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Prevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I

The prevalence of autoantibodies against nine intracellular enzyme autoantigens, namely 21-hydroxylase, side-chain cleavage enzyme (SCC), 17α-hydroxylase, glutamic acid decarboxylase 65, aromatic l-amino acid decarboxylase, tyrosine phosphatase-like protein IA-2, tryptophan hydroxylase (TPH), tyrosi... Full description

Journal Title: The journal of clinical endocrinology and metabolism 2004, Vol.89 (2), p.557-562
Main Author: Söderbergh, Annika
Other Authors: Myhre, Anne Grethe , Ekwall, Olov , Gebre-Medhin, Gennet , Hedstrand, Håkan , Landgren, Eva , Miettinen, Aaro , Eskelin, Petra , Halonen, Maria , Tuomi, Tiinamaija , Gustafsson, Jan , Husebye, Eystein S , Perheentupa, Jaakko , Gylling, Mikhail , Manns, Michael P , Rorsman, Fredrik , Kämpe, Olle , Nilsson, Thomas
Format: Electronic Article Electronic Article
Language: English
Subjects:
Publisher: Bethesda, MD: Endocrine Society
ID: ISSN: 0021-972X
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recordid: cdi_swepub_primary_oai_prod_swepub_kib_ki_se_19911774
title: Prevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I
format: Article
creator:
  • Söderbergh, Annika
  • Myhre, Anne Grethe
  • Ekwall, Olov
  • Gebre-Medhin, Gennet
  • Hedstrand, Håkan
  • Landgren, Eva
  • Miettinen, Aaro
  • Eskelin, Petra
  • Halonen, Maria
  • Tuomi, Tiinamaija
  • Gustafsson, Jan
  • Husebye, Eystein S
  • Perheentupa, Jaakko
  • Gylling, Mikhail
  • Manns, Michael P
  • Rorsman, Fredrik
  • Kämpe, Olle
  • Nilsson, Thomas
subjects:
  • Abridged Index Medicus
  • Adolescent
  • Adult
  • Autoantibodies - analysis
  • Autoantigens - immunology
  • Biological and medical sciences
  • Biological Markers
  • Biomarkers
  • Child
  • Child, Preschool
  • Cohort Studies
  • Endocrinopathies
  • Enzymes - immunology
  • Female
  • Fundamental and applied biological sciences. Psychology
  • Humans
  • Male
  • Medical and Health Sciences
  • Medical sciences
  • MEDICIN
  • Medicin och hälsovetenskap
  • MEDICINE
  • Middle Aged
  • Multivariate Analysis
  • Polyendocrinopathies, Autoimmune - complications
  • Polyendocrinopathies, Autoimmune - immunology
  • Polyendocrinopathies
  • Autoimmune/complications/immunology
  • Research Support
  • Non-U.S. Gov't
  • Vertebrates: endocrinology
ispartof: The journal of clinical endocrinology and metabolism, 2004, Vol.89 (2), p.557-562
description: The prevalence of autoantibodies against nine intracellular enzyme autoantigens, namely 21-hydroxylase, side-chain cleavage enzyme (SCC), 17α-hydroxylase, glutamic acid decarboxylase 65, aromatic l-amino acid decarboxylase, tyrosine phosphatase-like protein IA-2, tryptophan hydroxylase (TPH), tyrosine hydroxylase, cytochrome P450 1A2, and against the extracellular calcium-sensing receptor, was assessed in 90 patients with autoimmune polyendocrine syndrome type I. A multivariate logistic regression analysis was performed for the presence of autoantibodies as independent predictors for different disease manifestations. Reactivities against 21-hydroxylase and SCC were associated with Addison’s disease with odds ratios (ORs) of 7.8 and 6.8, respectively. Hypogonadism was exclusively associated with autoantibodies against SCC with an OR of 12.5. Autoantibodies against tyrosine phosphatase-like protein IA-2 were associated with insulin-dependent diabetes mellitus with an OR of 14.9, but with low sensitivity. Reactivities against TPH and, surprisingly, glutamic acid decarboxylase 65, were associated with intestinal dysfunction, with ORs of 3.9 and 6.7, respectively. TPH reactivity was the best predictor for autoimmune hepatitis, with an OR of 27.0. Hypoparathyroidism was not associated with reactivity against any of the autoantigens tested. No reactivity against the calcium-sensing receptor was found. Analysis of autoantibodies in autoimmune polyendocrine syndrome type I patients is a useful tool for establishing autoimmune manifestations of the disease as well as providing diagnosis in patients with suspected disease.
