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A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape

Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates a... Full description

Journal Title: Ried J. S., J. Jeff M., A. Y. Chu, J. L. Bragg-Gresham, J. van Dongen, J. E. Huffman, T. S. Ahluwalia, et al. 2016. “A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.” Nature Communications 7 (1): 13357. doi:10.1038/ncomms13357. http://dx.doi.org/10.1038/ncomms13357.
Main Author: Ried, Janina S.
Other Authors: Jeff M., Janina , Chu, Audrey Y. , Bragg-Gresham, Jennifer L. , Van Dongen, Jenny , Huffman, Jennifer E. , Ahluwalia, Tarunveer S. , Cadby, Gemma , Eklund, Niina , Eriksson, Joel , Esko, Tõnu , Feitosa, Mary F. , Goel, Anuj , Gorski, Mathias , Hayward, Caroline , Heard-Costa, Nancy L. , Jackson, Anne U. , Jokinen, Eero , Kanoni, Stavroula , Kristiansson, Kati , Kutalik, Zoltán , Lahti, Jari , Luan, Jian'An , Mägi, Reedik , Mahajan, Anubha , Mangino, Massimo , Medina-Gomez, Carolina , Monda, Keri L. , Nolte, Ilja M. , Pérusse, Louis , Prokopenko, Inga , Qi, Lu , Rose, Lynda M. , Salvi, Erika , Smith, Megan T. , Snieder, Harold , Stančáková, Alena , Ju Sung, Yun , Tachmazidou, Ioanna , Teumer, Alexander , Thorleifsson, Gudmar , Van Der Harst, Pim , Walker, Ryan W. , Wang, Sophie R. , Wild, Sarah H. , Willems, Sara M. , Wong, Andrew , Zhang, Weihua , Albrecht, Eva , Couto Alves, Alexessander , Bakker, Stephan J. L. , Barlassina, Cristina , Bartz, Traci M. , Beilby, John , Bellis, Claire , Bergman, Richard N. , Bergmann, Sven , Blangero, John , Blüher, Matthias , Boerwinkle, Eric , Bonnycastle, Lori L. , Bornstein, Stefan R. , Bruinenberg, Marcel , Campbell, Harry , Chen, Yii-Der Ida , Chiang, Charleston W. K. , Chines, Peter S. , Collins, Francis S , Cucca, Fracensco , Cupples, L Adrienne , D'Avila, Francesca , De Geus, Eco J .C. , Dedoussis, George , Dimitriou, Maria , Döring, Angela , Eriksson, Johan G. , Farmaki, Aliki-Eleni , Farrall, Martin , Ferreira, Teresa , Fischer, Krista , Forouhi, Nita G. , Friedrich, Nele , Gjesing, Anette Prior , Glorioso, Nicola , Graff, Mariaelisa , Grallert, Harald , Grarup, Niels , Gräßler, Jürgen , Grewal, Jagvir , Hamsten, Anders , Harder, Marie Neergaard , Hartman, Catharina A. , Hassinen, Maija , Hastie, Nicholas , Hattersley, Andrew Tym , Havulinna, Aki S. , Heliövaara, Markku , Hillege, Hans , Hofman, Albert , Holmen, Oddgeir , Homuth, Georg , Hottenga, Jouke-Jan , Hui, Jennie , Husemoen, Lise Lotte , Hysi, Pirro G. , Isaacs, Aaron , Ittermann, Till , Jalilzadeh, Shapour , James, Alan L. , Jørgensen, Torben , Jousilahti, Pekka , Jula, Antti , Marie Justesen, Johanne , Justice, Anne E. , Kähönen, Mika , Karaleftheri, Maria , Tee Khaw, Kay , Keinanen-Kiukaanniemi, Sirkka M. , Kinnunen, Leena , Knekt, Paul B. , Koistinen, Heikki A. , Kolcic, Ivana , Kooner, Ishminder K. , Koskinen, Seppo , Kovacs, Peter , Kyriakou, Theodosios , Laitinen, Tomi , Langenberg, Claudia , Lewin, Alexandra M. , Lichtner, Peter , Lindgren, Cecilia M. , Lindström, Jaana , Linneberg, Allan , Lorbeer, Roberto , Lorentzon, Mattias , Luben, Robert , Lyssenko, Valeriya , Männistö, Satu , Manunta, Paolo , Leach, Irene Mateo , Mcardle, Wendy L. , Mcknight, Barbara , Mohlke, Karen L. , Mihailov, Evelin , Milani, Lili , Mills, Rebecca , Montasser, May E. , Morris, Andrew P. , Müller, Gabriele , Musk, Arthur W. , Narisu, Narisu , Ong, Ken K. , Oostra, Ben A. , Osmond, Clive , Palotie, Aarno , Pankow, James S. , Paternoster, Lavinia , Penninx, Brenda W. , Pichler, Irene , Pilia, Maria G. , Polašek, Ozren , Pramstaller, Peter P. , Raitakari, Olli T , Rankinen, Tuomo , Rao, D. C. , Rayner, Nigel W. , Ribel-Madsen, Rasmus , Rice, Treva K. , Richards, Marcus , Ridker, Paul M. , Rivadeneira, Fernando , Ryan, Kathy A. , Sanna, Serena , Sarzynski, Mark A. , Scholtens, Salome , Scott, Robert A. , Sebert, Sylvain , Southam, Lorraine , Sparsø, Thomas Hempel , Steinthorsdottir, Valgerdur , Stirrups, Kathleen , Stolk, Ronald P. , Strauch, Konstantin , Stringham, Heather M. , Swertz, Morris A. , Swift, Amy