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减低剂量LMP方案联合α2b-干扰素治疗老年多发性骨髓瘤乳酸脱氢酶数值变化分析 - The Analysis on LDH Levels in Elderly Patients with Multiple Myeloma Treated with Low Dose LMP in Combination with Interferon

目的:临床观察减低剂量的LMP方案联合干扰素治疗老年多发性骨髓瘤的疗效,并分析其对乳酸脱氢酶的影响。方法:选取2009年1月-2013年11月在我院血液科就诊的初发性老年多发性骨髓瘤患者58例,随机分为试验组和对照组,试验组给予雷利度胺10mg/d、d(1-21),马法兰6mg/d、d1-8,强的松50mg/d、d1-8,α2b-干扰素300万u、3次/周对照组给予马法兰4mg/(m2·d)、d1-7;强的松40mg/(m2·d)、d1-8,沙利度胺100mg/d持续口服。在治疗5个疗程后,进行近期疗效评价,并比较两组患者乳酸脱氢酶的水平。结果:治疗组29例患者中完全缓解5例,非常好的完全缓解... Full description

Journal Title: 世界最新医学信息文摘(电子版) - World Latest Medicine 2017, Vol.17(06), pp.1-2
Main Author: 柴铁
Other Authors: 刘庆荣 , 刘洪涛 , 李骏 , 刘艳春 , 李伟 , 高彩凤 , 史妍 , 王欢 , 陈曦 , Chai Tie, Liu Qing-rong, Liu Hong-tao, Li Jun, Liu Yan-chun, Li Wei, Gao Cai-feng, Shi Yan, Wang Huan, Chen Xi
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title: 减低剂量LMP方案联合α2b-干扰素治疗老年多发性骨髓瘤乳酸脱氢酶数值变化分析 - The Analysis on LDH Levels in Elderly Patients with Multiple Myeloma Treated with Low Dose LMP in Combination with Interferon
format: Article
creator:
  • 柴铁
  • 刘庆荣
  • 刘洪涛
  • 李骏
  • 刘艳春
  • 李伟
  • 高彩凤
  • 史妍
  • 王欢
  • 陈曦
  • Chai Tie, Liu Qing-rong, Liu Hong-tao, Li Jun, Liu Yan-chun, Li Wei, Gao Cai-feng, Shi Yan, Wang Huan, Chen Xi
subjects:
  • 雷利度胺
  • 干扰素
  • 多发性骨髓瘤
  • 乳酸脱氢酶
  • Lenalidomide
  • Interferon
  • Multiple Myeloma
  • Lactate Dehydrogenase
ispartof: 世界最新医学信息文摘(电子版) - World Latest Medicine, 2017, Vol.17(06), pp.1-2
description: 目的:临床观察减低剂量的LMP方案联合干扰素治疗老年多发性骨髓瘤的疗效,并分析其对乳酸脱氢酶的影响。方法:选取2009年1月-2013年11月在我院血液科就诊的初发性老年多发性骨髓瘤患者58例,随机分为试验组和对照组,试验组给予雷利度胺10mg/d、d(1-21),马法兰6mg/d、d1-8,强的松50mg/d、d1-8,α2b-干扰素300万u、3次/周对照组给予马法兰4mg/(m2·d)、d1-7;强的松40mg/(m2·d)、d1-8,沙利度胺100mg/d持续口服。在治疗5个疗程后,进行近期疗效评价,并比较两组患者乳酸脱氢酶的水平。结果:治疗组29例患者中完全缓解5例,非常好的完全缓解7例,部分缓解13例,疾病稳定3例,疾病进展1例;而对照组依次为3例、4例、10例、8例和4例。试验组总有效率(完全缓解+非常好的完全缓解+部分缓解)为86.2%,对照组总有效率58.6%,两者差异有统计学意义(χ2=5.524,P=0.019)。治疗前,两组患者的乳酸脱氢酶无明显差别(P〉0.05),治疗后,两组患者均明显下降(P〈0.05),且试验组比对照组下降更为明显(t=-2.701,P=0.009)。结论:减低剂量的LMP方案联合干扰素可显著降低乳酸脱氢酶水平,对老年多发性骨髓瘤具有良好的疗效。
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source: 维普数据 (Chongqing VIP Information Co.)
