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Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial

Background: Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance. However, no previous epidemiological studies have eva... Full description

Journal Title: Tresserra-Rimbau A., E. B. Rimm, A. Medina-Remón, M. A. Martínez-González, M. C. López-Sabater, M. I. Covas, D. Corella, et al. 2014. “Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial.” BMC Medicine 12 (1): 77. doi:10.1186/1741-7015-12-77. http://dx.doi.org/10.1186/1741-7015-12-77.
Main Author: Tresserra-Rimbau, Anna
Other Authors: Rimm, Eric B , Medina-Remón, Alexander , Martínez-González, Miguel A , López-Sabater, M Carmen , Covas, María I , Corella, Dolores , Salas-Salvadó, Jordi , Gómez-Gracia, Enrique , Lapetra, José , Arós, Fernando , Fiol, Miquel , Ros, Emili , Serra-Majem, Lluis , Pintó, Xavier , Muñoz, Miguel A , Gea, Alfredo , Ruiz-Gutiérrez, Valentina , Estruch, Ramón , Lamuela-Raventós, Rosa M
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 1741-7015 ; DOI: 10.1186/1741-7015-12-77
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title: Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial
format: Article
creator:
  • Tresserra-Rimbau, Anna
  • Rimm, Eric B
  • Medina-Remón, Alexander
  • Martínez-González, Miguel A
  • López-Sabater, M Carmen
  • Covas, María I
  • Corella, Dolores
  • Salas-Salvadó, Jordi
  • Gómez-Gracia, Enrique
  • Lapetra, José
  • Arós, Fernando
  • Fiol, Miquel
  • Ros, Emili
  • Serra-Majem, Lluis
  • Pintó, Xavier
  • Muñoz, Miguel A
  • Gea, Alfredo
  • Ruiz-Gutiérrez, Valentina
  • Estruch, Ramón
  • Lamuela-Raventós, Rosa M
subjects:
  • Polyphenol Intake
  • All-Cause Mortality
  • Predimed
  • Mediterranean Diet
  • Stilbenes
  • Lignans
ispartof: Tresserra-Rimbau, A., E. B. Rimm, A. Medina-Remón, M. A. Martínez-González, M. C. López-Sabater, M. I. Covas, D. Corella, et al. 2014. “Polyphenol intake and mortality risk: a re-analysis of the PREDIMED trial.” BMC Medicine 12 (1): 77. doi:10.1186/1741-7015-12-77. http://dx.doi.org/10.1186/1741-7015-12-77.
description: Background: Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance. However, no previous epidemiological studies have evaluated the relationship between the intake of total polyphenols intake and polyphenol subclasses with overall mortality. Our aim was to evaluate whether polyphenol intake is associated with all-cause mortality in subjects at high cardiovascular risk. Methods: We used data from the PREDIMED study, a 7,447-participant, parallel-group, randomized, multicenter, controlled five-year feeding trial aimed at assessing the effects of the Mediterranean Diet in primary prevention of cardiovascular disease. Polyphenol intake was calculated by matching food consumption data from repeated food frequency questionnaires (FFQ) with the Phenol-Explorer database on the polyphenol content of each reported food. Hazard ratios (HR) and 95% confidence intervals (CI) between polyphenol intake and mortality were estimated using time-dependent Cox proportional hazard models. Results: Over an average of 4.8 years of follow-up, we observed 327 deaths. After multivariate adjustment, we found a 37% relative reduction in all-cause mortality comparing the highest versus the lowest quintiles of total polyphenol intake (hazard ratio (HR) = 0.63; 95% CI 0.41 to 0.97; P for trend = 0.12). Among the polyphenol subclasses, stilbenes and lignans were significantly associated with reduced all-cause mortality (HR =0.48; 95% CI 0.25 to 0.91; P for trend = 0.04 and HR = 0.60; 95% CI 0.37 to 0.97; P for trend = 0.03, respectively), with no significant associations apparent in the rest (flavonoids or phenolic acids). Conclusions: Among high-risk subjects, those who reported a high polyphenol intake, especially of stilbenes and lignans, showed a reduced risk of overall mortality compared to those with lower intakes. These results may be useful to determine optimal polyphenol intake or specific food sources of polyphenols that may reduce the risk of all-cause mortality. Clinical trial registration ISRCTN35739639.