J. , Tönjes, Anke , Tsafantakis, Emmanouil , Van Der Most, Peter J. , Van Vliet-Ostaptchouk, Jana V. , Vandenput, Liesbeth , Vartiainen, Erkki , Venturini, Cristina , Verweij, Niek , Viikari, Jorma S. , Vitart, Veronique , Vohl, Marie-Claude , Vonk, Judith M. , Waeber, Gérard , Widén, Elisabeth , Willemsen, Gonneke , Wilsgaard, Tom , Winkler, Thomas W. , Wright, Alan F. , Yerges-Armstrong, Laura M. , Hua Zhao, Jing , Carola Zillikens, M. , Boomsma, Dorret I. , Bouchard, Claude , Chambers, John C. , Chasman, Daniel I. , Cusi, Daniele , Gansevoort, Ron T. , Gieger, Christian , Hansen, Torben , Hicks, Andrew A. , Hu, Frank , Hveem, Kristian , Jarvelin, Marjo-Riitta , Kajantie, Eero , Kooner, Jaspal S. , Kuh, Diana , Kuusisto, Johanna , Laakso, Markku , Lakka, Timo A. , Lehtimäki, Terho , Metspalu, Andres , Njølstad, Inger , Ohlsson, Claes , Oldehinkel, Albertine J. , Palmer, Lyle J. , Pedersen, Oluf , Perola, Markus , Peters, Annette , Psaty, Bruce M. , Puolijoki, Hannu , Rauramaa, Rainer , Rudan, Igor , Salomaa, Veikko , Schwarz, Peter E. H. , Shudiner, Alan R. , Smit, Jan H. , Sørensen, Thorkild I. A. , Spector, Timothy D. , Stefansson, Kari , Stumvoll, Michael , Tremblay, Angelo , Tuomilehto, Jaakko , Uitterlinden, André G. , Uusitupa, Matti
Format: Electronic Article Electronic Article
Language: English
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ID: ISSN: 2041-1723 ; DOI: 10.1038/ncomms13357
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title: A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
format: Article
creator:
  • Ried, Janina S.
  • Jeff M., Janina
  • Chu, Audrey Y.
  • Bragg-Gresham, Jennifer L.
  • Van Dongen, Jenny
  • Huffman, Jennifer E.
  • Ahluwalia, Tarunveer S.
  • Cadby, Gemma
  • Eklund, Niina
  • Eriksson, Joel
  • Esko, Tõnu
  • Feitosa, Mary F.
  • Goel, Anuj
  • Gorski, Mathias
  • Hayward, Caroline
  • Heard-Costa, Nancy L.
  • Jackson, Anne U.
  • Jokinen, Eero
  • Kanoni, Stavroula
  • Kristiansson, Kati
  • Kutalik, Zoltán
  • Lahti, Jari
  • Luan, Jian'An
  • Mägi, Reedik
  • Mahajan, Anubha
  • Mangino, Massimo
  • Medina-Gomez, Carolina
  • Monda, Keri L.
  • Nolte, Ilja M.
  • Pérusse, Louis
  • Prokopenko, Inga
  • Qi, Lu
  • Rose, Lynda M.
  • Salvi, Erika
  • Smith, Megan T.
  • Snieder, Harold
  • Stančáková, Alena
  • Ju Sung, Yun
  • Tachmazidou, Ioanna
  • Teumer, Alexander
  • Thorleifsson, Gudmar
  • Van Der Harst, Pim
  • Walker, Ryan W.
  • Wang, Sophie R.
  • Wild, Sarah H.
  • Willems, Sara M.
  • Wong, Andrew
  • Zhang, Weihua
  • Albrecht, Eva
  • Couto Alves, Alexessander
  • Bakker, Stephan J. L.
  • Barlassina, Cristina
  • Bartz, Traci M.
  • Beilby, John
  • Bellis, Claire
  • Bergman, Richard N.
  • Bergmann, Sven
  • Blangero, John
  • Blüher, Matthias
  • Boerwinkle, Eric
  • Bonnycastle, Lori L.
  • Bornstein, Stefan R.
  • Bruinenberg, Marcel
  • Campbell, Harry
  • Chen, Yii-Der Ida
  • Chiang, Charleston W. K.
  • Chines, Peter S.
  • Collins, Francis S
  • Cucca, Fracensco
  • Cupples, L Adrienne
  • D'Avila, Francesca
  • De Geus, Eco J .C.
  • Dedoussis, George
  • Dimitriou, Maria
  • Döring, Angela
  • Eriksson, Johan G.
  • Farmaki, Aliki-Eleni
  • Farrall, Martin
  • Ferreira, Teresa
  • Fischer, Krista
  • Forouhi, Nita G.
  • Friedrich, Nele
  • Gjesing, Anette Prior
  • Glorioso, Nicola
  • Graff, Mariaelisa
  • Grallert, Harald
  • Grarup, Niels
  • Gräßler, Jürgen
  • Grewal, Jagvir
  • Hamsten, Anders
  • Harder, Marie Neergaard
  • Hartman, Catharina A.
  • Hassinen, Maija
  • Hastie, Nicholas
  • Hattersley, Andrew Tym
  • Havulinna, Aki S.
  • Heliövaara, Markku
  • Hillege, Hans
  • Hofman, Albert
  • Holmen, Oddgeir
  • Homuth, Georg
  • Hottenga, Jouke-Jan
  • Hui, Jennie
  • Husemoen, Lise Lotte
  • Hysi, Pirro G.
  • Isaacs, Aaron
  • Ittermann, Till
  • Jalilzadeh, Shapour
  • James, Alan L.
  • Jørgensen, Torben
  • Jousilahti, Pekka
  • Jula, Antti
  • Marie Justesen, Johanne
  • Justice, Anne E.
  • Kähönen, Mika
  • Karaleftheri, Maria
  • Tee Khaw, Kay
  • Keinanen-Kiukaanniemi, Sirkka M.