language: eng
source:
identifier: ISSN: 0021-972X
fulltext: no_fulltext
issn:
  • 0021-972X
  • 1945-7197
  • 1945-7197
url: Link


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titlePrevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I
creatorSöderbergh, Annika ; Myhre, Anne Grethe ; Ekwall, Olov ; Gebre-Medhin, Gennet ; Hedstrand, Håkan ; Landgren, Eva ; Miettinen, Aaro ; Eskelin, Petra ; Halonen, Maria ; Tuomi, Tiinamaija ; Gustafsson, Jan ; Husebye, Eystein S ; Perheentupa, Jaakko ; Gylling, Mikhail ; Manns, Michael P ; Rorsman, Fredrik ; Kämpe, Olle ; Nilsson, Thomas
creatorcontribSöderbergh, Annika ; Myhre, Anne Grethe ; Ekwall, Olov ; Gebre-Medhin, Gennet ; Hedstrand, Håkan ; Landgren, Eva ; Miettinen, Aaro ; Eskelin, Petra ; Halonen, Maria ; Tuomi, Tiinamaija ; Gustafsson, Jan ; Husebye, Eystein S ; Perheentupa, Jaakko ; Gylling, Mikhail ; Manns, Michael P ; Rorsman, Fredrik ; Kämpe, Olle ; Nilsson, Thomas
descriptionThe prevalence of autoantibodies against nine intracellular enzyme autoantigens, namely 21-hydroxylase, side-chain cleavage enzyme (SCC), 17α-hydroxylase, glutamic acid decarboxylase 65, aromatic l-amino acid decarboxylase, tyrosine phosphatase-like protein IA-2, tryptophan hydroxylase (TPH), tyrosine hydroxylase, cytochrome P450 1A2, and against the extracellular calcium-sensing receptor, was assessed in 90 patients with autoimmune polyendocrine syndrome type I. A multivariate logistic regression analysis was performed for the presence of autoantibodies as independent predictors for different disease manifestations. Reactivities against 21-hydroxylase and SCC were associated with Addison’s disease with odds ratios (ORs) of 7.8 and 6.8, respectively. Hypogonadism was exclusively associated with autoantibodies against SCC with an OR of 12.5. Autoantibodies against tyrosine phosphatase-like protein IA-2 were associated with insulin-dependent diabetes mellitus with an OR of 14.9, but with low sensitivity. Reactivities against TPH and, surprisingly, glutamic acid decarboxylase 65, were associated with intestinal dysfunction, with ORs of 3.9 and 6.7, respectively. TPH reactivity was the best predictor for autoimmune hepatitis, with an OR of 27.0. Hypoparathyroidism was not associated with reactivity against any of the autoantigens tested. No reactivity against the calcium-sensing receptor was found. Analysis of autoantibodies in autoimmune polyendocrine syndrome type I patients is a useful tool for establishing autoimmune manifestations of the disease as well as providing diagnosis in patients with suspected disease.
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subjectAbridged Index Medicus ; Adolescent ; Adult ; Autoantibodies - analysis ; Autoantigens - immunology ; Biological and medical sciences ; Biological Markers ; Biomarkers ; Child ; Child, Preschool ; Cohort Studies ; Endocrinopathies ; Enzymes - immunology ; Female ; Fundamental and applied biological sciences. Psychology ; Humans ; Male ; Medical and Health Sciences ; Medical sciences ; MEDICIN ; Medicin och hälsovetenskap ; MEDICINE ; Middle Aged ; Multivariate Analysis ; Polyendocrinopathies, Autoimmune - complications ; Polyendocrinopathies, Autoimmune - immunology ; Polyendocrinopathies; Autoimmune/complications/immunology ; Research Support; Non-U.S. Gov't ; Vertebrates: endocrinology
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5Landgren, Eva
6Miettinen, Aaro
7Eskelin, Petra
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10Gustafsson, Jan
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12Perheentupa, Jaakko
13Gylling, Mikhail
14Manns, Michael P
15Rorsman, Fredrik
16Kämpe, Olle
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0Prevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I
1The journal of clinical endocrinology and metabolism
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descriptionThe prevalence of autoantibodies against nine intracellular enzyme autoantigens, namely 21-hydroxylase, side-chain cleavage enzyme (SCC), 17α-hydroxylase, glutamic acid decarboxylase 65, aromatic l-amino acid decarboxylase, tyrosine phosphatase-like protein IA-2, tryptophan hydroxylase (TPH), tyrosine hydroxylase, cytochrome P450 1A2, and against the extracellular calcium-sensing receptor, was assessed in 90 patients with autoimmune polyendocrine syndrome type I. A multivariate logistic regression analysis was performed for the presence of autoantibodies as independent predictors for different disease manifestations. Reactivities against 21-hydroxylase and SCC were associated with Addison’s disease with odds ratios (ORs) of 7.8 and 6.8, respectively. Hypogonadism was exclusively associated with autoantibodies against SCC with an OR of 12.5. Autoantibodies against tyrosine phosphatase-like protein IA-2 were associated with insulin-dependent diabetes mellitus with an OR of 14.9, but with low sensitivity. Reactivities against TPH and, surprisingly, glutamic acid decarboxylase 65, were associated with intestinal dysfunction, with ORs of 3.9 and 6.7, respectively. TPH reactivity was the best predictor for autoimmune hepatitis, with an OR of 27.0. Hypoparathyroidism was not associated with reactivity against any of the autoantigens tested. No reactivity against the calcium-sensing receptor was found. Analysis of autoantibodies in autoimmune polyendocrine syndrome type I patients is a useful tool for establishing autoimmune manifestations of the disease as well as providing diagnosis in patients with suspected disease.
