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Effect of fluoxetine on contractile activity of pregnant rat uterine rings

We sought to compare the effects of fluoxetine, imipramine, and nortriptyline on spontaneous and serotonin-activated contractile activity of the uterine rings from midterm and term pregnant rats. Uterine rings from timed-pregnant Sprague-Dawley rats on day 14 (midgestation) and day 22 (term gestatio... Full description

Journal Title: American Journal of Obstetrics and Gynecology 2000, Vol.182(2), pp.296-299
Main Author: Vedernikov, Yuri
Other Authors: Bolanos, Sandra , Bytautiene, Egle , Fulep, Eva , Saade, George R , Garfield, Robert E
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-9378 ; E-ISSN: 1097-6868 ; DOI: 10.1016/S0002-9378(00)70214-6
Link: https://www.sciencedirect.com/science/article/pii/S0002937800702146
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recordid: elsevier_sdoi_10_1016_S0002_9378_00_70214_6
title: Effect of fluoxetine on contractile activity of pregnant rat uterine rings
format: Article
creator:
  • Vedernikov, Yuri
  • Bolanos, Sandra
  • Bytautiene, Egle
  • Fulep, Eva
  • Saade, George R
  • Garfield, Robert E
subjects:
  • Fluoxetine
  • Imipramine
  • Nortriptyline
  • Serotonin
  • Myometrium
  • Pregnancy
  • Medicine
ispartof: American Journal of Obstetrics and Gynecology, 2000, Vol.182(2), pp.296-299
description: We sought to compare the effects of fluoxetine, imipramine, and nortriptyline on spontaneous and serotonin-activated contractile activity of the uterine rings from midterm and term pregnant rats. Uterine rings from timed-pregnant Sprague-Dawley rats on day 14 (midgestation) and day 22 (term gestation) were used for isometric tension recording. Responses to cumulative concentrations of fluoxetine, imipramine, nortriptyline, and serotonin in the absence and presence of the monoamine reuptake inhibitors were studied. Neither of the monoamine reuptake inhibitors significantly influenced spontaneous contractile activity, whereas the concentration-dependent increase in activity induced by serotonin was inhibited in rings from both midterm and term pregnant rats. The reported increase in preterm delivery in women receiving fluoxetine during the third trimester cannot be explained by a...
language: eng
source:
identifier: ISSN: 0002-9378 ; E-ISSN: 1097-6868 ; DOI: 10.1016/S0002-9378(00)70214-6
fulltext: fulltext
issn:
  • 0002-9378
  • 00029378
  • 1097-6868
  • 10976868
url: Link


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titleEffect of fluoxetine on contractile activity of pregnant rat uterine rings
creatorVedernikov, Yuri ; Bolanos, Sandra ; Bytautiene, Egle ; Fulep, Eva ; Saade, George R ; Garfield, Robert E
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descriptionWe sought to compare the effects of fluoxetine, imipramine, and nortriptyline on spontaneous and serotonin-activated contractile activity of the uterine rings from midterm and term pregnant rats. Uterine rings from timed-pregnant Sprague-Dawley rats on day 14 (midgestation) and day 22 (term gestation) were used for isometric tension recording. Responses to cumulative concentrations of fluoxetine, imipramine, nortriptyline, and serotonin in the absence and presence of the monoamine reuptake inhibitors were studied. Neither of the monoamine reuptake inhibitors significantly influenced spontaneous contractile activity, whereas the concentration-dependent increase in activity induced by serotonin was inhibited in rings from both midterm and term pregnant rats. The reported increase in preterm delivery in women receiving fluoxetine during the third trimester cannot be explained by a...
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