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Evaluation of the analgesic, sedative-anxiolytic, cytotoxic and thrombolytic potentials of the different extracts of Kalanchoe pinnata leaves

Objective: To evaluate the analgesic, neuropharmacological, cytotoxic and thrombolytic potentials of the aqueous, ethanol and ethyl acetate extracts of Kalanchoe pinnata leaves. Methods: At the dose of 400 mg/kg body weight, the analgesic activity of the extracts were evaluated by the acetic acid-in... Full description

Journal Title: Journal of Coastal Life Medicine 01 December 2015, Vol.3(12), pp.982-986
Main Author: Md. Razibul Habib
Other Authors: Mohammad Mustakim Billah , Mohammad Mahfuz-E-Alam , Kashfia Nawrin , Md. Rakibul Hasan , Md. Mominur Rahman , Md. Anisul Islam , Irfan Newaz Khan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 2309-5288 ; E-ISSN: 2309-6152 ; DOI: 10.12980/jclm.3.2015j5-166
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recordid: doaj_soai_doaj_org_article_fac751a0bdd1443f82f0dec3dca1ce21
title: Evaluation of the analgesic, sedative-anxiolytic, cytotoxic and thrombolytic potentials of the different extracts of Kalanchoe pinnata leaves
format: Article
creator:
  • Md. Razibul Habib
  • Mohammad Mustakim Billah
  • Mohammad Mahfuz-E-Alam
  • Kashfia Nawrin
  • Md. Rakibul Hasan
  • Md. Mominur Rahman
  • Md. Anisul Islam
  • Irfan Newaz Khan
subjects:
  • Kalanchoe Pinnata
  • Writhing
  • Formalin
  • Open Field
  • Hole Cross
  • Anxiolytic
  • Lethality
  • Thrombolysis
  • Pharmacy, Therapeutics, & Pharmacology
ispartof: Journal of Coastal Life Medicine, 01 December 2015, Vol.3(12), pp.982-986
description: Objective: To evaluate the analgesic, neuropharmacological, cytotoxic and thrombolytic potentials of the aqueous, ethanol and ethyl acetate extracts of Kalanchoe pinnata leaves. Methods: At the dose of 400 mg/kg body weight, the analgesic activity of the extracts were evaluated by the acetic acid-induced writhing and formalin-induced persistent pain tests while neuropharmacological activity was evaluated by the open field, hole cross and elevated plus maze tests. The cytotoxic potential was observed by brine shrimp lethality bioassay and the thrombolytic potential was investigated by clot lysis test. Results: The aqueous extract significantly suppressed the number of writhing (96.78%) as well as the formalin-induced persistent pain on the early phase (46.92%) and on the late phase (40.98%). Again in case of hole cross and open field tests, the locomotor activity was decreased significantly (P < 0.001) mostly by the ethyl acetate extract. Furthermore, the sedative-anxiolytic activity was supported by the increased percent (P < 0.01) of frequency into the open arm on elevated plus maze test. Besides, the extracts showed moderate lethality and thrombolytic activity. Conclusions: The findings showed that activities are comparable to the standards and in some cases are stronger than the standards. Therefore, based on the results, it is evident that it has great analgesic and sedative-anxiolytic activity with moderate cytotoxic and thrombolytic potential.
language: eng
source:
identifier: ISSN: 2309-5288 ; E-ISSN: 2309-6152 ; DOI: 10.12980/jclm.3.2015j5-166
fulltext: fulltext_linktorsrc
issn:
  • 2309-5288
  • 23095288
  • 2309-6152
  • 23096152
url: Link


