schliessen

Filtern

 

Bibliotheken

TM4SF1蛋白在上皮性卵巢癌组织中的表达及其临床意义 - Expression and clinical significance of TM4SF1 protein in epithelial ovarian cancer

目的 探讨跨膜四超家族成员1(transmembrane 4 super family 1,TM4SF1)蛋白在人卵巢组织中的表达及其与上皮性卵巢癌临床病理因素的关系。方法 采用免疫组化SP法检测16例正常卵巢上皮组织、23例上皮性卵巢良性肿瘤组织及55例上皮性卵巢癌癌组织中TM4SF1蛋白的表达情况,分析其与上皮性卵巢癌临床病理因素及预后的关系。结果 ①TM4SF1蛋白在上皮性卵巢癌癌组织中的阳性表达率(90.90%)高于上皮性卵巢良性肿瘤组织(65.22%)及正常卵巢上皮组织(25.00%)的阳性表达率,差异有统计学意义(P〈0.05)。②TM4SF1蛋白在正常卵巢上皮细胞中的表达主要位于... Full description

Journal Title: 中国癌症防治杂志 - Journal of Chinese Medical Abstracts·Oncology 2014, Vol.6(01), pp.20-24
Main Author: 刘慧敏
Other Authors: 俸艳英 , 高彩云 , 阳志军 , LIU Hui-min , FENG Yan-ying, GAO Cai-yun ,YANG Zhi-jun
Format: Electronic Article Electronic Article
Language:
Subjects:
Quelle: 维普数据 (Chongqing VIP Information Co.)
ID: ISSN: 1674-5671
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: cqvip49024039
title: TM4SF1蛋白在上皮性卵巢癌组织中的表达及其临床意义 - Expression and clinical significance of TM4SF1 protein in epithelial ovarian cancer
format: Article
creator:
  • 刘慧敏
  • 俸艳英
  • 高彩云
  • 阳志军
  • LIU Hui-min , FENG Yan-ying, GAO Cai-yun ,YANG Zhi-jun
subjects:
  • 卵巢肿瘤
  • Tm4sf1
  • 上皮性卵巢癌
  • 免疫组织化学
  • Ovarian Neoplasm Tm4sf1 Epithelial Ovarian Cancer Immunohistochemistry
ispartof: 中国癌症防治杂志 - Journal of Chinese Medical Abstracts·Oncology, 2014, Vol.6(01), pp.20-24
description: 目的 探讨跨膜四超家族成员1(transmembrane 4 super family 1,TM4SF1)蛋白在人卵巢组织中的表达及其与上皮性卵巢癌临床病理因素的关系。方法 采用免疫组化SP法检测16例正常卵巢上皮组织、23例上皮性卵巢良性肿瘤组织及55例上皮性卵巢癌癌组织中TM4SF1蛋白的表达情况,分析其与上皮性卵巢癌临床病理因素及预后的关系。结果 ①TM4SF1蛋白在上皮性卵巢癌癌组织中的阳性表达率(90.90%)高于上皮性卵巢良性肿瘤组织(65.22%)及正常卵巢上皮组织(25.00%)的阳性表达率,差异有统计学意义(P〈0.05)。②TM4SF1蛋白在正常卵巢上皮细胞中的表达主要位于上皮细胞的细胞膜和细胞膜近基底膜处及细胞质中,在卵巢良性肿瘤组织中的表达主要集中在肿瘤细胞的细胞膜近基底膜处及细胞膜其他部位,而在卵巢癌细胞中则主要分布于癌细胞的细胞质中。③Ⅲ~Ⅳ期卵巢癌患者TM4SF1蛋白的阳性表达率高于Ⅰ~Ⅱ期患者,中低分化癌患者TM4SF1蛋白的阳性表达率高于高分化癌患者(P〈0.05)。④TM4SF1蛋白的阳性表达率与组织学类型、腹水量的多少无明显相关(P〉0.05),而与FIGO分期及组织学分级明显相关(P〈0.05)。⑤Cox比例风险回归模型多因素分析显示TM4SF1蛋白在卵巢癌癌组织中的阳性表达不是影响患者生存的独立预后因素。结论 TM4SF1蛋白在上皮性卵巢癌癌组织中呈高表达,可能与卵巢癌的发生、发展相关。
language:
source: 维普数据 (Chongqing VIP Information Co.)