identifier: ISSN: 1671-3141
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  • 1671-3141
  • 16713141
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title减低剂量LMP方案联合α2b-干扰素治疗老年多发性骨髓瘤乳酸脱氢酶数值变化分析 - The Analysis on LDH Levels in Elderly Patients with Multiple Myeloma Treated with Low Dose LMP in Combination with Interferon
creator柴铁 ; 刘庆荣 ; 刘洪涛 ; 李骏 ; 刘艳春 ; 李伟 ; 高彩凤 ; 史妍 ; 王欢 ; 陈曦 ; Chai Tie, Liu Qing-rong, Liu Hong-tao, Li Jun, Liu Yan-chun, Li Wei, Gao Cai-feng, Shi Yan, Wang Huan, Chen Xi
ispartof世界最新医学信息文摘(电子版) - World Latest Medicine, 2017, Vol.17(06), pp.1-2
identifierISSN: 1671-3141
subject雷利度胺 ; 干扰素 ; 多发性骨髓瘤 ; 乳酸脱氢酶 ; Lenalidomide; Interferon; Multiple Myeloma; Lactate Dehydrogenase
description
0目的:临床观察减低剂量的LMP方案联合干扰素治疗老年多发性骨髓瘤的疗效,并分析其对乳酸脱氢酶的影响。方法:选取2009年1月-2013年11月在我院血液科就诊的初发性老年多发性骨髓瘤患者58例,随机分为试验组和对照组,试验组给予雷利度胺10mg/d、d(1-21),马法兰6mg/d、d1-8,强的松50mg/d、d1-8,α2b-干扰素300万u、3次/周对照组给予马法兰4mg/(m2·d)、d1-7;强的松40mg/(m2·d)、d1-8,沙利度胺100mg/d持续口服。在治疗5个疗程后,进行近期疗效评价,并比较两组患者乳酸脱氢酶的水平。结果:治疗组29例患者中完全缓解5例,非常好的完全缓解7例,部分缓解13例,疾病稳定3例,疾病进展1例;而对照组依次为3例、4例、10例、8例和4例。试验组总有效率(完全缓解+非常好的完全缓解+部分缓解)为86.2%,对照组总有效率58.6%,两者差异有统计学意义(χ2=5.524,P=0.019)。治疗前,两组患者的乳酸脱氢酶无明显差别(P〉0.05),治疗后,两组患者均明显下降(P〈0.05),且试验组比对照组下降更为明显(t=-2.701,P=0.009)。结论:减低剂量的LMP方案联合干扰素可显著降低乳酸脱氢酶水平,对老年多发性骨髓瘤具有良好的疗效。
1Objective: To observe the therapeutic effects of low dose lenalidomide in combination with interferon on patients with multiple myeloma, and analysis the changes of Lactate dehydrogenase (LDH). Methods: Select January 2009 - November 2013 in our hospital onset of the early onset of old age 58 patients with multiple myeloma were randomly divided into trial group and control group, Amine group give reilly degrees 10 mg/d, d1-21, horse flange 6 mg/d, d1-8, prednisone 50 me/d, d1-8, interferon alpha α2b 3 million U, 3 times per week; The control group given horse flange 4 mg/(m2.d),, d1-7; Prednisone 40 me/(m2.d), d1-8, Sally amine 100 mg/d for oral. In the treatment of after five cycles, the recent curative effect evaluation, and compare the two groups of patients with lactate dehydrogenase levels. Results: Treatment group 29 cases in patients with complete remission in 5 cases, very good complete remission in 7 cases, partial in 13 cases, stable disease (3 cases), 1 case of disease progression; While the control group, in turn, for the 3 cases, 4 cases, 10 cases, 8 cases and 4 cases. Treatment group total effective rate (complete response + very good complete response, partial response) was 86. 2%, control group total effectiveness 58.6%, the difference was statistically significant (Z:=5.524, P=0.019). There were no difference in LDH levels before treatment (P〉0.05), but they all decreased after treatment (P〈0.05). Lower than the control group and test group (t=2.701, P=0.009). Conclusions: Reduce the dose of LMP scheme combined interferon can significantly reduce the level of lactate dehydrogenase, multiple myeloma has good curative effect of the age.
relation作者单位: 唐山市工人医院血液科,河北唐山
source维普数据 (Chongqing VIP Information Co.)
