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Why do so many clinical trials of therapies for Alzheimer's disease fail?

Alzheimer's disease is an irreversible, progressive brain disorder that accounts for about 50-75% of all cases of dementia.1 Alzheimer's disease is characterised by the presence of amyloid plaques (amyloid β) and neurofibrillary (tau) tangles, plus the loss of connections between neurons in the brai... Full description

Journal Title: The Lancet 25 November 2017, Vol.390(10110), pp.2327-2329
Main Author: Anderson, Roy M
Other Authors: Hadjichrysanthou, Christoforos , Evans, Stephanie , Wong, Mei Mei
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0140-6736 ; E-ISSN: 1474-547X ; DOI: 10.1016/S0140-6736(17)32399-1
Link: https://www.sciencedirect.com/science/article/pii/S0140673617323991
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recordid: elsevier_sdoi_10_1016_S0140_6736_17_32399_1
title: Why do so many clinical trials of therapies for Alzheimer's disease fail?
format: Article
creator:
  • Anderson, Roy M
  • Hadjichrysanthou, Christoforos
  • Evans, Stephanie
  • Wong, Mei Mei
subjects:
  • Medicine
ispartof: The Lancet, 25 November 2017, Vol.390(10110), pp.2327-2329
description: Alzheimer's disease is an irreversible, progressive brain disorder that accounts for about 50-75% of all cases of dementia.1 Alzheimer's disease is characterised by the presence of amyloid plaques (amyloid β) and neurofibrillary (tau) tangles, plus the loss of connections between neurons in the brain....
language: eng
source:
identifier: ISSN: 0140-6736 ; E-ISSN: 1474-547X ; DOI: 10.1016/S0140-6736(17)32399-1
fulltext: fulltext
issn:
  • 0140-6736
  • 01406736
  • 1474-547X
  • 1474547X
url: Link


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titleWhy do so many clinical trials of therapies for Alzheimer's disease fail?
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