schliessen

Filtern

 

Bibliotheken

Large (≥3cm) thyroid nodules with benign cytology: Can Thyroid Imaging Reporting and Data System (TIRADS) help predict false-negative cytology?

BACKGROUND: There is controversy about the accuracy of the fine-needle aspiration (FNA) cytology results in large sized thyroid nodules. Our aim was to evaluate the false-negative rate of FNA for large thyroid nodules and the usefulness of the Thyroid Imaging Reporting and Data System (TIRADS) in pr... Full description

Journal Title: PLoS ONE 01 January 2017, Vol.12(10), p.e0186242
Main Author: Se Jin Nam
Other Authors: Jin Young Kwak , Hee Jung Moon , Jung Hyun Yoon , Eun-Kyung Kim , Ja Seung Koo
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0186242
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: doaj_soai_doaj_org_article_4ef92990eed14f259444d8512a280432
title: Large (≥3cm) thyroid nodules with benign cytology: Can Thyroid Imaging Reporting and Data System (TIRADS) help predict false-negative cytology?
format: Article
creator:
  • Se Jin Nam
  • Jin Young Kwak
  • Hee Jung Moon
  • Jung Hyun Yoon
  • Eun-Kyung Kim
  • Ja Seung Koo
subjects:
  • Sciences (General)
ispartof: PLoS ONE, 01 January 2017, Vol.12(10), p.e0186242
description: BACKGROUND: There is controversy about the accuracy of the fine-needle aspiration (FNA) cytology results in large sized thyroid nodules. Our aim was to evaluate the false-negative rate of FNA for large thyroid nodules and the usefulness of the Thyroid Imaging Reporting and Data System (TIRADS) in predicting false-negative cytology for large thyroid nodules with benign cytology.METHODS: 632 thyroid nodules larger than or equal to 3cm in size with subsequent benign cytology on US-guided FNA were included. US features of internal composition, echogenicity, margin, calcifications, and shape were evaluated, and nodules were classified according to TIRADS. TIRADS category 3 included nodules without any of the following suspicious features:solidity, hypoechogenicity or marked hypoechogenicity, microlobulated or irregular margins, microcalcifications, and taller-than-wide shape. Category 4a, 4b, 4c, and 5 were assigned to nodules showing one, two, three or four, or five suspicious US features, respectively. US features associated with malignancy for these lesions were analyzed and malignancy risk according to TIRADS was calculated.RESULTS: Of the 632 lesions, 23 lesions(3.6%) were malignant and 609(96.4%) were benign, suggesting a 3.6% false-negative rate for FNA cytology. Of the 23 malignant lesions, final pathology was mainly follicular carcinoma minimally invasive(65.2%, 15/23) and the follicular variant of papillary carcinoma(26.1%, 6/23). The malignancy risks of categories 3, 4a, 4b, and 4c nodules were 0.9%, 4.6%, 10.0%, and 11.8%, respectively.CONCLUSION: Large thyroid nodules with benign cytology had a relatively high false-negative risk of 3.6% and TIRADS was helpful in predicting false-negative cytology for these lesions.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0186242
fulltext: fulltext_linktorsrc
issn:
  • 1932-6203
  • 19326203
url: Link


@attributes
ID468086620
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordidoai_doaj_org_article_4ef92990eed14f259444d8512a280432
sourceiddoaj_s
recordidTN_doaj_soai_doaj_org_article_4ef92990eed14f259444d8512a280432
sourcesystemPC
dbidDOA
pqid1950426002
galeid509259887
display
typearticle
titleLarge (≥3cm) thyroid nodules with benign cytology: Can Thyroid Imaging Reporting and Data System (TIRADS) help predict false-negative cytology?
creatorSe Jin Nam ; Jin Young Kwak ; Hee Jung Moon ; Jung Hyun Yoon ; Eun-Kyung Kim ; Ja Seung Koo
ispartofPLoS ONE, 01 January 2017, Vol.12(10), p.e0186242
identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0186242
subjectSciences (General)
languageeng
oafree_for_read
source
descriptionBACKGROUND: There is controversy about the accuracy of the fine-needle aspiration (FNA) cytology results in large sized thyroid nodules. Our aim was to evaluate the false-negative rate of FNA for large thyroid nodules and the usefulness of the Thyroid Imaging Reporting and Data System (TIRADS) in predicting false-negative cytology for large thyroid nodules with benign cytology.METHODS: 632 thyroid nodules larger than or equal to 3cm in size with subsequent benign cytology on US-guided FNA were included. US features of internal composition, echogenicity, margin, calcifications, and shape were evaluated, and nodules were classified according to TIRADS. TIRADS category 3 included nodules without any of the following suspicious features:solidity, hypoechogenicity or marked hypoechogenicity, microlobulated or irregular margins, microcalcifications, and taller-than-wide shape. Category 4a, 4b, 4c, and 5 were assigned to nodules showing one, two, three or four, or five suspicious US features, respectively. US features associated with malignancy for these lesions were analyzed and malignancy risk according to TIRADS was calculated.RESULTS: Of the 632 lesions, 23 lesions(3.6%) were malignant and 609(96.4%) were benign, suggesting a 3.6% false-negative rate for FNA cytology. Of the 23 malignant lesions, final pathology was mainly follicular carcinoma minimally invasive(65.2%, 15/23) and the follicular variant of papillary carcinoma(26.1%, 6/23). The malignancy risks of categories 3, 4a, 4b, and 4c nodules were 0.9%, 4.6%, 10.0%, and 11.8%, respectively.CONCLUSION: Large thyroid nodules with benign cytology had a relatively high false-negative risk of 3.6% and TIRADS was helpful in predicting false-negative cytology for these lesions.
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
linktorsrc$$Uhttps://doaj.org/article/4ef92990eed14f259444d8512a280432$$EView_full_text_in_DOAJ
search
creatorcontrib
0Se Jin Nam
1Jin Young Kwak
2Hee Jung Moon
3Jung Hyun Yoon
4Eun-Kyung Kim
5Ja Seung Koo
titleLarge (≥3cm) thyroid nodules with benign cytology: Can Thyroid Imaging Reporting and Data System (TIRADS) help predict false-negative cytology?
description

