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Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer

Copper is involved in different hallmarks of cancer, including metastasis, but responsible copper-binding proteins and pathways are not clear. The copper chaperone ATOX1 was recently shown to play a role in breast cancer cell migration, which is a key step in metastasis. Since most cancer-related de... Full description

Journal Title: Breast cancer (Tokyo Japan), 2020, Vol.27 (3), p.505-509
Main Author: Blockhuys, Stéphanie
Other Authors: Brady, Donita C. , Wittung-Stafshede, Pernilla
Format: Electronic Article Electronic Article
Language: English
Subjects:
RNA
Publisher: Tokyo: Springer Japan
ID: ISSN: 1340-6868
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title: Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer
format: Article
creator:
  • Blockhuys, Stéphanie
  • Brady, Donita C.
  • Wittung-Stafshede, Pernilla
subjects:
  • ATOX1
  • Binding proteins
  • Biomarker
  • Biomarkers, Tumor - genetics
  • Biomarkers, Tumor - metabolism
  • Breast cancer
  • Breast Neoplasms - genetics
  • Breast Neoplasms - metabolism
  • Breast Neoplasms - pathology
  • Cancer
  • Cancer and Oncology
  • Cancer och onkologi
  • Cancer patients
  • Cancer Research
  • Copper - metabolism
  • Copper Transport Proteins - genetics
  • Copper Transport Proteins - metabolism
  • Databases, Factual
  • Development and progression
  • Female
  • Follow-Up Studies
  • Humans
  • Medicine
  • Medicine & Public Health
  • METABRIC
  • Metastasis
  • Molecular Chaperones - genetics
  • Molecular Chaperones - metabolism
  • Oncology
  • Oncology, Experimental
  • Pathobiology
  • Patobiologi
  • Prognosis
  • Prognostic
  • Protein binding
  • Rapid Communication
  • Receptor, ErbB-2 - metabolism
  • Receptors, Estrogen - metabolism
  • Receptors, Progesterone - metabolism
  • RNA
  • RNA, Messenger - genetics
  • RNA, Messenger - metabolism
  • Surgery
  • Surgical Oncology
  • Survival
  • Survival Rate
  • Urologi och njurmedicin
  • Urology and Nephrology
ispartof: Breast cancer (Tokyo, Japan), 2020, Vol.27 (3), p.505-509
description: Copper is involved in different hallmarks of cancer, including metastasis, but responsible copper-binding proteins and pathways are not clear. The copper chaperone ATOX1 was recently shown to play a role in breast cancer cell migration, which is a key step in metastasis. Since most cancer-related deaths are due to metastasis, we hypothesized that ATOX1 mRNA expression may be associated with breast cancer disease progression and thus, a prognostic biomarker in breast cancer. We therefore studied the association of ATOX1 expression levels with clinicopathological parameters and survival for 1904 breast cancer patients using the METABRIC data set. Our results indicate ATOX1 expression levels as a potential prognostic biomarker for ER-positive subtypes and early stages of breast cancer. Pre-clinical studies and clinical trials are desired to identify the molecular roles of ATOX1 in these conditions.
language: eng
source:
identifier: ISSN: 1340-6868
fulltext: no_fulltext
issn:
  • 1340-6868
  • 1880-4233
url: Link


