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Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and... Full description

Journal Title: Paternoster L., M. Standl, J. Waage, H. Baurecht, M. Hotze, D. P. Strachan, J. A. Curtin, et al. 2015. “Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.” Nature genetics 47 (12): 1449-1456. doi:10.1038/ng.3424. http://dx.doi.org/10.1038/ng.3424.
Main Author: Paternoster, Lavinia
Other Authors: Standl, Marie , Waage, Johannes , Baurecht, Hansjörg , Hotze, Melanie , Strachan, David P , Curtin, John A , Bønnelykke, Klaus , Tian, Chao , Takahashi, Atsushi , Esparza-Gordillo, Jorge , Alves, Alexessander Couto , Thyssen, Jacob P , Den Dekker, Herman T , Ferreira, Manuel A , Altmaier, Elisabeth , Sleiman, Patrick Ma , Xiao, Feng Li , Gonzalez, Juan R , Marenholz, Ingo , Kalb, Birgit , Yanes, Maria Pino , Xu, Cheng-Jian , Carstensen, Lisbeth , Groen-Blokhuis, Maria M , Venturini, Cristina , Pennell, Craig E , Barton, Sheila J , Levin, Albert M , Curjuric, Ivan , Bustamante, Mariona , Kreiner-Møller, Eskil , Lockett, Gabrielle A , Bacelis, Jonas , Bunyavanich, Supinda , Myers, Rachel A , Matanovic, Anja , Kumar, Ashish , Tung, Joyce Y , Hirota, Tomomitsu , Kubo, Michiaki , Mcardle, Wendy L , Henderson, A J , Kemp, John P , Zheng, Jie , Smith, George Davey , Rüschendorf, Franz , Bauerfeind, Anja , Lee-Kirsch, Min Ae , Arnold, Andreas , Homuth, Georg , Schmidt, Carsten O , Mangold, Elisabeth , Cichon, Sven , Keil, Thomas , Rodríguez, Elke , Peters, Annette , Franke, Andre , Lieb, Wolfgang , Novak, Natalija , Fölster-Holst, Regina , Horikoshi, Momoko , Pekkanen, Juha , Sebert, Sylvain , Husemoen, Lise L , Grarup, Niels , De Jongste, Johan C , Rivadeneira, Fernando , Hofman, Albert , Jaddoe, Vincent Wv , Pasmans, Suzanne Gma , Elbert, Niels J , Uitterlinden, André G , Marks, Guy B , Thompson, Philip J , Matheson, Melanie C , Robertson, Colin F , Ried, Janina S , Li, Jin , Zuo, Xian Bo , Zheng, Xiao Dong , Yin, Xian Yong , Sun, Liang Dan , Mcaleer, Maeve A , O'Regan, Grainne M , Fahy, Caoimhe Mr , Campbell, Linda E , Macek, Milan , Kurek, Michael , Hu, Donglei , Eng, Celeste , Postma, Dirkje S , Feenstra, Bjarke , Geller, Frank , Hottenga, Jouke Jan , Middeldorp, Christel M , Hysi, Pirro , Bataille, Veronique , Spector, Tim , Tiesler, Carla Mt , Thiering, Elisabeth , Pahukasahasram, Badri , Yang, James J , Imboden, Medea , Huntsman, Scott , Vilor-Tejedor, Natàlia , Relton, Caroline L , Myhre, Ronny , Nystad, Wenche , Custovic, Adnan , Weiss, Scott T , Meyers, Deborah A , Söderhäll, Cilla , Melén, Erik , Ober, Carole , Raby, Benjamin A , Simpson, Angela , Jacobsson, Bo , Holloway, John W , Bisgaard, Hans , Sunyer, Jordi , Hensch, Nicole M Probst , Williams, L Keoki , Godfrey, Keith M , Wang, Carol A , Boomsma, Dorret I , Melbye, Mads , Koppelman, Gerard H , Jarvis, Deborah , Mclean, Wh