schliessen

Filtern

 

Bibliotheken

Probing the in vitro cytotoxicity of the veterinary drug oxytetracycline

The study investigated the effect of oxytetracycline (OTC) on the anti-oxidative defense system, the structure (hemolysis rate and morphology) and function (ATP enzyme activity) of human red blood cells (hRBCs) to investigate the possible toxic mechanism of OTC to hRBCs. The experimental results ind... Full description

Journal Title: PLoS ONE 01 January 2014, Vol.9(7), p.e102334
Main Author: Zhenxing Chi
Other Authors: Rutao Liu , Hong You , Shanshan Ma , Hao Cui , Qiang Zhang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0102334
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: doaj_soai_doaj_org_article_247195d5e3d74917bb0ad0e77bd9f673
title: Probing the in vitro cytotoxicity of the veterinary drug oxytetracycline
format: Article
creator:
  • Zhenxing Chi
  • Rutao Liu
  • Hong You
  • Shanshan Ma
  • Hao Cui
  • Qiang Zhang
subjects:
  • Sciences (General)
ispartof: PLoS ONE, 01 January 2014, Vol.9(7), p.e102334
description: The study investigated the effect of oxytetracycline (OTC) on the anti-oxidative defense system, the structure (hemolysis rate and morphology) and function (ATP enzyme activity) of human red blood cells (hRBCs) to investigate the possible toxic mechanism of OTC to hRBCs. The experimental results indicate that OTC can cause a decline in the function of the antioxidant defense system of hRBCs, resulting in oxidative stress. OTC can bring about morphological changes to hRBCs, and further leads to hemolysis, when the concentration of OTC is over 8×10(-5) M (about 164 µg/ml). At a low OTC concentration, below 4×10(-5) M (82 µg/ml), OTC can enhance the activity of ATP enzyme of hRBCs, known as hormesis. However, at a high concentration, above 4×10(-5) M (about 82 µg/ml), the ATP enzymatic activity was inhibited, affecting the function of hRBCs. The estalished mechanism of toxicity of OTC to hRBCs can facilitate a deeper understanding of the toxicity of OTC in vivo.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0102334
fulltext: fulltext_linktorsrc
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID527231650
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordidoai_doaj_org_article_247195d5e3d74917bb0ad0e77bd9f673
sourceiddoaj_s
recordidTN_doaj_soai_doaj_org_article_247195d5e3d74917bb0ad0e77bd9f673
sourcesystemOther
dbidDOA
pqid1545002668
galeid418553107
display
typearticle
titleProbing the in vitro cytotoxicity of the veterinary drug oxytetracycline
creatorZhenxing Chi ; Rutao Liu ; Hong You ; Shanshan Ma ; Hao Cui ; Qiang Zhang
ispartofPLoS ONE, 01 January 2014, Vol.9(7), p.e102334
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0102334
subjectSciences (General)
descriptionThe study investigated the effect of oxytetracycline (OTC) on the anti-oxidative defense system, the structure (hemolysis rate and morphology) and function (ATP enzyme activity) of human red blood cells (hRBCs) to investigate the possible toxic mechanism of OTC to hRBCs. The experimental results indicate that OTC can cause a decline in the function of the antioxidant defense system of hRBCs, resulting in oxidative stress. OTC can bring about morphological changes to hRBCs, and further leads to hemolysis, when the concentration of OTC is over 8×10(-5) M (about 164 µg/ml). At a low OTC concentration, below 4×10(-5) M (82 µg/ml), OTC can enhance the activity of ATP enzyme of hRBCs, known as hormesis. However, at a high concentration, above 4×10(-5) M (about 82 µg/ml), the ATP enzymatic activity was inhibited, affecting the function of hRBCs. The estalished mechanism of toxicity of OTC to hRBCs can facilitate a deeper understanding of the toxicity of OTC in vivo.
languageeng
oafree_for_read
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
linktorsrc$$Uhttps://doaj.org/article/247195d5e3d74917bb0ad0e77bd9f673$$EView_full_text_in_DOAJ
search
creatorcontrib
0Zhenxing Chi
1Rutao Liu
2Hong You
3Shanshan Ma
4Hao Cui
5Qiang Zhang
titleProbing the in vitro cytotoxicity of the veterinary drug oxytetracycline
description

