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Effects of pergolide mesylate on transduction efficiency of PEP-1-catalase protein

► We studied effects of pergolide mesylate (PM) on in vitro and in vivo transduction of PEP-1-catalase. ► PEP-1-catatase inhibited 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. ► PM enhanced the transduction of PEP-1-catalase into HaCaT cells and skin tissue. ► PM increased anti-... Full description

Journal Title: Biochemical and Biophysical Research Communications 2011, Vol.406(3), pp.336-340
Main Author: Sohn, Eun Jeong
Other Authors: Kim, Dae Won , Kim, Young Nam , Kim, So Mi , Lim, Soon Sung , Kang, Tae-Cheon , Kwon, Hyeok Yil , Kim, Duk-Soo , Cho, Sung-Woo , Han, Kyu Hyung , Park, Jinseu , Eum, Won Sik , Hwang, Hyun Sook , Choi, Soo Young
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2011.02.038
Link: http://dx.doi.org/10.1016/j.bbrc.2011.02.038
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recordid: elsevier_sdoi_10_1016_j_bbrc_2011_02_038
title: Effects of pergolide mesylate on transduction efficiency of PEP-1-catalase protein
format: Article
creator:
  • Sohn, Eun Jeong
  • Kim, Dae Won
  • Kim, Young Nam
  • Kim, So Mi
  • Lim, Soon Sung
  • Kang, Tae-Cheon
  • Kwon, Hyeok Yil
  • Kim, Duk-Soo
  • Cho, Sung-Woo
  • Han, Kyu Hyung
  • Park, Jinseu
  • Eum, Won Sik
  • Hwang, Hyun Sook
  • Choi, Soo Young
subjects:
  • Pergolide Mesylate
  • Inflammation
  • PEP-1-Catalase
  • Protein Transduction
  • Pergolide Mesylate
  • Inflammation
  • PEP-1-Catalase
  • Protein Transduction
  • Biology
  • Chemistry
  • Anatomy & Physiology
ispartof: Biochemical and Biophysical Research Communications, 2011, Vol.406(3), pp.336-340
description: ► We studied effects of pergolide mesylate (PM) on in vitro and in vivo transduction of PEP-1-catalase. ► PEP-1-catatase inhibited 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. ► PM enhanced the transduction of PEP-1-catalase into HaCaT cells and skin tissue. ► PM increased anti-inflammatory activity of PEP-1-catalase. ► PM stimulated therapeutic action of anti-oxidant enzyme catalase in oxidative-related diseases. The low transduction efficiency of various proteins is an obstacle to their therapeutic application. However, protein transduction domains (PTDs) are well-known for a highly effective tool for exogenous protein delivery to cells. We examined the effects of pergolide mesylate (PM) on the transduction of PEP-1-catalase into HaCaT human keratinocytes and mice skin and on the anti-inflammatory activity of PEP-1-catatase against 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation using Western blot and...
language: eng
source:
identifier: ISSN: 0006-291X ; E-ISSN: 1090-2104 ; DOI: 10.1016/j.bbrc.2011.02.038
fulltext: fulltext
issn:
  • 0006-291X
  • 0006291X
  • 1090-2104
  • 10902104
url: Link


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titleEffects of pergolide mesylate on transduction efficiency of PEP-1-catalase protein
creatorSohn, Eun Jeong ; Kim, Dae Won ; Kim, Young Nam ; Kim, So Mi ; Lim, Soon Sung ; Kang, Tae-Cheon ; Kwon, Hyeok Yil ; Kim, Duk-Soo ; Cho, Sung-Woo ; Han, Kyu Hyung ; Park, Jinseu ; Eum, Won Sik ; Hwang, Hyun Sook ; Choi, Soo Young
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subjectPergolide Mesylate ; Inflammation ; PEP-1-Catalase ; Protein Transduction ; Pergolide Mesylate ; Inflammation ; PEP-1-Catalase ; Protein Transduction ; Biology ; Chemistry ; Anatomy & Physiology
description► We studied effects of pergolide mesylate (PM) on in vitro and in vivo transduction of PEP-1-catalase. ► PEP-1-catatase inhibited 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. ► PM enhanced the transduction of PEP-1-catalase into HaCaT cells and skin tissue. ► PM increased anti-inflammatory activity of PEP-1-catalase. ► PM stimulated therapeutic action of anti-oxidant enzyme catalase in oxidative-related diseases. The low transduction efficiency of various proteins is an obstacle to their therapeutic application. However, protein transduction domains (PTDs) are well-known for a highly effective tool for exogenous protein delivery to cells. We examined the effects of pergolide mesylate (PM) on the transduction of PEP-1-catalase into HaCaT human keratinocytes and mice skin and on the anti-inflammatory activity of PEP-1-catatase against 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation using Western blot and...
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► We studied effects of pergolide mesylate (PM) on in vitro and in vivo transduction of PEP-1-catalase. ► PEP-1-catatase inhibited 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. ► PM enhanced the transduction of PEP-1-catalase into HaCaT cells and skin tissue. ► PM increased anti-inflammatory activity of PEP-1-catalase. ► PM stimulated therapeutic action of anti-oxidant enzyme catalase in oxidative-related diseases.

The low transduction efficiency of various proteins is an obstacle to their therapeutic application. However, protein transduction domains (PTDs) are well-known for a highly effective tool for exogenous protein delivery to cells. We examined the effects of pergolide mesylate (PM) on the transduction of PEP-1-catalase into HaCaT human keratinocytes and mice skin and on the anti-inflammatory activity of PEP-1-catatase against 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation using Western blot and...

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► We studied effects of pergolide mesylate (PM) on in vitro and in vivo transduction of PEP-1-catalase. ► PEP-1-catatase inhibited 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation. ► PM enhanced the transduction of PEP-1-catalase into HaCaT cells and skin tissue. ► PM increased anti-inflammatory activity of PEP-1-catalase. ► PM stimulated therapeutic action of anti-oxidant enzyme catalase in oxidative-related diseases.

The low transduction efficiency of various proteins is an obstacle to their therapeutic application. However, protein transduction domains (PTDs) are well-known for a highly effective tool for exogenous protein delivery to cells. We examined the effects of pergolide mesylate (PM) on the transduction of PEP-1-catalase into HaCaT human keratinocytes and mice skin and on the anti-inflammatory activity of PEP-1-catatase against 12- O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation using Western blot and...

pubElsevier Inc
doi10.1016/j.bbrc.2011.02.038
lad01Biochemical and Biophysical Research Communications
date2011-03-18