Irwin , Irvine, Alan D , Zhang, Xue Jun , Hakonarson, Hakon , Gieger, Christian , Burchard, Esteban G , Martin, Nicholas G , Duijts, Liesbeth , Linneberg, Allan , Jarvelin, Marjo-Riitta , Noethen, Markus M , Lau, Susanne , Hübner, Norbert , Lee, Young-Ae , Tamari, Mayumi , Hinds, David A , Glass, Daniel , Brown, Sara J , Heinrich, Joachim , Evans, David M , Weidinger, Stephan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1061-4036 ; DOI: 10.1038/ng.3424
Zum Text:
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title: Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
format: Article
creator:
  • Paternoster, Lavinia
  • Standl, Marie
  • Waage, Johannes
  • Baurecht, Hansjörg
  • Hotze, Melanie
  • Strachan, David P
  • Curtin, John A
  • Bønnelykke, Klaus
  • Tian, Chao
  • Takahashi, Atsushi
  • Esparza-Gordillo, Jorge
  • Alves, Alexessander Couto
  • Thyssen, Jacob P
  • Den Dekker, Herman T
  • Ferreira, Manuel A
  • Altmaier, Elisabeth
  • Sleiman, Patrick Ma
  • Xiao, Feng Li
  • Gonzalez, Juan R
  • Marenholz, Ingo
  • Kalb, Birgit
  • Yanes, Maria Pino
  • Xu, Cheng-Jian
  • Carstensen, Lisbeth
  • Groen-Blokhuis, Maria M
  • Venturini, Cristina
  • Pennell, Craig E
  • Barton, Sheila J
  • Levin, Albert M
  • Curjuric, Ivan
  • Bustamante, Mariona
  • Kreiner-Møller, Eskil
  • Lockett, Gabrielle A
  • Bacelis, Jonas
  • Bunyavanich, Supinda
  • Myers, Rachel A
  • Matanovic, Anja
  • Kumar, Ashish
  • Tung, Joyce Y
  • Hirota, Tomomitsu
  • Kubo, Michiaki
  • Mcardle, Wendy L
  • Henderson, A J
  • Kemp, John P
  • Zheng, Jie
  • Smith, George Davey
  • Rüschendorf, Franz
  • Bauerfeind, Anja
  • Lee-Kirsch, Min Ae
  • Arnold, Andreas
  • Homuth, Georg
  • Schmidt, Carsten O
  • Mangold, Elisabeth
  • Cichon, Sven
  • Keil, Thomas
  • Rodríguez, Elke
  • Peters, Annette
  • Franke, Andre
  • Lieb, Wolfgang
  • Novak, Natalija
  • Fölster-Holst, Regina
  • Horikoshi, Momoko
  • Pekkanen, Juha
  • Sebert, Sylvain
  • Husemoen, Lise L
  • Grarup, Niels
  • De Jongste, Johan C
  • Rivadeneira, Fernando
  • Hofman, Albert
  • Jaddoe, Vincent Wv
  • Pasmans, Suzanne Gma
  • Elbert, Niels J
  • Uitterlinden, André G
  • Marks, Guy B
  • Thompson, Philip J
  • Matheson, Melanie C
  • Robertson, Colin F
  • Ried, Janina S
  • Li, Jin
  • Zuo, Xian Bo
  • Zheng, Xiao Dong
  • Yin, Xian Yong
  • Sun, Liang Dan
  • Mcaleer, Maeve A
  • O'Regan, Grainne M
  • Fahy, Caoimhe Mr
  • Campbell, Linda E
  • Macek, Milan
  • Kurek, Michael
  • Hu, Donglei
  • Eng, Celeste
  • Postma, Dirkje S
  • Feenstra, Bjarke
  • Geller, Frank
  • Hottenga, Jouke Jan
  • Middeldorp, Christel M
  • Hysi, Pirro
  • Bataille, Veronique
  • Spector, Tim
  • Tiesler, Carla Mt
  • Thiering, Elisabeth
  • Pahukasahasram, Badri
  • Yang, James J
  • Imboden, Medea
  • Huntsman, Scott
  • Vilor-Tejedor, Natàlia
  • Relton, Caroline L