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0柴铁
1刘庆荣
2刘洪涛
3李骏
4刘艳春
5李伟
6高彩凤
7史妍
8王欢
9陈曦
10Chai Tie, Liu Qing-rong, Liu Hong-tao, Li Jun, Liu Yan-chun, Li Wei, Gao Cai-feng, Shi Yan, Wang Huan, Chen Xi
11唐山市工人医院血液科,河北唐山
title
0减低剂量LMP方案联合α2b-干扰素治疗老年多发性骨髓瘤乳酸脱氢酶数值变化分析
1The Analysis on LDH Levels in Elderly Patients with Multiple Myeloma Treated with Low Dose LMP in Combination with Interferon
description
0目的:临床观察减低剂量的LMP方案联合干扰素治疗老年多发性骨髓瘤的疗效,并分析其对乳酸脱氢酶的影响。方法:选取2009年1月-2013年11月在我院血液科就诊的初发性老年多发性骨髓瘤患者58例,随机分为试验组和对照组,试验组给予雷利度胺10mg/d、d(1-21),马法兰6mg/d、d1-8,强的松50mg/d、d1-8,α2b-干扰素300万u、3次/周对照组给予马法兰4mg/(m2·d)、d1-7;强的松40mg/(m2·d)、d1-8,沙利度胺100mg/d持续口服。在治疗5个疗程后,进行近期疗效评价,并比较两组患者乳酸脱氢酶的水平。结果:治疗组29例患者中完全缓解5例,非常好的完全缓解7例,部分缓解13例,疾病稳定3例,疾病进展1例;而对照组依次为3例、4例、10例、8例和4例。试验组总有效率(完全缓解+非常好的完全缓解+部分缓解)为86.2%,对照组总有效率58.6%,两者差异有统计学意义(χ2=5.524,P=0.019)。治疗前,两组患者的乳酸脱氢酶无明显差别(P〉0.05),治疗后,两组患者均明显下降(P〈0.05),且试验组比对照组下降更为明显(t=-2.701,P=0.009)。结论:减低剂量的LMP方案联合干扰素可显著降低乳酸脱氢酶水平,对老年多发性骨髓瘤具有良好的疗效。
1Objective: To observe the therapeutic effects of low dose lenalidomide in combination with interferon on patients with multiple myeloma, and analysis the changes of Lactate dehydrogenase (LDH). Methods: Select January 2009 - November 2013 in our hospital onset of the early onset of old age 58 patients with multiple myeloma were randomly divided into trial group and control group, Amine group give reilly degrees 10 mg/d, d1-21, horse flange 6 mg/d, d1-8, prednisone 50 me/d, d1-8, interferon alpha α2b 3 million U, 3 times per week; The control group given horse flange 4 mg/(m2.d),, d1-7; Prednisone 40 me/(m2.d), d1-8, Sally amine 100 mg/d for oral. In the treatment of after five cycles, the recent curative effect evaluation, and compare the two groups of patients with lactate dehydrogenase levels. Results: Treatment group 29 cases in patients with complete remission in 5 cases, very good complete remission in 7 cases, partial in 13 cases, stable disease (3 cases), 1 case of disease progression; While the control group, in turn, for the 3 cases, 4 cases, 10 cases, 8 cases and 4 cases. Treatment group total effective rate (complete response + very good complete response, partial response) was 86. 2%, control group total effectiveness 58.6%, the difference was statistically significant (Z:=5.524, P=0.019). There were no difference in LDH levels before treatment (P〉0.05), but they all decreased after treatment (P〈0.05). Lower than the control group and test group (t=2.701, P=0.009). Conclusions: Reduce the dose of LMP scheme combined interferon can significantly reduce the level of lactate dehydrogenase, multiple myeloma has good curative effect of the age.
subject
0雷利度胺
1干扰素
2多发性骨髓瘤
3乳酸脱氢酶
4Lenalidomide
5Interferon
6Multiple Myeloma
7Lactate Dehydrogenase
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1维普数据 (Chongqing VIP Information Co.)
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0唐山市工人医院血液科,河北唐山
1Chai Tie, Liu Qing-rong, Liu Hong-tao, Li Jun, Liu Yan-chun, Li Wei, Gao Cai-feng, Shi Yan, Wang Huan, Chen Xi (Department of Hematology, Tangshan Worker's Hospital, Tangshan, Hebei, China)
citationpf 1 pt 2 vol 17 issue 06
sort
title减低剂量LMP方案联合α2b-干扰素治疗老年多发性骨髓瘤乳酸脱氢酶数值变化分析 - The Analysis on LDH Levels in Elderly Patients with Multiple Myeloma Treated with Low Dose LMP in Combination with Interferon
author柴铁 ; 刘庆荣 ; 刘洪涛 ; 李骏 ; 刘艳春 ; 李伟 ; 高彩凤 ; 史妍 ; 王欢 ; 陈曦 ; Chai Tie, Liu Qing-rong, Liu Hong-tao, Li Jun, Liu Yan-chun, Li Wei, Gao Cai-feng, Shi Yan, Wang Huan, Chen Xi
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0雷利度胺
1干扰素
2多发性骨髓瘤
3乳酸脱氢酶
4Lenalidomide; Interferon; Multiple Myeloma; Lactate Dehydrogenase
collection维普资讯 (Chongqing VIP Information Co.)
