schliessen

Filtern

 

Bibliotheken

Prevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I

The prevalence of autoantibodies against nine intracellular enzyme autoantigens, namely 21-hydroxylase, side-chain cleavage enzyme (SCC), 17α-hydroxylase, glutamic acid decarboxylase 65, aromatic l-amino acid decarboxylase, tyrosine phosphatase-like protein IA-2, tryptophan hydroxylase (TPH), tyrosi... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2004, Vol.89 (2), p.557-562
Main Author: Söderbergh, Annika
Other Authors: Myhre, Anne Grethe , Ekwall, Olov , Gebre-Medhin, Gennet , Hedstrand, Håkan , Landgren, Eva , Miettinen, Aaro , Eskelin, Petra , Halonen, Maria , Tuomi, Tiinamaija , Gustafsson, Jan , Husebye, Eystein S , Perheentupa, Jaakko , Gylling, Mikhail , Manns, Michael P , Rorsman, Fredrik , Kämpe, Olle , Nilsson, Thomas
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Bethesda, MD: Endocrine Society
ID: ISSN: 0021-972X
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_19911774
title: Prevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I
format: Article
creator:
  • Söderbergh, Annika
  • Myhre, Anne Grethe
  • Ekwall, Olov
  • Gebre-Medhin, Gennet
  • Hedstrand, Håkan
  • Landgren, Eva
  • Miettinen, Aaro
  • Eskelin, Petra
  • Halonen, Maria
  • Tuomi, Tiinamaija
  • Gustafsson, Jan
  • Husebye, Eystein S
  • Perheentupa, Jaakko
  • Gylling, Mikhail
  • Manns, Michael P
  • Rorsman, Fredrik
  • Kämpe, Olle
  • Nilsson, Thomas
subjects:
  • Adolescent
  • Adult
  • Autoantibodies - analysis
  • Autoantigens - immunology
  • Biological and medical sciences
  • Biological Markers
  • Biomarkers
  • Child
  • Child, Preschool
  • Cohort Studies
  • Endocrinopathies
  • Enzymes - immunology
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Humans
  • Male
  • Medical and Health Sciences
  • Medical sciences
  • MEDICIN
  • Medicin och hälsovetenskap
  • MEDICINE
  • Middle Aged
  • Multivariate Analysis
  • Polyendocrinopathies, Autoimmune - complications
  • Polyendocrinopathies, Autoimmune - immunology
  • Polyendocrinopathies
  • Autoimmune/complications/immunology
  • Research Support
  • Non-U.S. Gov't
  • Vertebrates: endocrinology
ispartof: The journal of clinical endocrinology and metabolism, 2004, Vol.89 (2), p.557-562
description: The prevalence of autoantibodies against nine intracellular enzyme autoantigens, namely 21-hydroxylase, side-chain cleavage enzyme (SCC), 17α-hydroxylase, glutamic acid decarboxylase 65, aromatic l-amino acid decarboxylase, tyrosine phosphatase-like protein IA-2, tryptophan hydroxylase (TPH), tyrosine hydroxylase, cytochrome P450 1A2, and against the extracellular calcium-sensing receptor, was assessed in 90 patients with autoimmune polyendocrine syndrome type I. A multivariate logistic regression analysis was performed for the presence of autoantibodies as independent predictors for different disease manifestations. Reactivities against 21-hydroxylase and SCC were associated with Addison’s disease with odds ratios (ORs) of 7.8 and 6.8, respectively. Hypogonadism was exclusively associated with autoantibodies against SCC with an OR of 12.5. Autoantibodies against tyrosine phosphatase-like protein IA-2 were associated with insulin-dependent diabetes mellitus with an OR of 14.9, but with low sensitivity. Reactivities against TPH and, surprisingly, glutamic acid decarboxylase 65, were associated with intestinal dysfunction, with ORs of 3.9 and 6.7, respectively. TPH reactivity was the best predictor for autoimmune hepatitis, with an OR of 27.0. Hypoparathyroidism was not associated with reactivity against any of the autoantigens tested. No reactivity against the calcium-sensing receptor was found. Analysis of autoantibodies in autoimmune polyendocrine syndrome type I patients is a useful tool for establishing autoimmune manifestations of the disease as well as providing diagnosis in patients with suspected disease.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