  • Kinnunen, Leena
  • Knekt, Paul B.
  • Koistinen, Heikki A.
  • Kolcic, Ivana
  • Kooner, Ishminder K.
  • Koskinen, Seppo
  • Kovacs, Peter
  • Kyriakou, Theodosios
  • Laitinen, Tomi
  • Langenberg, Claudia
  • Lewin, Alexandra M.
  • Lichtner, Peter
  • Lindgren, Cecilia M.
  • Lindström, Jaana
  • Linneberg, Allan
  • Lorbeer, Roberto
  • Lorentzon, Mattias
  • Luben, Robert
  • Lyssenko, Valeriya
  • Männistö, Satu
  • Manunta, Paolo
  • Leach, Irene Mateo
  • Mcardle, Wendy L.
  • Mcknight, Barbara
  • Mohlke, Karen L.
  • Mihailov, Evelin
  • Milani, Lili
  • Mills, Rebecca
  • Montasser, May E.
  • Morris, Andrew P.
  • Müller, Gabriele
  • Musk, Arthur W.
  • Narisu, Narisu
  • Ong, Ken K.
  • Oostra, Ben A.
  • Osmond, Clive
  • Palotie, Aarno
  • Pankow, James S.
  • Paternoster, Lavinia
  • Penninx, Brenda W.
  • Pichler, Irene
  • Pilia, Maria G.
  • Polašek, Ozren
  • Pramstaller, Peter P.
  • Raitakari, Olli T
  • Rankinen, Tuomo
  • Rao, D. C.
  • Rayner, Nigel W.
  • Ribel-Madsen, Rasmus
  • Rice, Treva K.
  • Richards, Marcus
  • Ridker, Paul M.
  • Rivadeneira, Fernando
  • Ryan, Kathy A.
  • Sanna, Serena
  • Sarzynski, Mark A.
  • Scholtens, Salome
  • Scott, Robert A.
  • Sebert, Sylvain
  • Southam, Lorraine
  • Sparsø, Thomas Hempel
  • Steinthorsdottir, Valgerdur
  • Stirrups, Kathleen
  • Stolk, Ronald P.
  • Strauch, Konstantin
  • Stringham, Heather M.
  • Swertz, Morris A.
  • Swift, Amy J.
  • Tönjes, Anke
  • Tsafantakis, Emmanouil
  • Van Der Most, Peter J.
  • Van Vliet-Ostaptchouk, Jana V.
  • Vandenput, Liesbeth
  • Vartiainen, Erkki
  • Venturini, Cristina
  • Verweij, Niek
  • Viikari, Jorma S.
  • Vitart, Veronique
  • Vohl, Marie-Claude
  • Vonk, Judith M.
  • Waeber, Gérard
  • Widén, Elisabeth
  • Willemsen, Gonneke
  • Wilsgaard, Tom
  • Winkler, Thomas W.
  • Wright, Alan F.
  • Yerges-Armstrong, Laura M.
  • Hua Zhao, Jing
  • Carola Zillikens, M.
  • Boomsma, Dorret I.
  • Bouchard, Claude
  • Chambers, John C.
  • Chasman, Daniel I.
  • Cusi, Daniele
  • Gansevoort, Ron T.
  • Gieger, Christian
  • Hansen, Torben
  • Hicks, Andrew A.
  • Hu, Frank
  • Hveem, Kristian
  • Jarvelin, Marjo-Riitta
  • Kajantie, Eero
  • Kooner, Jaspal S.
  • Kuh, Diana
  • Kuusisto, Johanna
  • Laakso, Markku
  • Lakka, Timo A.
  • Lehtimäki, Terho
  • Metspalu, Andres
  • Njølstad, Inger
  • Ohlsson, Claes
  • Oldehinkel, Albertine J.
  • Palmer, Lyle J.
  • Pedersen, Oluf
  • Perola, Markus
  • Peters, Annette
  • Psaty, Bruce M.
  • Puolijoki, Hannu
  • Rauramaa, Rainer
  • Rudan, Igor
  • Salomaa, Veikko
  • Schwarz, Peter E. H.
  • Shudiner, Alan R.
  • Smit, Jan H.
  • Sørensen, Thorkild I. A.
  • Spector, Timothy D.
  • Stefansson, Kari
  • Stumvoll, Michael
  • Tremblay, Angelo
  • Tuomilehto, Jaakko
  • Uitterlinden, André G.
  • Uusitupa, Matti
subjects:
  • Science & Technology
  • Multidisciplinary Sciences
  • Science & Technology - Other Topics
  • Genome-Wide Association
  • Diet-Induced Obesity
  • Mass Index
  • Disease Associations
  • Fat Distribution
  • Early-Onset
  • Hip Ratio
  • Resource
  • Biology
  • Height
  • Science & Technology
  • Multidisciplinary Sciences
  • Science & Technology - Other Topics
  • Genome-Wide Association
  • Diet-Induced Obesity
  • Mass Index
  • Disease Associations
  • Fat Distribution
  • Early-Onset
  • Hip Ratio
  • Resource
  • Biology
  • Height
  • MD Multidisciplinary
ispartof: Ried, J. S., J. Jeff M., A. Y. Chu, J. L. Bragg-Gresham, J. van Dongen, J. E. Huffman, T. S. Ahluwalia, et al. 2016. “A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.” Nature Communications 7 (1): 13357. doi:10.1038/ncomms13357. http://dx.doi.org/10.1038/ncomms13357.