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0柴铁
1刘庆荣
2刘洪涛
3李骏
4刘艳春
5李伟
6高彩凤
7史妍
8王欢
9陈曦
10Chai Tie, Liu Qing-rong, Liu Hong-tao, Li Jun, Liu Yan-chun, Li Wei, Gao Cai-feng, Shi Yan, Wang Huan, Chen Xi
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0世界最新医学信息文摘(电子版)
1World Latest Medicine
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0柴铁
1刘庆荣
2刘洪涛
3李骏
4刘艳春
5李伟
6高彩凤
7史妍
8王欢
9陈曦
10Chai Tie, Liu Qing-rong, Liu Hong-tao, Li Jun, Liu Yan-chun, Li Wei, Gao Cai-feng, Shi Yan, Wang Huan, Chen Xi
atitle减低剂量LMP方案联合α2b-干扰素治疗老年多发性骨髓瘤乳酸脱氢酶数值变化分析 - The Analysis on LDH Levels in Elderly Patients with Multiple Myeloma Treated with Low Dose LMP in Combination with Interferon
jtitle世界最新医学信息文摘(电子版)
date2017
risdate2017
volume17
issue06
part71612X
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issn1671-3141
coden71612X
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abstract
0目的:临床观察减低剂量的LMP方案联合干扰素治疗老年多发性骨髓瘤的疗效,并分析其对乳酸脱氢酶的影响。方法:选取2009年1月-2013年11月在我院血液科就诊的初发性老年多发性骨髓瘤患者58例,随机分为试验组和对照组,试验组给予雷利度胺10mg/d、d(1-21),马法兰6mg/d、d1-8,强的松50mg/d、d1-8,α2b-干扰素300万u、3次/周对照组给予马法兰4mg/(m2·d)、d1-7;强的松40mg/(m2·d)、d1-8,沙利度胺100mg/d持续口服。在治疗5个疗程后,进行近期疗效评价,并比较两组患者乳酸脱氢酶的水平。结果:治疗组29例患者中完全缓解5例,非常好的完全缓解7例,部分缓解13例,疾病稳定3例,疾病进展1例;而对照组依次为3例、4例、10例、8例和4例。试验组总有效率(完全缓解+非常好的完全缓解+部分缓解)为86.2%,对照组总有效率58.6%,两者差异有统计学意义(χ2=5.524,P=0.019)。治疗前,两组患者的乳酸脱氢酶无明显差别(P〉0.05),治疗后,两组患者均明显下降(P〈0.05),且试验组比对照组下降更为明显(t=-2.701,P=0.009)。结论:减低剂量的LMP方案联合干扰素可显著降低乳酸脱氢酶水平,对老年多发性骨髓瘤具有良好的疗效。
1Objective: To observe the therapeutic effects of low dose lenalidomide in combination with interferon on patients with multiple myeloma, and analysis the changes of Lactate dehydrogenase (LDH). Methods: Select January 2009 - November 2013 in our hospital onset of the early onset of old age 58 patients with multiple myeloma were randomly divided into trial group and control group, Amine group give reilly degrees 10 mg/d, d1-21, horse flange 6 mg/d, d1-8, prednisone 50 me/d, d1-8, interferon alpha α2b 3 million U, 3 times per week; The control group given horse flange 4 mg/(m2.d),, d1-7; Prednisone 40 me/(m2.d), d1-8, Sally amine 100 mg/d for oral. In the treatment of after five cycles, the recent curative effect evaluation, and compare the two groups of patients with lactate dehydrogenase levels. Results: Treatment group 29 cases in patients with complete remission in 5 cases, very good complete remission in 7 cases, partial in 13 cases, stable disease (3 cases), 1 case of disease progression; While the control group, in turn, for the 3 cases, 4 cases, 10 cases, 8 cases and 4 cases. Treatment group total effective rate (complete response + very good complete response, partial response) was 86. 2%, control group total effectiveness 58.6%, the difference was statistically significant (Z:=5.524, P=0.019). There were no difference in LDH levels before treatment (P〉0.05), but they all decreased after treatment (P〈0.05). Lower than the control group and test group (t=2.701, P=0.009). Conclusions: Reduce the dose of LMP scheme combined interferon can significantly reduce the level of lactate dehydrogenase, multiple myeloma has good curative effect of the age.
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