  • 1945-7197
url: Link


@attributes
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
RANK2.4456778
LOCALfalse
PrimoNMBib
record
control
sourceidproquest_swepu
recordidTN_cdi_swepub_primary_oai_prod_swepub_kib_ki_se_19911774
sourceformatXML
sourcesystemPC
sourcerecordid80150413
originalsourceidFETCH-LOGICAL-15466-fac32885e993ebfca99ef7cca8b357b975617dd5e7feb63273f489e338fea37e0
addsrcrecordideNp1kktv1DAUhSMEokNhyxJ5AxuUwa_E8XI05VGpEpUoiJ3lODfUU8ee2gmj-fd4OlErIY3la1tX3zl3cVwUbwleEkrwp41ZUoxZiRmmQj4rFkTyqhREiufFAmNKSino77PiVUobjAnnFXtZnBEu6rzJohiuI_zVDrwBpH2H1s56a7RDq5SCsXq0wScUekQwuoDeeujQahqD9qNtQ2chIesfOnYYJg_oOrg9-C6YmFn0Y--7GAZAN_stoMvXxYteuwRv5vu8-Pnl8836W3n1_evlenVVkorXddlrw2jTVCAlg7Y3WkrohTG6aVklWimqmoiuq0D00NaMCtbzRgJjTQ-aCcDnRXP0TTvYTq3aRjvouFdB2_wOnZr7d_ZQKoEiUhIiBM_SjyelF_bXSoX4R02TEpTSKtMfjnR2vZ8gjWqwyYBz2kOYkmowqTAnLIPLI2hiSClC_2hMsDokqTZGHZJUxySz4N3sPLUDdE_4HF0G3s-ATjmwPmpvbHriKt5Qwg8c_2-yseNDrmPU1p2eP8t2wY0Q052bdhDVLWg33iqcF69FU2YJx_nAZS5SZ1l1lD3-gW2ElNQmTNHnyE-N-wcBY9pf
sourcetypeOpen Access Repository
isCDItrue
recordtypearticle
pqid80150413
display
typearticle
titlePrevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I
creatorSöderbergh, Annika ; Myhre, Anne Grethe ; Ekwall, Olov ; Gebre-Medhin, Gennet ; Hedstrand, Håkan ; Landgren, Eva ; Miettinen, Aaro ; Eskelin, Petra ; Halonen, Maria ; Tuomi, Tiinamaija ; Gustafsson, Jan ; Husebye, Eystein S ; Perheentupa, Jaakko ; Gylling, Mikhail ; Manns, Michael P ; Rorsman, Fredrik ; Kämpe, Olle ; Nilsson, Thomas
creatorcontribSöderbergh, Annika ; Myhre, Anne Grethe ; Ekwall, Olov ; Gebre-Medhin, Gennet ; Hedstrand, Håkan ; Landgren, Eva ; Miettinen, Aaro ; Eskelin, Petra ; Halonen, Maria ; Tuomi, Tiinamaija ; Gustafsson, Jan ; Husebye, Eystein S ; Perheentupa, Jaakko ; Gylling, Mikhail ; Manns, Michael P ; Rorsman, Fredrik ; Kämpe, Olle ; Nilsson, Thomas
descriptionThe prevalence of autoantibodies against nine intracellular enzyme autoantigens, namely 21-hydroxylase, side-chain cleavage enzyme (SCC), 17α-hydroxylase, glutamic acid decarboxylase 65, aromatic l-amino acid decarboxylase, tyrosine phosphatase-like protein IA-2, tryptophan hydroxylase (TPH), tyrosine hydroxylase, cytochrome P450 1A2, and against the extracellular calcium-sensing receptor, was assessed in 90 patients with autoimmune polyendocrine syndrome type I. A multivariate logistic regression analysis was performed for the presence of autoantibodies as independent predictors for different disease manifestations. Reactivities against 21-hydroxylase and SCC were associated with Addison’s disease with odds ratios (ORs) of 7.8 and 6.8, respectively. Hypogonadism was exclusively associated with autoantibodies against SCC with an OR of 12.5. Autoantibodies against tyrosine phosphatase-like protein IA-2 were associated with insulin-dependent diabetes mellitus with an OR of 14.9, but with low sensitivity. Reactivities against TPH and, surprisingly, glutamic acid decarboxylase 65, were associated with intestinal dysfunction, with ORs of 3.9 and 6.7, respectively. TPH reactivity was the best predictor for autoimmune hepatitis, with an OR of 27.0. Hypoparathyroidism was not associated with reactivity against any of the autoantigens tested. No reactivity against the calcium-sensing receptor was found. Analysis of autoantibodies in autoimmune polyendocrine syndrome type I patients is a useful tool for establishing autoimmune manifestations of the disease as well as providing diagnosis in patients with suspected disease.