  • Myhre, Ronny
  • Nystad, Wenche
  • Custovic, Adnan
  • Weiss, Scott T
  • Meyers, Deborah A
  • Söderhäll, Cilla
  • Melén, Erik
  • Ober, Carole
  • Raby, Benjamin A
  • Simpson, Angela
  • Jacobsson, Bo
  • Holloway, John W
  • Bisgaard, Hans
  • Sunyer, Jordi
  • Hensch, Nicole M Probst
  • Williams, L Keoki
  • Godfrey, Keith M
  • Wang, Carol A
  • Boomsma, Dorret I
  • Melbye, Mads
  • Koppelman, Gerard H
  • Jarvis, Deborah
  • Mclean, Wh Irwin
  • Irvine, Alan D
  • Zhang, Xue Jun
  • Hakonarson, Hakon
  • Gieger, Christian
  • Burchard, Esteban G
  • Martin, Nicholas G
  • Duijts, Liesbeth
  • Linneberg, Allan
  • Jarvelin, Marjo-Riitta
  • Noethen, Markus M
  • Lau, Susanne
  • Hübner, Norbert
  • Lee, Young-Ae
  • Tamari, Mayumi
  • Hinds, David A
  • Glass, Daniel
  • Brown, Sara J
  • Heinrich, Joachim
  • Evans, David M
  • Weidinger, Stephan
subjects:
  • Reproduktionsmedicin Och Gynekologi
  • Obstetrics, Gynecology And Reproductive Medicine
  • Inflammatory-Bowel-Disease
  • Susceptibility Loci
  • Interleukin-7 Receptor
  • Genetic Architecture
  • Japanese Population
  • Variants
  • Asthma
  • Metaanalysis
  • Psoriasis
  • Filaggrin
  • Genetics & Heredity
  • Ates Of America
  • V110
  • Pe1761
ispartof: Paternoster, L., M. Standl, J. Waage, H. Baurecht, M. Hotze, D. P. Strachan, J. A. Curtin, et al. 2015. “Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.” Nature genetics 47 (12): 1449-1456. doi:10.1038/ng.3424. http://dx.doi.org/10.1038/ng.3424.
description: Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified 10 novel risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with novel secondary signals at 4 of these). Notably, the new loci include candidate genes with roles in regulation of innate host defenses and T-cell function, underscoring the important contribution of (auto-)immune mechanisms to atopic dermatitis pathogenesis.
language: eng
source:
identifier: ISSN: 1061-4036 ; DOI: 10.1038/ng.3424
fulltext: fulltext_linktorsrc
issn:
  • 1061-4036
  • 10614036
url: Link


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titleMulti-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
creatorPaternoster, Lavinia ; Standl, Marie ; Waage, Johannes ; Baurecht, Hansjörg ; Hotze, Melanie ; Strachan, David P ; Curtin, John A ; Bønnelykke, Klaus ; Tian, Chao ; Takahashi, Atsushi ; Esparza-Gordillo, Jorge ; Alves, Alexessander Couto ; Thyssen, Jacob P ; Den Dekker, Herman T ; Ferreira, Manuel A ; Altmaier, Elisabeth ; Sleiman, Patrick Ma ; Xiao, Feng Li ; Gonzalez, Juan R ; Marenholz, Ingo ; Kalb, Birgit ; Yanes, Maria Pino ; Xu, Cheng-Jian ; Carstensen, Lisbeth ; Groen-Blokhuis, Maria M ; Venturini, Cristina ; Pennell, Craig E ; Barton, Sheila J ; Levin, Albert M ; Curjuric, Ivan ; Bustamante, Mariona ; Kreiner-Møller, Eskil ; Lockett, Gabrielle A ; Bacelis, Jonas ; Bunyavanich, Supinda ; Myers, Rachel A ; Matanovic, Anja ; Kumar, Ashish ; Tung, Joyce Y ; Hirota, Tomomitsu ; Kubo, Michiaki ; Mcardle, Wendy L ; Henderson, A J ; Kemp, John P ; Zheng, Jie ; Smith, George Davey ; Rüschendorf, Franz ; Bauerfeind, Anja ; Lee-Kirsch, Min Ae ; Arnold, Andreas ; Homuth, Georg ; Schmidt, Carsten O ; Mangold, Elisabeth ; Cichon, Sven ; Keil, Thomas ; Rodríguez, Elke ; Peters, Annette ; Franke, Andre ; Lieb, Wolfgang ; Novak, Natalija ; Fölster-Holst, Regina ; Horikoshi, Momoko ; Pekkanen, Juha ; Sebert, Sylvain ; Husemoen, Lise L ; Grarup, Niels ; De Jongste, Johan C ; Rivadeneira, Fernando ; Hofman, Albert ; Jaddoe, Vincent Wv ; Pasmans, Suzanne Gma ; Elbert, Niels J ; Uitterlinden, André G ; Marks, Guy B ; Thompson, Philip J ; Matheson, Melanie C ; Robertson, Colin F ; Ried, Janina S ; Li, Jin ; Zuo, Xian Bo ; Zheng, Xiao Dong ; Yin, Xian Yong ; Sun, Liang Dan ; Mcaleer, Maeve A ; O'Regan, Grainne M ; Fahy, Caoimhe Mr ; Campbell, Linda E ; Macek, Milan ; Kurek, Michael ; Hu, Donglei ; Eng, Celeste ; Postma, Dirkje S ; Feenstra, Bjarke ; Geller, Frank ; Hottenga, Jouke Jan ; Middeldorp, Christel M ; Hysi, Pirro ; Bataille, Veronique ; Spector, Tim ; Tiesler, Carla Mt ; Thiering, Elisabeth ; Pahukasahasram, Badri ; Yang, James J ; Imboden, Medea ; Huntsman, Scott ; Vilor-Tejedor, Natàlia ; Relton, Caroline L ; Myhre, Ronny ; Nystad, Wenche ; Custovic, Adnan ; Weiss, Scott T ; Meyers, Deborah A ; Söderhäll, Cilla ; Melén, Erik ; Ober, Carole ; Raby, Benjamin A ; Simpson, Angela ; Jacobsson, Bo ; Holloway, John W ; Bisgaard, Hans ; Sunyer, Jordi ; Hensch, Nicole M Probst ; Williams, L Keoki ; Godfrey, Keith M ; Wang, Carol A ; Boomsma, Dorret I ; Melbye, Mads ; Koppelman, Gerard H ; Jarvis, Deborah ; Mclean, Wh Irwin ; Irvine, Alan D ; Zhang, Xue Jun ; Hakonarson, Hakon ; Gieger, Christian ; Burchard, Esteban G ; Martin, Nicholas G ; Duijts, Liesbeth ; Linneberg, Allan ; Jarvelin, Marjo-Riitta ; Noethen, Markus M ; Lau, Susanne ; Hübner, Norbert ; Lee, Young-Ae ; Tamari, Mayumi ; Hinds, David A ; Glass, Daniel ; Brown, Sara J ; Heinrich, Joachim ; Evans, David M ; Weidinger, Stephan
ispartofPaternoster, L., M. Standl, J. Waage, H. Baurecht, M. Hotze, D. P. Strachan, J. A. Curtin, et al. 2015. “Multi-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis.” Nature genetics 47 (12): 1449-1456. doi:10.1038/ng.3424. http://dx.doi.org/10.1038/ng.3424.
identifierISSN: 1061-4036 ; DOI: 10.1038/ng.3424
descriptionGenetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified 10 novel risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with novel secondary signals at 4 of these). Notably, the new loci include candidate genes with roles in regulation of innate host defenses and T-cell function, underscoring the important contribution of (auto-)immune mechanisms to atopic dermatitis pathogenesis.