description: Large consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
language: eng
source:
identifier: ISSN: 2041-1723 ; DOI: 10.1038/ncomms13357
fulltext: fulltext_linktorsrc
issn:
  • 2041-1723
  • 20411723
url: Link


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titleA principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
creatorRied, Janina S. ; Jeff M., Janina ; Chu, Audrey Y. ; Bragg-Gresham, Jennifer L. ; Van Dongen, Jenny ; Huffman, Jennifer E. ; Ahluwalia, Tarunveer S. ; Cadby, Gemma ; Eklund, Niina ; Eriksson, Joel ; Esko, Tõnu ; Feitosa, Mary F. ; Goel, Anuj ; Gorski, Mathias ; Hayward, Caroline ; Heard-Costa, Nancy L. ; Jackson, Anne U. ; Jokinen, Eero ; Kanoni, Stavroula ; Kristiansson, Kati ; Kutalik, Zoltán ; Lahti, Jari ; Luan, Jian'An ; Mägi, Reedik ; Mahajan, Anubha ; Mangino, Massimo ; Medina-Gomez, Carolina ; Monda, Keri L. ; Nolte, Ilja M. ; Pérusse, Louis ; Prokopenko, Inga ; Qi, Lu ; Rose, Lynda M. ; Salvi, Erika ; Smith, Megan T. ; Snieder, Harold ; Stančáková, Alena ; Ju Sung, Yun ; Tachmazidou, Ioanna ; Teumer, Alexander ; Thorleifsson, Gudmar ; Van Der Harst, Pim ; Walker, Ryan W. ; Wang, Sophie R. ; Wild, Sarah H. ; Willems, Sara M. ; Wong, Andrew ; Zhang, Weihua ; Albrecht, Eva ; Couto Alves, Alexessander ; Bakker, Stephan J. L. ; Barlassina, Cristina ; Bartz, Traci M. ; Beilby, John ; Bellis, Claire ; Bergman, Richard N. ; Bergmann, Sven ; Blangero, John ; Blüher, Matthias ; Boerwinkle, Eric ; Bonnycastle, Lori L. ; Bornstein, Stefan R. ; Bruinenberg, Marcel ; Campbell, Harry ; Chen, Yii-Der Ida ; Chiang, Charleston W. K. ; Chines, Peter S. ; Collins, Francis S ; Cucca, Fracensco ; Cupples, L Adrienne ; D'Avila, Francesca ; De Geus, Eco J .C. ; Dedoussis, George ; Dimitriou, Maria ; Döring, Angela ; Eriksson, Johan G. ; Farmaki, Aliki-Eleni ; Farrall, Martin ; Ferreira, Teresa ; Fischer, Krista ; Forouhi, Nita G. ; Friedrich, Nele ; Gjesing, Anette Prior ; Glorioso, Nicola ; Graff, Mariaelisa ; Grallert, Harald ; Grarup, Niels ; Gräßler, Jürgen ; Grewal, Jagvir ; Hamsten, Anders ; Harder, Marie Neergaard ; Hartman, Catharina A. ; Hassinen, Maija ; Hastie, Nicholas ; Hattersley, Andrew Tym ; Havulinna, Aki S. ; Heliövaara, Markku ; Hillege, Hans ; Hofman, Albert ; Holmen, Oddgeir ; Homuth, Georg ; Hottenga, Jouke-Jan ; Hui, Jennie ; Husemoen, Lise Lotte ; Hysi, Pirro G. ; Isaacs, Aaron ; Ittermann, Till ; Jalilzadeh, Shapour ; James, Alan L. ; Jørgensen, Torben ; Jousilahti, Pekka ; Jula, Antti ; Marie Justesen, Johanne ; Justice, Anne E. ; Kähönen, Mika ; Karaleftheri, Maria ; Tee Khaw, Kay ; Keinanen-Kiukaanniemi, Sirkka M. ; Kinnunen, Leena ; Knekt, Paul B. ; Koistinen, Heikki A. ; Kolcic, Ivana ; Kooner, Ishminder K. ; Koskinen, Seppo ; Kovacs, Peter ; Kyriakou, Theodosios ; Laitinen, Tomi ; Langenberg, Claudia ; Lewin, Alexandra M. ; Lichtner, Peter ; Lindgren, Cecilia M. ; Lindström, Jaana ; Linneberg, Allan ; Lorbeer, Roberto ; Lorentzon, Mattias ; Luben, Robert ; Lyssenko, Valeriya ; Männistö, Satu ; Manunta, Paolo ; Leach, Irene Mateo ; Mcardle, Wendy L. ; Mcknight, Barbara ; Mohlke, Karen L. ; Mihailov, Evelin ; Milani, Lili ; Mills, Rebecca ; Montasser, May E. ; Morris, Andrew P. ; Müller, Gabriele ; Musk, Arthur W. ; Narisu, Narisu ; Ong, Ken K. ; Oostra, Ben A. ; Osmond, Clive ; Palotie, Aarno ; Pankow, James S. ; Paternoster, Lavinia ; Penninx, Brenda W. ; Pichler, Irene ; Pilia, Maria G. ; Polašek, Ozren ; Pramstaller, Peter P. ; Raitakari, Olli T ; Rankinen, Tuomo ; Rao, D. C. ; Rayner, Nigel W. ; Ribel-Madsen, Rasmus ; Rice, Treva K. ; Richards, Marcus ; Ridker, Paul M. ; Rivadeneira, Fernando ; Ryan, Kathy A. ; Sanna, Serena ; Sarzynski, Mark A. ; Scholtens, Salome ; Scott, Robert A. ; Sebert, Sylvain ; Southam, Lorraine ; Sparsø, Thomas Hempel ; Steinthorsdottir, Valgerdur ; Stirrups, Kathleen ; Stolk, Ronald P. ; Strauch, Konstantin ; Stringham, Heather M. ; Swertz, Morris A. ; Swift, Amy J. ; Tönjes, Anke ; Tsafantakis, Emmanouil ; Van