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titleEvaluation of the analgesic, sedative-anxiolytic, cytotoxic and thrombolytic potentials of the different extracts of Kalanchoe pinnata leaves
creatorMd. Razibul Habib ; Mohammad Mustakim Billah ; Mohammad Mahfuz-E-Alam ; Kashfia Nawrin ; Md. Rakibul Hasan ; Md. Mominur Rahman ; Md. Anisul Islam ; Irfan Newaz Khan
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subjectKalanchoe Pinnata ; Writhing ; Formalin ; Open Field ; Hole Cross ; Anxiolytic ; Lethality ; Thrombolysis ; Pharmacy, Therapeutics, & Pharmacology
descriptionObjective: To evaluate the analgesic, neuropharmacological, cytotoxic and thrombolytic potentials of the aqueous, ethanol and ethyl acetate extracts of Kalanchoe pinnata leaves. Methods: At the dose of 400 mg/kg body weight, the analgesic activity of the extracts were evaluated by the acetic acid-induced writhing and formalin-induced persistent pain tests while neuropharmacological activity was evaluated by the open field, hole cross and elevated plus maze tests. The cytotoxic potential was observed by brine shrimp lethality bioassay and the thrombolytic potential was investigated by clot lysis test. Results: The aqueous extract significantly suppressed the number of writhing (96.78%) as well as the formalin-induced persistent pain on the early phase (46.92%) and on the late phase (40.98%). Again in case of hole cross and open field tests, the locomotor activity was decreased significantly (P < 0.001) mostly by the ethyl acetate extract. Furthermore, the sedative-anxiolytic activity was supported by the increased percent (P < 0.01) of frequency into the open arm on elevated plus maze test. Besides, the extracts showed moderate lethality and thrombolytic activity. Conclusions: The findings showed that activities are comparable to the standards and in some cases are stronger than the standards. Therefore, based on the results, it is evident that it has great analgesic and sedative-anxiolytic activity with moderate cytotoxic and thrombolytic potential.
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titleEvaluation of the analgesic, sedative-anxiolytic, cytotoxic and thrombolytic potentials of the different extracts of Kalanchoe pinnata leaves
description

Objective: To evaluate the analgesic, neuropharmacological, cytotoxic and thrombolytic potentials of the aqueous, ethanol and ethyl acetate extracts of Kalanchoe pinnata leaves. Methods: At the dose of 400 mg/kg body weight, the analgesic activity of the extracts were evaluated by the acetic acid-induced writhing and formalin-induced persistent pain tests while neuropharmacological activity was evaluated by the open field, hole cross and elevated plus maze tests. The cytotoxic potential was observed by brine shrimp lethality bioassay and the thrombolytic potential was investigated by clot lysis test. Results: The aqueous extract significantly suppressed the number of writhing (96.78%) as well as the formalin-induced persistent pain on the early phase (46.92%) and on the late phase (40.98%). Again in case of hole cross and open field tests, the locomotor activity was decreased significantly (P < 0.001) mostly by the ethyl acetate extract. Furthermore, the sedative-anxiolytic activity was supported by the increased percent (P < 0.01) of frequency into the open arm on elevated plus maze test. Besides, the extracts showed moderate lethality and thrombolytic activity. Conclusions: The findings showed that activities are comparable to the standards and in some cases are stronger than the standards. Therefore, based on the results, it is evident that it has great analgesic and sedative-anxiolytic activity with moderate cytotoxic and thrombolytic potential.

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Objective: To evaluate the analgesic, neuropharmacological, cytotoxic and thrombolytic potentials of the aqueous, ethanol and ethyl acetate extracts of Kalanchoe pinnata leaves. Methods: At the dose of 400 mg/kg body weight, the analgesic activity of the extracts were evaluated by the acetic acid-induced writhing and formalin-induced persistent pain tests while neuropharmacological activity was evaluated by the open field, hole cross and elevated plus maze tests. The cytotoxic potential was observed by brine shrimp lethality bioassay and the thrombolytic potential was investigated by clot lysis test. Results: The aqueous extract significantly suppressed the number of writhing (96.78%) as well as the formalin-induced persistent pain on the early phase (46.92%) and on the late phase (40.98%). Again in case of hole cross and open field tests, the locomotor activity was decreased significantly (P < 0.001) mostly by the ethyl acetate extract. Furthermore, the sedative-anxiolytic activity was supported by the increased percent (P < 0.01) of frequency into the open arm on elevated plus maze test. Besides, the extracts showed moderate lethality and thrombolytic activity. Conclusions: The findings showed that activities are comparable to the standards and in some cases are stronger than the standards. Therefore, based on the results, it is evident that it has great analgesic and sedative-anxiolytic activity with moderate cytotoxic and thrombolytic potential.

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