languageeng
source
subjectReproduktionsmedicin Och Gynekologi ; Obstetrics, Gynecology And Reproductive Medicine ; Inflammatory-Bowel-Disease ; Susceptibility Loci ; Interleukin-7 Receptor ; Genetic Architecture ; Japanese Population ; Variants ; Asthma ; Metaanalysis ; Psoriasis ; Filaggrin ; Genetics & Heredity ; Ates Of America ; V110 ; Pe1761;
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0Paternoster, Lavinia
1Standl, Marie
2Waage, Johannes
3Baurecht, Hansjörg
4Hotze, Melanie
5Strachan, David P
6Curtin, John A
7Bønnelykke, Klaus
8Tian, Chao
9Takahashi, Atsushi
10Esparza-Gordillo, Jorge
11Alves, Alexessander Couto
12Thyssen, Jacob P
13den Dekker, Herman T
14Ferreira, Manuel A
15Altmaier, Elisabeth
16Sleiman, Patrick MA
17Xiao, Feng Li
18Gonzalez, Juan R
19Marenholz, Ingo
20Kalb, Birgit
21Yanes, Maria Pino
22Xu, Cheng-Jian
23Carstensen, Lisbeth
24Groen-Blokhuis, Maria M
25Venturini, Cristina
26Pennell, Craig E
27Barton, Sheila J
28Levin, Albert M
29Curjuric, Ivan
30Bustamante, Mariona
31Kreiner-Møller, Eskil
32Lockett, Gabrielle A
33Bacelis, Jonas
34Bunyavanich, Supinda
35Myers, Rachel A
36Matanovic, Anja
37Kumar, Ashish
38Tung, Joyce Y
39Hirota, Tomomitsu
40Kubo, Michiaki
41McArdle, Wendy L
42Henderson, A J
43Kemp, John P
44Zheng, Jie
45Smith, George Davey
46Rüschendorf, Franz
47Bauerfeind, Anja
48Lee-Kirsch, Min Ae
49Arnold, Andreas
50Homuth, Georg
51Schmidt, Carsten O
52Mangold, Elisabeth
53Cichon, Sven
54Keil, Thomas
55Rodríguez, Elke
56Peters, Annette
57Franke, Andre
58Lieb, Wolfgang
59Novak, Natalija
60Fölster-Holst, Regina
61Horikoshi, Momoko
62Pekkanen, Juha
63Sebert, Sylvain
64Husemoen, Lise L
65Grarup, Niels
66de Jongste, Johan C
67Rivadeneira, Fernando
68Hofman, Albert
69Jaddoe, Vincent WV
70Pasmans, Suzanne GMA
71Elbert, Niels J
72Uitterlinden, André G
73Marks, Guy B
74Thompson, Philip J
75Matheson, Melanie C
76Robertson, Colin F
77Ried, Janina S
78Li, Jin
79Zuo, Xian Bo
80Zheng, Xiao Dong
81Yin, Xian Yong
82Sun, Liang Dan
83McAleer, Maeve A
84O'Regan, Grainne M
85Fahy, Caoimhe MR
86Campbell, Linda E
87Macek, Milan
88Kurek, Michael
89Hu, Donglei
90Eng, Celeste
91Postma, Dirkje S
92Feenstra, Bjarke
93Geller, Frank
94Hottenga, Jouke Jan
95Middeldorp, Christel M
96Hysi, Pirro
97Bataille, Veronique
98Spector, Tim
99Tiesler, Carla MT
100...
titleMulti-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
descriptionGenetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified 10 novel risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with novel secondary signals at 4 of these). Notably, the new loci include candidate genes with roles in regulation of innate host defenses and T-cell function, underscoring the important contribution of (auto-)immune mechanisms to atopic dermatitis pathogenesis.
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titleMulti-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
