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Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts

Aim: Alcohol consumption during pregnancy is sometimes associated with adverse outcomes in offspring, potentially mediated by epigenetic modifications. We aimed to investigate genome-wide DNA methylation in cord blood of newborns exposed to alcohol in utero. Materials & methods: We meta-analyzed inf... Full description

Journal Title: Sharp G. C., R. Arathimos, S. E. Reese, C. M. Page, J. Felix, L. K. Küpers, S. L. Rifas-Shiman, et al. 2018. “Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts.” Epigenomics 10 (1): 27-42. doi:10.2217/epi-2017-0095. http://dx.doi.org/10.2217/epi-2017-0095.
Main Author: Sharp, Gemma C
Other Authors: Arathimos, Ryan , Reese, Sarah E , Page, Christian M , Felix, Janine , Küpers, Leanne K , Rifas-Shiman, Sheryl L , Liu, Chunyu , Burrows, Kimberley , Zhao, Shanshan , Magnus, Maria C , Duijts, Liesbeth , Corpeleijn, Eva , Demeo, Dawn L , Litonjua, Augusto , Baccarelli, Andrea , Hivert, Marie-France , Oken, Emily , Snieder, Harold , Jaddoe, Vincent , Nystad, Wenche , London, Stephanie J , Relton, Caroline L , Zuccolo, Luisa
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: DOI: 10.2217/epi-2017-0095
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recordid: dash1/34868963
title: Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts
format: Article
creator:
  • Sharp, Gemma C
  • Arathimos, Ryan
  • Reese, Sarah E
  • Page, Christian M
  • Felix, Janine
  • Küpers, Leanne K
  • Rifas-Shiman, Sheryl L
  • Liu, Chunyu
  • Burrows, Kimberley
  • Zhao, Shanshan
  • Magnus, Maria C
  • Duijts, Liesbeth
  • Corpeleijn, Eva
  • Demeo, Dawn L
  • Litonjua, Augusto
  • Baccarelli, Andrea
  • Hivert, Marie-France
  • Oken, Emily
  • Snieder, Harold
  • Jaddoe, Vincent
  • Nystad, Wenche
  • London, Stephanie J
  • Relton, Caroline L
  • Zuccolo, Luisa
subjects:
  • Alcohol
  • Cord Blood
  • Dna Methylation
  • Epidemiology
  • Epigenetics
  • Meta-Analysis
  • Pace Consortium
  • Pregnancy
ispartof: Sharp, G. C., R. Arathimos, S. E. Reese, C. M. Page, J. Felix, L. K. Küpers, S. L. Rifas-Shiman, et al. 2018. “Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts.” Epigenomics 10 (1): 27-42. doi:10.2217/epi-2017-0095. http://dx.doi.org/10.2217/epi-2017-0095.
description: Aim: Alcohol consumption during pregnancy is sometimes associated with adverse outcomes in offspring, potentially mediated by epigenetic modifications. We aimed to investigate genome-wide DNA methylation in cord blood of newborns exposed to alcohol in utero. Materials & methods: We meta-analyzed information from six population-based birth cohorts within the Pregnancy and Childhood Epigenetics consortium. Results: We found no strong evidence of association at either individual CpGs or across larger regions of the genome. Conclusion: Our findings suggest no association between maternal alcohol consumption and offspring cord blood DNA methylation. This is in stark contrast to the multiple strong associations previous studies have found for maternal smoking, which is similarly socially patterned. However, it is possible that a combination of a larger sample size, higher doses, different timings of exposure, exploration of a different tissue and a more global assessment of genomic DNA methylation might show evidence of association.
language: eng
source:
identifier: DOI: 10.2217/epi-2017-0095
fulltext: fulltext_linktorsrc
url: Link


