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Lack of usefulness of computed tomography for surveillance in patients with aggressive non-Hodgkin lymphoma

Surveillance computed tomography (CT) is usual practice for patients with aggressive non-Hodgkin lymphoma (aNHL) in complete remission (CR). However, evidence to support this strategy is lacking. We retrospectively analyzed our institutional lymphoma registry, including patients with lymphoma consec... Full description

Journal Title: PloS one 2018, Vol.13 (2), p.e0192656
Main Author: Kang, Ka-Won
Other Authors: Lee, Se Ryeon , Kim, Dae Sik , Yu, Eun Sang , Sung, Hwa Jung , Kim, Seok Jin , Choi, Chul Won , Park, Yong , Kim, Byung Soo
Format: Electronic Article Electronic Article
Language: English
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Publisher: United States: Public Library of Science
ID: ISSN: 1932-6203
Link: https://www.ncbi.nlm.nih.gov/pubmed/29444176
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title: Lack of usefulness of computed tomography for surveillance in patients with aggressive non-Hodgkin lymphoma
format: Article
creator:
  • Kang, Ka-Won
  • Lee, Se Ryeon
  • Kim, Dae Sik
  • Yu, Eun Sang
  • Sung, Hwa Jung
  • Kim, Seok Jin
  • Choi, Chul Won
  • Park, Yong
  • Kim, Byung Soo
subjects:
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anatomy
  • Animal Cells
  • Biology and Life Sciences
  • Blood Cells
  • Cancer therapies
  • Cancers and neoplasms
  • Care and treatment
  • Cell Biology
  • Cellular Types
  • Chemotherapy
  • Computation
  • Computed Axial Tomography
  • Computed tomography
  • Contrast agents
  • Contrast Media - adverse effects
  • CT imaging
  • Diagnosis
  • Diagnostic Medicine
  • Diagnostic Radiology
  • Drug Therapy
  • Female
  • Health Care
  • Hematologic cancers and related disorders
  • Hematology
  • Histology
  • Humans
  • Imaging Techniques
  • Immune Cells
  • Immunology
  • Internal medicine
  • Lymphoma
  • Lymphoma, Non-Hodgkin - diagnostic imaging
  • Lymphoma, Non-Hodgkin - pathology
  • Lymphomas
  • Male
  • Medical imaging
  • Medicine
  • Medicine and Health Sciences
  • Methods
  • Middle Aged
  • Neuroimaging
  • Neuroscience
  • Non-Hodgkin's lymphomas
  • Oncology
  • Patient monitoring
  • Patients
  • Peripheral T-cell lymphoma
  • Pharmaceutics
  • Radiology and Imaging
  • Recurrence
  • Remission
  • Research
  • Research and Analysis Methods
  • Research Article
  • Retrospective Studies
  • Science
  • Subgroups
  • Surveillance
  • Survival
  • Survival Analysis
  • T Cells
  • Tomography
  • Tomography, X-Ray Computed - methods
  • Usage
  • White Blood Cells
  • Young Adult
ispartof: PloS one, 2018, Vol.13 (2), p.e0192656
description: Surveillance computed tomography (CT) is usual practice for patients with aggressive non-Hodgkin lymphoma (aNHL) in complete remission (CR). However, evidence to support this strategy is lacking. We retrospectively analyzed our institutional lymphoma registry, including patients with lymphoma consecutively enrolled from June 1995 to October 2016. Of 1,385 patients with aNHL, 664 achieved CR and were followed up with or without surveillance CT. Surveillance CT was performed for 609 patients every 3 or 6 months for the first 2 years, then every 6 or 12 months thereafter. Relapse was detected in 171 patients, of whom 152 underwent surveillance CT during follow-up. Of these 152 patients, asymptomatic relapse was detected in 67 (44%) using surveillance CT, and symptomatic relapse outside the surveillance interval was detected in the remaining 85 (56%). Detection of asymptomatic relapse using surveillance CT did not improve the overall or post-relapse survival in patients with relapsed aNHL. Surveillance CT interval (3 or 6 months) did not affect survival. No subgroups were identified that favored the use of surveillance CT to detect relapse. The results of this study suggest that routine surveillance CT in patients with aNHL to detect asymptomatic relapse might have a limited role in improving survival. CT is recommended when a relapse is clinically suspected.
language: eng
source:
identifier: ISSN: 1932-6203
fulltext: no_fulltext
issn:
  • 1932-6203
  • 1932-6203
url: Link