authorPaternoster, Lavinia ; Standl, Marie ; Waage, Johannes ; Baurecht, Hansjörg ; Hotze, Melanie ; Strachan, David P ; Curtin, John A ; Bønnelykke, Klaus ; Tian, Chao ; Takahashi, Atsushi ; Esparza-Gordillo, Jorge ; Alves, Alexessander Couto ; Thyssen, Jacob P ; Den Dekker, Herman T ; Ferreira, Manuel A ; Altmaier, Elisabeth ; Sleiman, Patrick Ma ; Xiao, Feng Li ; Gonzalez, Juan R ; Marenholz, Ingo ; Kalb, Birgit ; Yanes, Maria Pino ; Xu, Cheng-Jian ; Carstensen, Lisbeth ; Groen-Blokhuis, Maria M ; Venturini, Cristina ; Pennell, Craig E ; Barton, Sheila J ; Levin, Albert M ; Curjuric, Ivan ; Bustamante, Mariona ; Kreiner-Møller, Eskil ; Lockett, Gabrielle A ; Bacelis, Jonas ; Bunyavanich, Supinda ; Myers, Rachel A ; Matanovic, Anja ; Kumar, Ashish ; Tung, Joyce Y ; Hirota, Tomomitsu ; Kubo, Michiaki ; Mcardle, Wendy L ; Henderson, A J ; Kemp, John P ; Zheng, Jie ; Smith, George Davey ; Rüschendorf, Franz ; Bauerfeind, Anja ; Lee-Kirsch, Min Ae ; Arnold, Andreas ; Homuth, Georg ; Schmidt, Carsten O ; Mangold, Elisabeth ; Cichon, Sven ; Keil, Thomas ; Rodríguez, Elke ; Peters, Annette ; Franke, Andre ; Lieb, Wolfgang ; Novak, Natalija ; Fölster-Holst, Regina ; Horikoshi, Momoko ; Pekkanen, Juha ; Sebert, Sylvain ; Husemoen, Lise L ; Grarup, Niels ; De Jongste, Johan C ; Rivadeneira, Fernando ; Hofman, Albert ; Jaddoe, Vincent Wv ; Pasmans, Suzanne Gma ; Elbert, Niels J ; Uitterlinden, André G ; Marks, Guy B ; Thompson, Philip J ; Matheson, Melanie C ; Robertson, Colin F ; Ried, Janina S ; Li, Jin ; Zuo, Xian Bo ; Zheng, Xiao Dong ; Yin, Xian Yong ; Sun, Liang Dan ; Mcaleer, Maeve A ; O'Regan, Grainne M ; Fahy, Caoimhe Mr ; Campbell, Linda E ; Macek, Milan ; Kurek, Michael ; Hu, Donglei ; Eng, Celeste ; Postma, Dirkje S ; Feenstra, Bjarke ; Geller, Frank ; Hottenga, Jouke Jan ; Middeldorp, Christel M ; Hysi, Pirro ; Bataille, Veronique ; Spector, Tim ; Tiesler, Carla Mt ; Thiering, Elisabeth ; Pahukasahasram, Badri ; Yang, James J ; Imboden, Medea ; Huntsman, Scott ; Vilor-Tejedor, Natàlia ; Relton, Caroline L ; Myhre, Ronny ; Nystad, Wenche ; Custovic, Adnan ; Weiss, Scott T ; Meyers, Deborah A ; Söderhäll, Cilla ; Melén, Erik ; Ober, Carole ; Raby, Benjamin A ; Simpson, Angela ; Jacobsson, Bo ; Holloway, John W ; Bisgaard, Hans ; Sunyer, Jordi ; Hensch, Nicole M Probst ; Williams, L Keoki ; Godfrey, Keith M ; Wang, Carol A ; Boomsma, Dorret I ; Melbye, Mads ; Koppelman, Gerard H ; Jarvis, Deborah ; Mclean, Wh Irwin ; Irvine, Alan D ; Zhang, Xue Jun ; Hakonarson, Hakon ; Gieger, Christian ; Burchard, Esteban G ; Martin, Nicholas G ; Duijts, Liesbeth ; Linneberg, Allan ; Jarvelin, Marjo-Riitta ; Noethen, Markus M ; Lau, Susanne ; Hübner, Norbert ; Lee, Young-Ae ; Tamari, Mayumi ; Hinds, David A ; Glass, Daniel ; Brown, Sara J ; Heinrich, Joachim ; Evans, David M ; Weidinger, Stephan
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0Paternoster, Lavinia
1Standl, Marie
2Waage, Johannes
3Baurecht, Hansjörg
4Hotze, Melanie
5Strachan, David P
6Curtin, John A
7Bønnelykke, Klaus
8Tian, Chao
9Takahashi, Atsushi
10Esparza-Gordillo, Jorge
11Alves, Alexessander Couto
12Thyssen, Jacob P
13den Dekker, Herman T
14Ferreira, Manuel A
15Altmaier, Elisabeth
16Sleiman, Patrick MA
17Xiao, Feng Li
18Gonzalez, Juan R
19Marenholz, Ingo
20Kalb, Birgit
21Yanes, Maria Pino
22Xu, Cheng-Jian
23Carstensen, Lisbeth
24Groen-Blokhuis, Maria M
25Venturini, Cristina
26Pennell, Craig E
27Barton, Sheila J
28Levin, Albert M
29Curjuric, Ivan
30Bustamante, Mariona
31Kreiner-Møller, Eskil
32Lockett, Gabrielle A
33Bacelis, Jonas
34Bunyavanich, Supinda
35Myers, Rachel A
36Matanovic, Anja
37Kumar, Ashish