The study investigated the effect of oxytetracycline (OTC) on the anti-oxidative defense system, the structure (hemolysis rate and morphology) and function (ATP enzyme activity) of human red blood cells (hRBCs) to investigate the possible toxic mechanism of OTC to hRBCs. The experimental results indicate that OTC can cause a decline in the function of the antioxidant defense system of hRBCs, resulting in oxidative stress. OTC can bring about morphological changes to hRBCs, and further leads to hemolysis, when the concentration of OTC is over 8×10(-5) M (about 164 µg/ml). At a low OTC concentration, below 4×10(-5) M (82 µg/ml), OTC can enhance the activity of ATP enzyme of hRBCs, known as hormesis. However, at a high concentration, above 4×10(-5) M (about 82 µg/ml), the ATP enzymatic activity was inhibited, affecting the function of hRBCs. The estalished mechanism of toxicity of OTC to hRBCs can facilitate a deeper understanding of the toxicity of OTC in vivo.

subjectSciences (General)
general
0English
1Public Library of Science (PLoS)
210.1371/journal.pone.0102334
3Directory of Open Access Journals (DOAJ)
sourceiddoaj_s
recordiddoaj_soai_doaj_org_article_247195d5e3d74917bb0ad0e77bd9f673
issn
01932-6203
119326203
rsrctypearticle
creationdate2014
addtitlePLoS ONE
searchscope
0doaj_full
1doaj1
scope
0doaj_full
1doaj1
lsr45$$EView_full_text_in_DOAJ
tmp01Directory of Open Access Journals (DOAJ)
tmp02DOA
startdate20140101
enddate20140101
lsr40PLoS ONE, 01 January 2014, Vol.9 (7), p.e102334
doi10.1371/journal.pone.0102334
citationpf e102334 vol 9 issue 7
lsr30VSR-Enriched:[pqid, galeid, pages]
sort
titleProbing the in vitro cytotoxicity of the veterinary drug oxytetracycline
authorZhenxing Chi ; Rutao Liu ; Hong You ; Shanshan Ma ; Hao Cui ; Qiang Zhang
creationdate20140101
lso0120140101
facets
frbrgroupid8982748815634538984
frbrtype5
newrecords20190714
languageeng
topicSciences (General)
collectionDirectory of Open Access Journals (DOAJ)
prefilterarticles
rsrctypearticles
creatorcontrib
0Zhenxing Chi
1Rutao Liu
2Hong You
3Shanshan Ma
4Hao Cui
5Qiang Zhang
jtitlePLoS ONE
creationdate2014
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext_linktorsrc
addata
au
0Zhenxing Chi
1Rutao Liu
2Hong You
3Shanshan Ma
4Hao Cui
5Qiang Zhang
atitleProbing the in vitro cytotoxicity of the veterinary drug oxytetracycline
jtitlePLoS ONE
risdate20140101
volume9
issue7
spagee102334
eissn1932-6203
formatjournal
genrearticle
ristypeJOUR
abstract

The study investigated the effect of oxytetracycline (OTC) on the anti-oxidative defense system, the structure (hemolysis rate and morphology) and function (ATP enzyme activity) of human red blood cells (hRBCs) to investigate the possible toxic mechanism of OTC to hRBCs. The experimental results indicate that OTC can cause a decline in the function of the antioxidant defense system of hRBCs, resulting in oxidative stress. OTC can bring about morphological changes to hRBCs, and further leads to hemolysis, when the concentration of OTC is over 8×10(-5) M (about 164 µg/ml). At a low OTC concentration, below 4×10(-5) M (82 µg/ml), OTC can enhance the activity of ATP enzyme of hRBCs, known as hormesis. However, at a high concentration, above 4×10(-5) M (about 82 µg/ml), the ATP enzymatic activity was inhibited, affecting the function of hRBCs. The estalished mechanism of toxicity of OTC to hRBCs can facilitate a deeper understanding of the toxicity of OTC in vivo.

pubPublic Library of Science (PLoS)
doi10.1371/journal.pone.0102334
urlhttps://doaj.org/article/247195d5e3d74917bb0ad0e77bd9f673
lad01PLoS ONE
oafree_for_read
pagese102334
date2014-01-01