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Mendelian randomization analysis of C-reactive protein on colorectal cancer risk.

Background: Chronic inflammation is a risk factor for colorectal cancer (CRC). Circulating C-reactive protein (CRP) is also moderately associated with CRC risk. However, observational studies are susceptible to unmeasured confounding or reverse causality. Using genetic risk variants as instrumental... Full description

Main Author: Wang, Xiaoliang
Other Authors: Dai, James Y , Albanes, Demetrius , Arndt, Volker , Berndt, Sonja I , Bézieau, Stéphane , Brenner, Hermann , Buchanan, Daniel D , Butterbach, Katja , Caan, Bette , Casey, Graham , Campbell, Peter T , Chan, Andrew T , Chen, Zhengyi , Chang-Claude, Jenny , Cotterchio, Michelle , Easton, Douglas Frederick , Giles, Graham G , Giovannucci, Edward , Grady, William M , Hoffmeister, Michael , Hopper, John L , Hsu, Li , Jenkins, Mark A , Joshi, Amit D , Lampe, Johanna W , Larsson, Susanna C , Lejbkowicz, Flavio , Li, Li , Lindblom, Annika , Le Marchand, Loic , Martin, Vicente , Milne, Roger L , Moreno, Victor , Newcomb, Polly A , Offitt, Kenneth , Ogino, Shuji , Pharoah, Paul David , Pinchev, Mila , Potter, John D , Rennert, Hedy S , Rennert, Gad , Saliba, Walid , Schafmayer, Clemens , Schoen, Robert E , Schrotz-King, Petra , Slattery, Martha L , Song, Mingyang , Stegmaier, Christa , Weinstein, Stephanie J , Wolk, Alicja , Woods, Michael O , Wu, Anna H , Gruber, Stephen B , Peters, Ulrike , White, Emily
Format: Electronic Article Electronic Article
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Quelle: DataCite
Publisher: Apollo - University of Cambridge Repository
Created: 2018
ID: DOI: 10.17863/CAM.34000 ; ISSN: 0300-5771
Link: http://data.datacite.org/10.17863/CAM.34000
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recordid: datacite17790613
title: Mendelian randomization analysis of C-reactive protein on colorectal cancer risk.
format: Article
creator:
  • Wang, Xiaoliang
  • Dai, James Y
  • Albanes, Demetrius
  • Arndt, Volker
  • Berndt, Sonja I
  • Bézieau, Stéphane
  • Brenner, Hermann
  • Buchanan, Daniel D
  • Butterbach, Katja
  • Caan, Bette
  • Casey, Graham
  • Campbell, Peter T
  • Chan, Andrew T
  • Chen, Zhengyi
  • Chang-Claude, Jenny
  • Cotterchio, Michelle
  • Easton, Douglas Frederick
  • Giles, Graham G
  • Giovannucci, Edward
  • Grady, William M
  • Hoffmeister, Michael
  • Hopper, John L
  • Hsu, Li
  • Jenkins, Mark A
  • Joshi, Amit D
  • Lampe, Johanna W
  • Larsson, Susanna C
  • Lejbkowicz, Flavio
  • Li, Li
  • Lindblom, Annika
  • Le Marchand, Loic
  • Martin, Vicente
  • Milne, Roger L
  • Moreno, Victor
  • Newcomb, Polly A
  • Offitt, Kenneth
  • Ogino, Shuji
  • Pharoah, Paul David
  • Pinchev, Mila
  • Potter, John D
  • Rennert, Hedy S
  • Rennert, Gad
  • Saliba, Walid
  • Schafmayer, Clemens
  • Schoen, Robert E
  • Schrotz-King, Petra
  • Slattery, Martha L
  • Song, Mingyang
  • Stegmaier, Christa
  • Weinstein, Stephanie J
  • Wolk, Alicja
  • Woods, Michael O
  • Wu, Anna H
  • Gruber, Stephen B
  • Peters, Ulrike
  • White, Emily
ispartof:
description: Background: Chronic inflammation is a risk factor for colorectal cancer (CRC). Circulating C-reactive protein (CRP) is also moderately associated with CRC risk. However, observational studies are susceptible to unmeasured confounding or reverse causality. Using genetic risk variants as instrumental variables, we investigated the causal relationship between genetically elevated CRP concentration and CRC risk using a Mendelian randomization approach. Methods: Individual-level data from 30 480 CRC cases and 22 844 controls from 33 participating studies in three international consortia were used: the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colorectal Transdisciplinary Study (CORECT) and the Colon Cancer Family Registry (CCFR). As instrumental variables, we included 19 SNPs previously associated with CRP concentration. The SNP-CRC associations were estimated using a logistic regression model adjusted for age, sex, principal components and genotyping phases. An inverse-variance weighted method was applied to estimate the causal effect of CRP on CRC risk. Results: Among the 19 CRP-associated SNPs, rs1260326 and rs6734238 were significantly associated with CRC risk (p=7.5×10-4, and p=0.003, respectively). A genetically predicted one-unit increase in the log-transformed CRP concentrations (mg/L) was not associated with increased risk of CRC (OR=1.04; 95% CI: 0.97-1.12; p=0.256). No evidence of association was observed in subgroup analyses...
