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A Study of Gene-Environment Interactions In Entrepreneurship

We examined the interactions between four genes associated with dyslexia (ROBO1, KIAA0319, DCDC2, DYX1C1) and education on the tendency to become an entrepreneur. We used a two-staged design consisting of a discovery sample of 692 individuals, and a replication sample of 797 participants from the Tw... Full description

Journal Title: Entrepreneurship Research Journal 2012, Vol.2(2)
Main Author: Quaye, Lydia
Other Authors: Nicolaou, Nicos , Shane, Scott , Harris, Juliette
Format: Electronic Article Electronic Article
Language:
Subjects:
Quelle: Walter de Gruyter GmbH
Publisher: De Gruyter
ID: E-ISSN: 2157-5665 ; DOI: 10.1515/2157-5665.1053
Link: http://www.degruyter.com/doi/10.1515/2157-5665.1053
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recordid: degruytera10.1515/2157-5665.1053
title: A Study of Gene-Environment Interactions In Entrepreneurship
format: Article
creator:
  • Quaye, Lydia
  • Nicolaou, Nicos
  • Shane, Scott
  • Harris, Juliette
subjects:
  • Entrepreneurship
  • Genetics
  • Gene-Environment Interactions
ispartof: Entrepreneurship Research Journal, 2012, Vol.2(2)
description: We examined the interactions between four genes associated with dyslexia (ROBO1, KIAA0319, DCDC2, DYX1C1) and education on the tendency to become an entrepreneur. We used a two-staged design consisting of a discovery sample of 692 individuals, and a replication sample of 797 participants from the TwinsUK cohort. Associations were identified between entrepreneurship and interactions of education and ROBO1 rs654867 and KIAA0319 rs6902039 with the stage 1 samples. However these were not independently replicated and the associations were no longer significant when the samples from the 2 stages were combined. A tagging SNP approach was used to investigate the effect of the interactions between education and 191 tagging SNPs from the candidate genes on entrepreneurship. While we found several significant interactions (DCDC2, KIAA0319 and ROBO1), none passed the stringent threshold for significance of a Bonferroni correction. Similar to the case with other behavioural genetics phenotypes, large sample sizes will be required to identify significant gene-environment interactions in entrepreneurship after making Bonferroni corrections.
language:
source: Walter de Gruyter GmbH
identifier: E-ISSN: 2157-5665 ; DOI: 10.1515/2157-5665.1053
fulltext: fulltext
issn:
  • 2157-5665
  • 21575665
url: Link


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subjectEntrepreneurship ; Genetics ; Gene-Environment Interactions
descriptionWe examined the interactions between four genes associated with dyslexia (ROBO1, KIAA0319, DCDC2, DYX1C1) and education on the tendency to become an entrepreneur. We used a two-staged design consisting of a discovery sample of 692 individuals, and a replication sample of 797 participants from the TwinsUK cohort. Associations were identified between entrepreneurship and interactions of education and ROBO1 rs654867 and KIAA0319 rs6902039 with the stage 1 samples. However these were not independently replicated and the associations were no longer significant when the samples from the 2 stages were combined. A tagging SNP approach was used to investigate the effect of the interactions between education and 191 tagging SNPs from the candidate genes on entrepreneurship. While we found several significant interactions (DCDC2, KIAA0319 and ROBO1), none passed the stringent threshold for significance of a Bonferroni correction. Similar to the case with other behavioural genetics phenotypes, large sample sizes will be required to identify significant gene-environment interactions in entrepreneurship after making Bonferroni corrections.
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abstractWe examined the interactions between four genes associated with dyslexia (ROBO1, KIAA0319, DCDC2, DYX1C1) and education on the tendency to become an entrepreneur. We used a two-staged design consisting of a discovery sample of 692 individuals, and a replication sample of 797 participants from the TwinsUK cohort. Associations were identified between entrepreneurship and interactions of education and ROBO1 rs654867 and KIAA0319 rs6902039 with the stage 1 samples. However these were not independently replicated and the associations were no longer significant when the samples from the 2 stages were combined. A tagging SNP approach was used to investigate the effect of the interactions between education and 191 tagging SNPs from the candidate genes on entrepreneurship. While we found several significant interactions (DCDC2, KIAA0319 and ROBO1), none passed the stringent threshold for significance of a Bonferroni correction. Similar to the case with other behavioural genetics phenotypes, large sample sizes will be required to identify significant gene-environment interactions in entrepreneurship after making Bonferroni corrections.
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