identifier
0ISSN: 0021-972X
1ISSN: 1945-7197
2EISSN: 1945-7197
3DOI: 10.1210/jc.2003-030279
4PMID: 14764761
5CODEN: JCEMAZ
languageeng
publisherBethesda, MD: Endocrine Society
subjectAdolescent ; Adult ; Autoantibodies - analysis ; Autoantigens - immunology ; Biological and medical sciences ; Biological Markers ; Biomarkers ; Child ; Child, Preschool ; Cohort Studies ; Endocrinopathies ; Enzymes - immunology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical and Health Sciences ; Medical sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Middle Aged ; Multivariate Analysis ; Polyendocrinopathies, Autoimmune - complications ; Polyendocrinopathies, Autoimmune - immunology ; Polyendocrinopathies; Autoimmune/complications/immunology ; Research Support; Non-U.S. Gov't ; Vertebrates: endocrinology
ispartofThe journal of clinical endocrinology and metabolism, 2004, Vol.89 (2), p.557-562
rights
0Copyright © 2004 by The Endocrine Society
12004 INIST-CNRS
lds50peer_reviewed
oafree_for_read
citedbyFETCH-LOGICAL-15466-fac32885e993ebfca99ef7cca8b357b975617dd5e7feb63273f489e338fea37e0
links
openurl$$Topenurl_article
thumbnail$$Usyndetics_thumb_exl
backlink
0$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=15482141$$DView record in Pascal Francis
1$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/14764761$$D View this record in MEDLINE/PubMed
2$$Uhttp://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-72225$$DView record from Swedish Publication Index
3$$Uhttp://kipublications.ki.se/Default.aspx?queryparsed=id:19911774$$DView record from Swedish Publication Index
search
creatorcontrib
0Söderbergh, Annika
1Myhre, Anne Grethe
2Ekwall, Olov
3Gebre-Medhin, Gennet
4Hedstrand, Håkan
5Landgren, Eva
6Miettinen, Aaro
7Eskelin, Petra
8Halonen, Maria
9Tuomi, Tiinamaija
10Gustafsson, Jan
11Husebye, Eystein S
12Perheentupa, Jaakko
13Gylling, Mikhail
14Manns, Michael P
15Rorsman, Fredrik
16Kämpe, Olle
17Nilsson, Thomas
title
0Prevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I
1The journal of clinical endocrinology and metabolism
addtitleJ Clin Endocrinol Metab
descriptionThe prevalence of autoantibodies against nine intracellular enzyme autoantigens, namely 21-hydroxylase, side-chain cleavage enzyme (SCC), 17α-hydroxylase, glutamic acid decarboxylase 65, aromatic l-amino acid decarboxylase, tyrosine phosphatase-like protein IA-2, tryptophan hydroxylase (TPH), tyrosine hydroxylase, cytochrome P450 1A2, and against the extracellular calcium-sensing receptor, was assessed in 90 patients with autoimmune polyendocrine syndrome type I. A multivariate logistic regression analysis was performed for the presence of autoantibodies as independent predictors for different disease manifestations. Reactivities against 21-hydroxylase and SCC were associated with Addison’s disease with odds ratios (ORs) of 7.8 and 6.8, respectively. Hypogonadism was exclusively associated with autoantibodies against SCC with an OR of 12.5. Autoantibodies against tyrosine phosphatase-like protein IA-2 were associated with insulin-dependent diabetes mellitus with an OR of 14.9, but with low sensitivity. Reactivities against TPH and, surprisingly, glutamic acid decarboxylase 65, were associated with intestinal dysfunction, with ORs of 3.9 and 6.7, respectively. TPH reactivity was the best predictor for autoimmune hepatitis, with an OR of 27.0. Hypoparathyroidism was not associated with reactivity against any of the autoantigens tested. No reactivity against the calcium-sensing receptor was found. Analysis of autoantibodies in autoimmune polyendocrine syndrome type I patients is a useful tool for establishing autoimmune manifestations of the disease as well as providing diagnosis in patients with suspected disease.
