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Dietary macronutrients, genetic variation, and progression of coronary atherosclerosis among women

Previous studies observed the surprising finding that saturated fat was inversely associated with atherosclerosis progression in postmenopausal women, whereas polyunsaturated fat (PUFA) and carbohydrates were positively associated. Whether certain genes modify the association of diet with atheroscle... Full description

Journal Title: American Heart Journal April 2014, Vol.167(4), pp.627-635.e1
Main Author: Kalantarian, Shadi
Other Authors: Rimm, Eric B , Herrington, David M , Mozaffarian, Dariush
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-8703 ; E-ISSN: 1097-6744 ; DOI: 10.1016/j.ahj.2014.01.001
Link: https://www.sciencedirect.com/science/article/pii/S0002870314000179
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recordid: elsevier_sdoi_10_1016_j_ahj_2014_01_001
title: Dietary macronutrients, genetic variation, and progression of coronary atherosclerosis among women
format: Article
creator:
  • Kalantarian, Shadi
  • Rimm, Eric B
  • Herrington, David M
  • Mozaffarian, Dariush
subjects:
  • Medicine
ispartof: American Heart Journal, April 2014, Vol.167(4), pp.627-635.e1
description: Previous studies observed the surprising finding that saturated fat was inversely associated with atherosclerosis progression in postmenopausal women, whereas polyunsaturated fat (PUFA) and carbohydrates were positively associated. Whether certain genes modify the association of diet with atherosclerotic progression is unknown. Using Haplotype-tagging single nucleotide polymorphisms, we evaluated gene-diet interactions with 3 preselected genes involved in fatty acid and carbohydrate metabolism: sterol regulatory element binding protein-1 ( ), insulin-induced gene-1 ( ), and SREBP cleavage-activating protein ( ). Diet was assessed at baseline. Quantitative coronary angiography was performed at baseline and after a mean of follow-up of 3.09 years in 2,227 coronary segments in 234 postmenopausal women. Global effects of each gene and gene-diet interactions for different fats, total fat,...
language: eng
source:
identifier: ISSN: 0002-8703 ; E-ISSN: 1097-6744 ; DOI: 10.1016/j.ahj.2014.01.001
fulltext: fulltext
issn:
  • 0002-8703
  • 00028703
  • 1097-6744
  • 10976744
url: Link


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descriptionPrevious studies observed the surprising finding that saturated fat was inversely associated with atherosclerosis progression in postmenopausal women, whereas polyunsaturated fat (PUFA) and carbohydrates were positively associated. Whether certain genes modify the association of diet with atherosclerotic progression is unknown. Using Haplotype-tagging single nucleotide polymorphisms, we evaluated gene-diet interactions with 3 preselected genes involved in fatty acid and carbohydrate metabolism: sterol regulatory element binding protein-1 ( ), insulin-induced gene-1 ( ), and SREBP cleavage-activating protein ( ). Diet was assessed at baseline. Quantitative coronary angiography was performed at baseline and after a mean of follow-up of 3.09 years in 2,227 coronary segments in 234 postmenopausal women. Global effects of each gene and gene-diet interactions for different fats, total fat,...
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