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titleLack of usefulness of computed tomography for surveillance in patients with aggressive non-Hodgkin lymphoma
creatorKang, Ka-Won ; Lee, Se Ryeon ; Kim, Dae Sik ; Yu, Eun Sang ; Sung, Hwa Jung ; Kim, Seok Jin ; Choi, Chul Won ; Park, Yong ; Kim, Byung Soo
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descriptionSurveillance computed tomography (CT) is usual practice for patients with aggressive non-Hodgkin lymphoma (aNHL) in complete remission (CR). However, evidence to support this strategy is lacking. We retrospectively analyzed our institutional lymphoma registry, including patients with lymphoma consecutively enrolled from June 1995 to October 2016. Of 1,385 patients with aNHL, 664 achieved CR and were followed up with or without surveillance CT. Surveillance CT was performed for 609 patients every 3 or 6 months for the first 2 years, then every 6 or 12 months thereafter. Relapse was detected in 171 patients, of whom 152 underwent surveillance CT during follow-up. Of these 152 patients, asymptomatic relapse was detected in 67 (44%) using surveillance CT, and symptomatic relapse outside the surveillance interval was detected in the remaining 85 (56%). Detection of asymptomatic relapse using surveillance CT did not improve the overall or post-relapse survival in patients with relapsed aNHL. Surveillance CT interval (3 or 6 months) did not affect survival. No subgroups were identified that favored the use of surveillance CT to detect relapse. The results of this study suggest that routine surveillance CT in patients with aNHL to detect asymptomatic relapse might have a limited role in improving survival. CT is recommended when a relapse is clinically suspected.
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subjectAdolescent ; Adult ; Aged ; Aged, 80 and over ; Anatomy ; Animal Cells ; Biology and Life Sciences ; Blood Cells ; Cancer therapies ; Cancers and neoplasms ; Care and treatment ; Cell Biology ; Cellular Types ; Chemotherapy ; Computation ; Computed Axial Tomography ; Computed tomography ; Contrast agents ; Contrast Media - adverse effects ; CT imaging ; Diagnosis ; Diagnostic Medicine ; Diagnostic Radiology ; Drug Therapy ; Female ; Health Care ; Hematologic cancers and related disorders ; Hematology ; Histology ; Humans ; Imaging Techniques ; Immune Cells ; Immunology ; Internal medicine ; Lymphoma ; Lymphoma, Non-Hodgkin - diagnostic imaging ; Lymphoma, Non-Hodgkin - pathology ; Lymphomas ; Male ; Medical imaging ; Medicine ; Medicine and Health Sciences ; Methods ; Middle Aged ; Neuroimaging ; Neuroscience ; Non-Hodgkin's lymphomas ; Oncology ; Patient monitoring ; Patients ; Peripheral T-cell lymphoma ; Pharmaceutics ; Radiology and Imaging ; Recurrence ; Remission ; Research ; Research and Analysis Methods ; Research Article ; Retrospective Studies ; Science ; Subgroups ; Surveillance ; Survival ; Survival Analysis ; T Cells ; Tomography ; Tomography, X-Ray Computed - methods ; Usage ; White Blood Cells ; Young Adult
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22018 Kang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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descriptionSurveillance computed tomography (CT) is usual practice for patients with aggressive non-Hodgkin lymphoma (aNHL) in complete remission (CR). However, evidence to support this strategy is lacking. We retrospectively analyzed our institutional lymphoma registry, including patients with lymphoma consecutively enrolled from June 1995 to October 2016. Of 1,385 patients with aNHL, 664 achieved CR and were followed up with or without surveillance CT. Surveillance CT was performed for 609 patients every 3 or 6 months for the first 2 years, then every 6 or 12 months thereafter. Relapse was detected in 171 patients, of whom 152 underwent surveillance CT during follow-up. Of these 152 patients, asymptomatic relapse was detected in 67 (44%) using surveillance CT, and symptomatic relapse outside the surveillance interval was detected in the remaining 85 (56%). Detection of asymptomatic relapse using surveillance CT did not improve the overall or post-relapse survival in patients with relapsed aNHL. Surveillance CT interval (3 or 6 months) did not affect survival. No subgroups were identified that favored the use of surveillance CT to detect relapse. The results of this study suggest that routine surveillance CT in patients with aNHL to detect asymptomatic relapse might have a limited role in improving survival. CT is recommended when a relapse is clinically suspected.
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titleLack of usefulness of computed tomography for surveillance in patients with aggressive non-Hodgkin lymphoma
authorKang, Ka-Won ; Lee, Se Ryeon ; Kim, Dae Sik ; Yu, Eun Sang ; Sung, Hwa Jung ; Kim, Seok Jin ; Choi, Chul Won ; Park, Yong ; Kim, Byung Soo
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0KWK and SRL contributed equally as co-first authors and YP and BSK contributed equally as co-corresponding authors.
1Competing Interests: The authors have declared that no competing interests exist.
abstractSurveillance computed tomography (CT) is usual practice for patients with aggressive non-Hodgkin lymphoma (aNHL) in complete remission (CR). However, evidence to support this strategy is lacking. We retrospectively analyzed our institutional lymphoma registry, including patients with lymphoma consecutively enrolled from June 1995 to October 2016. Of 1,385 patients with aNHL, 664 achieved CR and were followed up with or without surveillance CT. Surveillance CT was performed for 609 patients every 3 or 6 months for the first 2 years, then every 6 or 12 months thereafter. Relapse was detected in 171 patients, of whom 152 underwent surveillance CT during follow-up. Of these 152 patients, asymptomatic relapse was detected in 67 (44%) using surveillance CT, and symptomatic relapse outside the surveillance interval was detected in the remaining 85 (56%). Detection of asymptomatic relapse using surveillance CT did not improve the overall or post-relapse survival in patients with relapsed aNHL. Surveillance CT interval (3 or 6 months) did not affect survival. No subgroups were identified that favored the use of surveillance CT to detect relapse. The results of this study suggest that routine surveillance CT in patients with aNHL to detect asymptomatic relapse might have a limited role in improving survival. CT is recommended when a relapse is clinically suspected.
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