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Suppression of corneal epithelial choline acetyltransferase activity by lid closure

Unilateral lid closure lowered corneal epithelial choline acetyltransferase activity in eyes that grossly and histologically appeared normal. This effect on choline acetyltransferase activity was relatively specific and not the result of a generalized depression of metabolism since thymidine, uridin... Full description

Journal Title: Experimental Eye Research 1978, Vol.27(3), pp.359-364
Main Author: Mindel, Joel S
Other Authors: Mittag, Thomas W
Format: Electronic Article Electronic Article
Language: English
Subjects:
Eye
Eye
ID: ISSN: 0014-4835 ; E-ISSN: 1096-0007 ; DOI: 10.1016/0014-4835(78)90170-7
Link: http://dx.doi.org/10.1016/0014-4835(78)90170-7
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recordid: elsevier_sdoi_10_1016_0014_4835_78_90170_7
title: Suppression of corneal epithelial choline acetyltransferase activity by lid closure
format: Article
creator:
  • Mindel, Joel S
  • Mittag, Thomas W
subjects:
  • Choline Acetyltransferase
  • Eye
  • Ocular
  • Cornea
  • Epithelium
  • Blepharorrhaphy
  • Cholinergic
  • Choline Acetyltransferase
  • Eye
  • Ocular
  • Cornea
  • Epithelium
  • Blepharorrhaphy
  • Cholinergic
  • Medicine
  • Anatomy & Physiology
ispartof: Experimental Eye Research, 1978, Vol.27(3), pp.359-364
description: Unilateral lid closure lowered corneal epithelial choline acetyltransferase activity in eyes that grossly and histologically appeared normal. This effect on choline acetyltransferase activity was relatively specific and not the result of a generalized depression of metabolism since thymidine, uridine, leucine, and alanine incorporation rates into corneal epithelium were not significantly altered. Lactic dehydrogenase activity was not depressed. Decreased choline acetyltransferase activity was present 24 hr after lid closure and was maximum by the eighth day of lid closure. Recovery of enzyme activity after re-opening the lids required more than four weeks.
language: eng
source:
identifier: ISSN: 0014-4835 ; E-ISSN: 1096-0007 ; DOI: 10.1016/0014-4835(78)90170-7
fulltext: fulltext
issn:
  • 0014-4835
  • 00144835
  • 1096-0007
  • 10960007
url: Link


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titleSuppression of corneal epithelial choline acetyltransferase activity by lid closure
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subjectCholine Acetyltransferase ; Eye ; Ocular ; Cornea ; Epithelium ; Blepharorrhaphy ; Cholinergic ; Choline Acetyltransferase ; Eye ; Ocular ; Cornea ; Epithelium ; Blepharorrhaphy ; Cholinergic ; Medicine ; Anatomy & Physiology
descriptionUnilateral lid closure lowered corneal epithelial choline acetyltransferase activity in eyes that grossly and histologically appeared normal. This effect on choline acetyltransferase activity was relatively specific and not the result of a generalized depression of metabolism since thymidine, uridine, leucine, and alanine incorporation rates into corneal epithelium were not significantly altered. Lactic dehydrogenase activity was not depressed. Decreased choline acetyltransferase activity was present 24 hr after lid closure and was maximum by the eighth day of lid closure. Recovery of enzyme activity after re-opening the lids required more than four weeks.
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Unilateral lid closure lowered corneal epithelial choline acetyltransferase activity in eyes that grossly and histologically appeared normal. This effect on choline acetyltransferase activity was relatively specific and not the result of a generalized depression of metabolism since thymidine, uridine, leucine, and alanine incorporation rates into corneal epithelium were not significantly altered. Lactic dehydrogenase activity was not depressed. Decreased choline acetyltransferase activity was present 24 hr after lid closure and was maximum by the eighth day of lid closure. Recovery of enzyme activity after re-opening the lids required more than four weeks.

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atitleSuppression of corneal epithelial choline acetyltransferase activity by lid closure
jtitleExperimental Eye Research
date1978
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volume27
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pages359-364
issn0014-4835
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abstract

Unilateral lid closure lowered corneal epithelial choline acetyltransferase activity in eyes that grossly and histologically appeared normal. This effect on choline acetyltransferase activity was relatively specific and not the result of a generalized depression of metabolism since thymidine, uridine, leucine, and alanine incorporation rates into corneal epithelium were not significantly altered. Lactic dehydrogenase activity was not depressed. Decreased choline acetyltransferase activity was present 24 hr after lid closure and was maximum by the eighth day of lid closure. Recovery of enzyme activity after re-opening the lids required more than four weeks.

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lad01Experimental Eye Research