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Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma

Purpose Some patients with chronic asthma develop irreversible airflow obstruction. Our aim was to assess whether reported duration of asthma and induced sputum cell counts were associated with pulmonary function in patients with asthma who did not smoke. Subjects and methods Maximal forced expirato... Full description

Journal Title: The American Journal of Medicine 15 April 2002, Vol.112(6), pp.446-452
Main Author: Little, Stuart A
Other Authors: Macleod, Kirsten J , Chalmers, George W , Love, Janet G , Mcsharry, Charles , Thomson, Neil C
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-9343 ; E-ISSN: 1555-7162 ; DOI: 10.1016/S0002-9343(02)01047-1
Link: https://www.sciencedirect.com/science/article/pii/S0002934302010471
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recordid: elsevier_sdoi_10_1016_S0002_9343_02_01047_1
title: Association of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma
format: Article
creator:
  • Little, Stuart A
  • Macleod, Kirsten J
  • Chalmers, George W
  • Love, Janet G
  • Mcsharry, Charles
  • Thomson, Neil C
subjects:
  • Chronic Asthma
  • Irreversible Airflow Obstruction
  • Induced Sputum Neutrophils
  • Medicine
ispartof: The American Journal of Medicine, 15 April 2002, Vol.112(6), pp.446-452
description: Purpose Some patients with chronic asthma develop irreversible airflow obstruction. Our aim was to assess whether reported duration of asthma and induced sputum cell counts were associated with pulmonary function in patients with asthma who did not smoke. Subjects and methods Maximal forced expiratory volume in the first second (FEV 1 ) was determined following a steroid trial (oral prednisolone, 30 mg/d [n = 92 patients]; or inhaled fluticasone, 2000 μg/d [n = 5]; for 2 weeks) and 2.5 mg of nebulized albuterol. Asthma history was recorded with duration from first diagnosis. All subjects were nonsmokers, or were to have stopped smoking ≥5 years previously and smoked ≤5 pack-years (n = 12). Induced sputum was obtained from 59 subjects for analysis of airway cell counts. Results Maximal FEV 1 was inversely associated with asthma duration ( r = −0.47, P
language: eng
source:
identifier: ISSN: 0002-9343 ; E-ISSN: 1555-7162 ; DOI: 10.1016/S0002-9343(02)01047-1
fulltext: fulltext
issn:
  • 0002-9343
  • 00029343
  • 1555-7162
  • 15557162
url: Link


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titleAssociation of forced expiratory volume with disease duration and sputum neutrophils in chronic asthma
creatorLittle, Stuart A ; Macleod, Kirsten J ; Chalmers, George W ; Love, Janet G ; Mcsharry, Charles ; Thomson, Neil C
ispartofThe American Journal of Medicine, 15 April 2002, Vol.112(6), pp.446-452
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subjectChronic Asthma ; Irreversible Airflow Obstruction ; Induced Sputum Neutrophils ; Medicine
languageeng
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descriptionPurpose Some patients with chronic asthma develop irreversible airflow obstruction. Our aim was to assess whether reported duration of asthma and induced sputum cell counts were associated with pulmonary function in patients with asthma who did not smoke. Subjects and methods Maximal forced expiratory volume in the first second (FEV 1 ) was determined following a steroid trial (oral prednisolone, 30 mg/d [n = 92 patients]; or inhaled fluticasone, 2000 μg/d [n = 5]; for 2 weeks) and 2.5 mg of nebulized albuterol. Asthma history was recorded with duration from first diagnosis. All subjects were nonsmokers, or were to have stopped smoking ≥5 years previously and smoked ≤5 pack-years (n = 12). Induced sputum was obtained from 59 subjects for analysis of airway cell counts. Results Maximal FEV 1 was inversely associated with asthma duration ( r = −0.47, P <0.0001), age ( r = −0.40, P <0.0001), and the proportion of sputum neutrophils ( r s = −0.50, P = 0.00004). After adjusting for age, both duration of disease and sputum neutrophils were independently associated with maximal FEV 1 . Neutrophil activation, as measured by sputum myeloperoxidase levels, was positively associated with the proportion of sputum neutrophils ( r s = 0.45, P = 0.0004) and inversely associated with maximal FEV 1 ( r s = −0.59, P <0.0001). Conclusion Long disease duration may be a predisposing factor for the development of irreversible airflow obstruction in patients with chronic asthma. The negative associations of sputum neutrophil count and activation with maximal FEV 1 suggest that neutrophils may be involved in the pathophysiology of irreversible airflow obstruction in asthma.
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