language:
source: DataCite
identifier: DOI: 10.17863/CAM.34000 ; ISSN: 0300-5771
fulltext: fulltext_linktorsrc
issn:
  • 0300-5771
  • 03005771
url: Link


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titleMendelian randomization analysis of C-reactive protein on colorectal cancer risk.
creatorWang, Xiaoliang ; Dai, James Y ; Albanes, Demetrius ; Arndt, Volker ; Berndt, Sonja I ; Bézieau, Stéphane ; Brenner, Hermann ; Buchanan, Daniel D ; Butterbach, Katja ; Caan, Bette ; Casey, Graham ; Campbell, Peter T ; Chan, Andrew T ; Chen, Zhengyi ; Chang-Claude, Jenny ; Cotterchio, Michelle ; Easton, Douglas Frederick ; Giles, Graham G ; Giovannucci, Edward ; Grady, William M ; Hoffmeister, Michael ; Hopper, John L ; Hsu, Li ; Jenkins, Mark A ; Joshi, Amit D ; Lampe, Johanna W ; Larsson, Susanna C ; Lejbkowicz, Flavio ; Li, Li ; Lindblom, Annika ; Le Marchand, Loic ; Martin, Vicente ; Milne, Roger L ; Moreno, Victor ; Newcomb, Polly A ; Offitt, Kenneth ; Ogino, Shuji ; Pharoah, Paul David ; Pinchev, Mila ; Potter, John D ; Rennert, Hedy S ; Rennert, Gad ; Saliba, Walid ; Schafmayer, Clemens ; Schoen, Robert E ; Schrotz-King, Petra ; Slattery, Martha L ; Song, Mingyang ; Stegmaier, Christa ; Weinstein, Stephanie J ; Wolk, Alicja ; Woods, Michael O ; Wu, Anna H ; Gruber, Stephen B ; Peters, Ulrike ; White, Emily
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creationdate2018
identifierDOI: 10.17863/CAM.34000 ; ISSN: 0300-5771
descriptionBackground: Chronic inflammation is a risk factor for colorectal cancer (CRC). Circulating C-reactive protein (CRP) is also moderately associated with CRC risk. However, observational studies are susceptible to unmeasured confounding or reverse causality. Using genetic risk variants as instrumental variables, we investigated the causal relationship between genetically elevated CRP concentration and CRC risk using a Mendelian randomization approach. Methods: Individual-level data from 30 480 CRC cases and 22 844 controls from 33 participating studies in three international consortia were used: the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colorectal Transdisciplinary Study (CORECT) and the Colon Cancer Family Registry (CCFR). As instrumental variables, we included 19 SNPs previously associated with CRP concentration. The SNP-CRC associations were estimated using a logistic regression model adjusted for age, sex, principal components and genotyping phases. An inverse-variance weighted method was applied to estimate the causal effect of CRP on CRC risk. Results: Among the 19 CRP-associated SNPs, rs1260326 and rs6734238 were significantly associated with CRC risk (p=7.5×10-4, and p=0.003, respectively). A genetically predicted one-unit increase in the log-transformed CRP concentrations (mg/L) was not associated with increased risk of CRC (OR=1.04; 95% CI: 0.97-1.12; p=0.256). No evidence of association was observed in subgroup analyses...