identifier: ISSN: 1674-5671
fulltext: no_fulltext
issn:
  • 1674-5671
  • 16745671
url: Link


@attributes
ID519208950
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid49024039
sourceidcqvip
recordidTN_cqvip49024039
sourceformatDC
sourcesystemOther
display
typearticle
titleTM4SF1蛋白在上皮性卵巢癌组织中的表达及其临床意义 - Expression and clinical significance of TM4SF1 protein in epithelial ovarian cancer
creator刘慧敏 ; 俸艳英 ; 高彩云 ; 阳志军 ; LIU Hui-min , FENG Yan-ying, GAO Cai-yun ,YANG Zhi-jun
ispartof中国癌症防治杂志 - Journal of Chinese Medical Abstracts·Oncology, 2014, Vol.6(01), pp.20-24
identifierISSN: 1674-5671
subject卵巢肿瘤 ; Tm4sf1 ; 上皮性卵巢癌 ; 免疫组织化学 ; Ovarian Neoplasm Tm4sf1 Epithelial Ovarian Cancer Immunohistochemistry
description
0目的 探讨跨膜四超家族成员1(transmembrane 4 super family 1,TM4SF1)蛋白在人卵巢组织中的表达及其与上皮性卵巢癌临床病理因素的关系。方法 采用免疫组化SP法检测16例正常卵巢上皮组织、23例上皮性卵巢良性肿瘤组织及55例上皮性卵巢癌癌组织中TM4SF1蛋白的表达情况,分析其与上皮性卵巢癌临床病理因素及预后的关系。结果 ①TM4SF1蛋白在上皮性卵巢癌癌组织中的阳性表达率(90.90%)高于上皮性卵巢良性肿瘤组织(65.22%)及正常卵巢上皮组织(25.00%)的阳性表达率,差异有统计学意义(P〈0.05)。②TM4SF1蛋白在正常卵巢上皮细胞中的表达主要位于上皮细胞的细胞膜和细胞膜近基底膜处及细胞质中,在卵巢良性肿瘤组织中的表达主要集中在肿瘤细胞的细胞膜近基底膜处及细胞膜其他部位,而在卵巢癌细胞中则主要分布于癌细胞的细胞质中。③Ⅲ~Ⅳ期卵巢癌患者TM4SF1蛋白的阳性表达率高于Ⅰ~Ⅱ期患者,中低分化癌患者TM4SF1蛋白的阳性表达率高于高分化癌患者(P〈0.05)。④TM4SF1蛋白的阳性表达率与组织学类型、腹水量的多少无明显相关(P〉0.05),而与FIGO分期及组织学分级明显相关(P〈0.05)。⑤Cox比例风险回归模型多因素分析显示TM4SF1蛋白在卵巢癌癌组织中的阳性表达不是影响患者生存的独立预后因素。结论 TM4SF1蛋白在上皮性卵巢癌癌组织中呈高表达,可能与卵巢癌的发生、发展相关。
1Objective To investigate the expression of transmembrane 4 super family 1(TM4SF1) protein in human ovarian tissues and its relationship with clinicopathological factors. Methods The SP immunohistochemical method was used to analyze the expression of TM4SF1 protein in 16 normal ovarian epithelial tissues, 23 benign ovarian tumor tissues and 55 epithelial ovarian cancer (EOC) tissues.Relationships of TM4SF1 expression with clinicopathological features of EOC and patient prognosis were analyzed. Result ①EOC tissues showed a significantly higher rate of TM4SF1 protein expression(90.90%)than did benign ovarian tumor tissues(65.22%)or normal ovarian epithelial tissues(25.00%,P〈0.05).②The TM4SF1 protein showed markedly different localizations in various tissue types. In normal ovarian epithelial tissues,the protein localized primarily to the membranes and the basal surface of epithelial cells as well as cytoplasts; in benign ovarian tumors, the protein was observed mainly on the basal surface and in certain parts of tumor cell membranes;in EOC tissues,TM4SF1 showed a mainly cytoplasmic staining.③ Rate of TM4SF1 protein expression was significantly higher in tissues of patients with stage Ⅲ-Ⅳ EOC than in patients with stage Ⅰ-Ⅱ disease(P〈0.05).The rate of TM4SF1 protein expression was also significantly higher in tissues showing low-to intermediate tumor differentiation than in well-differentiated carcinoma tissues(P〈0.05).④ Rate of TM4SF1 protein expression showed no significant association with histological type or amount of ascites (P〉0.05),but association with FIGO stage and histological grade(P〈0.05).⑤ Cox multivariate analysis showed that positive expression of TM4SF1 protein was not an independent prognostic factor. Conclusion TM4SF1 protein is overexpressed in EOC tissue,so it may be associated with the disease.
