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Alternation of monocyte function in patients with obstructive jaundice

Patients with obstructive jaundice have a high susceptibility to infection in the process of treatment and the reason for this is not fully understood. It was postulated that it may bear some relations to abnormalities of immune function. In this article, 28 cases of obstructive jaundice were select... Full description

Journal Title: Journal of Tongji Medical University 12/1995, Vol.15(4), pp.238-241
Main Author: Xian-Zhong, Ding
Other Authors: Shu-Tao, Xiong , Hua, Li , Shou-Xi, Zhang , Kun-Zhang, Lü
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0257-716X ; DOI: http://dx.doi.org/10.1007/BF02887954
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recordid: crossref10.1007/BF02887954
title: Alternation of monocyte function in patients with obstructive jaundice
format: Article
creator:
  • Xian-Zhong, Ding
  • Shu-Tao, Xiong
  • Hua, Li
  • Shou-Xi, Zhang
  • Kun-Zhang, Lü
subjects:
  • Cholestasis, Extrahepatic -- Immunology
  • Monocytes -- Immunology
ispartof: Journal of Tongji Medical University, 12/1995, Vol.15(4), pp.238-241
description: Patients with obstructive jaundice have a high susceptibility to infection in the process of treatment and the reason for this is not fully understood. It was postulated that it may bear some relations to abnormalities of immune function. In this article, 28 cases of obstructive jaundice were selected to investigate alternation of monocyte immune function with the purpose of exploring mechanism of high susceptibility to infection from the perspective of immunology. The results showed that interleukin 1 production by monocytes significantly decreased and prostaglandin E2 increased, HLA-DR expression of monocytes was remarkably depressed. HLA-DR expression of monocytes was further decreased with recovery slower than non-jaundiced patients after operation. All this may be responsible for high susceptibility to infection in the process of treatment of obstructive jaundice.
language: eng
source:
identifier: ISSN: 0257-716X ; DOI: http://dx.doi.org/10.1007/BF02887954
fulltext: no_fulltext
issn:
  • 0257716X
  • 0257-716X
url: Link


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descriptionPatients with obstructive jaundice have a high susceptibility to infection in the process of treatment and the reason for this is not fully understood. It was postulated that it may bear some relations to abnormalities of immune function. In this article, 28 cases of obstructive jaundice were selected to investigate alternation of monocyte immune function with the purpose of exploring mechanism of high susceptibility to infection from the perspective of immunology. The results showed that interleukin 1 production by monocytes significantly decreased and prostaglandin E2 increased, HLA-DR expression of monocytes was remarkably depressed. HLA-DR expression of monocytes was further decreased with recovery slower than non-jaundiced patients after operation. All this may be responsible for high susceptibility to infection in the process of treatment of obstructive jaundice.
subjectCholestasis, Extrahepatic -- Immunology ; Monocytes -- Immunology;
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