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A Review on the Effect of Traditional Chinese Medicine Against Anthracycline-Induced Cardiac Toxicity

Anthracyclines are effective agents generally used to treat solid-tumor and hematologic malignancies. The use of anthracyclines for over 40 years has improved cancer survival statistics. Nevertheless, the clinical utility of anthracyclines is limited by its dose-dependent cardiotoxicity that adverse... Full description

Journal Title: Frontiers in Pharmacology 01 May 2018, Vol.9
Main Author: Xinyu Yang
Other Authors: Xinyu Yang , Nian Liu , Xinye Li , Xinye Li , Yihan Yang , Yihan Yang , Xiaofeng Wang , Linling Li , Le Jiang , Yonghong Gao , Hebin Tang , Yong Tang , Yanwei Xing , Hongcai Shang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1663-9812 ; DOI: 10.3389/fphar.2018.00444
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title: A Review on the Effect of Traditional Chinese Medicine Against Anthracycline-Induced Cardiac Toxicity
format: Article
creator:
  • Xinyu Yang
  • Xinyu Yang
  • Nian Liu
  • Xinye Li
  • Xinye Li
  • Yihan Yang
  • Yihan Yang
  • Xiaofeng Wang
  • Linling Li
  • Le Jiang
  • Yonghong Gao
  • Hebin Tang
  • Yong Tang
  • Yanwei Xing
  • Hongcai Shang
subjects:
  • Anthracyclines
  • Traditional Chinese Medicine
  • Cardiac Toxicity
  • Adverse Effects
  • Antineoplastic
  • Pharmacy, Therapeutics, & Pharmacology
ispartof: Frontiers in Pharmacology, 01 May 2018, Vol.9
description: Anthracyclines are effective agents generally used to treat solid-tumor and hematologic malignancies. The use of anthracyclines for over 40 years has improved cancer survival statistics. Nevertheless, the clinical utility of anthracyclines is limited by its dose-dependent cardiotoxicity that adversely affects 10–30% of patients. Anthracycline-induced cardiotoxicity may be classified as acute/subacute or chronic/late toxicity and leads to devastating adverse effects resulting in poor quality of life, morbidity, and premature mortality. Traditional Chinese medicine has a history of over 2,000 years, involving both unique theories and substantial experience. Several studies have investigated the potential of natural products to decrease the cardiotoxic effects of chemotherapeutic agents on healthy cells, without negatively affecting their antineoplastic activity. This article discusses the mechanism of anthracycline-induced cardiotoxicity, and summarizes traditional Chinese medicine treatment for anthracycline-induced heart failure (HF), cardiac arrhythmia, cardiomyopathy, and myocardial ischemia in recent years, in order to provide a reference for the clinical prevention and treatment of cardiac toxicity.
language: eng
source:
identifier: E-ISSN: 1663-9812 ; DOI: 10.3389/fphar.2018.00444
fulltext: fulltext_linktorsrc
issn:
  • 1663-9812
  • 16639812
url: Link


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titleA Review on the Effect of Traditional Chinese Medicine Against Anthracycline-Induced Cardiac Toxicity
creatorXinyu Yang ; Xinyu Yang ; Nian Liu ; Xinye Li ; Xinye Li ; Yihan Yang ; Yihan Yang ; Xiaofeng Wang ; Linling Li ; Le Jiang ; Yonghong Gao ; Hebin Tang ; Yong Tang ; Yanwei Xing ; Hongcai Shang
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identifierE-ISSN: 1663-9812 ; DOI: 10.3389/fphar.2018.00444
subjectAnthracyclines ; Traditional Chinese Medicine ; Cardiac Toxicity ; Adverse Effects ; Antineoplastic ; Pharmacy, Therapeutics, & Pharmacology
descriptionAnthracyclines are effective agents generally used to treat solid-tumor and hematologic malignancies. The use of anthracyclines for over 40 years has improved cancer survival statistics. Nevertheless, the clinical utility of anthracyclines is limited by its dose-dependent cardiotoxicity that adversely affects 10–30% of patients. Anthracycline-induced cardiotoxicity may be classified as acute/subacute or chronic/late toxicity and leads to devastating adverse effects resulting in poor quality of life, morbidity, and premature mortality. Traditional Chinese medicine has a history of over 2,000 years, involving both unique theories and substantial experience. Several studies have investigated the potential of natural products to decrease the cardiotoxic effects of chemotherapeutic agents on healthy cells, without negatively affecting their antineoplastic activity. This article discusses the mechanism of anthracycline-induced cardiotoxicity, and summarizes traditional Chinese medicine treatment for anthracycline-induced heart failure (HF), cardiac arrhythmia, cardiomyopathy, and myocardial ischemia in recent years, in order to provide a reference for the clinical prevention and treatment of cardiac toxicity.
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Anthracyclines are effective agents generally used to treat solid-tumor and hematologic malignancies. The use of anthracyclines for over 40 years has improved cancer survival statistics. Nevertheless, the clinical utility of anthracyclines is limited by its dose-dependent cardiotoxicity that adversely affects 10–30% of patients. Anthracycline-induced cardiotoxicity may be classified as acute/subacute or chronic/late toxicity and leads to devastating adverse effects resulting in poor quality of life, morbidity, and premature mortality. Traditional Chinese medicine has a history of over 2,000 years, involving both unique theories and substantial experience. Several studies have investigated the potential of natural products to decrease the cardiotoxic effects of chemotherapeutic agents on healthy cells, without negatively affecting their antineoplastic activity. This article discusses the mechanism of anthracycline-induced cardiotoxicity, and summarizes traditional Chinese medicine treatment for anthracycline-induced heart failure (HF), cardiac arrhythmia, cardiomyopathy, and myocardial ischemia in recent years, in order to provide a reference for the clinical prevention and treatment of cardiac toxicity.

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Anthracyclines are effective agents generally used to treat solid-tumor and hematologic malignancies. The use of anthracyclines for over 40 years has improved cancer survival statistics. Nevertheless, the clinical utility of anthracyclines is limited by its dose-dependent cardiotoxicity that adversely affects 10–30% of patients. Anthracycline-induced cardiotoxicity may be classified as acute/subacute or chronic/late toxicity and leads to devastating adverse effects resulting in poor quality of life, morbidity, and premature mortality. Traditional Chinese medicine has a history of over 2,000 years, involving both unique theories and substantial experience. Several studies have investigated the potential of natural products to decrease the cardiotoxic effects of chemotherapeutic agents on healthy cells, without negatively affecting their antineoplastic activity. This article discusses the mechanism of anthracycline-induced cardiotoxicity, and summarizes traditional Chinese medicine treatment for anthracycline-induced heart failure (HF), cardiac arrhythmia, cardiomyopathy, and myocardial ischemia in recent years, in order to provide a reference for the clinical prevention and treatment of cardiac toxicity.

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date2018-05-01