There is controversy about the accuracy of the fine-needle aspiration (FNA) cytology results in large sized thyroid nodules. Our aim was to evaluate the false-negative rate of FNA for large thyroid nodules and the usefulness of the Thyroid Imaging Reporting and Data System (TIRADS) in predicting false-negative cytology for large thyroid nodules with benign cytology.632 thyroid nodules larger than or equal to 3cm in size with subsequent benign cytology on US-guided FNA were included. US features of internal composition, echogenicity, margin, calcifications, and shape were evaluated, and nodules were classified according to TIRADS. TIRADS category 3 included nodules without any of the following suspicious features:solidity, hypoechogenicity or marked hypoechogenicity, microlobulated or irregular margins, microcalcifications, and taller-than-wide shape. Category 4a, 4b, 4c, and 5 were assigned to nodules showing one, two, three or four, or five suspicious US features, respectively....

subjectSciences (General)
general
0English
1Public Library of Science (PLoS)
210.1371/journal.pone.0186242
3Directory of Open Access Journals (DOAJ)
sourceiddoaj_s
recordiddoaj_soai_doaj_org_article_4ef92990eed14f259444d8512a280432
issn
01932-6203
119326203
rsrctypearticle
creationdate2017
addtitlePLoS ONE
searchscope
0doaj_full
1doaj1
scope
0doaj_full
1doaj1
lsr45$$EView_full_text_in_DOAJ
tmp01Directory of Open Access Journals (DOAJ)
tmp02DOA
startdate20170101
enddate20170101
lsr40PLoS ONE, 01 January 2017, Vol.12 (10), p.e0186242
doi10.1371/journal.pone.0186242
citationpf e0186242 vol 12 issue 10
lsr30VSR-Enriched:[description, pages, pqid, galeid]
sort
titleLarge (≥3cm) thyroid nodules with benign cytology: Can Thyroid Imaging Reporting and Data System (TIRADS) help predict false-negative cytology?
authorSe Jin Nam ; Jin Young Kwak ; Hee Jung Moon ; Jung Hyun Yoon ; Eun-Kyung Kim ; Ja Seung Koo
creationdate20170101
lso0120170101
facets
frbrgroupid6931419158938573134
frbrtype5
newrecords20200226
languageeng
topicSciences (General)
collectionDirectory of Open Access Journals (DOAJ)
prefilterarticles
rsrctypearticles
creatorcontrib
0Se Jin Nam
1Jin Young Kwak
2Hee Jung Moon
3Jung Hyun Yoon
4Eun-Kyung Kim
5Ja Seung Koo
jtitlePLoS ONE
creationdate2017
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext_linktorsrc
addata
au
0Se Jin Nam
1Jin Young Kwak
2Hee Jung Moon
3Jung Hyun Yoon
4Eun-Kyung Kim
5Ja Seung Koo
atitleLarge (≥3cm) thyroid nodules with benign cytology: Can Thyroid Imaging Reporting and Data System (TIRADS) help predict false-negative cytology?
jtitlePLoS ONE
risdate20170101
volume12
issue10
spagee0186242
eissn1932-6203
formatjournal
genrearticle
ristypeJOUR
abstract

There is controversy about the accuracy of the fine-needle aspiration (FNA) cytology results in large sized thyroid nodules. Our aim was to evaluate the false-negative rate of FNA for large thyroid nodules and the usefulness of the Thyroid Imaging Reporting and Data System (TIRADS) in predicting false-negative cytology for large thyroid nodules with benign cytology.632 thyroid nodules larger than or equal to 3cm in size with subsequent benign cytology on US-guided FNA were included. US features of internal composition, echogenicity, margin, calcifications, and shape were evaluated, and nodules were classified according to TIRADS. TIRADS category 3 included nodules without any of the following suspicious features:solidity, hypoechogenicity or marked hypoechogenicity, microlobulated or irregular margins, microcalcifications, and taller-than-wide shape. Category 4a, 4b, 4c, and 5 were assigned to nodules showing one, two, three or four, or five suspicious US features, respectively....

pubPublic Library of Science (PLoS)
doi10.1371/journal.pone.0186242
urlhttps://doaj.org/article/4ef92990eed14f259444d8512a280432
lad01PLoS ONE
oafree_for_read
pagese0186242
date2017-01-01