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Immunoglobulins drive terminal maturation of splenic dendritic cells

Nature and physiological status of antigen-presenting cells, such as dendritic cells DCs, are decisive for the immune reactions elicited. Multiple factors and cell interactions have been described that affect maturation of DCs. Here, we show that DCs arising in the absence of immunoglobulins (Ig) in... Full description

Journal Title: Proceedings of the National Academy of Sciences 02/05/2013, Vol.110(6), pp.2282-2287
Main Author: Zietara, N.
Other Authors: Lyszkiewicz, M. , Puchalka, J. , Pei, G. , Gutierrez, M. G. , Lienenklaus, S. , Hobeika, E. , Reth, M. , Martins Dos Santos, V. A. P. , Krueger, A. , Weiss, S.
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 0027-8424 ; E-ISSN: 1091-6490 ; DOI: http://dx.doi.org/10.1073/pnas.1210654110
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recordid: crossref10.1073/pnas.1210654110
title: Immunoglobulins drive terminal maturation of splenic dendritic cells
format: Article
creator:
  • Zietara, N.
  • Lyszkiewicz, M.
  • Puchalka, J.
  • Pei, G.
  • Gutierrez, M. G.
  • Lienenklaus, S.
  • Hobeika, E.
  • Reth, M.
  • Martins Dos Santos, V. A. P.
  • Krueger, A.
  • Weiss, S.
subjects:
  • Sciences (General)
ispartof: Proceedings of the National Academy of Sciences, 02/05/2013, Vol.110(6), pp.2282-2287
description: Nature and physiological status of antigen-presenting cells, such as dendritic cells DCs, are decisive for the immune reactions elicited. Multiple factors and cell interactions have been described that affect maturation of DCs. Here, we show that DCs arising in the absence of immunoglobulins (Ig) in vivo are impaired in crosspresentation of soluble antigen. This deficiency was due to aberrant cellular targeting of antigen to lysosomes and its rapid degradation. Function of DCs could be restored by transfer of Ig irrespective of antigen specificity and isotype. Modulation of cross-presentation by Ig was inhibited by coapplication of mannan and, thus, likely to be mediated by C-type lectin receptors. This unexpected dependency of splenic DCs on Ig to cross-present antigen provides insights into the interplay between cellular and humoral immunity and the immunomodulatory capacity of Ig.
language: eng
source:
identifier: ISSN: 0027-8424 ; E-ISSN: 1091-6490 ; DOI: http://dx.doi.org/10.1073/pnas.1210654110
fulltext: fulltext
issn:
  • 00278424
  • 0027-8424
  • 10916490
  • 1091-6490
url: Link


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Nature and physiological status of antigen-presenting cells, such as dendritic cells DCs, are decisive for the immune reactions elicited. Multiple factors and cell interactions have been described that affect maturation of DCs. Here, we show that DCs arising in the absence of immunoglobulins (Ig) in vivo are impaired in crosspresentation of soluble antigen. This deficiency was due to aberrant cellular targeting of antigen to lysosomes and its rapid degradation. Function of DCs could be restored by transfer of Ig irrespective of antigen specificity and isotype. Modulation of cross-presentation by Ig was inhibited by coapplication of mannan and, thus, likely to be mediated by C-type lectin receptors. This unexpected dependency of splenic DCs on Ig to cross-present antigen provides insights into the interplay between cellular and humoral immunity and the immunomodulatory capacity of Ig.

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date2013-02-05