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0Abridged Index Medicus
1Adolescent
2Adult
3Autoantibodies - analysis
4Autoantigens - immunology
5Biological and medical sciences
6Biological Markers
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9Child, Preschool
10Cohort Studies
11Endocrinopathies
12Enzymes - immunology
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14Fundamental and applied biological sciences. Psychology
15Humans
16Male
17Medical and Health Sciences
18Medical sciences
19MEDICIN
20Medicin och hälsovetenskap
21MEDICINE
22Middle Aged
23Multivariate Analysis
24Polyendocrinopathies, Autoimmune - complications
25Polyendocrinopathies, Autoimmune - immunology
26Polyendocrinopathies; Autoimmune/complications/immunology
27Research Support; Non-U.S. Gov't
28Vertebrates: endocrinology
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titlePrevalence and Clinical Associations of 10 Defined Autoantibodies in Autoimmune Polyendocrine Syndrome Type I
authorSöderbergh, Annika ; Myhre, Anne Grethe ; Ekwall, Olov ; Gebre-Medhin, Gennet ; Hedstrand, Håkan ; Landgren, Eva ; Miettinen, Aaro ; Eskelin, Petra ; Halonen, Maria ; Tuomi, Tiinamaija ; Gustafsson, Jan ; Husebye, Eystein S ; Perheentupa, Jaakko ; Gylling, Mikhail ; Manns, Michael P ; Rorsman, Fredrik ; Kämpe, Olle ; Nilsson, Thomas
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9Child, Preschool
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17Medical and Health Sciences
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20Medicin och hälsovetenskap
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23Multivariate Analysis
24Polyendocrinopathies, Autoimmune - complications
25Polyendocrinopathies, Autoimmune - immunology
26Polyendocrinopathies; Autoimmune/complications/immunology
27Research Support; Non-U.S. Gov't
28Vertebrates: endocrinology
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11Husebye, Eystein S
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abstractThe prevalence of autoantibodies against nine intracellular enzyme autoantigens, namely 21-hydroxylase, side-chain cleavage enzyme (SCC), 17α-hydroxylase, glutamic acid decarboxylase 65, aromatic l-amino acid decarboxylase, tyrosine phosphatase-like protein IA-2, tryptophan hydroxylase (TPH), tyrosine hydroxylase, cytochrome P450 1A2, and against the extracellular calcium-sensing receptor, was assessed in 90 patients with autoimmune polyendocrine syndrome type I. A multivariate logistic regression analysis was performed for the presence of autoantibodies as independent predictors for different disease manifestations. Reactivities against 21-hydroxylase and SCC were associated with Addison’s disease with odds ratios (ORs) of 7.8 and 6.8, respectively. Hypogonadism was exclusively associated with autoantibodies against SCC with an OR of 12.5. Autoantibodies against tyrosine phosphatase-like protein IA-2 were associated with insulin-dependent diabetes mellitus with an OR of 14.9, but with low sensitivity. Reactivities against TPH and, surprisingly, glutamic acid decarboxylase 65, were associated with intestinal dysfunction, with ORs of 3.9 and 6.7, respectively. TPH reactivity was the best predictor for autoimmune hepatitis, with an OR of 27.0. Hypoparathyroidism was not associated with reactivity against any of the autoantigens tested. No reactivity against the calcium-sensing receptor was found. Analysis of autoantibodies in autoimmune polyendocrine syndrome type I patients is a useful tool for establishing autoimmune manifestations of the disease as well as providing diagnosis in patients with suspected disease.
copBethesda, MD
pubEndocrine Society
pmid14764761
doi10.1210/jc.2003-030279
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