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Subacute Thrombosis and Vascular Injury Resulting From Slotted-Tube Nitinol and Stainless Steel Stents in a Rabbit Carotid Artery Model

BACKGROUNDOur objectives were to quantify the thrombogenicity and extent of vascular injury created by slotted-tube geometry stainless steel and nitinol coronary stents in a rabbit carotid artery model. METHODS AND RESULTSStents were implanted in rabbit right carotid arteries without antiplatelet th... Full description

Journal Title: Circulation 10/1996, Vol.94(7), pp.1733-1740
Main Author: Sheth, Sushil
Other Authors: Litvack, Frank , Dev, Vishva , Fishbein, Michael C. , Forrester, James S. , Eigler, Neal
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0009-7322 ; E-ISSN: 1524-4539 ; DOI: http://dx.doi.org/10.1161/01.CIR.94.7.1733
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recordid: crossref10.1161/01.CIR.94.7.1733
title: Subacute Thrombosis and Vascular Injury Resulting From Slotted-Tube Nitinol and Stainless Steel Stents in a Rabbit Carotid Artery Model
format: Article
creator:
  • Sheth, Sushil
  • Litvack, Frank
  • Dev, Vishva
  • Fishbein, Michael C.
  • Forrester, James S.
  • Eigler, Neal
subjects:
  • Acute Disease–Pathology
  • Alloys–Etiology
  • Animals–Pathology
  • Carotid Arteries–Adverse Effects
  • Carotid Artery Injuries–Pathology
  • Carotid Artery Thrombosis–Etiology
  • Equipment Design–Etiology
  • Male–Etiology
  • Microscopy, Electron, Scanning–Etiology
  • Necrosis–Etiology
  • Rabbits–Etiology
  • Stainless Steel–Etiology
  • Stents–Etiology
  • Tunica Media–Etiology
  • Wounds and Injuries–Etiology
  • Abridged
  • Alloys
  • Stainless Steel
  • Nitinol
ispartof: Circulation, 10/1996, Vol.94(7), pp.1733-1740
description: BACKGROUNDOur objectives were to quantify the thrombogenicity and extent of vascular injury created by slotted-tube geometry stainless steel and nitinol coronary stents in a rabbit carotid artery model. METHODS AND RESULTSStents were implanted in rabbit right carotid arteries without antiplatelet therapy. Stainless steel stents were implanted for 4 days while nitinol stents were placed for 4 and 14 days (n = 8, 8, and 6, respectively). Stent thrombosis was assessed by thrombus weight, grading thrombus encroachment of the lumen, and by blood flow in the stented and contralateral arteries. Stainless steel stents at 4 days contained more thrombus than 4- and 14-day nitinol stents (20.0 +/- 5.9 versus 2.5 +/- 0.6 and 2.7 +/- 0.3 mg, respectively; P < .000001). Stainless steel stents were more often occluded by thrombus (6 of 8) or contained more subocclusive thrombus (2 of 8) than nitinol stents (0 of 14, P < .002). Resting blood flow was reduced in arteries with stainless steel stents compared with 4- and 14-day nitinol stents (1.5 +/- 2.8 versus 24.0 +/- 2.0 and 25.5 +/- 1.9 mL/min, respectively, P < .000001). Stainless steel stents were less uniformly expanded, had deeper strut penetration into the vascular wall, and were associated with more extensive medial smooth muscle cell necrosis. There were strong correlations (r = .77 to .95) between variables of thrombosis extent (thrombus weight and grade) and histologically determined vascular injury (strut penetration and medial necrosis). CONCLUSIONSSlotted-tube stainless steel stents were more thrombogenic and created more extensive vascular injury than nitinol stents in a rabbit carotid artery model. The mechanisms underlying these differences probably are related to metallurgic and design geometry properties of the two stent types.
language: eng
source:
identifier: ISSN: 0009-7322 ; E-ISSN: 1524-4539 ; DOI: http://dx.doi.org/10.1161/01.CIR.94.7.1733
fulltext: fulltext
issn:
  • 00097322
  • 0009-7322
  • 15244539
  • 1524-4539
url: Link


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titleSubacute Thrombosis and Vascular Injury Resulting From Slotted-Tube Nitinol and Stainless Steel Stents in a Rabbit Carotid Artery Model
creatorSheth, Sushil ; Litvack, Frank ; Dev, Vishva ; Fishbein, Michael C. ; Forrester, James S. ; Eigler, Neal
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descriptionBACKGROUNDOur objectives were to quantify the thrombogenicity and extent of vascular injury created by slotted-tube geometry stainless steel and nitinol coronary stents in a rabbit carotid artery model. METHODS AND RESULTSStents were implanted in rabbit right carotid arteries without antiplatelet therapy. Stainless steel stents were implanted for 4 days while nitinol stents were placed for 4 and 14 days (n = 8, 8, and 6, respectively). Stent thrombosis was assessed by thrombus weight, grading thrombus encroachment of the lumen, and by blood flow in the stented and contralateral arteries. Stainless steel stents at 4 days contained more thrombus than 4- and 14-day nitinol stents (20.0 +/- 5.9 versus 2.5 +/- 0.6 and 2.7 +/- 0.3 mg, respectively; P < .000001). Stainless steel stents were more often occluded by thrombus (6 of 8) or contained more subocclusive thrombus (2 of 8) than nitinol stents (0 of 14, P < .002). Resting blood flow was reduced in arteries with stainless steel stents compared with 4- and 14-day nitinol stents (1.5 +/- 2.8 versus 24.0 +/- 2.0 and 25.5 +/- 1.9 mL/min, respectively, P < .000001). Stainless steel stents were less uniformly expanded, had deeper strut penetration into the vascular wall, and were associated with more extensive medial smooth muscle cell necrosis. There were strong correlations (r = .77 to .95) between variables of thrombosis extent (thrombus weight and grade) and histologically determined vascular injury (strut penetration and medial necrosis). CONCLUSIONSSlotted-tube stainless steel stents were more thrombogenic and created more extensive vascular injury than nitinol stents in a rabbit carotid artery model. The mechanisms underlying these differences probably are related to metallurgic and design geometry properties of the two stent types.
subjectAcute Disease–Pathology ; Alloys–Etiology ; Animals–Pathology ; Carotid Arteries–Adverse Effects ; Carotid Artery Injuries–Pathology ; Carotid Artery Thrombosis–Etiology ; Equipment Design–Etiology ; Male–Etiology ; Microscopy, Electron, Scanning–Etiology ; Necrosis–Etiology ; Rabbits–Etiology ; Stainless Steel–Etiology ; Stents–Etiology ; Tunica Media–Etiology ; Wounds and Injuries–Etiology ; Abridged ; Alloys ; Stainless Steel ; Nitinol;
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