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Transcutaneous Ultrasound Augments Lysis of Arterial Thrombi In Vivo

External ultrasound has a synergistic effect on thrombus disruption with thrombolytic agents in vitro. We hypothesized that transcutaneous ultrasound could augment thrombolysis in vivo. Thrombus formation was induced electrically in 48 pairs of iliofemoral arteries of 24 rabbits; arterial occlusions... Full description

Journal Title: Circulation 08/15/1996, Vol.94(4), pp.775-778
Main Author: Luo, Huai
Other Authors: Nishioka, Toshihiko , Fishbein, Michael C. , Cercek, Bojan , Forrester, James S. , Kim, Chong-Jin , Berglund, Hans , Siegel, Robert J.
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0009-7322 ; E-ISSN: 1524-4539 ; DOI: http://dx.doi.org/10.1161/01.CIR.94.4.775
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recordid: crossref10.1161/01.CIR.94.4.775
title: Transcutaneous Ultrasound Augments Lysis of Arterial Thrombi In Vivo
format: Article
creator:
  • Luo, Huai
  • Nishioka, Toshihiko
  • Fishbein, Michael C.
  • Cercek, Bojan
  • Forrester, James S.
  • Kim, Chong-Jin
  • Berglund, Hans
  • Siegel, Robert J.
subjects:
  • Femoral Artery
  • Iliac Artery
  • Ultrasonic Therapy
  • Fibrinolytic Agents -- Therapeutic Use
  • Streptokinase -- Therapeutic Use
  • Thrombosis -- Therapy
ispartof: Circulation, 08/15/1996, Vol.94(4), pp.775-778
description: External ultrasound has a synergistic effect on thrombus disruption with thrombolytic agents in vitro. We hypothesized that transcutaneous ultrasound could augment thrombolysis in vivo. Thrombus formation was induced electrically in 48 pairs of iliofemoral arteries of 24 rabbits; arterial occlusions were documented angiographically. In 17 of 24 rabbits, 25000 units/kg streptokinase was then administered intravenously. The pairs of iliofemoral arteries were randomized to receive ultrasound treatment or no ultrasound treatment. Low-frequency (26 kHz) ultrasound (continuous wave, 18 W/cm2) was applied transcutaneously over the area of occlusion. In 7 of 24 rabbits, 14 thrombotically occluded iliofemoral arteries were exposed to ultrasound alone without streptokinase. The results were evaluated through the use of angiography (TIMI grade flow) and histopathology. After 30 +/- 10 minutes of activated sonication combined with intravenous streptokinase, 10 of 17 iliofemoral arteries (59%) treated with transcutaneous ultrasound were widely patent angiographically, with TIMI grade 3 flow. Histologically, the patent arteries had only minimal focal moral thrombus. The angiographic... In vivo transcutaneous ultrasound significantly augments lysis of thrombi with streptokinase in rabbit iliofemoral arteries.
language: eng
source:
identifier: ISSN: 0009-7322 ; E-ISSN: 1524-4539 ; DOI: http://dx.doi.org/10.1161/01.CIR.94.4.775
fulltext: fulltext
issn:
  • 00097322
  • 0009-7322
  • 15244539
  • 1524-4539
url: Link


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descriptionExternal ultrasound has a synergistic effect on thrombus disruption with thrombolytic agents in vitro. We hypothesized that transcutaneous ultrasound could augment thrombolysis in vivo. Thrombus formation was induced electrically in 48 pairs of iliofemoral arteries of 24 rabbits; arterial occlusions were documented angiographically. In 17 of 24 rabbits, 25000 units/kg streptokinase was then administered intravenously. The pairs of iliofemoral arteries were randomized to receive ultrasound treatment or no ultrasound treatment. Low-frequency (26 kHz) ultrasound (continuous wave, 18 W/cm2) was applied transcutaneously over the area of occlusion. In 7 of 24 rabbits, 14 thrombotically occluded iliofemoral arteries were exposed to ultrasound alone without streptokinase. The results were evaluated through the use of angiography (TIMI grade flow) and histopathology. After 30 +/- 10 minutes of activated sonication combined with intravenous streptokinase, 10 of 17 iliofemoral arteries (59%) treated with transcutaneous ultrasound were widely patent angiographically, with TIMI grade 3 flow. Histologically, the patent arteries had only minimal focal moral thrombus. The angiographic... In vivo transcutaneous ultrasound significantly augments lysis of thrombi with streptokinase in rabbit iliofemoral arteries.
subjectFemoral Artery ; Iliac Artery ; Ultrasonic Therapy ; Fibrinolytic Agents -- Therapeutic Use ; Streptokinase -- Therapeutic Use ; Thrombosis -- Therapy;
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