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Plasma fibroblast growth factor 23, parathyroid hormone, phosphorus, and risk of coronary heart disease

Fibroblast growth factor 23 (FGF23), parathyroid hormone (PTH), and phosphorus all have been proposed as plasma biomarkers for the development of coronary heart disease (CHD) in individuals with normal renal function. In a nested case-control study of men in the Health Professionals Follow-up Study,... Full description

Journal Title: American Heart Journal 2011, Vol.161(5), pp.956-962
Main Author: Taylor, Eric N
Other Authors: Rimm, Eric B , Stampfer, Meir J , Curhan, Gary C
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-8703 ; E-ISSN: 1097-6744 ; DOI: 10.1016/j.ahj.2011.02.012
Link: https://www.sciencedirect.com/science/article/pii/S0002870311001657
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title: Plasma fibroblast growth factor 23, parathyroid hormone, phosphorus, and risk of coronary heart disease
format: Article
creator:
  • Taylor, Eric N
  • Rimm, Eric B
  • Stampfer, Meir J
  • Curhan, Gary C
subjects:
  • Medicine
ispartof: American Heart Journal, 2011, Vol.161(5), pp.956-962
description: Fibroblast growth factor 23 (FGF23), parathyroid hormone (PTH), and phosphorus all have been proposed as plasma biomarkers for the development of coronary heart disease (CHD) in individuals with normal renal function. In a nested case-control study of men in the Health Professionals Follow-up Study, free of diagnosed cardiovascular disease at blood draw, we prospectively examined associations between plasma FGF23, PTH, and phosphorus and risk of CHD. During 10 years of follow-up, 422 men developed nonfatal myocardial infarction or fatal CHD. Controls were selected in a 2:1 ratio and matched for age, date of blood collection, and smoking status. Mean estimated glomerular filtration rate was 86 mL/min per 1.73 m in cases and controls. At baseline, there were no statistically significant differences between cases and controls in plasma levels of FGF23, PTH, or phosphorus. After adjusting for matching factors, family history...
language: eng
source:
identifier: ISSN: 0002-8703 ; E-ISSN: 1097-6744 ; DOI: 10.1016/j.ahj.2011.02.012
fulltext: fulltext
issn:
  • 0002-8703
  • 00028703
  • 1097-6744
  • 10976744
url: Link


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descriptionFibroblast growth factor 23 (FGF23), parathyroid hormone (PTH), and phosphorus all have been proposed as plasma biomarkers for the development of coronary heart disease (CHD) in individuals with normal renal function. In a nested case-control study of men in the Health Professionals Follow-up Study, free of diagnosed cardiovascular disease at blood draw, we prospectively examined associations between plasma FGF23, PTH, and phosphorus and risk of CHD. During 10 years of follow-up, 422 men developed nonfatal myocardial infarction or fatal CHD. Controls were selected in a 2:1 ratio and matched for age, date of blood collection, and smoking status. Mean estimated glomerular filtration rate was 86 mL/min per 1.73 m in cases and controls. At baseline, there were no statistically significant differences between cases and controls in plasma levels of FGF23, PTH, or phosphorus. After adjusting for matching factors, family history...
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