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Schizophrenia: refining the phenotype, resolving endophenotypes

The conceptual history of the diagnosis of schizophrenia is reviewed and the current definition of the illness is examined (e.g. DSM-IV). A dimensional alternative to the traditional categorical model of diagnosis is discussed with a specific emphasis on the four dimensions of psychopathology repres... Full description

Journal Title: Behaviour Research and Therapy 1999, Vol.37(3), pp.281-295
Main Author: Lenzenweger, Mark F
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0005-7967 ; E-ISSN: 1873-622X ; DOI: 10.1016/S0005-7967(98)00138-7
Link: http://dx.doi.org/10.1016/S0005-7967(98)00138-7
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recordid: elsevier_sdoi_10_1016_S0005_7967_98_00138_7
title: Schizophrenia: refining the phenotype, resolving endophenotypes
format: Article
creator:
  • Lenzenweger, Mark F
subjects:
  • Medicine
  • Psychology
ispartof: Behaviour Research and Therapy, 1999, Vol.37(3), pp.281-295
description: The conceptual history of the diagnosis of schizophrenia is reviewed and the current definition of the illness is examined (e.g. DSM-IV). A dimensional alternative to the traditional categorical model of diagnosis is discussed with a specific emphasis on the four dimensions of psychopathology represented by reality distortion (hallucinations, delusions), disorganization (positive formal thought disorder, bizarre behavior), negative symptoms (flattened affect, avolition, alogia, asociality), and premorbid social functioning. Also discussed is the development of structured psychiatric interviews that emerged from the clinical/research context that gave rise to explicit (i.e. operational) diagnostic criteria for schizophrenia. The general methodological approach used to detect valid endophenotypes for schizophrenia liability—i.e. indicators of liability not visible to the unaided naked eye—as well as their potential diagnostic and research utility is presented in overview. The rationale...
language: eng
source:
identifier: ISSN: 0005-7967 ; E-ISSN: 1873-622X ; DOI: 10.1016/S0005-7967(98)00138-7
fulltext: fulltext
issn:
  • 0005-7967
  • 00057967
  • 1873-622X
  • 1873622X
url: Link


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descriptionThe conceptual history of the diagnosis of schizophrenia is reviewed and the current definition of the illness is examined (e.g. DSM-IV). A dimensional alternative to the traditional categorical model of diagnosis is discussed with a specific emphasis on the four dimensions of psychopathology represented by reality distortion (hallucinations, delusions), disorganization (positive formal thought disorder, bizarre behavior), negative symptoms (flattened affect, avolition, alogia, asociality), and premorbid social functioning. Also discussed is the development of structured psychiatric interviews that emerged from the clinical/research context that gave rise to explicit (i.e. operational) diagnostic criteria for schizophrenia. The general methodological approach used to detect valid endophenotypes for schizophrenia liability—i.e. indicators of liability not visible to the unaided naked eye—as well as their potential diagnostic and research utility is presented in overview. The rationale...
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The conceptual history of the diagnosis of schizophrenia is reviewed and the current definition of the illness is examined (e.g. DSM-IV). A dimensional alternative to the traditional categorical model of diagnosis is discussed with a specific emphasis on the four dimensions of psychopathology represented by reality distortion (hallucinations, delusions), disorganization (positive formal thought disorder, bizarre behavior), negative symptoms (flattened affect, avolition, alogia, asociality), and premorbid social functioning. Also discussed is the development of structured psychiatric interviews that emerged from the clinical/research context that gave rise to explicit (i.e. operational) diagnostic criteria for schizophrenia. The general methodological approach used to detect valid endophenotypes for schizophrenia liability—i.e. indicators of liability not visible to the unaided naked eye—as well as their potential diagnostic and research utility is presented in overview. The rationale...

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