Der Most, Peter J. ; Van Vliet-Ostaptchouk, Jana V. ; Vandenput, Liesbeth ; Vartiainen, Erkki ; Venturini, Cristina ; Verweij, Niek ; Viikari, Jorma S. ; Vitart, Veronique ; Vohl, Marie-Claude ; Vonk, Judith M. ; Waeber, Gérard ; Widén, Elisabeth ; Willemsen, Gonneke ; Wilsgaard, Tom ; Winkler, Thomas W. ; Wright, Alan F. ; Yerges-Armstrong, Laura M. ; Hua Zhao, Jing ; Carola Zillikens, M. ; Boomsma, Dorret I. ; Bouchard, Claude ; Chambers, John C. ; Chasman, Daniel I. ; Cusi, Daniele ; Gansevoort, Ron T. ; Gieger, Christian ; Hansen, Torben ; Hicks, Andrew A. ; Hu, Frank ; Hveem, Kristian ; Jarvelin, Marjo-Riitta ; Kajantie, Eero ; Kooner, Jaspal S. ; Kuh, Diana ; Kuusisto, Johanna ; Laakso, Markku ; Lakka, Timo A. ; Lehtimäki, Terho ; Metspalu, Andres ; Njølstad, Inger ; Ohlsson, Claes ; Oldehinkel, Albertine J. ; Palmer, Lyle J. ; Pedersen, Oluf ; Perola, Markus ; Peters, Annette ; Psaty, Bruce M. ; Puolijoki, Hannu ; Rauramaa, Rainer ; Rudan, Igor ; Salomaa, Veikko ; Schwarz, Peter E. H. ; Shudiner, Alan R. ; Smit, Jan H. ; Sørensen, Thorkild I. A. ; Spector, Timothy D. ; Stefansson, Kari ; Stumvoll, Michael ; Tremblay, Angelo ; Tuomilehto, Jaakko ; Uitterlinden, André G. ; Uusitupa, Matti
ispartofRied, J. S., J. Jeff M., A. Y. Chu, J. L. Bragg-Gresham, J. van Dongen, J. E. Huffman, T. S. Ahluwalia, et al. 2016. “A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape.” Nature Communications 7 (1): 13357. doi:10.1038/ncomms13357. http://dx.doi.org/10.1038/ncomms13357.
identifierISSN: 2041-1723 ; DOI: 10.1038/ncomms13357
descriptionLarge consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
languageeng
source
subjectScience & Technology ; Multidisciplinary Sciences ; Science & Technology - Other Topics ; Genome-Wide Association ; Diet-Induced Obesity ; Mass Index ; Disease Associations ; Fat Distribution ; Early-Onset ; Hip Ratio ; Resource ; Biology ; Height ; Science & Technology ; Multidisciplinary Sciences ; Science & Technology - Other Topics ; Genome-Wide Association ; Diet-Induced Obesity ; Mass Index ; Disease Associations ; Fat Distribution ; Early-Onset ; Hip Ratio ; Resource ; Biology ; Height ; MD Multidisciplinary;
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0Ried, Janina S.
1Jeff M., Janina
2Chu, Audrey Y.
3Bragg-Gresham, Jennifer L.
4van Dongen, Jenny
5Huffman, Jennifer E.
6Ahluwalia, Tarunveer S.
7Cadby, Gemma
8Eklund, Niina
9Eriksson, Joel
10Esko, Tõnu
11Feitosa, Mary F.
12Goel, Anuj
13Gorski, Mathias
14Hayward, Caroline
15Heard-Costa, Nancy L.
16Jackson, Anne U.
17Jokinen, Eero
18Kanoni, Stavroula
19Kristiansson, Kati
20Kutalik, Zoltán
21Lahti, Jari
22Luan, Jian'an
23Mägi, Reedik
24Mahajan, Anubha
25Mangino, Massimo
26Medina-Gomez, Carolina
27Monda, Keri L.
28Nolte, Ilja M.
29Pérusse, Louis
30Prokopenko, Inga
31Qi, Lu
32Rose, Lynda M.
33Salvi, Erika
34Smith, Megan T.
35Snieder, Harold
36Stančáková, Alena
37Ju Sung, Yun
38Tachmazidou, Ioanna
39Teumer, Alexander
40Thorleifsson, Gudmar
41van der Harst, Pim
42Walker, Ryan W.
43Wang, Sophie R.
44Wild, Sarah H.
45Willems, Sara M.
46Wong, Andrew
47Zhang, Weihua
48Albrecht, Eva
49Couto Alves, Alexessander
50Bakker, Stephan J. L.
51Barlassina, Cristina
52Bartz, Traci M.
53Beilby, John
54Bellis, Claire
55Bergman, Richard N.
56Bergmann, Sven
57Blangero, John
58Blüher, Matthias
59Boerwinkle, Eric
60Bonnycastle, Lori L.
61Bornstein, Stefan R.
62Bruinenberg, Marcel
63Campbell, Harry
64Chen, Yii-Der Ida
65Chiang, Charleston W. K.
66Chines, Peter S.
67Collins, Francis S
68Cucca, Fracensco
69Cupples, L Adrienne
70D'Avila, Francesca
71de Geus, Eco J .C.
72Dedoussis, George
73Dimitriou, Maria
74Döring, Angela
75Eriksson, Johan G.
76Farmaki, Aliki-Eleni
77Farrall, Martin
78Ferreira, Teresa
79Fischer, Krista
80Forouhi, Nita G.
81Friedrich, Nele
82Gjesing, Anette Prior
83Glorioso, Nicola
84Graff, Mariaelisa
85Grallert, Harald
86Grarup, Niels
87Gräßler, Jürgen
88Grewal, Jagvir
89Hamsten, Anders
90Harder, Marie Neergaard
91Hartman, Catharina A.
