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Vaccination of pigs against pseudorabies with highly attenuated vaccinia (NYVAC) recombinant viruses

Poxvirus recombinants, based on the highly attenuated NYVAC strain of vaccinia virus (Tartaglia et al., 1992), containing single gene inserts encoding the pseudorabies virus (PRV) gII, gIII, or gp50 glycoproteins were tested for their immunogenicity in pigs. Twenty-four pigs were randomly divided in... Full description

Journal Title: Veterinary microbiology 1993, Vol.38(1), pp.41-58
Main Author: Brockmeier, Susan L
Other Authors: Lager, Kelly M , Tartaglia, James , Riviere, Michel , Paoletti, Enzo , Mengeling, William L
Format: Electronic Article Electronic Article
Language: English
Subjects:
Pig
Pig
ID: ISSN: 0378-1135 ; E-ISSN: 1873-2542 ; DOI: 10.1016/0378-1135(93)90074-H
Link: https://dx.doi.org/10.1016/0378-1135(93)90074-H
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recordid: elsevier_sdoi_10_1016_0378_1135_93_90074_H
title: Vaccination of pigs against pseudorabies with highly attenuated vaccinia (NYVAC) recombinant viruses
format: Article
creator:
  • Brockmeier, Susan L
  • Lager, Kelly M
  • Tartaglia, James
  • Riviere, Michel
  • Paoletti, Enzo
  • Mengeling, William L
subjects:
  • Pseudorabies Virus
  • Pig
  • Vaccination
  • Pseudorabies Virus
  • Pig
  • Vaccination
  • Biology
  • Veterinary Medicine
ispartof: Veterinary microbiology, 1993, Vol.38(1), pp.41-58
description: Poxvirus recombinants, based on the highly attenuated NYVAC strain of vaccinia virus (Tartaglia et al., 1992), containing single gene inserts encoding the pseudorabies virus (PRV) gII, gIII, or gp50 glycoproteins were tested for their immunogenicity in pigs. Twenty-four pigs were randomly divided into six groups of four. Groups 1–3 were inoculated with 10 7 CCID 50 of NYVAC/PRV gII, NYVAC/PRV gIII, or NYVAC/PRV gp50, respectively, while groups 4 and 4 received the NYVAC parent virus or an inactivated PRV vaccine control, respectively. Group 6 represented the sham vaccinated control group. All inoculations were given by the intramuscular route on weeks 0 and 4. The candidate vaccines were shown to be safe with no local or systemic reactions. At 4 weeks following the second inoculation, all pigs were challenged by an oronasal administration of a virulent PRV strain. Pigs were monitored before and after challenge for clinical manifestations resulting from vaccination and challenge...
language: eng
source:
identifier: ISSN: 0378-1135 ; E-ISSN: 1873-2542 ; DOI: 10.1016/0378-1135(93)90074-H
fulltext: fulltext
issn:
  • 0378-1135
  • 03781135
  • 1873-2542
  • 18732542
url: Link


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titleVaccination of pigs against pseudorabies with highly attenuated vaccinia (NYVAC) recombinant viruses
creatorBrockmeier, Susan L ; Lager, Kelly M ; Tartaglia, James ; Riviere, Michel ; Paoletti, Enzo ; Mengeling, William L
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identifier
subjectPseudorabies Virus ; Pig ; Vaccination ; Pseudorabies Virus ; Pig ; Vaccination ; Biology ; Veterinary Medicine
descriptionPoxvirus recombinants, based on the highly attenuated NYVAC strain of vaccinia virus (Tartaglia et al., 1992), containing single gene inserts encoding the pseudorabies virus (PRV) gII, gIII, or gp50 glycoproteins were tested for their immunogenicity in pigs. Twenty-four pigs were randomly divided into six groups of four. Groups 1–3 were inoculated with 10 7 CCID 50 of NYVAC/PRV gII, NYVAC/PRV gIII, or NYVAC/PRV gp50, respectively, while groups 4 and 4 received the NYVAC parent virus or an inactivated PRV vaccine control, respectively. Group 6 represented the sham vaccinated control group. All inoculations were given by the intramuscular route on weeks 0 and 4. The candidate vaccines were shown to be safe with no local or systemic reactions. At 4 weeks following the second inoculation, all pigs were challenged by an oronasal administration of a virulent PRV strain. Pigs were monitored before and after challenge for clinical manifestations resulting from vaccination and challenge...
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Poxvirus recombinants, based on the highly attenuated NYVAC strain of vaccinia virus (Tartaglia et al., 1992), containing single gene inserts encoding the pseudorabies virus (PRV) gII, gIII, or gp50 glycoproteins were tested for their immunogenicity in pigs. Twenty-four pigs were randomly divided into six groups of four. Groups 1–3 were inoculated with 10 7 CCID 50 of NYVAC/PRV gII, NYVAC/PRV gIII, or NYVAC/PRV gp50, respectively, while groups 4 and 4 received the NYVAC parent virus or an inactivated PRV vaccine control, respectively. Group 6 represented the sham vaccinated control group. All inoculations were given by the intramuscular route on weeks 0 and 4. The candidate vaccines were shown to be safe with no local or systemic reactions. At 4 weeks following the second inoculation, all pigs were challenged by an oronasal administration of a virulent PRV strain. Pigs were monitored before and after challenge for clinical manifestations resulting from vaccination and challenge...

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Poxvirus recombinants, based on the highly attenuated NYVAC strain of vaccinia virus (Tartaglia et al., 1992), containing single gene inserts encoding the pseudorabies virus (PRV) gII, gIII, or gp50 glycoproteins were tested for their immunogenicity in pigs. Twenty-four pigs were randomly divided into six groups of four. Groups 1–3 were inoculated with 10 7 CCID 50 of NYVAC/PRV gII, NYVAC/PRV gIII, or NYVAC/PRV gp50, respectively, while groups 4 and 4 received the NYVAC parent virus or an inactivated PRV vaccine control, respectively. Group 6 represented the sham vaccinated control group. All inoculations were given by the intramuscular route on weeks 0 and 4. The candidate vaccines were shown to be safe with no local or systemic reactions. At 4 weeks following the second inoculation, all pigs were challenged by an oronasal administration of a virulent PRV strain. Pigs were monitored before and after challenge for clinical manifestations resulting from vaccination and challenge...

pubElsevier B.V
doi10.1016/0378-1135(93)90074-H
lad01Veterinary microbiology