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8Butterbach, Katja
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10Casey, Graham
11Campbell, Peter T
12Chan, Andrew T
13Chen, Zhengyi
14Chang-Claude, Jenny
15Cotterchio, Michelle
16Easton, Douglas Frederick
17Giles, Graham G
18Giovannucci, Edward
19Grady, William M
20Hoffmeister, Michael
21Hopper, John L
22Hsu, Li
23Jenkins, Mark A
24Joshi, Amit D
25Lampe, Johanna W
26Larsson, Susanna C
27Lejbkowicz, Flavio
28Li, Li
29Lindblom, Annika
30Le Marchand, Loic
31Martin, Vicente
32Milne, Roger L
33Moreno, Victor
34Newcomb, Polly A
35Offitt, Kenneth
36Ogino, Shuji
37Pharoah, Paul David
38Pinchev, Mila
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40Rennert, Hedy S
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43Schafmayer, Clemens
44Schoen, Robert E
45Schrotz-King, Petra
46Slattery, Martha L
47Song, Mingyang
48Stegmaier, Christa
49Weinstein, Stephanie J
50Wolk, Alicja
51Woods, Michael O
52Wu, Anna H
53Gruber, Stephen B
54Peters, Ulrike
55White, Emily
56Apollo - University of Cambridge Repository; Apollo - University of Cambridge Repository
titleMendelian randomization analysis of C-reactive protein on colorectal cancer risk.
descriptionBackground: Chronic inflammation is a risk factor for colorectal cancer (CRC). Circulating C-reactive protein (CRP) is also moderately associated with CRC risk. However, observational studies are susceptible to unmeasured confounding or reverse causality. Using genetic risk variants as instrumental variables, we investigated the causal relationship between genetically elevated CRP concentration and CRC risk using a Mendelian randomization approach. Methods: Individual-level data from 30 480 CRC cases and 22 844 controls from 33 participating studies in three international consortia were used: the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colorectal Transdisciplinary Study (CORECT) and the Colon Cancer Family Registry (CCFR). As instrumental variables, we included 19 SNPs previously associated with CRP concentration. The SNP-CRC associations were estimated using a logistic regression model adjusted for age, sex, principal components and genotyping phases. An inverse-variance weighted method was applied to estimate the causal effect of CRP on CRC risk. Results: Among the 19 CRP-associated SNPs, rs1260326 and rs6734238 were significantly associated with CRC risk (p=7.5×10-4, and p=0.003, respectively). A genetically predicted one-unit increase in the log-transformed CRP concentrations (mg/L) was not associated with increased risk of CRC (OR=1.04; 95% CI: 0.97-1.12; p=0.256). No evidence of association was observed in subgroup analyses...
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titleMendelian randomization analysis of C-reactive protein on colorectal cancer risk.
authorWang, Xiaoliang ; Dai, James Y ; Albanes, Demetrius ; Arndt, Volker ; Berndt, Sonja I ; Bézieau, Stéphane ; Brenner, Hermann ; Buchanan, Daniel D ; Butterbach, Katja ; Caan, Bette ; Casey, Graham ; Campbell, Peter T ; Chan, Andrew T ; Chen, Zhengyi ; Chang-Claude, Jenny ; Cotterchio, Michelle ; Easton, Douglas Frederick ; Giles, Graham G ; Giovannucci, Edward ; Grady, William M ; Hoffmeister, Michael ; Hopper, John L ; Hsu, Li ; Jenkins, Mark A ; Joshi, Amit D ; Lampe, Johanna W ; Larsson, Susanna C ; Lejbkowicz, Flavio ; Li, Li ; Lindblom, Annika ; Le Marchand, Loic ; Martin, Vicente ; Milne, Roger L ; Moreno, Victor ; Newcomb, Polly A ; Offitt, Kenneth ; Ogino, Shuji ; Pharoah, Paul David ; Pinchev, Mila ; Potter, John D ; Rennert, Hedy S ; Rennert, Gad ; Saliba, Walid ; Schafmayer, Clemens ; Schoen, Robert E ; Schrotz-King, Petra ; Slattery, Martha L ; Song, Mingyang ; Stegmaier, Christa ; Weinstein, Stephanie J ; Wolk, Alicja ; Woods, Michael O ; Wu, Anna H ; Gruber, Stephen B ; Peters, Ulrike ; White, Emily