language: eng
source:
identifier: ISSN: 1741-7015 ; DOI: 10.1186/1741-7015-12-77
fulltext: fulltext_linktorsrc
issn:
  • 1741-7015
  • 17417015
url: Link


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titlePolyphenol intake and mortality risk: a re-analysis of the PREDIMED trial
creatorTresserra-Rimbau, Anna ; Rimm, Eric B ; Medina-Remón, Alexander ; Martínez-González, Miguel A ; López-Sabater, M Carmen ; Covas, María I ; Corella, Dolores ; Salas-Salvadó, Jordi ; Gómez-Gracia, Enrique ; Lapetra, José ; Arós, Fernando ; Fiol, Miquel ; Ros, Emili ; Serra-Majem, Lluis ; Pintó, Xavier ; Muñoz, Miguel A ; Gea, Alfredo ; Ruiz-Gutiérrez, Valentina ; Estruch, Ramón ; Lamuela-Raventós, Rosa M
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identifierISSN: 1741-7015 ; DOI: 10.1186/1741-7015-12-77
subjectPolyphenol Intake ; All-Cause Mortality ; Predimed ; Mediterranean Diet ; Stilbenes ; Lignans
descriptionBackground: Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance. However, no previous epidemiological studies have evaluated the relationship between the intake of total polyphenols intake and polyphenol subclasses with overall mortality. Our aim was to evaluate whether polyphenol intake is associated with all-cause mortality in subjects at high cardiovascular risk. Methods: We used data from the PREDIMED study, a 7,447-participant, parallel-group, randomized, multicenter, controlled five-year feeding trial aimed at assessing the effects of the Mediterranean Diet in primary prevention of cardiovascular disease. Polyphenol intake was calculated by matching food consumption data from repeated food frequency questionnaires (FFQ) with the Phenol-Explorer database on the polyphenol content of each reported food. Hazard ratios (HR) and 95% confidence intervals (CI) between polyphenol intake and mortality were estimated using time-dependent Cox proportional hazard models. Results: Over an average of 4.8 years of follow-up, we observed 327 deaths. After multivariate adjustment, we found a 37% relative reduction in all-cause mortality comparing the highest versus the lowest quintiles of total polyphenol intake (hazard ratio (HR) = 0.63; 95% CI 0.41 to 0.97; P for trend = 0.12). Among the polyphenol subclasses, stilbenes and lignans were significantly associated with reduced all-cause mortality (HR =0.48; 95% CI 0.25 to 0.91; P for trend = 0.04 and HR = 0.60; 95% CI 0.37 to 0.97; P for trend = 0.03, respectively), with no significant associations apparent in the rest (flavonoids or phenolic acids). Conclusions: Among high-risk subjects, those who reported a high polyphenol intake, especially of stilbenes and lignans, showed a reduced risk of overall mortality compared to those with lower intakes. These results may be useful to determine optimal polyphenol intake or specific food sources of polyphenols that may reduce the risk of all-cause mortality. Clinical trial registration ISRCTN35739639.
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19Lamuela-Raventós, Rosa M
titlePolyphenol intake and mortality risk: a re-analysis of the PREDIMED trial
descriptionBackground: Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance. However, no previous epidemiological studies have evaluated the relationship between the intake of total polyphenols intake and polyphenol subclasses with overall mortality. Our aim was to evaluate whether polyphenol intake is associated with all-cause mortality in subjects at high cardiovascular risk. Methods: We used data from the PREDIMED study, a 7,447-participant, parallel-group, randomized, multicenter, controlled five-year feeding trial aimed at assessing the effects of the Mediterranean Diet in primary prevention of cardiovascular disease. Polyphenol intake was calculated by matching food consumption data from repeated food frequency questionnaires (FFQ) with the Phenol-Explorer database on the polyphenol content of each reported food. Hazard ratios (HR) and 95% confidence intervals (CI) between polyphenol intake and mortality were estimated using time-dependent Cox proportional hazard models. Results: Over an average of 4.8 years of follow-up, we observed 327 deaths. After multivariate adjustment, we found a 37% relative reduction in all-cause mortality comparing the highest versus the lowest quintiles of total polyphenol intake (hazard ratio (HR) = 0.63; 95% CI 0.41 to 0.97; P for trend = 0.12). Among the polyphenol subclasses, stilbenes and lignans were significantly associated with reduced all-cause mortality (HR =0.48; 95% CI 0.25 to 0.91; P for trend = 0.04 and HR = 0.60; 95% CI 0.37 to 0.97; P for trend = 0.03, respectively), with no significant associations apparent in the rest (flavonoids or phenolic acids). Conclusions: Among high-risk subjects, those who reported a high polyphenol intake, especially of stilbenes and lignans, showed a reduced risk of overall mortality compared to those with lower intakes. These results may be useful to determine optimal polyphenol intake or specific food sources of polyphenols that may reduce the risk of all-cause mortality. Clinical trial registration ISRCTN35739639.