92Hassinen, Maija
93Hastie, Nicholas
94Hattersley, Andrew Tym
95Havulinna, Aki S.
96Heliövaara, Markku
97Hillege, Hans
98Hofman, Albert
99Holmen, Oddgeir
100...
titleA principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
descriptionLarge consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
general
0Digital Access to Scholarship at Harvard (DASH)
1Nature Publishing Group
2English
310.1038/ncomms13357
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02041-1723
120411723
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creationdate2016
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lsr30VSR-Enriched:[pages, orcidid, subject, vol, isbn, issue, pqid]
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titleA principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
authorRied, Janina S. ; Jeff M., Janina ; Chu, Audrey Y. ; Bragg-Gresham, Jennifer L. ; Van Dongen, Jenny ; Huffman, Jennifer E. ; Ahluwalia, Tarunveer S. ; Cadby, Gemma ; Eklund, Niina ; Eriksson, Joel ; Esko, Tõnu ; Feitosa, Mary F. ; Goel, Anuj ; Gorski, Mathias ; Hayward, Caroline ; Heard-Costa, Nancy L. ; Jackson, Anne U. ; Jokinen, Eero ; Kanoni, Stavroula ; Kristiansson, Kati ; Kutalik, Zoltán ; Lahti, Jari ; Luan, Jian'An ; Mägi, Reedik ; Mahajan, Anubha ; Mangino, Massimo ; Medina-Gomez, Carolina ; Monda, Keri L. ; Nolte, Ilja M. ; Pérusse, Louis ; Prokopenko, Inga ; Qi, Lu ; Rose, Lynda M. ; Salvi, Erika ; Smith, Megan T. ; Snieder, Harold ; Stančáková, Alena ; Ju Sung, Yun ; Tachmazidou, Ioanna ; Teumer, Alexander ; Thorleifsson, Gudmar ; Van Der Harst, Pim ; Walker, Ryan W. ; Wang, Sophie R. ; Wild, Sarah H. ; Willems, Sara M. ; Wong, Andrew ; Zhang, Weihua ; Albrecht, Eva ; Couto Alves, Alexessander ; Bakker, Stephan J. L. ; Barlassina, Cristina ; Bartz, Traci M. ; Beilby, John ; Bellis, Claire ; Bergman, Richard N. ; Bergmann, Sven ; Blangero, John ; Blüher, Matthias ; Boerwinkle, Eric ; Bonnycastle, Lori L. ; Bornstein, Stefan R. ; Bruinenberg, Marcel ; Campbell, Harry ; Chen, Yii-Der Ida ; Chiang, Charleston W. K. ; Chines, Peter S. ; Collins, Francis S ; Cucca, Fracensco ; Cupples, L Adrienne ; D'Avila, Francesca ; De Geus, Eco J .C. ; Dedoussis, George ; Dimitriou, Maria ; Döring, Angela ; Eriksson, Johan G. ; Farmaki, Aliki-Eleni ; Farrall, Martin ; Ferreira, Teresa ; Fischer, Krista ; Forouhi, Nita G. ; Friedrich, Nele ; Gjesing, Anette Prior ; Glorioso, Nicola ; Graff, Mariaelisa ; Grallert, Harald ; Grarup, Niels ; Gräßler, Jürgen ; Grewal, Jagvir ; Hamsten, Anders ; Harder, Marie Neergaard ; Hartman, Catharina A. ; Hassinen, Maija ; Hastie, Nicholas ; Hattersley, Andrew Tym ; Havulinna, Aki S. ; Heliövaara, Markku ; Hillege, Hans ; Hofman, Albert ; Holmen, Oddgeir ; Homuth, Georg ; Hottenga, Jouke-Jan ; Hui, Jennie ; Husemoen, Lise Lotte ; Hysi, Pirro G. ; Isaacs, Aaron ; Ittermann, Till ; Jalilzadeh, Shapour ; James, Alan L. ; Jørgensen, Torben ; Jousilahti, Pekka ; Jula, Antti ; Marie Justesen, Johanne ; Justice, Anne E. ; Kähönen, Mika ; Karaleftheri, Maria ; Tee Khaw, Kay ; Keinanen-Kiukaanniemi, Sirkka M. ; Kinnunen, Leena ; Knekt, Paul B. ; Koistinen, Heikki A. ; Kolcic, Ivana ; Kooner, Ishminder K. ; Koskinen, Seppo ; Kovacs, Peter ; Kyriakou, Theodosios ; Laitinen, Tomi ; Langenberg, Claudia ; Lewin, Alexandra M. ; Lichtner, Peter ; Lindgren, Cecilia M. ; Lindström, Jaana ; Linneberg, Allan ; Lorbeer, Roberto ; Lorentzon, Mattias ; Luben, Robert ; Lyssenko, Valeriya ; Männistö, Satu ; Manunta, Paolo ; Leach, Irene Mateo ; Mcardle, Wendy L. ; Mcknight, Barbara ; Mohlke, Karen L. ; Mihailov, Evelin ; Milani, Lili ; Mills, Rebecca ; Montasser, May E. ; Morris, Andrew P. ; Müller, Gabriele ; Musk, Arthur W. ; Narisu, Narisu ; Ong, Ken K. ; Oostra, Ben A. ; Osmond, Clive ; Palotie, Aarno ; Pankow, James S. ; Paternoster, Lavinia ; Penninx, Brenda W. ; Pichler, Irene ; Pilia, Maria G. ; Polašek, Ozren ; Pramstaller, Peter P. ; Raitakari, Olli T ; Rankinen, Tuomo ; Rao, D. C. ; Rayner, Nigel