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titleEvaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer
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descriptionCopper is involved in different hallmarks of cancer, including metastasis, but responsible copper-binding proteins and pathways are not clear. The copper chaperone ATOX1 was recently shown to play a role in breast cancer cell migration, which is a key step in metastasis. Since most cancer-related deaths are due to metastasis, we hypothesized that ATOX1 mRNA expression may be associated with breast cancer disease progression and thus, a prognostic biomarker in breast cancer. We therefore studied the association of ATOX1 expression levels with clinicopathological parameters and survival for 1904 breast cancer patients using the METABRIC data set. Our results indicate ATOX1 expression levels as a potential prognostic biomarker for ER-positive subtypes and early stages of breast cancer. Pre-clinical studies and clinical trials are desired to identify the molecular roles of ATOX1 in these conditions.
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languageeng
publisherTokyo: Springer Japan
subjectATOX1 ; Binding proteins ; Biomarker ; Biomarkers, Tumor - genetics ; Biomarkers, Tumor - metabolism ; Breast cancer ; Breast Neoplasms - genetics ; Breast Neoplasms - metabolism ; Breast Neoplasms - pathology ; Cancer ; Cancer and Oncology ; Cancer och onkologi ; Cancer patients ; Cancer Research ; Copper - metabolism ; Copper Transport Proteins - genetics ; Copper Transport Proteins - metabolism ; Databases, Factual ; Development and progression ; Female ; Follow-Up Studies ; Humans ; Medicine ; Medicine & Public Health ; METABRIC ; Metastasis ; Molecular Chaperones - genetics ; Molecular Chaperones - metabolism ; Oncology ; Oncology, Experimental ; Pathobiology ; Patobiologi ; Prognosis ; Prognostic ; Protein binding ; Rapid Communication ; Receptor, ErbB-2 - metabolism ; Receptors, Estrogen - metabolism ; Receptors, Progesterone - metabolism ; RNA ; RNA, Messenger - genetics ; RNA, Messenger - metabolism ; Surgery ; Surgical Oncology ; Survival ; Survival Rate ; Urologi och njurmedicin ; Urology and Nephrology
ispartofBreast cancer (Tokyo, Japan), 2020, Vol.27 (3), p.505-509
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0Evaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer
1Breast cancer (Tokyo, Japan)
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descriptionCopper is involved in different hallmarks of cancer, including metastasis, but responsible copper-binding proteins and pathways are not clear. The copper chaperone ATOX1 was recently shown to play a role in breast cancer cell migration, which is a key step in metastasis. Since most cancer-related deaths are due to metastasis, we hypothesized that ATOX1 mRNA expression may be associated with breast cancer disease progression and thus, a prognostic biomarker in breast cancer. We therefore studied the association of ATOX1 expression levels with clinicopathological parameters and survival for 1904 breast cancer patients using the METABRIC data set. Our results indicate ATOX1 expression levels as a potential prognostic biomarker for ER-positive subtypes and early stages of breast cancer. Pre-clinical studies and clinical trials are desired to identify the molecular roles of ATOX1 in these conditions.
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1Binding proteins
2Biomarker
3Biomarkers, Tumor - genetics
4Biomarkers, Tumor - metabolism
5Breast cancer
6Breast Neoplasms - genetics
7Breast Neoplasms - metabolism
8Breast Neoplasms - pathology
9Cancer
10Cancer and Oncology
11Cancer och onkologi
12Cancer patients
13Cancer Research
14Copper - metabolism
15Copper Transport Proteins - genetics
16Copper Transport Proteins - metabolism
17Databases, Factual
18Development and progression
19Female
20Follow-Up Studies
21Humans
22Medicine
23Medicine & Public Health
24METABRIC
25Metastasis
26Molecular Chaperones - genetics
27Molecular Chaperones - metabolism
28Oncology
29Oncology, Experimental
30Pathobiology
31Patobiologi
32Prognosis
33Prognostic
34Protein binding
35Rapid Communication
36Receptor, ErbB-2 - metabolism
37Receptors, Estrogen - metabolism
38Receptors, Progesterone - metabolism
39RNA
40RNA, Messenger - genetics
41RNA, Messenger - metabolism
42Surgery
43Surgical Oncology
44Survival
45Survival Rate
46Urologi och njurmedicin
47Urology and Nephrology
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titleEvaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer
authorBlockhuys, Stéphanie ; Brady, Donita C. ; Wittung-Stafshede, Pernilla
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0ATOX1
1Binding proteins
2Biomarker
3Biomarkers, Tumor - genetics
4Biomarkers, Tumor - metabolism
5Breast cancer
6Breast Neoplasms - genetics
7Breast Neoplasms - metabolism
8Breast Neoplasms - pathology
9Cancer
10Cancer and Oncology
11Cancer och onkologi
12Cancer patients
13Cancer Research
14Copper - metabolism
15Copper Transport Proteins - genetics
16Copper Transport Proteins - metabolism
17Databases, Factual
18Development and progression
19Female
20Follow-Up Studies
21Humans
22Medicine
23Medicine & Public Health
24METABRIC
25Metastasis
26Molecular Chaperones - genetics
27Molecular Chaperones - metabolism
28Oncology
29Oncology, Experimental
30Pathobiology
31Patobiologi
32Prognosis
33Prognostic
34Protein binding
35Rapid Communication
36Receptor, ErbB-2 - metabolism
37Receptors, Estrogen - metabolism
38Receptors, Progesterone - metabolism
39RNA
40RNA, Messenger - genetics
41RNA, Messenger - metabolism
42Surgery
43Surgical Oncology
44Survival
45Survival Rate
46Urologi och njurmedicin
47Urology and Nephrology
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atitleEvaluation of copper chaperone ATOX1 as prognostic biomarker in breast cancer
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date2020-01-02
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volume27
issue3
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pages505-509
issn1340-6868
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abstractCopper is involved in different hallmarks of cancer, including metastasis, but responsible copper-binding proteins and pathways are not clear. The copper chaperone ATOX1 was recently shown to play a role in breast cancer cell migration, which is a key step in metastasis. Since most cancer-related deaths are due to metastasis, we hypothesized that ATOX1 mRNA expression may be associated with breast cancer disease progression and thus, a prognostic biomarker in breast cancer. We therefore studied the association of ATOX1 expression levels with clinicopathological parameters and survival for 1904 breast cancer patients using the METABRIC data set. Our results indicate ATOX1 expression levels as a potential prognostic biomarker for ER-positive subtypes and early stages of breast cancer. Pre-clinical studies and clinical trials are desired to identify the molecular roles of ATOX1 in these conditions.
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pubSpringer Japan
pmid31898157
doi10.1007/s12282-019-01044-4
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