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titlePolyphenol intake and mortality risk: a re-analysis of the PREDIMED trial
authorTresserra-Rimbau, Anna ; Rimm, Eric B ; Medina-Remón, Alexander ; Martínez-González, Miguel A ; López-Sabater, M Carmen ; Covas, María I ; Corella, Dolores ; Salas-Salvadó, Jordi ; Gómez-Gracia, Enrique ; Lapetra, José ; Arós, Fernando ; Fiol, Miquel ; Ros, Emili ; Serra-Majem, Lluis ; Pintó, Xavier ; Muñoz, Miguel A ; Gea, Alfredo ; Ruiz-Gutiérrez, Valentina ; Estruch, Ramón ; Lamuela-Raventós, Rosa M
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9Lapetra, José
10Arós, Fernando
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13Serra-Majem, Lluis
14Pintó, Xavier
15Muñoz, Miguel A
16Gea, Alfredo
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atitlePolyphenol intake and mortality risk: a re-analysis of the PREDIMED trial
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abstractBackground: Polyphenols may lower the risk of cardiovascular disease (CVD) and other chronic diseases due to their antioxidant and anti-inflammatory properties, as well as their beneficial effects on blood pressure, lipids and insulin resistance. However, no previous epidemiological studies have evaluated the relationship between the intake of total polyphenols intake and polyphenol subclasses with overall mortality. Our aim was to evaluate whether polyphenol intake is associated with all-cause mortality in subjects at high cardiovascular risk. Methods: We used data from the PREDIMED study, a 7,447-participant, parallel-group, randomized, multicenter, controlled five-year feeding trial aimed at assessing the effects of the Mediterranean Diet in primary prevention of cardiovascular disease. Polyphenol intake was calculated by matching food consumption data from repeated food frequency questionnaires (FFQ) with the Phenol-Explorer database on the polyphenol content of each reported food. Hazard ratios (HR) and 95% confidence intervals (CI) between polyphenol intake and mortality were estimated using time-dependent Cox proportional hazard models. Results: Over an average of 4.8 years of follow-up, we observed 327 deaths. After multivariate adjustment, we found a 37% relative reduction in all-cause mortality comparing the highest versus the lowest quintiles of total polyphenol intake (hazard ratio (HR) = 0.63; 95% CI 0.41 to 0.97; P for trend = 0.12). Among the polyphenol subclasses, stilbenes and lignans were significantly associated with reduced all-cause mortality (HR =0.48; 95% CI 0.25 to 0.91; P for trend = 0.04 and HR = 0.60; 95% CI 0.37 to 0.97; P for trend = 0.03, respectively), with no significant associations apparent in the rest (flavonoids or phenolic acids). Conclusions: Among high-risk subjects, those who reported a high polyphenol intake, especially of stilbenes and lignans, showed a reduced risk of overall mortality compared to those with lower intakes. These results may be useful to determine optimal polyphenol intake or specific food sources of polyphenols that may reduce the risk of all-cause mortality. Clinical trial registration ISRCTN35739639.
pubBioMed Central
doi10.1186/1741-7015-12-77
urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4102266/pdf/
issue1
pages77
volume12
oafree_for_read
date2014-05-13