subject
0Adolescent
1Adult
2Autoantibodies - analysis
3Autoantigens - immunology
4Biological and medical sciences
5Biological Markers
6Biomarkers
7Child
8Child, Preschool
9Cohort Studies
10Endocrinopathies
11Enzymes - immunology
12Female
13Fundamental and applied biological sciences. Psychology
14Humans
15Male
16Medical and Health Sciences
17Medical sciences
18MEDICIN
19Medicin och hälsovetenskap
20MEDICINE
21Middle Aged
22Multivariate Analysis
23Polyendocrinopathies, Autoimmune - complications
24Polyendocrinopathies, Autoimmune - immunology
25Polyendocrinopathies; Autoimmune/complications/immunology
26Research Support; Non-U.S. Gov't
27Vertebrates: endocrinology
issn
00021-972X
11945-7197
21945-7197
fulltextfalse
rsrctypearticle
creationdate2004
recordtypearticle
recordideNp1kktv1DAUhSMEokNhyxJ5AxuUwa_E8XI05VGpEpUoiJ3lODfUU8ee2gmj-fd4OlErIY3la1tX3zl3cVwUbwleEkrwp41ZUoxZiRmmQj4rFkTyqhREiufFAmNKSino77PiVUobjAnnFXtZnBEu6rzJohiuI_zVDrwBpH2H1s56a7RDq5SCsXq0wScUekQwuoDeeujQahqD9qNtQ2chIesfOnYYJg_oOrg9-C6YmFn0Y--7GAZAN_stoMvXxYteuwRv5vu8-Pnl8836W3n1_evlenVVkorXddlrw2jTVCAlg7Y3WkrohTG6aVklWimqmoiuq0D00NaMCtbzRgJjTQ-aCcDnRXP0TTvYTq3aRjvouFdB2_wOnZr7d_ZQKoEiUhIiBM_SjyelF_bXSoX4R02TEpTSKtMfjnR2vZ8gjWqwyYBz2kOYkmowqTAnLIPLI2hiSClC_2hMsDokqTZGHZJUxySz4N3sPLUDdE_4HF0G3s-ATjmwPmpvbHriKt5Qwg8c_2-yseNDrmPU1p2eP8t2wY0Q052bdhDVLWg33iqcF69FU2YJx_nAZS5SZ1l1lD3-gW2ElNQmTNHnyE-N-wcBY9pf
startdate200402
enddate200402
creator
0Söderbergh, Annika
1Myhre, Anne Grethe
2Ekwall, Olov
3Gebre-Medhin, Gennet
4Hedstrand, Håkan
5Landgren, Eva
6Miettinen, Aaro
7Eskelin, Petra
8Halonen, Maria
9Tuomi, Tiinamaija
10Gustafsson, Jan
11Husebye, Eystein S
12Perheentupa, Jaakko
13Gylling, Mikhail
14Manns, Michael P
15Rorsman, Fredrik
16Kämpe, Olle
17Nilsson, Thomas
general
0Endocrine Society
1Copyright by The Endocrine Society
scope
0IQODW
1CGR
2CUY
3CVF
4ECM
5EIF
6NPM
7AAYXX
8CITATION
97X8
10ADTPV
11AOWAS
12D8T
sort
creationdate200402
titlePrevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I
authorSöderbergh, Annika ; Myhre, Anne Grethe ; Ekwall, Olov ; Gebre-Medhin, Gennet ; Hedstrand, Håkan ; Landgren, Eva ; Miettinen, Aaro ; Eskelin, Petra ; Halonen, Maria ; Tuomi, Tiinamaija ; Gustafsson, Jan ; Husebye, Eystein S ; Perheentupa, Jaakko ; Gylling, Mikhail ; Manns, Michael P ; Rorsman, Fredrik ; Kämpe, Olle ; Nilsson, Thomas
facets
frbrtype5
frbrgroupidcdi_FETCH-LOGICAL-15466-fac32885e993ebfca99ef7cca8b357b975617dd5e7feb63273f489e338fea37e0
rsrctypearticles
prefilterarticles
languageeng
creationdate2004
topic
0Adolescent
1Adult
2Autoantibodies - analysis
3Autoantigens - immunology
4Biological and medical sciences
5Biological Markers
6Biomarkers
7Child
8Child, Preschool
9Cohort Studies
10Endocrinopathies
11Enzymes - immunology
12Female
13Fundamental and applied biological sciences. Psychology
14Humans
15Male
16Medical and Health Sciences
17Medical sciences
18MEDICIN
19Medicin och hälsovetenskap
20MEDICINE
21Middle Aged
22Multivariate Analysis
23Polyendocrinopathies, Autoimmune - complications
24Polyendocrinopathies, Autoimmune - immunology
25Polyendocrinopathies; Autoimmune/complications/immunology
