Vaccination of pigs against pseudorabies with highly attenuated vaccinia (NYVAC) recombinant viruses
| Journal Title: | Veterinary microbiology 1993, Vol.38(1), pp.41-58 |
| Main Author: | Brockmeier, Susan L |
| Other Authors: | Lager, Kelly M , Tartaglia, James , Riviere, Michel , Paoletti, Enzo , Mengeling, William L |
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 Electronic Article
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English |
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| ID: | ISSN: 0378-1135 ; E-ISSN: 1873-2542 ; DOI: 10.1016/0378-1135(93)90074-H |
| Link: | http://dx.doi.org/10.1016/0378-1135(93)90074-H |
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| recordid: | elsevier_sdoi_10_1016_0378_1135_93_90074_H |
| title: | Vaccination of pigs against pseudorabies with highly attenuated vaccinia (NYVAC) recombinant viruses |
| format: | Article |
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| ispartof: | Veterinary microbiology, 1993, Vol.38(1), pp.41-58 |
| description: | Poxvirus recombinants, based on the highly attenuated NYVAC strain of vaccinia virus (Tartaglia et al., 1992), containing single gene inserts encoding the pseudorabies virus (PRV) gII, gIII, or gp50 glycoproteins were tested for their immunogenicity in pigs. Twenty-four pigs were randomly divided into six groups of four. Groups 1–3 were inoculated with 10 7 CCID 50 of NYVAC/PRV gII, NYVAC/PRV gIII, or NYVAC/PRV gp50, respectively, while groups 4 and 4 received the NYVAC parent virus or an inactivated PRV vaccine control, respectively. Group 6 represented the sham vaccinated control group. All inoculations were given by the intramuscular route on weeks 0 and 4. The candidate vaccines were shown to be safe with no local or systemic reactions. At 4 weeks following the second inoculation, all pigs were challenged by an oronasal administration of a virulent PRV strain. Pigs were monitored before and after challenge for clinical manifestations resulting from vaccination and challenge... |
| language: | eng |
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| identifier: | ISSN: 0378-1135 ; E-ISSN: 1873-2542 ; DOI: 10.1016/0378-1135(93)90074-H |
| fulltext: | fulltext |
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| url: | Link |
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