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Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor

The gut mucosal homing integrin receptor α4β7 present on activated CD4+ T cells interacts with the HIV-1 gp120 second variable loop (V2). Case control analysis of the RV144 phase III vaccine trial demonstrated that plasma IgG binding antibodies specific to scaffolded proteins expressing the...

Journal Title: PLoS ONE 01 January 2015, Vol.10(12), p.e0143895
Main Author: Kristina K Peachman
Other Authors: Nicos Karasavvas , Agnes-Laurence Chenine , Robert Mclinden , Supachai Rerks-Ngarm , Kaewkungwal Jaranit , Sorachai Nitayaphan , Punnee Pitisuttithum , Sodsai Tovanabutra , Susan Zolla-Pazner , Nelson L Michael , Jerome H Kim , Carl R Alving , Mangala Rao
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0143895
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title: Identification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor
format: Article
creator:
  • Kristina K Peachman
  • Nicos Karasavvas
  • Agnes-Laurence Chenine
  • Robert Mclinden
  • Supachai Rerks-Ngarm
  • Kaewkungwal Jaranit
  • Sorachai Nitayaphan
  • Punnee Pitisuttithum
  • Sodsai Tovanabutra
  • Susan Zolla-Pazner
  • Nelson L Michael
  • Jerome H Kim
  • Carl R Alving
  • Mangala Rao
subjects:
  • Sciences (General)
ispartof: PLoS ONE, 01 January 2015, Vol.10(12), p.e0143895
description: The gut mucosal homing integrin receptor α4β7 present on activated CD4+ T cells interacts with the HIV-1 gp120 second variable loop (V2). Case control analysis of the RV144 phase III vaccine trial demonstrated that plasma IgG binding antibodies specific to scaffolded proteins expressing the...
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0143895
fulltext: fulltext_linktorsrc
issn:
  • 1932-6203
  • 19326203
url: Link


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titleIdentification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor
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descriptionThe gut mucosal homing integrin receptor α4β7 present on activated CD4+ T cells interacts with the HIV-1 gp120 second variable loop (V2). Case control analysis of the RV144 phase III vaccine trial demonstrated that plasma IgG binding antibodies specific to scaffolded proteins expressing the...
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The gut mucosal homing integrin receptor α4β7 present on activated CD4+ T cells interacts with the HIV-1 gp120 second variable loop (V2). Case control analysis of the RV144 phase III vaccine trial demonstrated that plasma IgG binding antibodies specific to scaffolded proteins expressing the...

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titleIdentification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor
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atitleIdentification of New Regions in HIV-1 gp120 Variable 2 and 3 Loops that Bind to α4β7 Integrin Receptor
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The gut mucosal homing integrin receptor α4β7 present on activated CD4+ T cells interacts with the HIV-1 gp120 second variable loop (V2). Case control analysis of the RV144 phase III vaccine trial demonstrated that plasma IgG binding antibodies specific to scaffolded proteins expressing the...

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