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Autoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial

Elevated levels of lipoprotein(a) [Lp(a)] and oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) predict the progression of pre-existing mild-to-moderate calcific aortic valve stenosis (CAVS). Whether indirect markers of oxidation-specific epitopes (OSE) are also predictive is not known. The... Full description

Journal Title: Atherosclerosis May 2017, Vol.260, pp.1-7
Main Author: Capoulade, Romain
Other Authors: Chan, Kwan L , Mathieu, Patrick , Bossé, Yohan , Dumesnil, Jean G , Tam, James W , Teo, Koon K , Yang, Xiaohong , Witztum, Joseph L , Arsenault, Benoit J , Després, Jean-Pierre , Pibarot, Philippe , Tsimikas, Sotirios
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0021-9150 ; E-ISSN: 1879-1484 ; DOI: 10.1016/j.atherosclerosis.2017.03.013
Link: https://www.sciencedirect.com/science/article/pii/S002191501730103X
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recordid: elsevier_sdoi_10_1016_j_atherosclerosis_2017_03_013
title: Autoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial
format: Article
creator:
  • Capoulade, Romain
  • Chan, Kwan L
  • Mathieu, Patrick
  • Bossé, Yohan
  • Dumesnil, Jean G
  • Tam, James W
  • Teo, Koon K
  • Yang, Xiaohong
  • Witztum, Joseph L
  • Arsenault, Benoit J
  • Després, Jean-Pierre
  • Pibarot, Philippe
  • Tsimikas, Sotirios
subjects:
  • Aortic Stenosis
  • Calcific Aortic Valve Stenosis
  • Oxidation-Specific Biomarkers
  • Lipoprotein(a)
  • Doppler Echocardiography
  • Medicine
ispartof: Atherosclerosis, May 2017, Vol.260, pp.1-7
description: Elevated levels of lipoprotein(a) [Lp(a)] and oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) predict the progression of pre-existing mild-to-moderate calcific aortic valve stenosis (CAVS). Whether indirect markers of oxidation-specific epitopes (OSE) are also predictive is not known. The association between IgG and IgM autoantibodies and malondialdehyde-modified low density lipoprotein (MDA-LDL) and IgG and IgM apolipoprotein B immune complexes (apoB-IC), and the hemodynamic progression rate of CAVS was determined in the ASTRONOMER (Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin, NCT00800800) trial. Plasma levels of IgG and IgM MDA-LDL and apoB-IC were measured in 220 patients with mild-to-moderate CAVS from the ASTRONOMER trial. The endpoint of this study was the progression rate of CAVS, measured by the annualized increase in peak aortic jet velocity (V ) over a median follow-up...
language: eng
source:
identifier: ISSN: 0021-9150 ; E-ISSN: 1879-1484 ; DOI: 10.1016/j.atherosclerosis.2017.03.013
fulltext: fulltext
issn:
  • 0021-9150
  • 00219150
  • 1879-1484
  • 18791484
url: Link


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titleAutoantibodies and immune complexes to oxidation-specific epitopes and progression of aortic stenosis: Results from the ASTRONOMER trial
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subjectAortic Stenosis ; Calcific Aortic Valve Stenosis ; Oxidation-Specific Biomarkers ; Lipoprotein(a) ; Doppler Echocardiography ; Medicine
descriptionElevated levels of lipoprotein(a) [Lp(a)] and oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) predict the progression of pre-existing mild-to-moderate calcific aortic valve stenosis (CAVS). Whether indirect markers of oxidation-specific epitopes (OSE) are also predictive is not known. The association between IgG and IgM autoantibodies and malondialdehyde-modified low density lipoprotein (MDA-LDL) and IgG and IgM apolipoprotein B immune complexes (apoB-IC), and the hemodynamic progression rate of CAVS was determined in the ASTRONOMER (Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin, NCT00800800) trial. Plasma levels of IgG and IgM MDA-LDL and apoB-IC were measured in 220 patients with mild-to-moderate CAVS from the ASTRONOMER trial. The endpoint of this study was the progression rate of CAVS, measured by the annualized increase in peak aortic jet velocity (V ) over a median follow-up...
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