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titleMaternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts
creatorSharp, Gemma C ; Arathimos, Ryan ; Reese, Sarah E ; Page, Christian M ; Felix, Janine ; Küpers, Leanne K ; Rifas-Shiman, Sheryl L ; Liu, Chunyu ; Burrows, Kimberley ; Zhao, Shanshan ; Magnus, Maria C ; Duijts, Liesbeth ; Corpeleijn, Eva ; Demeo, Dawn L ; Litonjua, Augusto ; Baccarelli, Andrea ; Hivert, Marie-France ; Oken, Emily ; Snieder, Harold ; Jaddoe, Vincent ; Nystad, Wenche ; London, Stephanie J ; Relton, Caroline L ; Zuccolo, Luisa
ispartofSharp, G. C., R. Arathimos, S. E. Reese, C. M. Page, J. Felix, L. K. Küpers, S. L. Rifas-Shiman, et al. 2018. “Maternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts.” Epigenomics 10 (1): 27-42. doi:10.2217/epi-2017-0095. http://dx.doi.org/10.2217/epi-2017-0095.
identifierDOI: 10.2217/epi-2017-0095
subjectAlcohol ; Cord Blood ; Dna Methylation ; Epidemiology ; Epigenetics ; Meta-Analysis ; Pace Consortium ; Pregnancy
descriptionAim: Alcohol consumption during pregnancy is sometimes associated with adverse outcomes in offspring, potentially mediated by epigenetic modifications. We aimed to investigate genome-wide DNA methylation in cord blood of newborns exposed to alcohol in utero. Materials & methods: We meta-analyzed information from six population-based birth cohorts within the Pregnancy and Childhood Epigenetics consortium. Results: We found no strong evidence of association at either individual CpGs or across larger regions of the genome. Conclusion: Our findings suggest no association between maternal alcohol consumption and offspring cord blood DNA methylation. This is in stark contrast to the multiple strong associations previous studies have found for maternal smoking, which is similarly socially patterned. However, it is possible that a combination of a larger sample size, higher doses, different timings of exposure, exploration of a different tissue and a more global assessment of genomic DNA methylation might show evidence of association.
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titleMaternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts
descriptionAim: Alcohol consumption during pregnancy is sometimes associated with adverse outcomes in offspring, potentially mediated by epigenetic modifications. We aimed to investigate genome-wide DNA methylation in cord blood of newborns exposed to alcohol in utero. Materials & methods: We meta-analyzed information from six population-based birth cohorts within the Pregnancy and Childhood Epigenetics consortium. Results: We found no strong evidence of association at either individual CpGs or across larger regions of the genome. Conclusion: Our findings suggest no association between maternal alcohol consumption and offspring cord blood DNA methylation. This is in stark contrast to the multiple strong associations previous studies have found for maternal smoking, which is similarly socially patterned. However, it is possible that a combination of a larger sample size, higher doses, different timings of exposure, exploration of a different tissue and a more global assessment of genomic DNA methylation might show evidence of association.
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titleMaternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts
authorSharp, Gemma C ; Arathimos, Ryan ; Reese, Sarah E ; Page, Christian M ; Felix, Janine ; Küpers, Leanne K ; Rifas-Shiman, Sheryl L ; Liu, Chunyu ; Burrows, Kimberley ; Zhao, Shanshan ; Magnus, Maria C ; Duijts, Liesbeth ; Corpeleijn, Eva ; Demeo, Dawn L ; Litonjua, Augusto ; Baccarelli, Andrea ; Hivert, Marie-France ; Oken, Emily ; Snieder, Harold ; Jaddoe, Vincent ; Nystad, Wenche ; London, Stephanie J ; Relton, Caroline L ; Zuccolo, Luisa
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atitleMaternal alcohol consumption and offspring DNA methylation: findings from six general population-based birth cohorts
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abstractAim: Alcohol consumption during pregnancy is sometimes associated with adverse outcomes in offspring, potentially mediated by epigenetic modifications. We aimed to investigate genome-wide DNA methylation in cord blood of newborns exposed to alcohol in utero. Materials & methods: We meta-analyzed information from six population-based birth cohorts within the Pregnancy and Childhood Epigenetics consortium. Results: We found no strong evidence of association at either individual CpGs or across larger regions of the genome. Conclusion: Our findings suggest no association between maternal alcohol consumption and offspring cord blood DNA methylation. This is in stark contrast to the multiple strong associations previous studies have found for maternal smoking, which is similarly socially patterned. However, it is possible that a combination of a larger sample size, higher doses, different timings of exposure, exploration of a different tissue and a more global assessment of genomic DNA methylation might show evidence of association.
pubFuture Medicine Ltd
doi10.2217/epi-2017-0095
urlhttp://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753623/pdf/
issue1
pages27-42
volume10
issn17501911
eissn1750192X
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