W. ; Ribel-Madsen, Rasmus ; Rice, Treva K. ; Richards, Marcus ; Ridker, Paul M. ; Rivadeneira, Fernando ; Ryan, Kathy A. ; Sanna, Serena ; Sarzynski, Mark A. ; Scholtens, Salome ; Scott, Robert A. ; Sebert, Sylvain ; Southam, Lorraine ; Sparsø, Thomas Hempel ; Steinthorsdottir, Valgerdur ; Stirrups, Kathleen ; Stolk, Ronald P. ; Strauch, Konstantin ; Stringham, Heather M. ; Swertz, Morris A. ; Swift, Amy J. ; Tönjes, Anke ; Tsafantakis, Emmanouil ; Van Der Most, Peter J. ; Van Vliet-Ostaptchouk, Jana V. ; Vandenput, Liesbeth ; Vartiainen, Erkki ; Venturini, Cristina ; Verweij, Niek ; Viikari, Jorma S. ; Vitart, Veronique ; Vohl, Marie-Claude ; Vonk, Judith M. ; Waeber, Gérard ; Widén, Elisabeth ; Willemsen, Gonneke ; Wilsgaard, Tom ; Winkler, Thomas W. ; Wright, Alan F. ; Yerges-Armstrong, Laura M. ; Hua Zhao, Jing ; Carola Zillikens, M. ; Boomsma, Dorret I. ; Bouchard, Claude ; Chambers, John C. ; Chasman, Daniel I. ; Cusi, Daniele ; Gansevoort, Ron T. ; Gieger, Christian ; Hansen, Torben ; Hicks, Andrew A. ; Hu, Frank ; Hveem, Kristian ; Jarvelin, Marjo-Riitta ; Kajantie, Eero ; Kooner, Jaspal S. ; Kuh, Diana ; Kuusisto, Johanna ; Laakso, Markku ; Lakka, Timo A. ; Lehtimäki, Terho ; Metspalu, Andres ; Njølstad, Inger ; Ohlsson, Claes ; Oldehinkel, Albertine J. ; Palmer, Lyle J. ; Pedersen, Oluf ; Perola, Markus ; Peters, Annette ; Psaty, Bruce M. ; Puolijoki, Hannu ; Rauramaa, Rainer ; Rudan, Igor ; Salomaa, Veikko ; Schwarz, Peter E. H. ; Shudiner, Alan R. ; Smit, Jan H. ; Sørensen, Thorkild I. A. ; Spector, Timothy D. ; Stefansson, Kari ; Stumvoll, Michael ; Tremblay, Angelo ; Tuomilehto, Jaakko ; Uitterlinden, André G. ; Uusitupa, Matti
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0Ried, Janina S
1Jeff M., Janina
2Chu, Audrey Y
3Bragg-Gresham, Jennifer L
4van Dongen, Jenny
5Huffman, Jennifer E
6Ahluwalia, Tarunveer S
7Cadby, Gemma
8Eklund, Niina
9Eriksson, Joel
10Esko, Tõnu
11Feitosa, Mary F
12Goel, Anuj
13Gorski, Mathias
14Hayward, Caroline
15Heard-Costa, Nancy L
16Jackson, Anne U
17Jokinen, Eero
18Kanoni, Stavroula
19Kristiansson, Kati
20Kutalik, Zoltán
21Lahti, Jari
22Luan, Jian'an
23Mägi, Reedik
24Mahajan, Anubha
25Mangino, Massimo
26Medina-Gomez, Carolina
27Monda, Keri L
28Nolte, Ilja M
29Pérusse, Louis
30Prokopenko, Inga
31Qi, Lu
32Rose, Lynda M
33Salvi, Erika
34Smith, Megan T
35Snieder, Harold
36Stančáková, Alena
37Ju Sung, Yun
38Tachmazidou, Ioanna
39Teumer, Alexander
40Thorleifsson, Gudmar
41van der Harst, Pim
42Walker, Ryan W
43Wang, Sophie R
44Wild, Sarah H
45Willems, Sara M
46Wong, Andrew
47Zhang, Weihua
48Albrecht, Eva
49Couto Alves, Alexessander
50Bakker, Stephan J. L
51Barlassina, Cristina
52Bartz, Traci M
53Beilby, John
54Bellis, Claire
55Bergman, Richard N
56Bergmann, Sven
57Blangero, John
58Blüher, Matthias
59Boerwinkle, Eric
60Bonnycastle, Lori L
61Bornstein, Stefan R
62Bruinenberg, Marcel
63Campbell, Harry
64Chen, Yii-Der Ida
65Chiang, Charleston W. K
66Chines, Peter S
67Collins, Francis S
68Cucca, Fracensco
69Cupples, L Adrienne
70D'Avila, Francesca
71de Geus, Eco J .C
72Dedoussis, George
73Dimitriou, Maria
74Döring, Angela
75Eriksson, Johan G
76Farmaki, Aliki-Eleni
77Farrall, Martin
78Ferreira, Teresa
79Fischer, Krista
80Forouhi, Nita G
81Friedrich, Nele
82Gjesing, Anette Prior
83Glorioso, Nicola
84Graff, Mariaelisa
85Grallert, Harald
86Grarup, Niels
87Gräßler, Jürgen
88Grewal, Jagvir
89Hamsten, Anders
90Harder, Marie Neergaard
91Hartman, Catharina A
92Hassinen, Maija
93Hastie, Nicholas
94Hattersley, Andrew Tym
95Havulinna, Aki S
96Heliövaara, Markku
97Hillege, Hans
98Hofman, Albert
99Holmen, Oddgeir
100...
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0Ried
1Jeff M.
2Chu
3Bragg-Gresham
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5Huffman
6Ahluwalia
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9Eriksson
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11Feitosa
12Goel
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8Niina
9Joel
10Tõnu
11Mary F.
