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Assessing the Hepatotoxicity of Industrial Leachate; Histopathology and Heavy Metal Contents in Liver of Wistar Rats

The process of paper production requires a huge quantity of water and energy and in turn contributes a number of effluents in the form of phenolics, toxic organic compounds and heavy metals in wastewater (leachate). The present investigation was aimed to assess the toxic effects of leachate on liver... Full description

Journal Title: RADS Journal of Biological Research & Applied Science 01 December 2018, Vol.9(2)
Main Author: Muhammad Babar Khawar
Other Authors: Rabia Mehmood , Muddasir Hassan Abbasi , Nadeem Sheikh
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: Directory of Open Access Journals (DOAJ)
ID: ISSN: 2305-8722 ; E-ISSN: 2521-8573
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recordid: doaj_soai_doaj_org_article_8b5c499bb2b34236a11796b374d6b6fe
title: Assessing the Hepatotoxicity of Industrial Leachate; Histopathology and Heavy Metal Contents in Liver of Wistar Rats
format: Article
creator:
  • Muhammad Babar Khawar
  • Rabia Mehmood
  • Muddasir Hassan Abbasi
  • Nadeem Sheikh
subjects:
  • Heavy Metals
  • Histopathology
  • Leachate
  • Toxicity
  • Wastewater
ispartof: RADS Journal of Biological Research & Applied Science, 01 December 2018, Vol.9(2)
description: The process of paper production requires a huge quantity of water and energy and in turn contributes a number of effluents in the form of phenolics, toxic organic compounds and heavy metals in wastewater (leachate). The present investigation was aimed to assess the toxic effects of leachate on liver micro-architecture and heavy metal elements of the liver. Eighteen (18) healthy male Wistar rats (240 ± 10g) were selected and acclimatized prior to experimental treatment. These rats were randomly divided into three groups viz, Control group (received 4ml/ kg normal saline), Group 1 (4ml/ kg leachate) and Group 2 (4ml/ kg 1:10 diluted leachate). All the animals were dissected and liver tissues were collected and processed accordingly after 24 h of leachate treatment. High level of cadmium and chromium were found in Group 1 as compared to the control group upon liver metal contents analysis found out by flame atomic absorption spectrometer. A clear disruption of micro-architecture...
language: eng
source: Directory of Open Access Journals (DOAJ)
identifier: ISSN: 2305-8722 ; E-ISSN: 2521-8573
fulltext: fulltext_linktorsrc
issn:
  • 2305-8722
  • 23058722
  • 2521-8573
  • 25218573
url: Link


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titleAssessing the Hepatotoxicity of Industrial Leachate; Histopathology and Heavy Metal Contents in Liver of Wistar Rats
creatorMuhammad Babar Khawar ; Rabia Mehmood ; Muddasir Hassan Abbasi ; Nadeem Sheikh
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identifierISSN: 2305-8722 ; E-ISSN: 2521-8573
subjectHeavy Metals ; Histopathology ; Leachate ; Toxicity ; Wastewater
descriptionThe process of paper production requires a huge quantity of water and energy and in turn contributes a number of effluents in the form of phenolics, toxic organic compounds and heavy metals in wastewater (leachate). The present investigation was aimed to assess the toxic effects of leachate on liver micro-architecture and heavy metal elements of the liver. Eighteen (18) healthy male Wistar rats (240 ± 10g) were selected and acclimatized prior to experimental treatment. These rats were randomly divided into three groups viz, Control group (received 4ml/ kg normal saline), Group 1 (4ml/ kg leachate) and Group 2 (4ml/ kg 1:10 diluted leachate). All the animals were dissected and liver tissues were collected and processed accordingly after 24 h of leachate treatment. High level of cadmium and chromium were found in Group 1 as compared to the control group upon liver metal contents analysis found out by flame atomic absorption spectrometer. A clear disruption of micro-architecture...
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The process of paper production requires a huge quantity of water and energy and in turn contributes a number of effluents in the form of phenolics, toxic organic compounds and heavy metals in wastewater (leachate). The present investigation was aimed to assess the toxic effects of leachate on liver micro-architecture and heavy metal elements of the liver. Eighteen (18) healthy male Wistar rats (240 ± 10g) were selected and acclimatized prior to experimental treatment. These rats were randomly divided into three groups viz, Control group (received 4ml/ kg normal saline), Group 1 (4ml/ kg leachate) and Group 2 (4ml/ kg 1:10 diluted leachate). All the animals were dissected and liver tissues were collected and processed accordingly after 24 h of leachate treatment. High level of cadmium and chromium were found in Group 1 as compared to the control group upon liver metal contents analysis found out by flame atomic absorption spectrometer. A clear disruption of micro-architecture...

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The process of paper production requires a huge quantity of water and energy and in turn contributes a number of effluents in the form of phenolics, toxic organic compounds and heavy metals in wastewater (leachate). The present investigation was aimed to assess the toxic effects of leachate on liver micro-architecture and heavy metal elements of the liver. Eighteen (18) healthy male Wistar rats (240 ± 10g) were selected and acclimatized prior to experimental treatment. These rats were randomly divided into three groups viz, Control group (received 4ml/ kg normal saline), Group 1 (4ml/ kg leachate) and Group 2 (4ml/ kg 1:10 diluted leachate). All the animals were dissected and liver tissues were collected and processed accordingly after 24 h of leachate treatment. High level of cadmium and chromium were found in Group 1 as compared to the control group upon liver metal contents analysis found out by flame atomic absorption spectrometer. A clear disruption of micro-architecture...

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