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Emerging role of lipid metabolism alterations in Cancer stem cells

Background Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refractory to traditional therapy and are responsible for relapse or disease recurrenc... Full description

Journal Title: Journal of Experimental & Clinical Cancer Research 01 June 2018, Vol.37(1), pp.1-18
Main Author: Mei Yi
Other Authors: Junjun Li , Shengnan Chen , Jing Cai , Yuanyuan Ban , Qian Peng , Ying Zhou , Zhaoyang Zeng , Shuping Peng , Xiaoling Li , Wei Xiong , Guiyuan Li , Bo Xiang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1756-9966 ; DOI: 10.1186/s13046-018-0784-5
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recordid: doaj_soai_doaj_org_article_d0e5babf8c2b4ffd92af8f4d431085a4
title: Emerging role of lipid metabolism alterations in Cancer stem cells
format: Article
creator:
  • Mei Yi
  • Junjun Li
  • Shengnan Chen
  • Jing Cai
  • Yuanyuan Ban
  • Qian Peng
  • Ying Zhou
  • Zhaoyang Zeng
  • Shuping Peng
  • Xiaoling Li
  • Wei Xiong
  • Guiyuan Li
  • Bo Xiang
subjects:
  • Cancer Stem Cells
  • Lipid Metabolism
  • Metabolomics
  • Lipid Droplets
  • Lipid Desaturation
  • de Novo Lipogenesis
  • Medicine
ispartof: Journal of Experimental & Clinical Cancer Research, 01 June 2018, Vol.37(1), pp.1-18
description: Background Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refractory to traditional therapy and are responsible for relapse or disease recurrence in cancer patients. Stem cells have distinct metabolic properties compared to differentiated cells, and metabolic rewiring contributes to self-renewal and stemness maintenance in CSCs. Main body Recent advances in metabolomic detection, particularly in hyperspectral-stimulated raman scattering microscopy, have expanded our knowledge of the contribution of lipid metabolism to the generation and maintenance of CSCs. Alterations in lipid uptake, de novo lipogenesis, lipid droplets, lipid desaturation, and fatty acid oxidation are all clearly implicated in CSCs regulation. Alterations on lipid metabolism not only satisfies the energy demands and biomass production of CSCs, but also contributes to the activation of several important oncogenic signaling pathways, including Wnt/[beta]-catenin and Hippo/YAP signaling. In this review, we summarize the current progress in this attractive field and describe some recent therapeutic agents specifically targeting CSCs based on their modulation of lipid metabolism. Conclusion Increased reliance on lipid metabolism makes it a promising therapeutic strategy to eliminate CSCs. Targeting key players of fatty acids metabolism shows promising to anti-CSCs and tumor prevention effects. Keywords: Cancer stem cells, Lipid metabolism, Metabolomics, Lipid droplets, Lipid desaturation, de novo lipogenesis, Fatty acid oxidation
language: eng
source:
identifier: E-ISSN: 1756-9966 ; DOI: 10.1186/s13046-018-0784-5
fulltext: fulltext_linktorsrc
issn:
  • 1756-9966
  • 17569966
url: Link


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titleEmerging role of lipid metabolism alterations in Cancer stem cells
creatorMei Yi ; Junjun Li ; Shengnan Chen ; Jing Cai ; Yuanyuan Ban ; Qian Peng ; Ying Zhou ; Zhaoyang Zeng ; Shuping Peng ; Xiaoling Li ; Wei Xiong ; Guiyuan Li ; Bo Xiang
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descriptionBackground Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refractory to traditional therapy and are responsible for relapse or disease recurrence in cancer patients. Stem cells have distinct metabolic properties compared to differentiated cells, and metabolic rewiring contributes to self-renewal and stemness maintenance in CSCs. Main body Recent advances in metabolomic detection, particularly in hyperspectral-stimulated raman scattering microscopy, have expanded our knowledge of the contribution of lipid metabolism to the generation and maintenance of CSCs. Alterations in lipid uptake, de novo lipogenesis, lipid droplets, lipid desaturation, and fatty acid oxidation are all clearly implicated in CSCs regulation. Alterations on lipid metabolism not only satisfies the energy demands and biomass production of CSCs, but also contributes to the activation of several important oncogenic signaling pathways, including Wnt/[beta]-catenin and Hippo/YAP signaling. In this review, we summarize the current progress in this attractive field and describe some recent therapeutic agents specifically targeting CSCs based on their modulation of lipid metabolism. Conclusion Increased reliance on lipid metabolism makes it a promising therapeutic strategy to eliminate CSCs. Targeting key players of fatty acids metabolism shows promising to anti-CSCs and tumor prevention effects. Keywords: Cancer stem cells, Lipid metabolism, Metabolomics, Lipid droplets, Lipid desaturation, de novo lipogenesis, Fatty acid oxidation
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titleEmerging role of lipid metabolism alterations in Cancer stem cells
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Abstract Background Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refractory to traditional therapy and are responsible for relapse or disease recurrence in cancer patients. Stem cells have distinct metabolic properties compared to differentiated cells, and metabolic rewiring contributes to self-renewal and stemness maintenance in CSCs. Main body Recent advances in metabolomic detection, particularly in hyperspectral-stimulated raman scattering microscopy, have expanded our knowledge of the contribution of lipid metabolism to the generation and maintenance of CSCs. Alterations in lipid uptake, de novo lipogenesis, lipid droplets, lipid desaturation, and fatty acid oxidation are all clearly implicated in CSCs regulation. Alterations on lipid metabolism not only satisfies the energy demands and biomass production of CSCs, but...

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Abstract Background Cancer stem cells (CSCs) or tumor-initiating cells (TICs) represent a small population of cancer cells with self-renewal and tumor-initiating properties. Unlike the bulk of tumor cells, CSCs or TICs are refractory to traditional therapy and are responsible for relapse or disease recurrence in cancer patients. Stem cells have distinct metabolic properties compared to differentiated cells, and metabolic rewiring contributes to self-renewal and stemness maintenance in CSCs. Main body Recent advances in metabolomic detection, particularly in hyperspectral-stimulated raman scattering microscopy, have expanded our knowledge of the contribution of lipid metabolism to the generation and maintenance of CSCs. Alterations in lipid uptake, de novo lipogenesis, lipid droplets, lipid desaturation, and fatty acid oxidation are all clearly implicated in CSCs regulation. Alterations on lipid metabolism not only satisfies the energy demands and biomass production of CSCs, but...

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