38Tung, Joyce Y
39Hirota, Tomomitsu
40Kubo, Michiaki
41McArdle, Wendy L
42Henderson, A J
43Kemp, John P
44Zheng, Jie
45Smith, George Davey
46Rüschendorf, Franz
47Bauerfeind, Anja
48Lee-Kirsch, Min Ae
49Arnold, Andreas
50Homuth, Georg
51Schmidt, Carsten O
52Mangold, Elisabeth
53Cichon, Sven
54Keil, Thomas
55Rodríguez, Elke
56Peters, Annette
57Franke, Andre
58Lieb, Wolfgang
59Novak, Natalija
60Fölster-Holst, Regina
61Horikoshi, Momoko
62Pekkanen, Juha
63Sebert, Sylvain
64Husemoen, Lise L
65Grarup, Niels
66de Jongste, Johan C
67Rivadeneira, Fernando
68Hofman, Albert
69Jaddoe, Vincent WV
70Pasmans, Suzanne GMA
71Elbert, Niels J
72Uitterlinden, André G
73Marks, Guy B
74Thompson, Philip J
75Matheson, Melanie C
76Robertson, Colin F
77Ried, Janina S
78Li, Jin
79Zuo, Xian Bo
80Zheng, Xiao Dong
81Yin, Xian Yong
82Sun, Liang Dan
83McAleer, Maeve A
84O'Regan, Grainne M
85Fahy, Caoimhe MR
86Campbell, Linda E
87Macek, Milan
88Kurek, Michael
89Hu, Donglei
90Eng, Celeste
91Postma, Dirkje S
92Feenstra, Bjarke
93Geller, Frank
94Hottenga, Jouke Jan
95Middeldorp, Christel M
96Hysi, Pirro
97Bataille, Veronique
98Spector, Tim
99Tiesler, Carla MT
100...
jtitleNature genetics
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext_linktorsrc
addata
aulast
0Paternoster
1Standl
2Waage
3Baurecht
4Hotze
5Strachan
6Curtin
7Bønnelykke
8Tian
9Takahashi
10Esparza-Gordillo
11Alves
12Thyssen
13den Dekker
14Ferreira
15Altmaier
16Sleiman
17Xiao
18Gonzalez
19Marenholz
20Kalb
21Yanes
22Xu
23Carstensen
24Groen-Blokhuis
25Venturini
26Pennell
27Barton
28Levin
29Curjuric
30Bustamante
31Kreiner-Møller
32Lockett
33Bacelis
34Bunyavanich
35Myers
36Matanovic
37Kumar
38Tung
39Hirota
40Kubo
41McArdle
42Henderson
43Kemp
44Zheng
45Smith
46Rüschendorf
47Bauerfeind
48Lee-Kirsch
49Arnold
50Homuth
51Schmidt
52Mangold
53Cichon
54Keil
55Rodríguez
56Peters
57Franke
58Lieb
59Novak
60Fölster-Holst
61Horikoshi
62Pekkanen
63Sebert
64Husemoen
65Grarup
66de Jongste
67Rivadeneira
68Hofman
69Jaddoe
70Pasmans
71Elbert
72Uitterlinden
73Marks
74Thompson
75Matheson
76Robertson
77Ried
78Li
79Zuo
80Yin
81Sun
82McAleer
83O'Regan
84Fahy
85Campbell
86Macek
87Kurek
88Hu
89Eng
90Postma
91Feenstra
92Geller
93Hottenga
94Middeldorp
95Hysi
96Bataille
97Spector
98Tiesler
99Thiering
100...
aufirst
0Lavinia
1Marie
2Johannes
3Hansjörg
4Melanie
5David P
6John A
7Klaus
8Chao
9Atsushi
10Jorge
11Alexessander Couto
12Jacob P
13Herman T
14Manuel A
15Elisabeth
16Patrick MA
17Feng Li
18Juan R
19Ingo
20Birgit
21Maria Pino
22Cheng-Jian
23Lisbeth
24Maria M
25Cristina
26Craig E
27Sheila J
28Albert M
29Ivan
30Mariona
31Eskil
32Gabrielle A
33Jonas
34Supinda
35Rachel A
36Anja
37Ashish
38Joyce Y
39Tomomitsu
40Michiaki
41Wendy L
42A J
43John P
44Jie
45George Davey
46Franz
47Min Ae
48Andreas
49Georg
50Carsten O
51Sven
52Thomas
53Elke
54Annette
55Andre
56Wolfgang
57Natalija
58Regina
59Momoko
60Juha
61Sylvain
62Lise L
63Niels
64Johan C
65Fernando
66Albert
67Vincent WV
68Suzanne GMA
69Niels J
70André G
71Guy B
72Philip J
73Melanie C
74Colin F
75Janina S
76Jin
77Xian Bo
78Xiao Dong
79Xian Yong
80Liang Dan
81Maeve A
82Grainne M
83Caoimhe MR
84Linda E
85Milan
86Michael
87Donglei
88Celeste
89Dirkje S
90Bjarke
91Frank
92Jouke Jan
93Christel M
94Pirro
95Veronique
96Tim
97Carla MT
98Badri
99James J
100...
