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One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I

We aimed to prospectively derive and validate a novel 0-/1-hour algorithm using high-sensitivity cardiac troponin I (hs-cTnI) for the early “rule-out” and “rule-in” of acute myocardial infarction (AMI). In a prospective multicenter diagnostic study, we enrolled 1,500 patients presenting with suspect... Full description

Journal Title: American Heart Journal January 2016, Vol.171(1), pp.92-102.e5
Main Author: Jaeger, Cedric
Other Authors: Wildi, Karin , Twerenbold, Raphael , Reichlin, Tobias , Rubini Gimenez, Maria , Neuhaus, Jean-Daniel , Grimm, Karin , Boeddinghaus, Jasper , Hillinger, Petra , Nestelberger, Thomas , Singeisen, Helene , Gugala, Mathias , Pretre, Gil , Puelacher, Christian , Wagener, Max , Honegger, Ursina , Schumacher, Carmela , Moreno Weidmann, Zoraida , Kreutzinger, Philipp , Krivoshei, Lian
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0002-8703 ; E-ISSN: 1097-6744 ; DOI: 10.1016/j.ahj.2015.07.022
Link: http://dx.doi.org/10.1016/j.ahj.2015.07.022
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recordid: elsevier_sdoi_10_1016_j_ahj_2015_07_022
title: One-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I
format: Article
creator:
  • Jaeger, Cedric
  • Wildi, Karin
  • Twerenbold, Raphael
  • Reichlin, Tobias
  • Rubini Gimenez, Maria
  • Neuhaus, Jean-Daniel
  • Grimm, Karin
  • Boeddinghaus, Jasper
  • Hillinger, Petra
  • Nestelberger, Thomas
  • Singeisen, Helene
  • Gugala, Mathias
  • Pretre, Gil
  • Puelacher, Christian
  • Wagener, Max
  • Honegger, Ursina
  • Schumacher, Carmela
  • Moreno Weidmann, Zoraida
  • Kreutzinger, Philipp
  • Krivoshei, Lian
subjects:
  • Medicine
ispartof: American Heart Journal, January 2016, Vol.171(1), pp.92-102.e5
description: We aimed to prospectively derive and validate a novel 0-/1-hour algorithm using high-sensitivity cardiac troponin I (hs-cTnI) for the early “rule-out” and “rule-in” of acute myocardial infarction (AMI). In a prospective multicenter diagnostic study, we enrolled 1,500 patients presenting with suspected AMI to the emergency department. The final diagnosis was centrally adjudicated by 2 independent cardiologists blinded to hs-cTnI concentrations. The hs-cTnI (Siemens Vista) 0-/1-hour algorithm incorporated measurements performed at baseline and absolute changes within 1 hour, was derived in the first 750 patients (derivation cohort), and then validated in the second 750 (validation cohort). Overall, AMI was the final diagnosis in 16% of patients. Applying the hs-cTnI 0-/1-hour algorithm developed in the derivation cohort to the validation cohort, 57% of patients could be classified as “rule-out”; 10%, as “rule-in”; and 33%, as “observe.” In the...
language: eng
source:
identifier: ISSN: 0002-8703 ; E-ISSN: 1097-6744 ; DOI: 10.1016/j.ahj.2015.07.022
fulltext: fulltext
issn:
  • 0002-8703
  • 00028703
  • 1097-6744
  • 10976744
url: Link


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titleOne-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I
creatorJaeger, Cedric ; Wildi, Karin ; Twerenbold, Raphael ; Reichlin, Tobias ; Rubini Gimenez, Maria ; Neuhaus, Jean-Daniel ; Grimm, Karin ; Boeddinghaus, Jasper ; Hillinger, Petra ; Nestelberger, Thomas ; Singeisen, Helene ; Gugala, Mathias ; Pretre, Gil ; Puelacher, Christian ; Wagener, Max ; Honegger, Ursina ; Schumacher, Carmela ; Moreno Weidmann, Zoraida ; Kreutzinger, Philipp ; Krivoshei, Lian
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descriptionWe aimed to prospectively derive and validate a novel 0-/1-hour algorithm using high-sensitivity cardiac troponin I (hs-cTnI) for the early “rule-out” and “rule-in” of acute myocardial infarction (AMI). In a prospective multicenter diagnostic study, we enrolled 1,500 patients presenting with suspected AMI to the emergency department. The final diagnosis was centrally adjudicated by 2 independent cardiologists blinded to hs-cTnI concentrations. The hs-cTnI (Siemens Vista) 0-/1-hour algorithm incorporated measurements performed at baseline and absolute changes within 1 hour, was derived in the first 750 patients (derivation cohort), and then validated in the second 750 (validation cohort). Overall, AMI was the final diagnosis in 16% of patients. Applying the hs-cTnI 0-/1-hour algorithm developed in the derivation cohort to the validation cohort, 57% of patients could be classified as “rule-out”; 10%, as “rule-in”; and 33%, as “observe.” In the...
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titleOne-hour rule-in and rule-out of acute myocardial infarction using high-sensitivity cardiac troponin I
description

We aimed to prospectively derive and validate a novel 0-/1-hour algorithm using high-sensitivity cardiac troponin I (hs-cTnI) for the early “rule-out” and “rule-in” of acute myocardial infarction (AMI).

In a prospective multicenter diagnostic study, we enrolled 1,500 patients presenting with suspected AMI to the emergency department. The final diagnosis was centrally adjudicated by 2 independent cardiologists blinded to hs-cTnI concentrations. The hs-cTnI (Siemens Vista) 0-/1-hour algorithm incorporated measurements performed at baseline and absolute changes within 1 hour, was derived in the first 750 patients (derivation cohort), and then validated in the second 750 (validation cohort).

Overall, AMI was the final diagnosis in 16% of patients. Applying the hs-cTnI 0-/1-hour algorithm developed in the derivation cohort to the validation cohort, 57% of patients could be classified as “rule-out”; 10%, as “rule-in”; and 33%, as “observe.” In the...

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abstract

We aimed to prospectively derive and validate a novel 0-/1-hour algorithm using high-sensitivity cardiac troponin I (hs-cTnI) for the early “rule-out” and “rule-in” of acute myocardial infarction (AMI).

In a prospective multicenter diagnostic study, we enrolled 1,500 patients presenting with suspected AMI to the emergency department. The final diagnosis was centrally adjudicated by 2 independent cardiologists blinded to hs-cTnI concentrations. The hs-cTnI (Siemens Vista) 0-/1-hour algorithm incorporated measurements performed at baseline and absolute changes within 1 hour, was derived in the first 750 patients (derivation cohort), and then validated in the second 750 (validation cohort).

Overall, AMI was the final diagnosis in 16% of patients. Applying the hs-cTnI 0-/1-hour algorithm developed in the derivation cohort to the validation cohort, 57% of patients could be classified as “rule-out”; 10%, as “rule-in”; and 33%, as “observe.” In the...

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date2016-01