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The impact of baseline serum C-reactive protein and C-reactive protein kinetics on the prognosis of metastatic nasopharyngeal carcinoma patients treated with palliative chemotherapy

Background The aim of this study was to determine whether baseline C-reactive protein (CRP) levels and CRP kinetics predict the overall survival in metastatic nasopharyngeal carcinoma (mNPC) patients. Methods A total of 116 mNPC patients from January 2006 to July 2011 were retrospectively reviewed.... Full description

Journal Title: PLoS ONE 01 January 2013, Vol.8(10), p.e76958
Main Author: Wei-Xiong Xia
Other Authors: Yan-Fang Ye , Xing Lu , Lin Wang , Liang-Ru Ke , Hai-Bo Zhang , Mark D Roycik , Jing Yang , Jun-Li Shi , Ka-Jia Cao , Xiang Guo , Yan-Qun Xiang
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0076958
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recordid: doaj_soai_doaj_org_article_5651119cff5340a8881f0c218ec70608
title: The impact of baseline serum C-reactive protein and C-reactive protein kinetics on the prognosis of metastatic nasopharyngeal carcinoma patients treated with palliative chemotherapy
format: Article
creator:
  • Wei-Xiong Xia
  • Yan-Fang Ye
  • Xing Lu
  • Lin Wang
  • Liang-Ru Ke
  • Hai-Bo Zhang
  • Mark D Roycik
  • Jing Yang
  • Jun-Li Shi
  • Ka-Jia Cao
  • Xiang Guo
  • Yan-Qun Xiang
subjects:
  • Sciences (General)
ispartof: PLoS ONE, 01 January 2013, Vol.8(10), p.e76958
description: Background The aim of this study was to determine whether baseline C-reactive protein (CRP) levels and CRP kinetics predict the overall survival in metastatic nasopharyngeal carcinoma (mNPC) patients. Methods A total of 116 mNPC patients from January 2006 to July 2011 were retrospectively reviewed. Serum CRP level was measured at baseline and thereafter at the start of each palliative chemotherapy cycle for all patients. Results Patients with higher values of baseline CRP ([greater than or equal to] 3.4 mg/L) had significantly worse survival than those with lower baseline CRP values ( 3.4 mg/L). Patients were divided into four groups according to baseline CRP and CRP kinetics: (1) patients whose CRP 3.4 mg/L and never elevated during treatment; (2) patients whose CRP 3.4 mg/L and elevated at least one time during treatment; (3) patients whose CRP [greater than or equal to] 3.4 mg/L and normalized at least one time during treatment; and (4) patients whose CRP [greater than or equal to] 3.4 mg/L and never normalized during treatment. The patients were further assigned to non-elevated, elevated, normalized, and non-normalized CRP groups. Overall survival rates were significantly different among the four groups, with three-year survival rates of 68%, 41%, 33%, and 0.03% for non-elevated, elevated, normalized, and non-normalized CRP groups respectively. When compared with the non-elevated group, hazard ratios of death were 1.69, 2.57, and 10.34 in the normalized, elevated, and non-normalized groups (P 0.001). Conclusions Baseline CRP and CRP kinetics may be useful to predict the prognosis of metastatic NPC patients treated with palliative chemotherapy and facilitate individualized treatment. A prospective study to validate this prognostic model is still needed however.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0076958
fulltext: fulltext_linktorsrc
issn:
  • 1932-6203
  • 19326203
url: Link


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titleThe impact of baseline serum C-reactive protein and C-reactive protein kinetics on the prognosis of metastatic nasopharyngeal carcinoma patients treated with palliative chemotherapy
creatorWei-Xiong Xia ; Yan-Fang Ye ; Xing Lu ; Lin Wang ; Liang-Ru Ke ; Hai-Bo Zhang ; Mark D Roycik ; Jing Yang ; Jun-Li Shi ; Ka-Jia Cao ; Xiang Guo ; Yan-Qun Xiang
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descriptionBackground The aim of this study was to determine whether baseline C-reactive protein (CRP) levels and CRP kinetics predict the overall survival in metastatic nasopharyngeal carcinoma (mNPC) patients. Methods A total of 116 mNPC patients from January 2006 to July 2011 were retrospectively reviewed. Serum CRP level was measured at baseline and thereafter at the start of each palliative chemotherapy cycle for all patients. Results Patients with higher values of baseline CRP ([greater than or equal to] 3.4 mg/L) had significantly worse survival than those with lower baseline CRP values ( 3.4 mg/L). Patients were divided into four groups according to baseline CRP and CRP kinetics: (1) patients whose CRP 3.4 mg/L and never elevated during treatment; (2) patients whose CRP 3.4 mg/L and elevated at least one time during treatment; (3) patients whose CRP [greater than or equal to] 3.4 mg/L and normalized at least one time during treatment; and (4) patients whose CRP [greater than or equal to] 3.4 mg/L and never normalized during treatment. The patients were further assigned to non-elevated, elevated, normalized, and non-normalized CRP groups. Overall survival rates were significantly different among the four groups, with three-year survival rates of 68%, 41%, 33%, and 0.03% for non-elevated, elevated, normalized, and non-normalized CRP groups respectively. When compared with the non-elevated group, hazard ratios of death were 1.69, 2.57, and 10.34 in the normalized, elevated, and non-normalized groups (P 0.001). Conclusions Baseline CRP and CRP kinetics may be useful to predict the prognosis of metastatic NPC patients treated with palliative chemotherapy and facilitate individualized treatment. A prospective study to validate this prognostic model is still needed however.
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titleThe impact of baseline serum C-reactive protein and C-reactive protein kinetics on the prognosis of metastatic nasopharyngeal carcinoma patients treated with palliative chemotherapy
description

BACKGROUND:The aim of this study was to determine whether baseline C-reactive protein (CRP) levels and CRP kinetics predict the overall survival in metastatic nasopharyngeal carcinoma (mNPC) patients. METHODS:A total of 116 mNPC patients from January 2006 to July 2011 were retrospectively reviewed. Serum CRP level was measured at baseline and thereafter at the start of each palliative chemotherapy cycle for all patients. RESULTS:Patients with higher values of baseline CRP (≥ 3.4 mg/L) had significantly worse survival than those with lower baseline CRP values (< 3.4 mg/L). Patients were divided into four groups according to baseline CRP and CRP kinetics: (1) patients whose CRP < 3.4 mg/L and never elevated during treatment; (2) patients whose CRP < 3.4 mg/L and elevated at least one time during treatment; (3) patients whose CRP ≥ 3.4 mg/L and normalized at least one time during treatment; and (4) patients whose CRP ≥ 3.4 mg/L and never normalized during treatment. The...

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BACKGROUND:The aim of this study was to determine whether baseline C-reactive protein (CRP) levels and CRP kinetics predict the overall survival in metastatic nasopharyngeal carcinoma (mNPC) patients. METHODS:A total of 116 mNPC patients from January 2006 to July 2011 were retrospectively reviewed. Serum CRP level was measured at baseline and thereafter at the start of each palliative chemotherapy cycle for all patients. RESULTS:Patients with higher values of baseline CRP (≥ 3.4 mg/L) had significantly worse survival than those with lower baseline CRP values (< 3.4 mg/L). Patients were divided into four groups according to baseline CRP and CRP kinetics: (1) patients whose CRP < 3.4 mg/L and never elevated during treatment; (2) patients whose CRP < 3.4 mg/L and elevated at least one time during treatment; (3) patients whose CRP ≥ 3.4 mg/L and normalized at least one time during treatment; and (4) patients whose CRP ≥ 3.4 mg/L and never normalized during treatment. The...

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date2013-01-01