au
0Paternoster, Lavinia
1Standl, Marie
2Waage, Johannes
3Baurecht, Hansjörg
4Hotze, Melanie
5Strachan, David P
6Curtin, John A
7Bønnelykke, Klaus
8Tian, Chao
9Takahashi, Atsushi
10Esparza-Gordillo, Jorge
11Alves, Alexessander Couto
12Thyssen, Jacob P
13den Dekker, Herman T
14Ferreira, Manuel A
15Altmaier, Elisabeth
16Sleiman, Patrick MA
17Xiao, Feng Li
18Gonzalez, Juan R
19Marenholz, Ingo
20Kalb, Birgit
21Yanes, Maria Pino
22Xu, Cheng-Jian
23Carstensen, Lisbeth
24Groen-Blokhuis, Maria M
25Venturini, Cristina
26Pennell, Craig E
27Barton, Sheila J
28Levin, Albert M
29Curjuric, Ivan
30Bustamante, Mariona
31Kreiner-Møller, Eskil
32Lockett, Gabrielle A
33Bacelis, Jonas
34Bunyavanich, Supinda
35Myers, Rachel A
36Matanovic, Anja
37Kumar, Ashish
38Tung, Joyce Y
39Hirota, Tomomitsu
40Kubo, Michiaki
41McArdle, Wendy L
42Henderson, A J
43Kemp, John P
44Zheng, Jie
45Smith, George Davey
46Rüschendorf, Franz
47Bauerfeind, Anja
48Lee-Kirsch, Min Ae
49Arnold, Andreas
50Homuth, Georg
51Schmidt, Carsten O
52Mangold, Elisabeth
53Cichon, Sven
54Keil, Thomas
55Rodríguez, Elke
56Peters, Annette
57Franke, Andre
58Lieb, Wolfgang
59Novak, Natalija
60Fölster-Holst, Regina
61Horikoshi, Momoko
62Pekkanen, Juha
63Sebert, Sylvain
64Husemoen, Lise L
65Grarup, Niels
66de Jongste, Johan C
67Rivadeneira, Fernando
68Hofman, Albert
69Jaddoe, Vincent WV
70Pasmans, Suzanne GMA
71Elbert, Niels J
72Uitterlinden, André G
73Marks, Guy B
74Thompson, Philip J
75Matheson, Melanie C
76Robertson, Colin F
77Ried, Janina S
78Li, Jin
79Zuo, Xian Bo
80Zheng, Xiao Dong
81Yin, Xian Yong
82Sun, Liang Dan
83McAleer, Maeve A
84O'Regan, Grainne M
85Fahy, Caoimhe MR
86Campbell, Linda E
87Macek, Milan
88Kurek, Michael
89Hu, Donglei
90Eng, Celeste
91Postma, Dirkje S
92Feenstra, Bjarke
93Geller, Frank
94Hottenga, Jouke Jan
95Middeldorp, Christel M
96Hysi, Pirro
97Bataille, Veronique
98Spector, Tim
99Tiesler, Carla MT
100...
atitleMulti-ethnic genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis
jtitleNature genetics
date2015
risdate2015
issn1061-4036
genrearticle
ristypeJOUR
abstractGenetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified 10 novel risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with novel secondary signals at 4 of these). Notably, the new loci include candidate genes with roles in regulation of innate host defenses and T-cell function, underscoring the important contribution of (auto-)immune mechanisms to atopic dermatitis pathogenesis.
doi10.1038/ng.3424
urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC4753676/pdf/
volume47
issue12
pages1449-1456
eissn15461718
oafree_for_read