relation作者单位: 广西医科大学附属肿瘤医院妇瘤科,南宁530021 广西医科大学研究生学院
source维普数据 (Chongqing VIP Information Co.)
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
thumbnail$$Uhttp://image.cqvip.com/vip1000/qk/85188A/85188A.jpg
search
creatorcontrib
0刘慧敏
1俸艳英
2高彩云
3阳志军
4LIU Hui-min , FENG Yan-ying, GAO Cai-yun ,YANG Zhi-jun
5广西医科大学附属肿瘤医院妇瘤科,南宁530021 广西医科大学研究生学院
title
0TM4SF1蛋白在上皮性卵巢癌组织中的表达及其临床意义
1Expression and clinical significance of TM4SF1 protein in epithelial ovarian cancer
description
0目的 探讨跨膜四超家族成员1(transmembrane 4 super family 1,TM4SF1)蛋白在人卵巢组织中的表达及其与上皮性卵巢癌临床病理因素的关系。方法 采用免疫组化SP法检测16例正常卵巢上皮组织、23例上皮性卵巢良性肿瘤组织及55例上皮性卵巢癌癌组织中TM4SF1蛋白的表达情况,分析其与上皮性卵巢癌临床病理因素及预后的关系。结果 ①TM4SF1蛋白在上皮性卵巢癌癌组织中的阳性表达率(90.90%)高于上皮性卵巢良性肿瘤组织(65.22%)及正常卵巢上皮组织(25.00%)的阳性表达率,差异有统计学意义(P〈0.05)。②TM4SF1蛋白在正常卵巢上皮细胞中的表达主要位于上皮细胞的细胞膜和细胞膜近基底膜处及细胞质中,在卵巢良性肿瘤组织中的表达主要集中在肿瘤细胞的细胞膜近基底膜处及细胞膜其他部位,而在卵巢癌细胞中则主要分布于癌细胞的细胞质中。③Ⅲ~Ⅳ期卵巢癌患者TM4SF1蛋白的阳性表达率高于Ⅰ~Ⅱ期患者,中低分化癌患者TM4SF1蛋白的阳性表达率高于高分化癌患者(P〈0.05)。④TM4SF1蛋白的阳性表达率与组织学类型、腹水量的多少无明显相关(P〉0.05),而与FIGO分期及组织学分级明显相关(P〈0.05)。⑤Cox比例风险回归模型多因素分析显示TM4SF1蛋白在卵巢癌癌组织中的阳性表达不是影响患者生存的独立预后因素。结论 TM4SF1蛋白在上皮性卵巢癌癌组织中呈高表达,可能与卵巢癌的发生、发展相关。
1Objective To investigate the expression of transmembrane 4 super family 1(TM4SF1) protein in human ovarian tissues and its relationship with clinicopathological factors. Methods The SP immunohistochemical method was used to analyze the expression of TM4SF1 protein in 16 normal ovarian epithelial tissues, 23 benign ovarian tumor tissues and 55 epithelial ovarian cancer (EOC) tissues.Relationships of TM4SF1 expression with clinicopathological features of EOC and patient prognosis were analyzed. Result ①EOC tissues showed a significantly higher rate of TM4SF1 protein expression(90.90%)than did benign ovarian tumor tissues(65.22%)or normal ovarian epithelial tissues(25.00%,P〈0.05).②The TM4SF1 protein showed markedly different localizations in various tissue types. In normal ovarian epithelial tissues,the protein localized primarily to the membranes and the basal surface of epithelial cells as well as cytoplasts; in benign ovarian tumors, the protein was observed mainly on the basal surface and in certain parts of tumor cell membranes;in EOC tissues,TM4SF1 showed a mainly cytoplasmic staining.