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Tunable Pentapeptide Self-Assembled β-Sheet Hydrogels.

Oligopeptide-based supramolecular hydrogels shold promise in a range of applications. The gelation of these systems is hard to control with minor alterations in the peptide sequence significantly influencing the self-assembly process. This makes sequence design difficult whereby typical self-assembl... Full description

Main Author: Clarke, David E
Other Authors: Parmenter, Christopher DJ , Scherman, Oren Alexander
Format: Electronic Article Electronic Article
Language:
Quelle: DataCite
Publisher: Apollo - University of Cambridge Repository
Created: 2018
ID: DOI: 10.17863/CAM.24125 ; ISSN: 1433-7851
Link: http://data.datacite.org/10.17863/CAM.24125
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recordid: datacite15224341
title: Tunable Pentapeptide Self-Assembled β-Sheet Hydrogels.
format: Article
creator:
  • Clarke, David E
  • Parmenter, Christopher DJ
  • Scherman, Oren Alexander
ispartof:
description: Oligopeptide-based supramolecular hydrogels shold promise in a range of applications. The gelation of these systems is hard to control with minor alterations in the peptide sequence significantly influencing the self-assembly process. This makes sequence design difficult whereby typical self-assembly rules cannot be applied. We explored the design of pentapeptide sequences with different charge distributions and discovered that they formed robust, pH-responsive hydrogels. Through altering the concentration and charge distribution of the peptide sequence, we demonstrated that the stiffness of the hydrogels can be tuned across two orders of magnitude (2-200 kPa). Also, through the reassembly of the β-sheet interactions, the hydrogels can both selfheal and shear thin. Using spectroscopic and cryo-imaging techniques, we investigated the relationship between peptide sequence, molecular structure and how these influence the mechanical properties of the hydrogel. These pentapetide hydrogels attributed with tunable morphology and mechanical properties have promise in tissue engineering, injectable delivery vectors and 3D printing applications....
language:
source: DataCite
identifier: DOI: 10.17863/CAM.24125 ; ISSN: 1433-7851
fulltext: fulltext_linktorsrc
issn:
  • 1433-7851
  • 14337851
url: Link


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descriptionOligopeptide-based supramolecular hydrogels shold promise in a range of applications. The gelation of these systems is hard to control with minor alterations in the peptide sequence significantly influencing the self-assembly process. This makes sequence design difficult whereby typical self-assembly rules cannot be applied. We explored the design of pentapeptide sequences with different charge distributions and discovered that they formed robust, pH-responsive hydrogels. Through altering the concentration and charge distribution of the peptide sequence, we demonstrated that the stiffness of the hydrogels can be tuned across two orders of magnitude (2-200 kPa). Also, through the reassembly of the β-sheet interactions, the hydrogels can both selfheal and shear thin. Using spectroscopic and cryo-imaging techniques, we investigated the relationship between peptide sequence, molecular structure and how these influence the mechanical properties of the hydrogel. These pentapetide hydrogels attributed with tunable morphology and mechanical properties have promise in tissue engineering, injectable delivery vectors and 3D printing applications....
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descriptionOligopeptide-based supramolecular hydrogels shold promise in a range of applications. The gelation of these systems is hard to control with minor alterations in the peptide sequence significantly influencing the self-assembly process. This makes sequence design difficult whereby typical self-assembly rules cannot be applied. We explored the design of pentapeptide sequences with different charge distributions and discovered that they formed robust, pH-responsive hydrogels. Through altering the concentration and charge distribution of the peptide sequence, we demonstrated that the stiffness of the hydrogels can be tuned across two orders of magnitude (2-200 kPa). Also, through the reassembly of the β-sheet interactions, the hydrogels can both selfheal and shear thin. Using spectroscopic and cryo-imaging techniques, we investigated the relationship between peptide sequence, molecular structure and how these influence the mechanical properties of the hydrogel. These pentapetide hydrogels attributed with tunable morphology and mechanical properties have promise in tissue engineering, injectable delivery vectors and 3D printing applications....
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abstractOligopeptide-based supramolecular hydrogels shold promise in a range of applications. The gelation of these systems is hard to control with minor alterations in the peptide sequence significantly influencing the self-assembly process. This makes sequence design difficult whereby typical self-assembly rules cannot be applied. We explored the design of pentapeptide sequences with different charge distributions and discovered that they formed robust, pH-responsive hydrogels. Through altering the concentration and charge distribution of the peptide sequence, we demonstrated that the stiffness of the hydrogels can be tuned across two orders of magnitude (2-200 kPa). Also, through the reassembly of the β-sheet interactions, the hydrogels can both selfheal and shear thin. Using spectroscopic and cryo-imaging techniques, we investigated the relationship between peptide sequence, molecular structure and how these influence the mechanical properties of the hydrogel. These pentapetide hydrogels attributed with tunable morphology and mechanical properties have promise in tissue engineering, injectable delivery vectors and 3D printing applications....
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