last immunisation. The study demonstrates a prime-boost strategy that efficiently induces both humoral and cellular immune responses.
subject
0AIDS Vaccines - administration & dosage
1AIDS Vaccines - isolation & purification
2Animals
3Antibodies, Viral - biosynthesis
4Antibody Specificity
5Bacteriology
6Biological and medical sciences
7Fundamental and applied biological sciences. Psychology
8Genetic Vectors
9Immunity, Cellular
10Immunization, Secondary
11Immunogenicity
12Lymphocyte Activation
13Lymphocyte Count
14Macaca fascicularis
15Macaca mulatta
16Medicin och hälsovetenskap
17Microbiology
18Modified vaccinia virus Ankara
19Prime-boost
20RNA, Viral - blood
21SAIDS Vaccines - administration & dosage
22SAIDS Vaccines - genetics
23Semliki Forest virus
24Semliki forest virus - genetics
25Semliki forest virus - immunology
26Simian immunodeficiency virus
27Simian Immunodeficiency Virus - immunology
28T-Lymphocytes - immunology
29Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
30Vaccines, Synthetic - administration & dosage
31Vaccines, Synthetic - genetics
32vaccinia virus
33Vaccinia virus - genetics
34Vaccinia virus - immunology
35Virology
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titleEnhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara
authorNilsson, Charlotta ; Mäkitalo, Barbro ; Berglund, Peter ; Bex, Francoise ; Liljeström, Peter ; Sutter, Gerd ; Erfle, Volker ; ten Haaft, Peter ; Heeney, Jonathan ; Biberfeld, Gunnel ; Thorstensson, Rigmor
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1AIDS Vaccines - isolation & purification
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3Antibodies, Viral - biosynthesis
4Antibody Specificity
5Bacteriology
6Biological and medical sciences
7Fundamental and applied biological sciences. Psychology
8Genetic Vectors
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10Immunization, Secondary
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12Lymphocyte Activation
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14Macaca fascicularis
15Macaca mulatta
16Medicin och hälsovetenskap
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18Modified vaccinia virus Ankara
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20RNA, Viral - blood
21SAIDS Vaccines - administration & dosage
22SAIDS Vaccines - genetics
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30Vaccines, Synthetic - administration & dosage
31Vaccines, Synthetic - genetics
32vaccinia virus
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atitleEnhanced simian immunodeficiency virus-specific immune responses in macaques induced by priming with recombinant Semliki Forest virus and boosting with modified vaccinia virus Ankara
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abstractThe immunogenicity of two vector-based vaccines, either given alone or in a prime-boost regimen, was investigated. Cynomolgus macaques were immunised with modified vaccinia virus Ankara (MVA) expressing simian immunodeficiency virus (SIV)macJ5 env, gag–pol, nef, rev, and tat genes (MVA–SIVmac) or primed with a Semliki forest virus (SFV) vaccine expressing the same genes (SFV–SIVmac) and boosted with MVA–SIVmac. Generally, antibody responses, T-cell proliferative responses and cytotoxic T-cell responses remained low or undetectable in vaccinees receiving MVA–SIVmac or SFV–SIVmac alone. In contrast, monkeys who first received SFV–SIVmac twice and then were boosted with MVA–SIVmac showed increased antibody responses as well as high T-cell proliferative responses. Three of these vaccinees had cytotoxic T-lymphocytes directed against three or four of the gene products. No evidence of protection was seen against an intrarectal heterologous SIVsm challenge given 3 months after the last immunisation. The study demonstrates a prime-boost strategy that efficiently induces both humoral and cellular immune responses.
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pubElsevier Ltd
pmid11348720
doi10.1016/S0264-410X(01)00034-2