③ Rate of TM4SF1 protein expression was significantly higher in tissues of patients with stage Ⅲ-Ⅳ EOC than in patients with stage Ⅰ-Ⅱ disease(P〈0.05).The rate of TM4SF1 protein expression was also significantly higher in tissues showing low-to intermediate tumor differentiation than in well-differentiated carcinoma tissues(P〈0.05).④ Rate of TM4SF1 protein expression showed no significant association with histological type or amount of ascites (P〉0.05),but association with FIGO stage and histological grade(P〈0.05).⑤ Cox multivariate analysis showed that positive expression of TM4SF1 protein was not an independent prognostic factor. Conclusion TM4SF1 protein is overexpressed in EOC tissue,so it may be associated with the disease.
subject
0卵巢肿瘤
1Tm4sf1
2上皮性卵巢癌
3免疫组织化学
4Ovarian Neoplasm Tm4sf1 Epithelial Ovarian Cancer Immunohistochemistry
general
0chinese
1维普数据 (Chongqing VIP Information Co.)
sourceidcqvip
recordidcqvip49024039
issn
01674-5671
116745671
rsrctypearticle
creationdate2014
startdate20140101
enddate20141231
addtitle
0中国癌症防治杂志
1Journal of Chinese Medical Abstracts·Oncology
searchscopecqvip
scopecqvip
lsr01
0广西医科大学附属肿瘤医院妇瘤科,南宁530021 广西医科大学研究生学院
1LIU Hui-min , FENG Yan-ying, GAO Cai-yun ,YANG Zhi-jun (1.Department of Gynecologic Oncology,Affiliated Tumor Hospital of Guangxi Medical University;2.Graduate School of Guangxi Medical University, Nanning 530021, P.R.China)
citationpf 20 pt 24 vol 6 issue 01
sort
titleTM4SF1蛋白在上皮性卵巢癌组织中的表达及其临床意义 - Expression and clinical significance of TM4SF1 protein in epithelial ovarian cancer
author刘慧敏 ; 俸艳英 ; 高彩云 ; 阳志军 ; LIU Hui-min , FENG Yan-ying, GAO Cai-yun ,YANG Zhi-jun
creationdate20140000
lso0120140000
facets
frbrgroupid1244661963291629988
frbrtype6
creationdate2014
topic
0卵巢肿瘤
1Tm4sf1
2上皮性卵巢癌
3免疫组织化学
4Ovarian Neoplasm Tm4sf1 Epithelial Ovarian Cancer Immunohistochemistry
collection维普资讯 (Chongqing VIP Information Co.)