26Research Support; Non-U.S. Gov't
27Vertebrates: endocrinology
toplevelpeer_reviewed
creatorcontrib
0Söderbergh, Annika
1Myhre, Anne Grethe
2Ekwall, Olov
3Gebre-Medhin, Gennet
4Hedstrand, Håkan
5Landgren, Eva
6Miettinen, Aaro
7Eskelin, Petra
8Halonen, Maria
9Tuomi, Tiinamaija
10Gustafsson, Jan
11Husebye, Eystein S
12Perheentupa, Jaakko
13Gylling, Mikhail
14Manns, Michael P
15Rorsman, Fredrik
16Kämpe, Olle
17Nilsson, Thomas
collection
0Pascal-Francis
1Medline
2MEDLINE
3MEDLINE (Ovid)
4MEDLINE
5MEDLINE
6PubMed
7CrossRef
8MEDLINE - Academic
9SwePub
10SwePub Articles
11SWEPUB Freely available online
jtitleThe journal of clinical endocrinology and metabolism
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0Söderbergh, Annika
1Myhre, Anne Grethe
2Ekwall, Olov
3Gebre-Medhin, Gennet
4Hedstrand, Håkan
5Landgren, Eva
6Miettinen, Aaro
7Eskelin, Petra
8Halonen, Maria
9Tuomi, Tiinamaija
10Gustafsson, Jan
11Husebye, Eystein S
12Perheentupa, Jaakko
13Gylling, Mikhail
14Manns, Michael P
15Rorsman, Fredrik
16Kämpe, Olle
17Nilsson, Thomas
formatjournal
genrearticle
ristypeJOUR
atitlePrevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I
jtitleThe journal of clinical endocrinology and metabolism
addtitleJ Clin Endocrinol Metab
date2004-02
risdate2004
volume89
issue2
spage557
epage562
pages557-562
issn
00021-972X
11945-7197
eissn1945-7197
codenJCEMAZ
abstractThe prevalence of autoantibodies against nine intracellular enzyme autoantigens, namely 21-hydroxylase, side-chain cleavage enzyme (SCC), 17α-hydroxylase, glutamic acid decarboxylase 65, aromatic l-amino acid decarboxylase, tyrosine phosphatase-like protein IA-2, tryptophan hydroxylase (TPH), tyrosine hydroxylase, cytochrome P450 1A2, and against the extracellular calcium-sensing receptor, was assessed in 90 patients with autoimmune polyendocrine syndrome type I. A multivariate logistic regression analysis was performed for the presence of autoantibodies as independent predictors for different disease manifestations. Reactivities against 21-hydroxylase and SCC were associated with Addison’s disease with odds ratios (ORs) of 7.8 and 6.8, respectively. Hypogonadism was exclusively associated with autoantibodies against SCC with an OR of 12.5. Autoantibodies against tyrosine phosphatase-like protein IA-2 were associated with insulin-dependent diabetes mellitus with an OR of 14.9, but with low sensitivity. Reactivities against TPH and, surprisingly, glutamic acid decarboxylase 65, were associated with intestinal dysfunction, with ORs of 3.9 and 6.7, respectively. TPH reactivity was the best predictor for autoimmune hepatitis, with an OR of 27.0. Hypoparathyroidism was not associated with reactivity against any of the autoantigens tested. No reactivity against the calcium-sensing receptor was found. Analysis of autoantibodies in autoimmune polyendocrine syndrome type I patients is a useful tool for establishing autoimmune manifestations of the disease as well as providing diagnosis in patients with suspected disease.
copBethesda, MD
pubEndocrine Society
pmid14764761
doi10.1210/jc.2003-030279
oafree_for_read