12Anuj
13Mathias
14Caroline
15Nancy L.
16Anne U.
17Eero
18Stavroula
19Kati
20Zoltán
21Jari
22Jian'an
23Reedik
24Anubha
25Massimo
26Carolina
27Keri L.
28Ilja M.
29Louis
30Inga
31Lu
32Lynda M.
33Erika
34Megan T.
35Harold
36Alena
37Yun
38Ioanna
39Alexander
40Gudmar
41Pim
42Ryan W.
43Sophie R.
44Sarah H.
45Sara M.
46Andrew
47Weihua
48Eva
49Alexessander
50Stephan J. L.
51Cristina
52Traci M.
53John
54Claire
55Richard N.
56Sven
57Matthias
58Eric
59Lori L.
60Stefan R.
61Marcel
62Harry
63Yii-Der Ida
64Charleston W. K.
65Peter S.
66Francis S
67Fracensco
68L Adrienne
69Francesca
70Eco J .C.
71George
72Maria
73Angela
74Johan G.
75Aliki-Eleni
76Martin
77Teresa
78Krista
79Nita G.
80Nele
81Anette Prior
82Nicola
83Mariaelisa
84Harald
85Niels
86Jürgen
87Jagvir
88Anders
89Marie Neergaard
90Catharina A.
91Maija
92Nicholas
93Andrew Tym
94Aki S.
95Markku
96Hans
97Albert
98Oddgeir
99Georg
100...
au
0Ried, Janina S.
1Jeff M., Janina
2Chu, Audrey Y.
3Bragg-Gresham, Jennifer L.
4van Dongen, Jenny
5Huffman, Jennifer E.
6Ahluwalia, Tarunveer S.
7Cadby, Gemma
8Eklund, Niina
9Eriksson, Joel
10Esko, Tõnu
11Feitosa, Mary F.
12Goel, Anuj
13Gorski, Mathias
14Hayward, Caroline
15Heard-Costa, Nancy L.
16Jackson, Anne U.
17Jokinen, Eero
18Kanoni, Stavroula
19Kristiansson, Kati
20Kutalik, Zoltán
21Lahti, Jari
22Luan, Jian'an
23Mägi, Reedik
24Mahajan, Anubha
25Mangino, Massimo
26Medina-Gomez, Carolina
27Monda, Keri L.
28Nolte, Ilja M.
29Pérusse, Louis
30Prokopenko, Inga
31Qi, Lu
32Rose, Lynda M.
33Salvi, Erika
34Smith, Megan T.
35Snieder, Harold
36Stančáková, Alena
37Ju Sung, Yun
38Tachmazidou, Ioanna
39Teumer, Alexander
40Thorleifsson, Gudmar
41van der Harst, Pim
42Walker, Ryan W.
43Wang, Sophie R.
44Wild, Sarah H.
45Willems, Sara M.
46Wong, Andrew
47Zhang, Weihua
48Albrecht, Eva
49Couto Alves, Alexessander
50Bakker, Stephan J. L.
51Barlassina, Cristina
52Bartz, Traci M.
53Beilby, John
54Bellis, Claire
55Bergman, Richard N.
56Bergmann, Sven
57Blangero, John
58Blüher, Matthias
59Boerwinkle, Eric
60Bonnycastle, Lori L.
61Bornstein, Stefan R.
62Bruinenberg, Marcel
63Campbell, Harry
64Chen, Yii-Der Ida
65Chiang, Charleston W. K.
66Chines, Peter S.
67Collins, Francis S
68Cucca, Fracensco
69Cupples, L Adrienne
70D'Avila, Francesca
71de Geus, Eco J .C.
72Dedoussis, George
73Dimitriou, Maria
74Döring, Angela
75Eriksson, Johan G.
76Farmaki, Aliki-Eleni
77Farrall, Martin
78Ferreira, Teresa
79Fischer, Krista
80Forouhi, Nita G.
81Friedrich, Nele
82Gjesing, Anette Prior
83Glorioso, Nicola
84Graff, Mariaelisa
85Grallert, Harald
86Grarup, Niels
87Gräßler, Jürgen
88Grewal, Jagvir
89Hamsten, Anders
90Harder, Marie Neergaard
91Hartman, Catharina A.
92Hassinen, Maija
93Hastie, Nicholas
94Hattersley, Andrew Tym
95Havulinna, Aki S.
96Heliövaara, Markku
97Hillege, Hans
98Hofman, Albert
99Holmen, Oddgeir
100...
atitleA principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
jtitleNature Communications
date2016
risdate2016
issn2041-1723
genrearticle
ristypeJOUR
abstractLarge consortia have revealed hundreds of genetic loci associated with anthropometric traits, one trait at a time. We examined whether genetic variants affect body shape as a composite phenotype that is represented by a combination of anthropometric traits. We developed an approach that calculates averaged PCs (AvPCs) representing body shape derived from six anthropometric traits (body mass index, height, weight, waist and hip circumference, waist-to-hip ratio). The first four AvPCs explain >99% of the variability, are heritable, and associate with cardiometabolic outcomes. We performed genome-wide association analyses for each body shape composite phenotype across 65 studies and meta-analysed summary statistics. We identify six novel loci: LEMD2 and CD47 for AvPC1, RPS6KA5/C14orf159 and GANAB for AvPC3, and ARL15 and ANP32 for AvPC4. Our findings highlight the value of using multiple traits to define complex phenotypes for discovery, which are not captured by single-trait analyses, and may shed light onto new pathways.
pubNature Publishing Group
doi10.1038/ncomms13357
urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5114527/pdf/
pages13357
orcidid0000-0002-9672-2547
volume7
issue1
isbn0003883197000
oafree_for_read