prefilterarticles
rsrctypearticles
creatorcontrib
0刘慧敏
1俸艳英
2高彩云
3阳志军
4LIU Hui-min , FENG Yan-ying, GAO Cai-yun ,YANG Zhi-jun
jtitle
0中国癌症防治杂志
1Journal of Chinese Medical Abstracts·Oncology
delivery
delcategoryRemote Search Resource
fulltextno_fulltext
addata
au
0刘慧敏
1俸艳英
2高彩云
3阳志军
4LIU Hui-min , FENG Yan-ying, GAO Cai-yun ,YANG Zhi-jun
atitleTM4SF1蛋白在上皮性卵巢癌组织中的表达及其临床意义 - Expression and clinical significance of TM4SF1 protein in epithelial ovarian cancer
jtitle中国癌症防治杂志
date2014
risdate2014
volume6
issue01
part85188A
spage20
epage24
issn1674-5671
coden85188A
formatjournal
genrearticle
ristypeJOUR
abstract
0目的 探讨跨膜四超家族成员1(transmembrane 4 super family 1,TM4SF1)蛋白在人卵巢组织中的表达及其与上皮性卵巢癌临床病理因素的关系。方法 采用免疫组化SP法检测16例正常卵巢上皮组织、23例上皮性卵巢良性肿瘤组织及55例上皮性卵巢癌癌组织中TM4SF1蛋白的表达情况,分析其与上皮性卵巢癌临床病理因素及预后的关系。结果 ①TM4SF1蛋白在上皮性卵巢癌癌组织中的阳性表达率(90.90%)高于上皮性卵巢良性肿瘤组织(65.22%)及正常卵巢上皮组织(25.00%)的阳性表达率,差异有统计学意义(P〈0.05)。②TM4SF1蛋白在正常卵巢上皮细胞中的表达主要位于上皮细胞的细胞膜和细胞膜近基底膜处及细胞质中,在卵巢良性肿瘤组织中的表达主要集中在肿瘤细胞的细胞膜近基底膜处及细胞膜其他部位,而在卵巢癌细胞中则主要分布于癌细胞的细胞质中。③Ⅲ~Ⅳ期卵巢癌患者TM4SF1蛋白的阳性表达率高于Ⅰ~Ⅱ期患者,中低分化癌患者TM4SF1蛋白的阳性表达率高于高分化癌患者(P〈0.05)。④TM4SF1蛋白的阳性表达率与组织学类型、腹水量的多少无明显相关(P〉0.05),而与FIGO分期及组织学分级明显相关(P〈0.05)。⑤Cox比例风险回归模型多因素分析显示TM4SF1蛋白在卵巢癌癌组织中的阳性表达不是影响患者生存的独立预后因素。结论 TM4SF1蛋白在上皮性卵巢癌癌组织中呈高表达,可能与卵巢癌的发生、发展相关。
1Objective To investigate the expression of transmembrane 4 super family 1(TM4SF1) protein in human ovarian tissues and its relationship with clinicopathological factors. Methods The SP immunohistochemical method was used to analyze the expression of TM4SF1 protein in 16 normal ovarian epithelial tissues, 23 benign ovarian tumor tissues and 55 epithelial ovarian cancer (EOC) tissues.Relationships of TM4SF1 expression with clinicopathological features of EOC and patient prognosis were analyzed. Result ①EOC tissues showed a significantly higher rate of TM4SF1 protein expression(90.90%)than did benign ovarian tumor tissues(65.22%)or normal ovarian epithelial tissues(25.00%,P〈0.05).②The TM4SF1 protein showed markedly different localizations in various tissue types. In normal ovarian epithelial tissues,the protein localized primarily to the membranes and the basal surface of epithelial cells as well as cytoplasts; in benign ovarian tumors, the protein was observed mainly on the basal surface and in certain parts of tumor cell membranes;in EOC tissues,TM4SF1 showed a mainly cytoplasmic staining.③ Rate of TM4SF1 protein expression was significantly higher in tissues of patients with stage Ⅲ-Ⅳ EOC than in patients with stage Ⅰ-Ⅱ disease(P〈0.05).The rate of TM4SF1 protein expression was also significantly higher in tissues showing low-to intermediate tumor differentiation than in well-differentiated carcinoma tissues(P〈0.05).④ Rate of TM4SF1 protein expression showed no significant association with histological type or amount of ascites (P〉0.05),but association with FIGO stage and histological grade(P〈0.05).⑤ Cox multivariate analysis showed that positive expression of TM4SF1 protein was not an independent prognostic factor. Conclusion TM4SF1 protein is overexpressed in EOC tissue,so it may be associated with the disease.
lad0185188A