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6Brenner, Hermann
7Buchanan, Daniel D
8Butterbach, Katja
9Caan, Bette
10Casey, Graham
11Campbell, Peter T
12Chan, Andrew T
13Chen, Zhengyi
14Chang-Claude, Jenny
15Cotterchio, Michelle
16Easton, Douglas Frederick
17Giles, Graham G
18Giovannucci, Edward
19Grady, William M
20Hoffmeister, Michael
21Hopper, John L
22Hsu, Li
23Jenkins, Mark A
24Joshi, Amit D
25Lampe, Johanna W
26Larsson, Susanna C
27Lejbkowicz, Flavio
28Li, Li
29Lindblom, Annika
30Le Marchand, Loic
31Martin, Vicente
32Milne, Roger L
33Moreno, Victor
34Newcomb, Polly A
35Offitt, Kenneth
36Ogino, Shuji
37Pharoah, Paul David
38Pinchev, Mila
39Potter, John D
40Rennert, Hedy S
41Rennert, Gad
42Saliba, Walid
43Schafmayer, Clemens
44Schoen, Robert E
45Schrotz-King, Petra
46Slattery, Martha L
47Song, Mingyang
48Stegmaier, Christa
49Weinstein, Stephanie J
50Wolk, Alicja
51Woods, Michael O
52Wu, Anna H
53Gruber, Stephen B
54Peters, Ulrike
55White, Emily
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1Dai, James Y
2Albanes, Demetrius
3Arndt, Volker
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6Brenner, Hermann
7Buchanan, Daniel D
8Butterbach, Katja
9Caan, Bette
10Casey, Graham
11Campbell, Peter T
12Chan, Andrew T
13Chen, Zhengyi
14Chang-Claude, Jenny
15Cotterchio, Michelle
16Easton, Douglas Frederick
17Giles, Graham G
18Giovannucci, Edward
19Grady, William M
20Hoffmeister, Michael
21Hopper, John L
22Hsu, Li
23Jenkins, Mark A
24Joshi, Amit D
25Lampe, Johanna W
26Larsson, Susanna C
27Lejbkowicz, Flavio
28Li, Li
29Lindblom, Annika
30Le Marchand, Loic
31Martin, Vicente
32Milne, Roger L
33Moreno, Victor
34Newcomb, Polly A
35Offitt, Kenneth
36Ogino, Shuji
37Pharoah, Paul David
38Pinchev, Mila
39Potter, John D
40Rennert, Hedy S
41Rennert, Gad
42Saliba, Walid
43Schafmayer, Clemens
44Schoen, Robert E
45Schrotz-King, Petra
46Slattery, Martha L
47Song, Mingyang
48Stegmaier, Christa
49Weinstein, Stephanie J
50Wolk, Alicja
51Woods, Michael O
52Wu, Anna H
53Gruber, Stephen B
54Peters, Ulrike
55White, Emily
addauApollo - University of Cambridge Repository; Apollo - University of Cambridge Repository
atitleMendelian randomization analysis of C-reactive protein on colorectal cancer risk.
risdate20180000
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abstractBackground: Chronic inflammation is a risk factor for colorectal cancer (CRC). Circulating C-reactive protein (CRP) is also moderately associated with CRC risk. However, observational studies are susceptible to unmeasured confounding or reverse causality. Using genetic risk variants as instrumental variables, we investigated the causal relationship between genetically elevated CRP concentration and CRC risk using a Mendelian randomization approach. Methods: Individual-level data from 30 480 CRC cases and 22 844 controls from 33 participating studies in three international consortia were used: the Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), the Colorectal Transdisciplinary Study (CORECT) and the Colon Cancer Family Registry (CCFR). As instrumental variables, we included 19 SNPs previously associated with CRP concentration. The SNP-CRC associations were estimated using a logistic regression model adjusted for age, sex, principal components and genotyping phases. An inverse-variance weighted method was applied to estimate the causal effect of CRP on CRC risk. Results: Among the 19 CRP-associated SNPs, rs1260326 and rs6734238 were significantly associated with CRC risk (p=7.5×10-4, and p=0.003, respectively). A genetically predicted one-unit increase in the log-transformed CRP concentrations (mg/L) was not associated with increased risk of CRC (OR=1.04; 95% CI: 0.97-1.12; p=0.256). No evidence of association was observed in subgroup analyses...
pubApollo - University of Cambridge Repository
doi10.17863/CAM.34000
oafree_for_read
date2018-00-00